LOCUS       NM_031236               2719 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus fucosyltransferase 1 (Fut1), mRNA.
ACCESSION   NM_031236
VERSION     NM_031236.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2719)
  AUTHORS   Palumberi,D., Aldi,S., Ermini,L., Ziche,M., Finetti,F., Donnini,S.
            and Rosati,F.
  TITLE     RNA-mediated gene silencing of FUT1 and FUT2 influences expression
            and activities of bovine and human fucosylated nucleolin and
            inhibits cell adhesion and proliferation
  JOURNAL   J Cell Biochem 111 (1), 229-238 (2010)
   PUBMED   20506485
REFERENCE   2  (bases 1 to 2719)
  AUTHORS   Moehler,T.M., Sauer,S., Witzel,M., Andrulis,M.,
            Garcia-Vallejo,J.J., Grobholz,R., Willhauck-Fleckenstein,M.,
            Greiner,A., Goldschmidt,H. and Schwartz-Albiez,R.
  TITLE     Involvement of alpha 1-2-fucosyltransferase I (FUT1) and
            surface-expressed Lewis(y) (CD174) in first endothelial cell-cell
            contacts during angiogenesis
  JOURNAL   J Cell Physiol 215 (1), 27-36 (2008)
   PUBMED   18205178
REFERENCE   3  (bases 1 to 2719)
  AUTHORS   St John,J.A., Claxton,C., Robinson,M.W., Yamamoto,F., Domino,S.E.
            and Key,B.
  TITLE     Genetic manipulation of blood group carbohydrates alters
            development and pathfinding of primary sensory axons of the
            olfactory systems
  JOURNAL   Dev Biol 298 (2), 470-484 (2006)
   PUBMED   16884711
REFERENCE   4  (bases 1 to 2719)
  AUTHORS   Iwamori,M. and Domino,S.E.
  TITLE     Tissue-specific loss of fucosylated glycolipids in mice with
            targeted deletion of alpha(1,2)fucosyltransferase genes
  JOURNAL   Biochem J 380 (Pt 1), 75-81 (2004)
   PUBMED   14967068
REFERENCE   5  (bases 1 to 2719)
  AUTHORS   Lin,B., Saito,M., Sakakibara,Y., Hayashi,Y., Yanagisawa,M. and
            Iwamori,M.
  TITLE     Characterization of three members of murine
            alpha1,2-fucosyltransferases: change in the expression of the Se
            gene in the intestine of mice after administration of microbes
  JOURNAL   Arch Biochem Biophys 388 (2), 207-215 (2001)
   PUBMED   11368156
REFERENCE   6  (bases 1 to 2719)
  AUTHORS   Bureau,V., Marionneau,S., Cailleau-Thomas,A., Le Moullac-Vaidye,B.,
            Liehr,T. and Le Pendu,J.
  TITLE     Comparison of the three rat GDP-L-fucose:beta-D-galactoside
            2-alpha-L-fucosyltransferases FTA, FTB and FTC
  JOURNAL   Eur J Biochem 268 (4), 1006-1019 (2001)
   PUBMED   11179967
REFERENCE   7  (bases 1 to 2719)
  AUTHORS   Soejima,M., Koda,Y., Wang,B. and Kimura,H.
  TITLE     Functional analysis of the 5'-flanking region of FTA for expression
            of rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase
  JOURNAL   Eur J Biochem 266 (1), 274-281 (1999)
   PUBMED   10542075
REFERENCE   8  (bases 1 to 2719)
  AUTHORS   Domino,S.E., Hiraiwa,N. and Lowe,J.B.
  TITLE     Molecular cloning, chromosomal assignment and tissue-specific
            expression of a murine alpha(1,2)fucosyltransferase expressed in
            thymic and epididymal epithelial cells
  JOURNAL   Biochem J 327 (Pt 1) (Pt 1), 105-115 (1997)
   PUBMED   9355741
REFERENCE   9  (bases 1 to 2719)
  AUTHORS   Piau,J.P., Labarriere,N., Dabouis,G. and Denis,M.G.
  TITLE     Evidence for two distinct alpha(1,2)-fucosyltransferase genes
            differentially expressed throughout the rat colon
  JOURNAL   Biochem J 300 (Pt 3) (Pt 3), 623-626 (1994)
   PUBMED   8010942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031236.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006137.1, SRR26643295.2287.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06680425
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               JAXUCZ010000001.1  105223399-105223877
            480-2719            JAXUCZ010000001.1  105224578-105226817
FEATURES             Location/Qualifiers
     source          1..2719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2719
                     /gene="Fut1"
                     /gene_synonym="Futa"
                     /note="fucosyltransferase 1"
                     /db_xref="GeneID:81919"
                     /db_xref="RGD:2638"
     exon            1..479
                     /gene="Fut1"
                     /gene_synonym="Futa"
                     /inference="alignment:Splign:2.1.0"
     exon            480..2719
                     /gene="Fut1"
                     /gene_synonym="Futa"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..1612
                     /gene="Fut1"
                     /gene_synonym="Futa"
                     /EC_number="2.4.1.69"
                     /EC_number="2.4.1.344"
                     /note="galactoside 2-alpha-L-fucosyltransferase 1;
                     alpha(1,2)FT 1; alpha 1,2-fucosyltransferase A;
                     GDP-L-fucose:beta-D-galactoside
                     2-alpha-L-fucosyltransferase 1; type 1 galactoside
                     alpha-(1,2)-fucosyltransferase FUT1; type 2 galactoside
                     alpha-(1,2)-fucosyltransferase FUT1; fucosyltransferase 1
                     (galactoside 2-alpha-L-fucosyltransferase);
                     alpha12-fucosyltransferase a; alpha 12-fucosyltransferase"
                     /codon_start=1
                     /product="galactoside alpha-(1,2)-fucosyltransferase 1"
                     /protein_id="NP_112515.1"
                     /db_xref="GeneID:81919"
                     /db_xref="RGD:2638"
                     /translation="MWTPSRKQLCLAFLSVCVLSAGSFFFHLNGGNFFQNALTFSVLC
                     PDYHLLKSPVAMVCLPYPSNASSGSPSCPEQSLLSGTWTITPGGRFGNQMGQYATLLA
                     LAQLNGRRAFIQPEMHTTLAPVFRISLPVLDPEVDSLTPWQHLVLHDWMSEEYSHLED
                     PFLKLSGFPCSWTFFHHLREQIRREFTLHDHLREDAQRLLSGLRIGPAGIRPRTYVGV
                     HVRRGDYLEVMPNRWKGVVGDRAYLQKAMDWFRARHKDPIFVVTSNGMRWCLENIDTS
                     HGDVVFAGNGQEGTPGKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTVYLANFTLPDS
                     EFLKIFRPKAAFLPEWVGINADLSPLQAQFDPWETDSLFRLA"
ORIGIN      
        1 ctaagggaag cagaagtccc ggcaccggag agggaaacgc acatgggacc tgagctcctg
       61 gcttcagcct tgccgcccgg gcgctagtcc cctggtccat acagaggata cggcagcttc
      121 tggatacgaa ctgggttgtc catcgtggag tcagagaacc cagaagaaga gacagggccg
      181 cagcgcccat ccacctgggc ggaggagagg gcgcagggcc aggtaggatg cggctccgcc
      241 tcctgctacc agccctaccc gaagggcgga ggctgtgcac cttggaaccc tgcctctccc
      301 tctctctctc cccacgggtc tctgagcccc agccttcagt cagtttcagg aaggaagctt
      361 gaagcggagg gctacggagc cagggctccc cacctccaag cgcggccgat gaaggctaca
      421 ttttggaact ggaagctcag acaaaaagaa ttcgtttgca ccaccagcaa gaagctcagc
      481 tatgtggact cccagccgga agcagctctg cctggcattt ctgtcggtct gtgtgctctc
      541 tgccggctcc ttcttcttcc acctgaatgg aggaaacttc tttcaaaatg ctctaacttt
      601 ctctgtcctg tgtccagact atcacctgct gaagtcccca gtggccatgg tatgcctacc
      661 ttatccgtcg aacgcatcca gtggctcccc ttcctgtccc gagcagtcct tgctctctgg
      721 gacttggaca atcacccccg gaggcaggtt tggtaaccag atgggacagt atgccacatt
      781 gctggcccta gcccagctca atggccgccg ggctttcatc cagcctgaga tgcataccac
      841 cctggcccct gtgttccgaa tctccctgcc agtgctggac cctgaggtgg acagtctcac
      901 gccttggcag cacttagtcc tacatgactg gatgtcagag gagtactccc acctggagga
      961 cccgtttctc aagctgtctg gtttcccctg ctcttggacc tttttccatc acctccggga
     1021 acagattcgc cgggaattca ccctgcatga ccacctacgg gaagacgcac agcgcctgtt
     1081 gagtgggctc cggataggcc ctgcaggcat ccgtcctcgt acctatgtgg gtgttcacgt
     1141 gcgtcgtgga gactatttgg aggtgatgcc taaccgctgg aagggagtgg tgggtgaccg
     1201 agcttacctc cagaaagcca tggactggtt ccgggcccgg cacaaagacc ccatctttgt
     1261 ggtcaccagc aatggcatga gatggtgttt ggagaacatt gacacatccc acggtgatgt
     1321 ggtcttcgct ggcaatggac aggagggtac gccggggaag gacttcgcac tgctcaccca
     1381 gtgtaatcac accatcatga ctattgggac ctttggcttc tgggctgcct acctggctgg
     1441 tggagacact gtctaccttg ctaacttcac ccttccagat tcagagtttc tgaagatctt
     1501 caggcctaag gctgccttcc tgcccgagtg ggtgggcatt aacgcagact tgtccccgct
     1561 gcaggctcag tttgacccct gggagacaga cagtcttttt agactggctt gactcatcaa
     1621 gggtcagcca tctgtgtctc tctgctttgg agtatgtctg ccatcatcct ggagctgggg
     1681 gcactcatgg ctggacttgc agatgagcct tttggagtgc tggagtgctt tacagacatt
     1741 tcaacagggt agcattttct gacggcaggg gaagcccaag tcagcactgt aagtcacagt
     1801 ctcttctgac tttcctggct caccttagaa tctctggaca gctgcttctg ggttagggag
     1861 gctaaagaaa atccagactt accagctggg cctcctgaat tcttggagtc cttctagaat
     1921 gttcctgaga gcctggtctg gtccccatgc agcaccctgc agggcccttc caagactcta
     1981 gacagtgaag aatttaatga cggtggatgg aaaagctcag tgccacctcc tgctggaaac
     2041 acggagtgat gcaaaccttt caggagccag attcttgtta gggagatgag aataatttga
     2101 gcacatatga agtctgtcca actccttggc cccagagaaa cttcaaagac ttttatttag
     2161 ggtgggctaa aagtgggcta gaggagagaa ccgctgttga aatgctcctt aaggagcaat
     2221 gtttaaggtg ctctttaaaa aaaaaattct agaaactttt ttaaaaaaga gagcttaaaa
     2281 gttaaagaat tatacaaatt agtcctgaat ttaggatcga gaaggtttct tcttctgaag
     2341 atgctataag ggatctggga tctgtgttct ggaggtaacc aggcctccag aaaagaaggg
     2401 tatacccctg ggctcacaaa atcttaaatc cggctttgag aaggtcaagg gtgaaggatc
     2461 agaaggtgtt ccagaactgt gagctcagcc taagtcccta taaaacacgg gctggaagca
     2521 aagatgggac atttggctga catcaggtat acttgatgct ttttcaagaa cggagaaagt
     2581 ttcctcagat agcatttaat ctaattgtat tcccttccaa gaccaacttc tattcttctc
     2641 agggagtttc tgtgcctttc ccccaacttg gcctgtacaa gctagagaag ggggctgtga
     2701 attaaagggc cacatcgcc
//
