LOCUS       NM_199491               2064 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus fucosyltransferase 7 (Fut7), mRNA.
ACCESSION   NM_199491 XM_231061
VERSION     NM_199491.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Zhang,J., Ju,N., Yang,X., Chen,L. and Yu,C.
  TITLE     The alpha1,3-fucosyltransferase FUT7 regulates IL-1beta-induced
            monocyte-endothelial adhesion via fucosylation of endomucin
  JOURNAL   Life Sci 192, 231-237 (2018)
   PUBMED   29138114
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Buffone,A. Jr., Mondal,N., Gupta,R., McHugh,K.P., Lau,J.T. and
            Neelamegham,S.
  TITLE     Silencing alpha1,3-fucosyltransferases in human leukocytes reveals
            a role for FUT9 enzyme during E-selectin-mediated cell adhesion
  JOURNAL   J Biol Chem 288 (3), 1620-1633 (2013)
   PUBMED   23192350
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2064)
  AUTHORS   Dudda,J.C., Perdue,N., Bachtanian,E. and Campbell,D.J.
  TITLE     Foxp3+ regulatory T cells maintain immune homeostasis in the skin
  JOURNAL   J Exp Med 205 (7), 1559-1565 (2008)
   PUBMED   18573908
REFERENCE   5  (bases 1 to 2064)
  AUTHORS   Liu,S., Zhang,Y., Liu,Y., Qin,H., Wang,X. and Yan,Q.
  TITLE     FUT7 antisense sequence inhibits the expression of FUT7/sLeX and
            adhesion between embryonic and uterine cells
  JOURNAL   IUBMB Life 60 (7), 461-466 (2008)
   PUBMED   18553500
REFERENCE   6  (bases 1 to 2064)
  AUTHORS   Stroud,M.R. and Holmes,E.H.
  TITLE     Fucosylation of complex glycosphingolipids by recombinant
            fucosyltransferase-VII
  JOURNAL   Biochem Biophys Res Commun 238 (1), 165-168 (1997)
   PUBMED   9299472
REFERENCE   7  (bases 1 to 2064)
  AUTHORS   Maly,P., Thall,A., Petryniak,B., Rogers,C.E., Smith,P.L.,
            Marks,R.M., Kelly,R.J., Gersten,K.M., Cheng,G., Saunders,T.L.,
            Camper,S.A., Camphausen,R.T., Sullivan,F.X., Isogai,Y.,
            Hindsgaul,O., von Andrian,U.H. and Lowe,J.B.
  TITLE     The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte
            trafficking through an essential role in L-, E-, and P-selectin
            ligand biosynthesis
  JOURNAL   Cell 86 (4), 643-653 (1996)
   PUBMED   8752218
REFERENCE   8  (bases 1 to 2064)
  AUTHORS   Knibbs,R.N., Craig,R.A., Natsuka,S., Chang,A., Cameron,M.,
            Lowe,J.B. and Stoolman,L.M.
  TITLE     The fucosyltransferase FucT-VII regulates E-selectin ligand
            synthesis in human T cells
  JOURNAL   J Cell Biol 133 (4), 911-920 (1996)
   PUBMED   8666674
REFERENCE   9  (bases 1 to 2064)
  AUTHORS   Smith,P.L., Gersten,K.M., Petryniak,B., Kelly,R.J., Rogers,C.,
            Natsuka,Y., Alford,J.A. 3rd, Scheidegger,E.P., Natsuka,S. and
            Lowe,J.B.
  TITLE     Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid
            aggregate high endothelial venules correlates with expression of
            L-selectin ligands
  JOURNAL   J Biol Chem 271 (14), 8250-8259 (1996)
   PUBMED   8626519
REFERENCE   10 (bases 1 to 2064)
  AUTHORS   Natsuka,S., Gersten,K.M., Zenita,K., Kannagi,R. and Lowe,J.B.
  TITLE     Molecular cloning of a cDNA encoding a novel human leukocyte
            alpha-1,3-fucosyltransferase capable of synthesizing the sialyl
            Lewis x determinant
  JOURNAL   J Biol Chem 269 (24), 16789-16794 (1994)
   PUBMED   8207002
  REMARK    Erratum:[J Biol Chem 1994 Aug 12;269(32):20806]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Jul 17, 2024 this sequence was replaced by
            NM_199491.3.
            
            On Nov 27, 2020 this sequence version replaced NM_199491.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            100 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ276068.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680426, SAMN06680428
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               JAXUCZ010000003.1  28637535-28637948
            415-501             JAXUCZ010000003.1  28638656-28638742
            502-2064            JAXUCZ010000003.1  28638845-28640407
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2064
                     /gene="Fut7"
                     /gene_synonym="Fuc-TVII; FucT-VII"
                     /note="fucosyltransferase 7"
                     /db_xref="GeneID:296564"
                     /db_xref="RGD:735019"
     exon            1..414
                     /gene="Fut7"
                     /gene_synonym="Fuc-TVII; FucT-VII"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1517
                     /gene="Fut7"
                     /gene_synonym="Fuc-TVII; FucT-VII"
                     /EC_number="2.4.1.-"
                     /note="alpha (1,3) fucosyltransferase; selectin ligand
                     synthase; galactoside 3-L-fucosyltransferase;
                     fucosyltransferase VII"
                     /codon_start=1
                     /product="alpha-(1,3)-fucosyltransferase 7"
                     /protein_id="NP_955785.1"
                     /db_xref="GeneID:296564"
                     /db_xref="RGD:735019"
                     /translation="MVQGCLCWRGCCDLKTSFPWVTNSRRLWMNCIGCNPVWRLRAWG
                     CLAGGTTLMVIWLFWLLRSVPGGAPAPQPTLTILIWHWPFTNRSPELSSDTCTRYGMA
                     SCHLSANRSLLASADAVVFHHRELQTRHSRLPLDQRPHGQPWVWATMESPSNTHGLRH
                     FRGIFNWVLSYRRDSDIFVPYGRLEPFSGPTPPLPAKSRMAAWVVSNFQERQQRAKLY
                     RQLAPHLKVDVFGRASGRPLCPNCLLPTVARYRFYLSFENSQHRDYITEKFWRNALAA
                     GAVPVVLGPPRTTYEAFVPPDAFIHVDDFSSARELAVFLVSMNESRYRGFFAWRDRLR
                     VRLLNDWRERFCTICARYPYLPRSQVYEDLESWFQA"
     exon            415..501
                     /gene="Fut7"
                     /gene_synonym="Fuc-TVII; FucT-VII"
                     /inference="alignment:Splign:2.1.0"
     exon            502..2064
                     /gene="Fut7"
                     /gene_synonym="Fuc-TVII; FucT-VII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctagtcc tggtcagcag agtaggggat ctggtggggc tggaggaagc ttggctaaag
       61 ctttgtacag gttccagctc tgggtgaccc tggcaggcta cctaccctgg tctgtgtcat
      121 tgcaccccca gagtgggagg cttggtaaag tggaggagaa ccttagctac aagctatagg
      181 ttagcccatc agagccagct ggagagaaac cagacaagtc caaacctgag actggtacta
      241 gcctttctgt tgctggagtg gaagccaacc cctgcctacc agcctgcctg tccacgtcag
      301 ggacacacag actccttccc tttccagact ggaaagcccc ctcctgggat agcaggaagg
      361 aggcaacctg caactcttcc tggcctggcc tttgggctga gcctatggtt caagggtgcc
      421 tctgttggag aggctgctgt gatttgaaaa cctcctttcc ctgggtgact aattccagaa
      481 ggctctggat gaattgtatt gggtgcaacc ccgtctggag gctgcgggcc tgggggtgtc
      541 tggctggagg tacaacactc atggtaatct ggctcttctg gctgctgcga tcagttcctg
      601 ggggtgcccc agcgccccag cccacactca ccatccttat ctggcactgg cctttcacca
      661 accggtcgcc agagctgtct agcgacacct gcactcgcta tggcatggcc agctgccacc
      721 tgagtgctaa ccggagtctg ctagccagtg ctgatgctgt ggtcttccac catcgtgagc
      781 tgcagacccg gcactctcgc ctgcccctgg accagaggcc gcacggacag ccttgggtct
      841 gggccaccat ggaatcaccc agtaataccc atggtctccg tcacttccgg ggcatcttca
      901 actgggtgct gagctatcgg cgtgattcag atatctttgt accctatggt cgcttagagc
      961 ccttctctgg gcctacgccc ccactaccag ccaaaagcag gatggctgcc tgggtggtca
     1021 gcaatttcca ggagcggcag cagcgggcaa agctgtaccg gcagctggcc cctcatctga
     1081 aggtggatgt gttcggtcgc gccagtggac ggcccctgtg ccctaactgt ctgctgccca
     1141 ctgtggcccg gtaccgcttc tacctgtcct ttgagaactc acagcaccgg gactacatca
     1201 ccgagaagtt ctggcgcaat gcactggccg ctggcgctgt gcctgtggtg ctgggacctc
     1261 ctcggactac ctacgaggct ttcgtgccac cagatgcctt tatacacgta gatgacttca
     1321 gctctgcccg tgaactagct gtcttccttg tcagcatgaa tgagagtcgc tatcgtggct
     1381 tctttgcttg gcgagaccgg ctccgtgtgc ggctcctgaa tgactggagg gagcgcttct
     1441 gcaccatctg cgcccgctac ccttacttgc cccgcagcca ggtctatgaa gacctggaaa
     1501 gctggttcca agcttgaact cctgctgctg ggagaggctg tgtgcgtgga agactgatga
     1561 tgaaatggaa gggcttttgg gtcaccatgg gactaaccct aggcttaggt cagtgaatag
     1621 gaagtcagga tatgaggaga aggctgggct gagaagccat atggatgagg actctggtgg
     1681 gctttagagt agggacccag ggaaggagac aattaatgag gagcgtgtgg gaaaagctag
     1741 tcaaacgggg aaagtggctg agggtcctgg acttaccttg agtatgctca tggctcaagg
     1801 ctcaggtgaa aaggggaggc agtgtctctg gagctgggag catccaaagc tgggatttgt
     1861 ggggacaaac atggtgccct gaacctccac aatcaaggtg cttagcctca gggatacagg
     1921 tgtgtgttcc agaactccac atgcaaactg tatgctgagc ccaggggttg tgggagaagg
     1981 atggtgtgga tgattctggg cctttgacac cacagttccc tgagggaaag aggcaccact
     2041 aataataaaa ttattcactt gtaa
//
