LOCUS       NM_031635               2984 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus fucosyltransferase 2 (Fut2), mRNA.
ACCESSION   NM_031635 NM_020541
VERSION     NM_031635.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Terahara,K., Nochi,T., Yoshida,M., Takahashi,Y., Goto,Y., Hatai,H.,
            Kurokawa,S., Jang,M.H., Kweon,M.N., Domino,S.E., Hiroi,T., Yuki,Y.,
            Tsunetsugu-Yokota,Y., Kobayashi,K. and Kiyono,H.
  TITLE     Distinct fucosylation of M cells and epithelial cells by Fut1 and
            Fut2, respectively, in response to intestinal environmental stress
  JOURNAL   Biochem Biophys Res Commun 404 (3), 822-828 (2011)
   PUBMED   21172308
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Iwamori,M. and Domino,S.E.
  TITLE     Tissue-specific loss of fucosylated glycolipids in mice with
            targeted deletion of alpha(1,2)fucosyltransferase genes
  JOURNAL   Biochem J 380 (Pt 1), 75-81 (2004)
   PUBMED   14967068
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Domino,S.E., Zhang,L., Gillespie,P.J., Saunders,T.L. and Lowe,J.B.
  TITLE     Deficiency of reproductive tract alpha(1,2)fucosylated glycans and
            normal fertility in mice with targeted deletions of the FUT1 or
            FUT2 alpha(1,2)fucosyltransferase locus
  JOURNAL   Mol Cell Biol 21 (24), 8336-8345 (2001)
   PUBMED   11713270
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   Domino,S.E., Zhang,L. and Lowe,J.B.
  TITLE     Molecular cloning, genomic mapping, and expression of two secretor
            blood group alpha (1,2)fucosyltransferase genes differentially
            regulated in mouse uterine epithelium and gastrointestinal tract
  JOURNAL   J Biol Chem 276 (26), 23748-23756 (2001)
   PUBMED   11323419
REFERENCE   6  (bases 1 to 2984)
  AUTHORS   Lin,B., Saito,M., Sakakibara,Y., Hayashi,Y., Yanagisawa,M. and
            Iwamori,M.
  TITLE     Characterization of three members of murine
            alpha1,2-fucosyltransferases: change in the expression of the Se
            gene in the intestine of mice after administration of microbes
  JOURNAL   Arch Biochem Biophys 388 (2), 207-215 (2001)
   PUBMED   11368156
REFERENCE   7  (bases 1 to 2984)
  AUTHORS   Bureau,V., Marionneau,S., Cailleau-Thomas,A., Le Moullac-Vaidye,B.,
            Liehr,T. and Le Pendu,J.
  TITLE     Comparison of the three rat GDP-L-fucose:beta-D-galactoside
            2-alpha-L-fucosyltransferases FTA, FTB and FTC
  JOURNAL   Eur J Biochem 268 (4), 1006-1019 (2001)
   PUBMED   11179967
REFERENCE   8  (bases 1 to 2984)
  AUTHORS   Lin,B., Hayashi,Y., Saito,M., Sakakibara,Y., Yanagisawa,M. and
            Iwamori,M.
  TITLE     GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II,
            and not MFUT-I or -III, is induced in a restricted region of the
            digestive tract of germ-free mice by host-microbe interactions and
            cycloheximide
  JOURNAL   Biochim Biophys Acta 1487 (2-3), 275-285 (2000)
   PUBMED   11018479
REFERENCE   9  (bases 1 to 2984)
  AUTHORS   Sherwood,A.L. and Holmes,E.H.
  TITLE     Cloning and expression of the catalytic domain from rat hepatoma
            H35 cell GDP-fucose:GM1 alpha 1-->2fucosyltransferase, an enzyme
            which is activated during early stages of chemical carcinogenesis
            in rat liver
  JOURNAL   Arch Biochem Biophys 355 (2), 215-221 (1998)
   PUBMED   9675030
REFERENCE   10 (bases 1 to 2984)
  AUTHORS   Piau,J.P., Labarriere,N., Dabouis,G. and Denis,M.G.
  TITLE     Evidence for two distinct alpha(1,2)-fucosyltransferase genes
            differentially expressed throughout the rat colon
  JOURNAL   Biochem J 300 (Pt 3) (Pt 3), 623-626 (1994)
   PUBMED   8010942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB006138.1.
            
            On Nov 4, 2002 this sequence version replaced NM_020541.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006138.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN06680445,
                                           SAMN06680453 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2984
                     /gene="Fut2"
                     /gene_synonym="Ftc; Futb"
                     /note="fucosyltransferase 2"
                     /db_xref="GeneID:58924"
                     /db_xref="RGD:2639"
     exon            1..107
                     /gene="Fut2"
                     /gene_synonym="Ftc; Futb"
                     /inference="alignment:Splign:2.1.0"
     exon            108..211
                     /gene="Fut2"
                     /gene_synonym="Ftc; Futb"
                     /inference="alignment:Splign:2.1.0"
     exon            212..2984
                     /gene="Fut2"
                     /gene_synonym="Ftc; Futb"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1278
                     /gene="Fut2"
                     /gene_synonym="Ftc; Futb"
                     /EC_number="2.4.1.69"
                     /EC_number="2.4.1.344"
                     /note="galactoside 2-alpha-L-fucosyltransferase 2;
                     alpha1,2-fucosyltransferase b; alpha(1,2)FT 2; alpha 1-2
                     fucosyltransferase; alpha 1,2-fucosyltransferase B;
                     secretor blood group alpha-2-fucosyltransferase;
                     GDP-L-fucose:beta-D-galactoside
                     2-alpha-L-fucosyltransferase 2; fucosyltransferase 2
                     (secretor status included); alpha 12-fucosyltransferase C;
                     type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2;
                     type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2"
                     /codon_start=1
                     /product="galactoside alpha-(1,2)-fucosyltransferase 2"
                     /protein_id="NP_113823.1"
                     /db_xref="GeneID:58924"
                     /db_xref="RGD:2639"
                     /translation="MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQPLSEKELP
                     MTTQMSSGNTESPEMRRDSEQHGNGELRGMFTINSIGRLGNQMGEYATLFALARMNGR
                     LAFIPASMHNALAPIFRISLPVLHSDTAKKIPWQNYHLNDWMEERYRHIPGHFVRFTG
                     YPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVH
                     VMPNVWKGVVADRGYLEKALDMFRARYSSPVFVVTSNGMAWCRENINASRGDVVFAGN
                     GIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKVFKPE
                     AAFLPEWVGIPADLSPLLKH"
ORIGIN      
        1 tgaagagcca agctggaagg taccctgagc caccagtctg cagagccacc ctgccgtcca
       61 ttcgaaggtc atttccctgt taccacagcc agaagaggtg cgtacaggac tgttggagac
      121 cctggagaga ggccaccttg atctcccccg agactggaga gtctcgccgg aatccttacc
      181 tgcgaactct cagctaagtt aaatccagca gccatggcca gcgcccaggt tcctttctcc
      241 tttcctctgg cccacttcct catctttgtc ttcgtgactt ccaccatcat ccacctccag
      301 cagcgaatag tgaagctcca acccctgtca gagaaggaat taccgatgac gactcaaatg
      361 tcctcgggaa acacagaaag cccagagatg cgacgggaca gcgagcagca tgggaatgga
      421 gagctgcggg gcatgttcac gatcaattcc attggccggc tggggaacca gatgggcgaa
      481 tacgccacac tctttgcact ggccaggatg aacggacggc ttgcgttcat ccccgcatcc
      541 atgcacaacg ctctagcgcc catcttcagg atcagcctcc cggtgttaca cagcgacacg
      601 gccaaaaaga tcccatggca gaattaccat ctcaacgact ggatggagga gcgttaccgc
      661 cacattccgg gacactttgt gcgcttcacg ggatacccgt gctcctggac cttctaccac
      721 cacctgcgcc cagagatcct gaaggagttc actctgcatg accacgtgcg ggaggaggcc
      781 caggccttcc tgcgtggtct gcgggtgaat gggagccagc cgagtacttt tgtgggtgtc
      841 catgtgcgcc gaggggacta tgtgcatgtc atgcctaatg tgtggaaggg cgtggtggct
      901 gaccggggtt acctggaaaa ggccctggat atgttccggg cacgctattc atctccagtc
      961 ttcgtggtta caagcaacgg tatggcctgg tgccgggaga acattaatgc ttcccgagga
     1021 gacgtggtgt tcgcgggcaa tggtattgag gggtcgccag ccaaggactt cgcgctgctc
     1081 acccagtgca accacaccat catgactatt gggacctttg ggatttgggc tgcctacctg
     1141 gcaggtggtg ataccatcta cttagccaac tacacccttc cggattctcc gttcctcaaa
     1201 gtctttaagc cagaggcagc cttcctaccc gaatgggtgg gcatccctgc cgatctgtcc
     1261 ccactcctta agcactaaca ccagcctgtc ctcggtccca cttccacctc aaggcaaaag
     1321 gagtcacttg ttacgtcgca ggaagagcct tctgatggga agaagtgtgc cttgggctgc
     1381 caacgagaag tactaacatg ttcagaaagc atatttacat gttagatgcg gccagctcag
     1441 ctccaacatt tgttaacagc tcagacatca tcagtggccc ctgttcctga agactcctag
     1501 cagtgccatc accgtttttc agcacagctg acccatggcg ccagacgggc tgctacccgc
     1561 agacagccac ttccagaggc agcaagaaaa ggcacgctat ggtcttttct ttaggttcct
     1621 tttgaagggt gagacaaact tgagtctgcc tacttttttt tttttttcca cggtggggca
     1681 gcatgtgaca ggcaagagtc agatagggag cctgagcaag gagaggaggc cagcttgtct
     1741 ttttatagca actgccttcc cccgactgac tggagtctgc taagaacctt tgaaggtggt
     1801 gacctaggaa cttctcatag tctctcaaga ttctttctct ttttaaatta tgggtgtatg
     1861 tgtggacgtg tggagtacct tcagaggcca gagctgggtg tcggatccct ggaagtggag
     1921 tcataggcag ctggcactgc gagaggcagg tctcaccagc agcacacaga ggaccaaagg
     1981 caagtccagt gaaagccacc cctctacaag catccagcta gctcctctgt ccccttgaca
     2041 agagttgtgt cactgtgtgc ctacatggct cgttatgagt caaggggagg aagaatgctg
     2101 ggattggttt accctgggat ccaaagtagg agttattcac tgcacaaagg cacttgatca
     2161 aaagggatgt gggagctacc atgagcccac agtcccctca cccagttgct tgcccttggg
     2221 actgggtccg ccaaggactc cttctttacc tactctgtcc atctgagaag acctgtgtgg
     2281 gcggaattca gatgcaccgg ttgcatgtct gcctctgcag ccctggtagg acacctccaa
     2341 tcctagggaa cccctccaga tgtttcagag ttatcttacc atcttgttac acttcaagtg
     2401 tgagcacaca cgatgcatcc ctctcacaat taaaaaatac aacctatgca gctaccatta
     2461 tgaaaacagc cagggtgatc tggggggaag aggcctcgga aaggtgttct ttttggacag
     2521 cagaaaccca aggtgtctct ccagaacccc tgctaagttg gtagtgctga tcctgtgcat
     2581 aagaagtagc ctggagtggc catggtagca cctgactttc acctttgtac tgtgaaggct
     2641 aaggcaggag gccctacatc ctcaggccct ctctcaacaa agaaaattct caaactgggt
     2701 atagcaatgc acacctgtga tcctagcatc aggatcagga gttggaagtc atccccagcc
     2761 acacagggaa tgcagatcag tctgagctgc atgagacccc catctcagaa gtagaaagaa
     2821 aattgcaaaa atctaggctc aacagtggtg gcatacactt aaggagacag aggccaatag
     2881 atctctgagt ttgaggctag cctgggctac acagaaatct tatttttaaa aaatatatat
     2941 tttttcaaaa atccaaaaca aataaaaatg tgcctttcca tcac
//
