LOCUS       NM_001012137            1842 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus Fus RNA binding protein (Fus), mRNA.
ACCESSION   NM_001012137 XM_228776
VERSION     NM_001012137.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1842)
  AUTHORS   Kang,Q., Zhang,J., Xie,C., Fang,S. and Chai,W.
  TITLE     Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by
            regulating FUS-mediated ATF3 mRNA stability in epilepsy
  JOURNAL   Exp Cell Res 434 (1), 113848 (2024)
   PUBMED   37918704
  REMARK    GeneRIF: Circular RNA SLC8A1 triggers hippocampal neuronal
            ferroptosis by regulating FUS-mediated ATF3 mRNA stability in
            epilepsy.
REFERENCE   2  (bases 1 to 1842)
  AUTHORS   Salam,S., Tacconelli,S., Smith,B.N., Mitchell,J.C., Glennon,E.,
            Nikolaou,N., Houart,C. and Vance,C.
  TITLE     Identification of a novel interaction of FUS and syntaphilin may
            explain synaptic and mitochondrial abnormalities caused by ALS
            mutations
  JOURNAL   Sci Rep 11 (1), 13613 (2021)
   PUBMED   34193962
  REMARK    GeneRIF: Identification of a novel interaction of FUS and
            syntaphilin may explain synaptic and mitochondrial abnormalities
            caused by ALS mutations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1842)
  AUTHORS   Luo,X., He,S., Hu,Y., Liu,J. and Chen,X.
  TITLE     Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte
            hypertrophy by interacting with FUS to stabilize TLR4
  JOURNAL   Cardiovasc Pathol 42, 21-29 (2019)
   PUBMED   31220774
  REMARK    GeneRIF: Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in
            cardiomyocyte hypertrophy by interacting with FUS to stabilize
            TLR4.
REFERENCE   4  (bases 1 to 1842)
  AUTHORS   Zhang,T., Jiang,X., Xu,M., Wang,H., Sang,X., Qin,M., Bao,P.,
            Wang,R., Zhang,C., Lu,H., Li,Y., Ren,J., Chang,H.C., Yan,J., Sun,Q.
            and Xu,J.
  TITLE     Sleep and circadian abnormalities precede cognitive deficits in
            R521C FUS knockin rats
  JOURNAL   Neurobiol Aging 72, 159-170 (2018)
   PUBMED   30273830
  REMARK    GeneRIF: FUS could cause sleep-wake and circadian disturbance as
            early symptoms in cognitive deficits.
REFERENCE   5  (bases 1 to 1842)
  AUTHORS   Luo,F., Gui,X., Zhou,H., Gu,J., Li,Y., Liu,X., Zhao,M., Li,D.,
            Li,X. and Liu,C.
  TITLE     Atomic structures of FUS LC domain segments reveal bases for
            reversible amyloid fibril formation
  JOURNAL   Nat Struct Mol Biol 25 (4), 341-346 (2018)
   PUBMED   29610493
REFERENCE   6  (bases 1 to 1842)
  AUTHORS   Radic,M.Z., Shah,K., Zhang,W., Lu,Q., Lemke,G. and Hilliard,G.M.
  TITLE     Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody
            target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine
            kinases
  JOURNAL   J Immunol 176 (1), 68-74 (2006)
   PUBMED   16365397
REFERENCE   7  (bases 1 to 1842)
  AUTHORS   Belly,A., Moreau-Gachelin,F., Sadoul,R. and Goldberg,Y.
  TITLE     Delocalization of the multifunctional RNA splicing factor TLS/FUS
            in hippocampal neurones: exclusion from the nucleus and
            accumulation in dendritic granules and spine heads
  JOURNAL   Neurosci Lett 379 (3), 152-157 (2005)
   PUBMED   15843054
REFERENCE   8  (bases 1 to 1842)
  AUTHORS   Alappat,S.R., Zhang,M., Zhao,X., Alliegro,M.A., Alliegro,M.C. and
            Burdsal,C.A.
  TITLE     Mouse pigpen encodes a nuclear protein whose expression is
            developmentally regulated during craniofacial morphogenesis
  JOURNAL   Dev Dyn 228 (1), 59-71 (2003)
   PUBMED   12950080
REFERENCE   9  (bases 1 to 1842)
  AUTHORS   Baechtold,H., Kuroda,M., Sok,J., Ron,D., Lopez,B.S. and
            Akhmedov,A.T.
  TITLE     Human 75-kDa DNA-pairing protein is identical to the
            pro-oncoprotein TLS/FUS and is able to promote D-loop formation
  JOURNAL   J Biol Chem 274 (48), 34337-34342 (1999)
   PUBMED   10567410
REFERENCE   10 (bases 1 to 1842)
  AUTHORS   Powers,C.A., Mathur,M., Raaka,B.M., Ron,D. and Samuels,H.H.
  TITLE     TLS (translocated-in-liposarcoma) is a high-affinity interactor for
            steroid, thyroid hormone, and retinoid receptors
  JOURNAL   Mol Endocrinol 12 (1), 4-18 (1998)
   PUBMED   9440806
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087153.1.
            
            On Feb 11, 2005 this sequence version replaced XM_228776.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1842
                     /gene="Fus"
                     /note="Fus RNA binding protein"
                     /db_xref="GeneID:317385"
                     /db_xref="RGD:1308864"
     exon            1..78
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1622
                     /gene="Fus"
                     /note="fusion, derived from t(12;16) malignant
                     liposarcoma; 16) in malignant liposarcoma); fusion
                     (involved in t(12; fused in sarcoma RNA binding protein"
                     /codon_start=1
                     /product="RNA-binding protein FUS"
                     /protein_id="NP_001012137.1"
                     /db_xref="GeneID:317385"
                     /db_xref="RGD:1308864"
                     /translation="MASNDYTQQATQSYGAYPTQPGQGYSQQSNQPYGQQSYSGYGQS
                     ADTSGYGQSSYGSSYGQTQNTGYGTQSAPQGYGSTGGYGSSQSSQSSYGQQSSYPGYG
                     QQPAPSSTSGSYGGSSQSSSYGQPQSGGYGQQSGYGGQQQSYGQQQSSYNPPQGYGQQ
                     NQYNSSSGGGGGGGGGNYGQDQSSMSGGGGGGGYGNQDQSGGGGGGYGGGQQDRGGRG
                     RGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSD
                     NNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSF
                     DDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGG
                     GGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRSECNQCKAPKPDGPGG
                     GPGGSHMGGNYGDDRRGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGE
                     HRQDRRERPY"
     exon            79..103
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            104..258
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            259..403
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            404..591
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            592..808
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            809..843
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            844..876
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            877..980
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1110
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1212
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1336
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1437
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1582
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1817
                     /gene="Fus"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggcgtcc cttcgcagtc gtctggaatc ctgttgcttg gcggcctgtg cgcgcgtgcg
       61 cggacatggc ttcaaacgac tatacccaac aagcaactca aagctatggg gcctatccta
      121 cccagcctgg gcagggctat tcccaacaga gcaatcagcc ctatggccag cagagttaca
      181 gtggttatgg ccaatcagct gacacttcag gatacggcca gagcagctat ggttcttctt
      241 atggacagac ccaaaacaca ggctatggaa ctcagtcagc accccaggga tatggttcca
      301 ctggtggcta tggcagcagc caaagttccc agtcttctta tgggcagcag tcctcctacc
      361 ccggttatgg ccaacagcca gctcctagta gcacctcagg aagttatggt ggaagttctc
      421 agagcagcag ctatgggcag ccccagagtg gaggctatgg tcaacagtct ggctatggtg
      481 gacagcaaca aagctacgga cagcaacaaa gctcctataa cccacctcag ggttatggac
      541 aacagaacca gtacaacagc agcagtggag gtggtggagg gggtggtgga ggcaactatg
      601 gccaagatca gtcctctatg agtggcggcg gcggtggtgg tggttatggc aatcaggacc
      661 agagtggtgg cggcggtggt ggctacgggg gaggccagca ggatcgtggg ggccgtggca
      721 ggggcggtgg aggtggttac aaccgaagca gtggtggcta tgaacccaga ggccgtggag
      781 gtggccgagg aggcagaggc ggcatgggcg gaagtgaccg tggtggcttc aataaatttg
      841 gtggtcctcg ggatcaagga tctcgtcatg attctgaaca ggataattca gacaataata
      901 ccatcttcgt gcaaggccta ggcgagaatg ttacaattga atctgtggcg gattacttca
      961 agcagattgg aattattaag acaaacaaga aaactggaca gcctatgatt aatttgtata
     1021 cagacagaga aactggcaag ttgaagggtg aggcaacagt ctcatttgat gacccacctt
     1081 ctgctaaagc tgcaatcgac tggtttgatg gaaaagaatt ctctgggaat cctattaaag
     1141 tttcatttgc tacccggcgt gctgacttca accggggtgg tggaaatggt cgtggaggcc
     1201 gagggcgagg aggacccatg ggccgtggag gctatggagg aggtggcagc ggtggtggtg
     1261 gccggggagg atttcccagt ggaggtggtg gaggtggagg acagcaacga gctggggact
     1321 ggaagtgtcc taatcctaca tgtgagaaca tgaacttctc ttggagaagt gaatgcaacc
     1381 agtgtaaggc acctaagcca gatggcccag gagggggacc aggaggctct catatggggg
     1441 gaaactacgg agatgatcgg cgtggcagag gaggatatga tcggggcggc taccggggcc
     1501 gaggagggga ccgagggggc ttcagagggg gccggggtgg tggggacaga ggtggttttg
     1561 gccctggcaa gatggactcc aggggtgagc acagacagga tcgcagggag aggccatatt
     1621 agcctgactc ctgaagttct ggaacagctc ttcctgtacc cagtgttacc cttgttattt
     1681 tgtaaactta caattcagga ttgctcatgg atattttttg ggggggtggg caacggtatg
     1741 tgtgtgtgtg tgagtgtgtc agactaccgt aattgtaacc atatctctgg ttcccattaa
     1801 aaaccatttt agttaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
