LOCUS       NM_022219               3962 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus fucosyltransferase 4 (Fut4), mRNA.
ACCESSION   NM_022219
VERSION     NM_022219.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3962)
  AUTHORS   Othman,E.R., Meligy,F.Y., Sayed,A.A., El-Mokhtar,M.A. and
            Refaiy,A.M.
  TITLE     Stem Cell Markers Describe a Transition From Somatic to Pluripotent
            Cell States in a Rat Model of Endometriosis
  JOURNAL   Reprod Sci 25 (6), 873-881 (2018)
   PUBMED   28325116
  REMARK    GeneRIF: Study shows that using a rat model of endometriosis,
            ectopic endometrium showed significantly higher Oct4 (POU5F1), and
            SSEA1, but similar Thy1 gene expression to that of control
            endometrium. This indicates increased transition from somatic to
            pluripotent cell states in ectopic endometrium which may play a
            role in endometriosis pathogenesis.
REFERENCE   2  (bases 1 to 3962)
  AUTHORS   Buffone,A. Jr., Mondal,N., Gupta,R., McHugh,K.P., Lau,J.T. and
            Neelamegham,S.
  TITLE     Silencing alpha1,3-fucosyltransferases in human leukocytes reveals
            a role for FUT9 enzyme during E-selectin-mediated cell adhesion
  JOURNAL   J Biol Chem 288 (3), 1620-1633 (2013)
   PUBMED   23192350
REFERENCE   3  (bases 1 to 3962)
  AUTHORS   Brito,C., Danglot,L., Galli,T. and Costa,J.
  TITLE     Subcellular localization of the carbohydrate Lewis(x) adhesion
            structure in hippocampus cell cultures
  JOURNAL   Brain Res 1287, 39-46 (2009)
   PUBMED   19576189
  REMARK    GeneRIF: The carbohydrate Le(x) epitope has been found in the
            tetanus neurotoxin insensitive vesicle-associated membrane protein
            (TI-VAMP) compartment of rat hippocampus neurons in culture, at 7
            days in vitro, when neurite extension is abundant.
REFERENCE   4  (bases 1 to 3962)
  AUTHORS   Siva,K. and Inamdar,M.S.
  TITLE     Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic
            stem cells and during embryonic erythropoiesis
  JOURNAL   Gene Expr Patterns 6 (2), 225-234 (2006)
   PUBMED   16099728
REFERENCE   5  (bases 1 to 3962)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 3962)
  AUTHORS   Shimoda,Y., Tajima,Y., Osanai,T., Katsume,A., Kohara,M., Kudo,T.,
            Narimatsu,H., Takashima,N., Ishii,Y., Nakamura,S., Osumi,N. and
            Sanai,Y.
  TITLE     Pax6 controls the expression of Lewis x epitope in the embryonic
            forebrain by regulating alpha 1,3-fucosyltransferase IX expression
  JOURNAL   J Biol Chem 277 (3), 2033-2039 (2002)
   PUBMED   11675393
REFERENCE   7  (bases 1 to 3962)
  AUTHORS   Nakayama,F., Nishihara,S., Iwasaki,H., Kudo,T., Okubo,R.,
            Kaneko,M., Nakamura,M., Karube,M., Sasaki,K. and Narimatsu,H.
  TITLE     CD15 expression in mature granulocytes is determined by alpha
            1,3-fucosyltransferase IX, but in promyelocytes and monocytes by
            alpha 1,3-fucosyltransferase IV
  JOURNAL   J Biol Chem 276 (19), 16100-16106 (2001)
   PUBMED   11278338
REFERENCE   8  (bases 1 to 3962)
  AUTHORS   Weninger,W., Ulfman,L.H., Cheng,G., Souchkova,N., Quackenbush,E.J.,
            Lowe,J.B. and von Andrian,U.H.
  TITLE     Specialized contributions by alpha(1,3)-fucosyltransferase-IV and
            FucT-VII during leukocyte rolling in dermal microvessels
  JOURNAL   Immunity 12 (6), 665-676 (2000)
   PUBMED   10894166
REFERENCE   9  (bases 1 to 3962)
  AUTHORS   Sajdel-Sulkowska,E.M., Smith,F.I., Wiederschain,G. and McCluer,R.H.
  TITLE     Cloning of a rat alpha1,3-fucosyltransferase gene: a member of the
            fucosyltransferase IV family
  JOURNAL   Glycoconj J 14 (2), 249-258 (1997)
   PUBMED   9111142
REFERENCE   10 (bases 1 to 3962)
  AUTHORS   Weston,B.W., Nair,R.P., Larsen,R.D. and Lowe,J.B.
  TITLE     Isolation of a novel human alpha (1,3)fucosyltransferase gene and
            molecular comparison to the human Lewis blood group alpha
            (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic
            genes encoding enzymes with distinct acceptor substrate
            specificities
  JOURNAL   J Biol Chem 267 (6), 4152-4160 (1992)
   PUBMED   1740457
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Oct 19, 2010 this sequence version replaced NM_022219.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC061776.1, SRR23984936.940716.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3962              JAXUCZ010000008.1  19868178-19872139   c
FEATURES             Location/Qualifiers
     source          1..3962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..3962
                     /gene="Fut4"
                     /gene_synonym="Fuct"
                     /note="fucosyltransferase 4"
                     /db_xref="GeneID:60670"
                     /db_xref="RGD:619954"
     exon            1..3962
                     /gene="Fut4"
                     /gene_synonym="Fuct"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1657
                     /gene="Fut4"
                     /gene_synonym="Fuct"
                     /EC_number="2.4.1.152"
                     /note="fuc-TIV; fucT-IV; fucosyltransferase IV;
                     galactoside 3-L-fucosyltransferase;
                     4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase; fucosyltransferase 4 (alpha
                     (1,3) fucosyltransferase, myeloid-specific); alpha
                     13-fucosyltransferase Fuc-T (similar to mouse Fut4); alpha
                     1,3-fucosyltransferase Fuc-T (similar to mouse Fut4)"
                     /codon_start=1
                     /product="alpha-(1,3)-fucosyltransferase 4"
                     /protein_id="NP_071555.3"
                     /db_xref="GeneID:60670"
                     /db_xref="RGD:619954"
                     /translation="MAPAGRKLQHESRCRPSRPVDAWRAAATTRGRCMGTPGARRRAR
                     RGGWGLPRTSSGLAAAGLLCTALTACLCWGQLPPLPWASPAPQRPVSVLLWWEPFGGR
                     GGHSKPPPDCSLRFNISGCRLLTDRAAYGEAQAVLFHHRDLVKGPPDWPPPWGAQERT
                     DEAPELRVFDDQEGAVMLAREALETTGSRPPGQRWVWMNFESPSHTPGLRGLAKDLFN
                     WTLSYRTDSDIFVPYGFLYPRSHPAEQPSGLGPPLARKRGLVAWVVSHWNERQARVRY
                     YHQLRRHVSVDVFGRAGPGQPVPAVGLLHTVARYKFYLAFENSQHVDYITEKLWRNAF
                     LAGAVPVVLGPDRANYERFVPRGSFIHVDDFPSAASLAAYLLFLDRNVAVYRRYFHWR
                     RSYAVHITSFWDEPWCQTCRAVQTSGDQPKSIHNLADWFQR"
ORIGIN      
        1 cgcaccccta ccccgccacc ccttcgaggt gcaggtctcc agtgcaagac tctctctgca
       61 aggcgaggac tcaggtcacc tagtcgcggg accagcgaac gcatcaagag gccacgaccc
      121 ccggtgaggc gccatccggg cgcagtttcg gagcccagga tccttggctg ggcaggggaa
      181 ccagcgcagg cgcagcagga aacgccccag gccgggcccg cagggcttgg agagcagtgt
      241 ctgggaaggc cagcgtggcg ccgcgccagg gccaccggcc cggttcacct cgtcctggac
      301 ttgggagggg cgaggcaccg cccgtgggcc cgccgatgcc ccgcccgccc cctctatggc
      361 cccggccggg cgaaagctac agcatgagag ccggtgccgc ccctcacggc ccgtggacgc
      421 gtggcgagcc gcggcgacca ctcgtgggcg ctgcatgggg accccagggg cccggcgacg
      481 cgcacggcgc ggaggctggg gattaccccg gacctcctct gggctggcag cagcgggact
      541 actatgcacc gcgttgactg cctgcctctg ttggggacag ctgccgccgc tgccctgggc
      601 gtccccagcc ccgcaacgcc cggtgagtgt gctgctctgg tgggaaccct ttggggggcg
      661 cggcggccac tccaagcctc cccccgattg cagcctgcgc ttcaacatca gcggctgccg
      721 cttgctcacc gaccgcgcgg cctacgggga ggctcaagca gtgctgttcc accaccgcga
      781 cctggtgaag ggaccccccg actggccccc gccctggggc gcccaagaac gcaccgatga
      841 ggctccggag ctacgcgtgt tcgacgacca ggagggagcg gtgatgctag ctagagaagc
      901 cctggagacc acaggctctc gtcccccggg tcagcggtgg gtgtggatga acttcgaatc
      961 accctcccac actccagggc tgcggggctt ggctaaggac ctcttcaatt ggacactatc
     1021 ctaccggacc gattcggata tcttcgtgcc ctatggcttc ctctatccca ggagccatcc
     1081 agccgaacag ccttcaggtc tgggcccccc gctggcccgc aagcggggac tggtggcctg
     1141 ggttgtgagc cactggaacg agcgccaggc acgggtccgt tactaccatc agctgaggcg
     1201 gcacgtgtct gtggacgtgt ttggccgggc gggacccgga caaccagtgc cagccgtcgg
     1261 gttgctgcac acggtggccc gctacaagtt ttacctggcg tttgagaact cacagcacgt
     1321 ggattacatc actgagaagc tgtggcggaa tgccttcctg gctggggccg tgccagtggt
     1381 acttggtccc gatcgtgcca actatgagcg cttcgtgcct cgtggttcct tcatccatgt
     1441 ggatgatttc cctagtgctg cctccctggc tgcctacctg ctctttctgg accgaaacgt
     1501 ggctgtctat cgccgctact tccactggcg tcggagctat gcggtgcaca tcacttcttt
     1561 ctgggatgag ccatggtgcc agacatgcag ggccgtccag acctctgggg accagcccaa
     1621 gagtatccac aacttggcag actggttcca gcgatgaggc tattctgctg tgaattgatg
     1681 acatctcctt gactgttttt ctaaataccc aattttgctt tatgggaaga agatgagtta
     1741 ccagttaata ttatttagca caaggatggg gaaattgcca ggccctcatg gcttttttac
     1801 agagaggtgg gctggctctc tgttaaaggg ctatggtgtc ctgggtgaag aaggaggccc
     1861 ttccttccct gttacctttc tttggccata ggccttacca cgacctatgt ggcctctgaa
     1921 ttttagatgg atttgttctc tgctccatga ttggttggac caatgaggag cagaccacag
     1981 gtttttgaaa ggcagtgggt gtgagatagt ggaaggcttg tcccctcggg tggtgttttc
     2041 tttggtggtt ggagtcctca atccctctga acctggaaaa gataagaagc cattgagttc
     2101 cttcaccagc cgctgtgttc ccagccctgc gaatagaaac gagaggcgag attatcctca
     2161 aagggaaatt cagatgaatt cgtggggaca cctcacctca cactagaacc ctactcccga
     2221 gaagctgcat ttaagtgaca ccctaaattc agggacctaa gggagtgaga gtatctcata
     2281 gaaatcaatg aaaaatccct ttgcaatgtg aattatttct cgcctttata gtcccataac
     2341 tggatcagga aaacgttaaa aatacagata tgaaagaacc acaagcaatc gtctctcttt
     2401 tcccagccag tgtttacaaa tggaagggac ataaatggtg acctcttgtg cacaaatttg
     2461 tttgttctgt gtctctgatg gacctgaaat ttaaacagga acgtttcgtt agtccttcag
     2521 cagggttggc agtgctgtgc agagagaaca ctaaaagatt ccggtgaact atgggtatgt
     2581 gcagaagcaa cacgcttgtg gtgtctgtgt accgttgttt ggtttctgtc cagcttttgt
     2641 tcaatggaac tgacctgtgc ttacagttag tttctgtcct ttgtcctccc gttgctctct
     2701 gctcctaggt acactcattc actccagtgc cttggaccct gcgctgtggg actaatcttg
     2761 aaaacagtca ttgattttcc acattcaaca gatgtcaggg catgcctgct tgtgccaaat
     2821 actggccttg agctcccagg ggaaggaagg tacagaaagg tgtgaggaat tgcctcctct
     2881 ttggggctcc tacactctac tactgccgca ggggaatagg gatttttggt tacacaaagt
     2941 attgttcatg aatcagttgg ttgactagag gcctcgagtt attaaactag gaccctcaga
     3001 tcaacgtgct gtataccaag ttctacccat tttgggtcag gacagttatt tgaatcttat
     3061 atcagattta tatctaagat tcttcattac acagaagctt gcaaaactac ttaggcccag
     3121 gtgcttctag tccccatctt ccataaaaag gagtaattaa aagctgtgaa taacattgcc
     3181 tcattaaagt gttaaggtgt gggcagagcc acagttgaag aattaaaaga aaacaaaagt
     3241 tcggggggcg ggggagcgtt tgtttgctta ctttggtttt cagacagggt ttctctgtaa
     3301 tagtcctgga actctctttg tagaccaggc tggccttgaa ctccagagga tccacctgcc
     3361 tctggcttcc tagggctggg attaaaggtg tgtgccacga tgcccagctt gaaaattctg
     3421 tttttaagac aaatatcaat ggaatgttgg ccaggggtct cagtgttgtc ggaatctaca
     3481 gtggacattg ggatttggta atctggctta gctttgcctt ccggcctgga gcactgggat
     3541 gaggaatgag cctgagcaca aaattcctct tctgtgaagt gtggggggag ggcgcctgag
     3601 gctctactgt gtgacgtaag agatgccgcc ttgtgcttgg cgggcagttg gcgggatatg
     3661 tgtagccatg agcacattgg ctacttttct ttgcagggat tttctgtact ctcatatgca
     3721 ttttacatcc gaaattaaat gtcaagatct attacagaaa aaaatctaaa aagaaaggaa
     3781 agtcagtcat gtattgtgta tttcaaataa atccttaaaa ctgagccata tctcaggatc
     3841 agacaatttc tatgaagctt gtattttcag accagaagta tgtatgtttt gataaagcta
     3901 cgtaattaaa attgtttgga ttgtttcacc tatgtcttct gcattaaatc catgtaaaac
     3961 ta
//
