LOCUS       NM_001412189            3001 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus fucosyltransferase 8 (Fut8), transcript variant
            2, mRNA.
ACCESSION   NM_001412189 XM_008764825
VERSION     NM_001412189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Kurimoto,A., Kitazume,S., Kizuka,Y., Nakajima,K., Oka,R.,
            Fujinawa,R., Korekane,H., Yamaguchi,Y., Wada,Y. and Taniguchi,N.
  TITLE     The absence of core fucose up-regulates GnT-III and Wnt target
            genes: a possible mechanism for an adaptive response in terms of
            glycan function
  JOURNAL   J Biol Chem 289 (17), 11704-11714 (2014)
   PUBMED   24619415
REFERENCE   2  (bases 1 to 3001)
  AUTHORS   Teylaert,B., Meurice,E., Bobowski,M., Harduin-Lepers,A.,
            Gaucher,C., Fontayne,A., Jorieux,S. and Delannoy,P.
  TITLE     Molecular cloning, characterization, genomic organization and
            promoter analysis of the alpha1,6-fucosyltransferase gene (fut8)
            expressed in the rat hybridoma cell line YB2/0
  JOURNAL   BMC Biotechnol 11, 1 (2011)
   PUBMED   21208406
  REMARK    GeneRIF: The cDNAs encoding the rat alpha1,6-fucosyltransferase
            (FucT VIII) were cloned from YB2/0 cells by polymerase chain
            reaction-based and 5' RNA-Ligase-Mediated RACE methods.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3001)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3001)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 3001)
  AUTHORS   Ihara,H., Ikeda,Y., Toma,S., Wang,X., Suzuki,T., Gu,J., Miyoshi,E.,
            Tsukihara,T., Honke,K., Matsumoto,A., Nakagawa,A. and Taniguchi,N.
  TITLE     Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8
  JOURNAL   Glycobiology 17 (5), 455-466 (2007)
   PUBMED   17172260
REFERENCE   6  (bases 1 to 3001)
  AUTHORS   Zhao,Y., Itoh,S., Wang,X., Isaji,T., Miyoshi,E., Kariya,Y.,
            Miyazaki,K., Kawasaki,N., Taniguchi,N. and Gu,J.
  TITLE     Deletion of core fucosylation on alpha3beta1 integrin
            down-regulates its functions
  JOURNAL   J Biol Chem 281 (50), 38343-38350 (2006)
   PUBMED   17043354
REFERENCE   7  (bases 1 to 3001)
  AUTHORS   Wang,X., Inoue,S., Gu,J., Miyoshi,E., Noda,K., Li,W.,
            Mizuno-Horikawa,Y., Nakano,M., Asahi,M., Takahashi,M., Uozumi,N.,
            Ihara,S., Lee,S.H., Ikeda,Y., Yamaguchi,Y., Aze,Y., Tomiyama,Y.,
            Fujii,J., Suzuki,K., Kondo,A., Shapiro,S.D., Lopez-Otin,C.,
            Kuwaki,T., Okabe,M., Honke,K. and Taniguchi,N.
  TITLE     Dysregulation of TGF-beta1 receptor activation leads to abnormal
            lung development and emphysema-like phenotype in core
            fucose-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (44), 15791-15796 (2005)
   PUBMED   16236725
REFERENCE   8  (bases 1 to 3001)
  AUTHORS   Hayashi,H., Yoneda,A., Asada,M., Ikekita,M. and Imamura,T.
  TITLE     Molecular cloning of mouse alpha-1,6-fucosyltransferase and
            expression of its mRNA in the developing cerebrum
  JOURNAL   DNA Seq 11 (1-2), 91-96 (2000)
   PUBMED   10902914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 23, 2022 this sequence version replaced XM_008764825.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN668936.1, SRR22582424.2196626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000006.1  101683288-101683476
            190-284             JAXUCZ010000006.1  101712422-101712516
            285-377             JAXUCZ010000006.1  101757332-101757424
            378-805             JAXUCZ010000006.1  101771275-101771702
            806-921             JAXUCZ010000006.1  101809041-101809156
            922-1084            JAXUCZ010000006.1  101809266-101809428
            1085-1199           JAXUCZ010000006.1  101829277-101829391
            1200-1437           JAXUCZ010000006.1  101848143-101848380
            1438-1684           JAXUCZ010000006.1  101884007-101884253
            1685-1861           JAXUCZ010000006.1  101885657-101885833
            1862-2012           JAXUCZ010000006.1  101897649-101897799
            2013-3001           JAXUCZ010000006.1  101908796-101909784
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3001
                     /gene="Fut8"
                     /note="fucosyltransferase 8"
                     /db_xref="GeneID:432392"
                     /db_xref="RGD:1303096"
     exon            1..189
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            190..284
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            285..377
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            378..805
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     CDS             603..2330
                     /gene="Fut8"
                     /EC_number="2.4.1.68"
                     /note="alpha1-6FucT; glycoprotein
                     6-alpha-L-fucosyltransferase; GDP-fucose--glycoprotein
                     fucosyltransferase;
                     GDP-L-Fuc:N-acetyl-beta-D-glucosaminide
                     alpha1,6-fucosyltransferase; fucosyltransferase 8 (alpha
                     (1,6) fucosyltransferase)"
                     /codon_start=1
                     /product="alpha-(1,6)-fucosyltransferase"
                     /protein_id="NP_001399118.1"
                     /db_xref="GeneID:432392"
                     /db_xref="RGD:1303096"
                     /translation="MRAWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELS
                     KILAKLERLKQQNEDLRRMAESLRIPEGPIDQGTATGRVRVLEEQLVKAKEQIENYKK
                     QARNGLGKDHEILRRRIENGAKELWFFLQSELKKLKHLEGNELQRHADEILLDLGHHE
                     RSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKARKLVCNINKGC
                     GYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWETVFRPVSETCTDRSGLSTGH
                     WSGEVNDKNIQVVELPIVDSLHPRPPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKY
                     LIRPQPWLEKEIEEATKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQL
                     LARRMQVDKKRVYLATDDPALLKEAKTKYSNYEFISDNSISWSAGLHNRYTENSLRGV
                     ILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQI
                     AVYPHKPRTDEEIPMEPGDIIGVAGNHWDGYSKGVNRKLGKTGLYPSYKVREKIETVK
                     YPTYPEAEK"
     exon            806..921
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1084
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1199
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1437
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1684
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1861
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2012
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..3001
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcagtggc gccgaaggct ccgttaagcg gcggccgcgg ttcctgtttc cgtttcttcc
       61 tctcccttca gtcgggagta gcatcctcca ccccagcacc cctcccactc tcccggcgcg
      121 gccagctgca gctgaaggca gcggctgtgg cgacggggga cggcgccgat cgcctcgctc
      181 ccgccgcggg ctgctgttct ggctgaggct gtctatggcc ctggtggtgt tttcatccaa
      241 gatcaagtcc tttccattat tatttattaa ctgaacagat tcagctaata atcttcaaga
      301 cccagatcca agcaataata cacttctctg cagtaccatg tggctttcct cagcatcctg
      361 agtctatggg aaggaagcat gtagaattca tgaagcacaa gactttaaag cttcctgcct
      421 gcatcaccag gaaaacttct ttgtaagagt cgccacagga ttaccagagg ttaacctgtt
      481 tgaagcatca tgtgttaaaa caacagaaac ctgttttctt gtgtggctaa ctagaaccag
      541 agcacaatgt ttccagttct ttgagctcca ggaagataga ggacagagtt gaaactctga
      601 aaatgcgggc atggactggt tcctggcgtt ggattatgct cattcttttt gcctggggga
      661 ccttgttgtt ttatataggt ggtcatttgg ttcgagataa tgaccaccct gatcactcta
      721 gcagagaact ctccaagatt cttgcaaagc ttgaacgctt aaaacaacaa aatgaagact
      781 tgaggcgaat ggctgagtct ctacgaatac cagaaggccc cattgaccag gggacggcta
      841 cgggaagagt ccgtgtttta gaagaacagc ttgttaaggc caaagaacag attgaaaatt
      901 acaagaaaca agccagaaat ggtctgggga aggatcatga aatcttaagg aggaggattg
      961 aaaatggagc taaagagctc tggttttttc tacaaagtga actgaagaaa ttaaagcatt
     1021 tagaaggaaa tgaactccaa agacatgcag atgaaattct tttggattta ggacaccatg
     1081 aaaggtctat catgacggat ctatactacc tcagtcaaac agatggagca ggggattggc
     1141 gtgaaaaaga ggccaaagat ctgacagagc tggtccagcg gagaataact tatctccaga
     1201 atcccaagga ctgcagcaaa gccaggaagc tggtgtgtaa catcaataag ggctgtggct
     1261 atggttgcca actccatcac gtggtctact gtttcatgat tgcttatggc acccagcgaa
     1321 cactcatctt ggaatctcag aattggcgct atgctactgg tggatgggag actgtgttta
     1381 gacctgtaag tgagacatgc acagacagat ctggcctctc cactggacac tggtcaggtg
     1441 aagtgaatga caaaaatatt caagtggtgg agctccccat tgtagacagc ctccatcctc
     1501 ggcctcctta cttaccactg gctgttccag aagaccttgc agatcgactc gtaagagtcc
     1561 atggtgatcc tgcagtgtgg tgggtgtccc agttcgtcaa atatttgatt cgtccacaac
     1621 cttggctaga aaaggaaata gaagaagcca ccaagaagct tggcttcaaa catccagtca
     1681 ttggagtcca tgtcagacgc acagacaaag tgggaacaga ggcagccttc catcccatcg
     1741 aagagtacat ggtacatgtt gaagaacatt ttcagcttct cgcacgcaga atgcaagtgg
     1801 ataaaaaaag agtatatctg gctaccgatg accctgcttt gttaaaggag gcaaagacaa
     1861 agtactccaa ttatgaattt attagtgata actctatttc ttggtcagct ggattacaca
     1921 atcggtacac agaaaattca cttcggggcg tgatcctgga tatacacttt ctctctcagg
     1981 ctgacttcct agtgtgtact ttttcatccc aggtctgtcg ggttgcttat gaaatcatgc
     2041 aaaccctgca tcctgatgcc tctgcaaact tccactcttt agatgacatc tactattttg
     2101 gaggccaaaa tgcccacaac cagattgccg tttatcctca caaacctcga actgatgagg
     2161 aaattccaat ggaacctgga gatatcattg gtgtggctgg aaaccattgg gatggttatt
     2221 ctaaaggtgt caacagaaaa cttggaaaaa caggcttata tccctcctac aaagtccgag
     2281 agaagataga aacagtcaag tatcccacat atcctgaagc tgaaaaatag agataaagta
     2341 gaagagatta accacagaac tcagttcaga ccatctcggc taagcagatg acccagacta
     2401 acacgtggtt cgttgacaga cacgctccac accaagaccg agtgggaacc ctcagatgct
     2461 gcactggtgg aatgcctcgt tatgaagggc tgcggtgccc tcaagcccat gcacagtaca
     2521 ataatgtact cacacataac atgcaaatgg attattttct actttgcccc tttaaatatt
     2581 atgtccccat taaacaaaca ctgccacgtt gtgtaattta agtgacacag acattttgtg
     2641 tgagacttaa aacatggtgc ctatatctga gagacctctg tgacttaccg agaagatgtg
     2701 aacagctccc ttctctgggg aagctagtgg tggtgtggcc actgaattca ctccagtcaa
     2761 caggttcaga acgagaatgg atgttttccc ttcatatggt tgtctggatt ttttttaaag
     2821 taatttcatc agttcagttt atccacctca tcattaataa atgaaggata catcaataaa
     2881 gtaaaatgaa atattcactc tccattagga agttttgtaa aacaatgcca tgaacaaatt
     2941 ctttagtact caatgtttct ggacattctc tttgataaca aaaataaatt ttaaaaagga
     3001 a
//
