LOCUS       NM_053465               2151 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus fucosyltransferase 9 (Fut9), mRNA.
ACCESSION   NM_053465
VERSION     NM_053465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Chen,J., Zeng,X., Zhang,W., Li,G., Zhong,H., Xu,C., Li,X. and
            Lin,T.
  TITLE     Fucosyltransferase 9 promotes neuronal differentiation and
            functional recovery after spinal cord injury by suppressing the
            activation of Notch signaling
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1571-1581 (2023)
   PUBMED   37674364
  REMARK    GeneRIF: Fucosyltransferase 9 promotes neuronal differentiation and
            functional recovery after spinal cord injury by suppressing the
            activation of Notch signaling.
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Buffone,A. Jr., Mondal,N., Gupta,R., McHugh,K.P., Lau,J.T. and
            Neelamegham,S.
  TITLE     Silencing alpha1,3-fucosyltransferases in human leukocytes reveals
            a role for FUT9 enzyme during E-selectin-mediated cell adhesion
  JOURNAL   J Biol Chem 288 (3), 1620-1633 (2013)
   PUBMED   23192350
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Gouveia,R., Schaffer,L., Papp,S., Grammel,N., Kandzia,S.,
            Head,S.R., Kleene,R., Schachner,M., Conradt,H.S. and Costa,J.
  TITLE     Expression of glycogenes in differentiating human NT2N neurons.
            Downregulation of fucosyltransferase 9 leads to decreased Lewis(x)
            levels and impaired neurite outgrowth
  JOURNAL   Biochim Biophys Acta 1820 (12), 2007-2019 (2012)
   PUBMED   23000574
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Brito,C., Kandzia,S., Graca,T., Conradt,H.S. and Costa,J.
  TITLE     Human fucosyltransferase IX: specificity towards N-linked
            glycoproteins and relevance of the cytoplasmic domain in
            intra-Golgi localization
  JOURNAL   Biochimie 90 (9), 1279-1290 (2008)
   PUBMED   18395013
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Brito,C., Escrevente,C., Reis,C.A., Lee,V.M., Trojanowski,J.Q. and
            Costa,J.
  TITLE     Increased levels of fucosyltransferase IX and carbohydrate Lewis(x)
            adhesion determinant in human NT2N neurons
  JOURNAL   J Neurosci Res 85 (6), 1260-1270 (2007)
   PUBMED   17335083
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Toivonen,S., Nishihara,S., Narimatsu,H., Renkonen,O. and
            Renkonen,R.
  TITLE     Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct
            acceptor- and site-specificity profile
  JOURNAL   Glycobiology 12 (6), 361-368 (2002)
   PUBMED   12107078
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Shimoda,Y., Tajima,Y., Osanai,T., Katsume,A., Kohara,M., Kudo,T.,
            Narimatsu,H., Takashima,N., Ishii,Y., Nakamura,S., Osumi,N. and
            Sanai,Y.
  TITLE     Pax6 controls the expression of Lewis x epitope in the embryonic
            forebrain by regulating alpha 1,3-fucosyltransferase IX expression
  JOURNAL   J Biol Chem 277 (3), 2033-2039 (2002)
   PUBMED   11675393
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Nakayama,F., Nishihara,S., Iwasaki,H., Kudo,T., Okubo,R.,
            Kaneko,M., Nakamura,M., Karube,M., Sasaki,K. and Narimatsu,H.
  TITLE     CD15 expression in mature granulocytes is determined by alpha
            1,3-fucosyltransferase IX, but in promyelocytes and monocytes by
            alpha 1,3-fucosyltransferase IV
  JOURNAL   J Biol Chem 276 (19), 16100-16106 (2001)
   PUBMED   11278338
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   Baboval,T., Henion,T., Kinnally,E. and Smith,F.I.
  TITLE     Molecular cloning of rat alpha1,3-fucosyltransferase IX (Fuc-TIX)
            and comparison of the expression of Fuc-TIV and Fuc-TIX genes
            during rat postnatal cerebellum development
  JOURNAL   J Neurosci Res 62 (2), 206-215 (2000)
   PUBMED   11020213
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Nishihara,S., Iwasaki,H., Kaneko,M., Tawada,A., Ito,M. and
            Narimatsu,H.
  TITLE     Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially
            fucosylates the distal GlcNAc residue of polylactosamine chain
            while the other four alpha1,3FUT members preferentially fucosylate
            the inner GlcNAc residue
  JOURNAL   FEBS Lett 462 (3), 289-294 (1999)
   PUBMED   10622713
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053465.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049819.1, SRR26643298.26729.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000005.1  44360957-44361209   c
            254-338             JAXUCZ010000005.1  44252849-44252933   c
            339-2151            JAXUCZ010000005.1  44158300-44160112   c
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..2151
                     /gene="Fut9"
                     /note="fucosyltransferase 9"
                     /db_xref="GeneID:84597"
                     /db_xref="RGD:619955"
     exon            1..253
                     /gene="Fut9"
                     /inference="alignment:Splign:2.1.0"
     exon            254..338
                     /gene="Fut9"
                     /inference="alignment:Splign:2.1.0"
     exon            339..2151
                     /gene="Fut9"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1426
                     /gene="Fut9"
                     /EC_number="2.4.1.152"
                     /note="fuc-TIX; fucT-IX; fucosyltransferase 9 (alpha (1,3)
                     fucosyltransferase); fucosyltransferase IX; galactoside
                     3-L-fucosyltransferase; alpha-(1,3)-fucosyltransferase 9"
                     /codon_start=1
                     /product="4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase 9"
                     /protein_id="NP_445917.1"
                     /db_xref="GeneID:84597"
                     /db_xref="RGD:619955"
                     /translation="MTSTSKGILRPFLIVCIILGCFVACLLIYIKPTNSWVFSPMESA
                     SSVLKMKNFFSRKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNK
                     SHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRR
                     DSDIQVPYGFLTVSTSPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTY
                     GQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSREN
                     YENYIPADSFIHVEDFNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHA
                     CLACDHVKRHQEYKSVGNLEKWFWN"
ORIGIN      
        1 cctgtctgct ctgggcagcg gcaacctcgg cagccgggga gatgggaaga gagcgcgcgg
       61 ggcgctgcac ctctggagcc gccgatcttt cctactccgg ttccctgagc ccccgccgcc
      121 actctcgccc cctggctacc caccgattcc cgctacgctg ctaggacagc gccgccgtca
      181 ccgccagccc tcgtcccgcc cgcgcctctc tgccctcacg cgccctggat ggagctttcc
      241 cttgctggga tcgatttaga atgtgataag tcaagtatct gaacacagtg gagtagttca
      301 acactcatct cagctttcca tgatatgttc tctaccgtga aaaattatga cctcaacatc
      361 caaaggcatt cttcgcccat ttctaatcgt ctgcattatc ctgggctgct tcgtggcatg
      421 tctacttatc tacatcaagc ccaccaacag ctgggtcttc agtccaatgg agtctgcaag
      481 ctctgtgctg aaaatgaaaa atttcttctc caggaaaact gattatttta atgaaactac
      541 tattctggtt tgggtgtggc catttgggca gacctttgac cttacatcct gccaagccat
      601 gttcaacatc caagggtgcc atctcacaac ggaccgctcg ttgtacaaca aatcccatgc
      661 ggtcctgata caccacagag acatcagctg ggatctgact aacttacctc agcaggccag
      721 gccgcccttt cagaaatgga tttggatgaa cttagagtca cccactcaca ccccccaaaa
      781 gagtggcatt gagcacttgt tcaacctgac tctaacttat cgccgtgatt cagatataca
      841 agtgccttac ggcttcttga cggtgagcac aagccccttt gtgtttgaag tgccaagcaa
      901 agagaagtta gtgtgctggg ttgtgagtaa ctggaatccc gagcatgcca gggtcaagta
      961 ttacaacgag ctcagcaaga gtattgaaat ccacacctat gggcaagcat ttggagaata
     1021 tgtgaatgat aaaaatctga ttcccaccat atctacttgt aaattttatc tttcctttga
     1081 aaactcaatt cacaaagatt acatcacaga aaagctctac aatgcatttt tggctggttc
     1141 ggtacctgtt gtcctgggac catctaggga aaactatgag aattatattc cagctgattc
     1201 attcattcat gtggaagatt ttaactcacc cagtgagttg gcaaaatatc tgaaggaggt
     1261 tgacaaaaac aataagttat atcttagtta cttcaactgg aggaaggatt ttactgtaaa
     1321 cctcccacgg ttttgggaat cacatgcatg cctggcatgc gatcatgtaa aaaggcatca
     1381 agaatataag tctgttggca atttagagaa atggttttgg aattaaaatg tccatcatcg
     1441 tcacagtgaa atagattaat gagacaccat tcaagtgttc aggataagaa gaaacacgct
     1501 gcatttgggt cacagtttat ttttcctgct ctcccttgag gaccatgtat attttgatga
     1561 aatttttaag agaccagaat cagcaaatca ctcaatttgg ttttaaatta tcctgtatat
     1621 atgtgataac aagcactgga aataatttat tcatcattct catttgtgaa gcattctgtt
     1681 tttacatttt atagttgact gtaaagtaag tttgtgattt aattgtttcc acatcaatca
     1741 gatctttcat ctacttggga aatgaaaata catattctaa aatatgaagg actctttgcc
     1801 aagtgttatg aaatttagat tctaacttgt ataatgctaa caaaaaagga ttattgaacc
     1861 acttaattct taatctctct gacttcagag ctgaacacta ctcacaattg atgtaggttt
     1921 tacctgtacc atgtttgtga tggtggacta attgatgtag tgaagaagaa aggcaggaag
     1981 cagaaatgtt agtagactcc acactcattt tcattaagtt gttttacaaa tgcagatctc
     2041 aatattttaa gttaaagaaa gcaagaaata caatttatgt ggttggggga ggctgtttgt
     2101 tttgtttttg tttttttttt tttttgccta ataatacatg agagaatctt c
//
