LOCUS       NM_019331               4264 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus furin (paired basic amino acid cleaving enzyme)
            (Furin), mRNA.
ACCESSION   NM_019331 XM_346546
VERSION     NM_019331.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4264)
  AUTHORS   Lu,W., Liu,X., Zhao,L., Yan,S., Song,Q., Zou,C. and Li,X.
  TITLE     MiR-22-3p in exosomes increases the risk of heart failure after
            down-regulation of FURIN
  JOURNAL   Chem Biol Drug Des 101 (3), 550-567 (2023)
   PUBMED   36063111
  REMARK    GeneRIF: MiR-22-3p in exosomes increases the risk of heart failure
            after down-regulation of FURIN.
REFERENCE   2  (bases 1 to 4264)
  AUTHORS   Baumann,J., Huang,S.F., Gassmann,M., Tsao,C.C. and Ogunshola,O.O.
  TITLE     Furin inhibition prevents hypoxic and TGFbeta-mediated blood-brain
            barrier disruption
  JOURNAL   Exp Cell Res 383 (2), 111503 (2019)
   PUBMED   31336100
  REMARK    GeneRIF: TGFbeta treatment aggravated hypoxia-induced BBB
            permeability but ALK5 or Furin blockade reversed injury-induced
            permeability changes. Thus during insult Furin compromises
            endothelial integrity by mediating the effects of TGFbeta.
            Targeting the Furin or ALK5 pathway may offer novel therapeutic
            strategies for improving BBB stability and CNS function during
            disease.
REFERENCE   3  (bases 1 to 4264)
  AUTHORS   Bessonnard,S., Mesnard,D. and Constam,D.B.
  TITLE     PC7 and the related proteases Furin and Pace4 regulate E-cadherin
            function during blastocyst formation
  JOURNAL   J Cell Biol 210 (7), 1185-1197 (2015)
   PUBMED   26416966
REFERENCE   4  (bases 1 to 4264)
  AUTHORS   Essalmani,R., Susan-Resiga,D., Chamberland,A., Asselin,M.C.,
            Canuel,M., Constam,D., Creemers,J.W., Day,R., Gauthier,D., Prat,A.
            and Seidah,N.G.
  TITLE     Furin is the primary in vivo convertase of angiopoietin-like 3 and
            endothelial lipase in hepatocytes
  JOURNAL   J Biol Chem 288 (37), 26410-26418 (2013)
   PUBMED   23918928
REFERENCE   5  (bases 1 to 4264)
  AUTHORS   Kato,S., Zhang,R. and Roberts,J.D. Jr.
  TITLE     Proprotein convertases play an important role in regulating PKGI
            endoproteolytic cleavage and nuclear transport
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 305 (2), L130-L140 (2013)
   PUBMED   23686857
  REMARK    GeneRIF: overexpression of PCs, furin and PC5, but not PC7, which
            are all expressed in SMC, increase PKGI cleavage in a
            dose-dependent manner
REFERENCE   6  (bases 1 to 4264)
  AUTHORS   Decroly,E., Wouters,S., Di Bello,C., Lazure,C., Ruysschaert,J.M.
            and Seidah,N.G.
  TITLE     Identification of the paired basic convertases implicated in HIV
            gp160 processing based on in vitro assays and expression in CD4(+)
            cell lines
  JOURNAL   J Biol Chem 271 (48), 30442-30450 (1996)
   PUBMED   8940009
  REMARK    Erratum:[J Biol Chem 1997 Mar 28;272(13):8836]
REFERENCE   7  (bases 1 to 4264)
  AUTHORS   Seidah,N.G., Benjannet,S., Pareek,S., Savaria,D., Hamelin,J.,
            Goulet,B., Laliberte,J., Lazure,C., Chretien,M. and Murphy,R.A.
  TITLE     Cellular processing of the nerve growth factor precursor by the
            mammalian pro-protein convertases
  JOURNAL   Biochem J 314 (Pt 3) (Pt 3), 951-960 (1996)
   PUBMED   8615794
REFERENCE   8  (bases 1 to 4264)
  AUTHORS   Dubois,C.M., Laprise,M.H., Blanchette,F., Gentry,L.E. and Leduc,R.
  TITLE     Processing of transforming growth factor beta 1 precursor by human
            furin convertase
  JOURNAL   J Biol Chem 270 (18), 10618-10624 (1995)
   PUBMED   7737999
REFERENCE   9  (bases 1 to 4264)
  AUTHORS   Breslin,M.B., Lindberg,I., Benjannet,S., Mathis,J.P., Lazure,C. and
            Seidah,N.G.
  TITLE     Differential processing of proenkephalin by prohormone convertases
            1(3) and 2 and furin
  JOURNAL   J Biol Chem 268 (36), 27084-27093 (1993)
   PUBMED   8262946
REFERENCE   10 (bases 1 to 4264)
  AUTHORS   Misumi,Y., Sohda,M. and Ikehara,Y.
  TITLE     Sequence of the cDNA encoding rat furin, a possible
            propeptide-processing endoprotease
  JOURNAL   Nucleic Acids Res 18 (22), 6719 (1990)
   PUBMED   2251148
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019331.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X55660.1, SRR26643297.2425.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               JAXUCZ010000001.1  143769195-143769481 c
            288-621             JAXUCZ010000001.1  143766345-143766678 c
            622-720             JAXUCZ010000001.1  143765856-143765954 c
            721-816             JAXUCZ010000001.1  143765669-143765764 c
            817-945             JAXUCZ010000001.1  143764915-143765043 c
            946-1022            JAXUCZ010000001.1  143764734-143764810 c
            1023-1111           JAXUCZ010000001.1  143763971-143764059 c
            1112-1284           JAXUCZ010000001.1  143763357-143763529 c
            1285-1497           JAXUCZ010000001.1  143761526-143761738 c
            1498-1598           JAXUCZ010000001.1  143760995-143761095 c
            1599-1702           JAXUCZ010000001.1  143760787-143760890 c
            1703-1820           JAXUCZ010000001.1  143760583-143760700 c
            1821-2000           JAXUCZ010000001.1  143760313-143760492 c
            2001-2125           JAXUCZ010000001.1  143759844-143759968 c
            2126-2236           JAXUCZ010000001.1  143759626-143759736 c
            2237-4264           JAXUCZ010000001.1  143757391-143759418 c
FEATURES             Location/Qualifiers
     source          1..4264
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..4264
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /note="furin (paired basic amino acid cleaving enzyme)"
                     /db_xref="GeneID:54281"
                     /db_xref="RGD:3274"
     exon            1..287
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            288..621
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..2826
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /EC_number="3.4.21.75"
                     /note="Proprotein convertase subtilisin/kexin type 3
                     (paired basic amino acid cleaving enzyme, furin, membrane
                     associated receptor protein); prohormone convertase 3;
                     dibasic-processing enzyme; paired basic amino acid
                     residue-cleaving enzyme; Paired basic amino acid cleaving
                     enzyme (furin); proprotein convertase subtilisin/kexin
                     type3"
                     /codon_start=1
                     /product="furin precursor"
                     /protein_id="NP_062204.2"
                     /db_xref="GeneID:54281"
                     /db_xref="RGD:3274"
                     /translation="MELRPWLLWVVAAAGALVLLAAEARGQKIFTNTWAVHISGGPAV
                     ADSVARKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAK
                     QRAKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNH
                     PDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYN
                     ARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFR
                     GVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACS
                     STLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRD
                     MQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKC
                     IIEILAEPKDIGKRLEVRKTVTACLGEPNHISRLEHVQARLTLSYNRRGDLAIHLISP
                     MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKF
                     TLVLYGTASEGLSAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPGFTPQVLD
                     THYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSS
                     RESRPQQPPPALRPEVEVEPRLRAGLASHLPEVLAGLSCLIIALIFGIVFLFLHRCSG
                     FSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL"
     exon            622..720
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            721..816
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..945
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1022
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1111
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1284
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1497
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1598
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1702
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1820
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2000
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2125
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2236
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..4264
                     /gene="Furin"
                     /gene_synonym="Pace; Pcsk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaaagagg attccgtggc ttaaaaaaaa agtttgaaag cctctgactt aatagttttc
       61 caccaccaag gaaactgagg cccagagaga ggaaatgacc tgggtaagat ctccgaggga
      121 ccagtagttg aacagggact aggagttaaa atttcatggg aggtgcctgt aacaggacct
      181 gccttggggt ctctgctgga aagagagacc tgattgggtt tcccagcagt cttcagtggc
      241 ttgctccgtg gctgcctcag ccaggtctcc agcagccaca cctggggatc tggcccccgt
      301 cctgtcctcc agccccaccc acctcggctc catgcccccc ccagtcagct tcgggaccct
      361 ggcagtgagc aggcacgtgg cagccaaggc cctgtgacca ggccagggag acggagctct
      421 ggggtcccag tcacctgccc ccccatggag ctgagaccct ggttgctatg ggtggtagca
      481 gcagcaggag ccttggtcct gctagcagct gaagctcgcg gccagaagat cttcaccaac
      541 acgtgggctg tgcacatttc tggaggccca gctgtggctg atagtgtggc acggaagcat
      601 gggttccaca acctgggcca gatcttcggt gactattacc acttctggca cagagcagtg
      661 acaaagcggt ccctgtcgcc tcaccgcccg cggcacagcc ggctacagag ggagcctcaa
      721 gtgaagtggc tggagcagca ggtagccaag caaagggcca agagggacgt gtatcaggag
      781 cccacagacc ccaagttccc tcagcagtgg tacctgtctg gggtcactca gcgagacctg
      841 aatgtgaagg aagcctgggc ccagggcttc acagggcgtg gcattgtggt ctccatcctg
      901 gatgacggca ttgaaaagaa ccatcctgac ttggcaggca attatgaccc gggagccagc
      961 tttgatgtca atgaccagga ccctgaccca cagcctcggt acacgcagat gaatgacaac
     1021 aggcacggca ctcggtgtgc cggggaagtg gcagcggtgg ccaacaatgg tgtctgtggt
     1081 gtaggtgtag cttacaatgc ccggattgga ggggtgcgta tgttggatgg cgaggtgact
     1141 gacgcggtag aggcacgttc gctgggcctg aatcccaacc acatccacat ctacagcgcc
     1201 agctggggcc ccgaggacga cggcaagacc gtggatgggc cagcccggct cgccgaggag
     1261 gccttctttc ggggagttag ccagggccgc ggagggctgg gctccatctt tgtctgggcc
     1321 tcagggaacg ggggccggga acatgacagc tgtaactgtg acggctacac caacagcatc
     1381 tacacgctgt ccatcagcag tgccacacaa ttcggcaacg tgccctggta cagtgaggcc
     1441 tgctcctcca cactggccac cacctacagc agtggcaacc agaatgagaa gcagattgtg
     1501 acaactgacc tgaggcagaa gtgcactgag tctcacacag gcacctcagc ctccgcccct
     1561 ttggcagctg gtatcattgc tctcaccctg gaggccaaca agaacctcac ctggcgggac
     1621 atgcagcacc tggtggtgca gacctcaaag ccagcacatc tcaacgctaa cgattgggcc
     1681 accaatggcg tgggccggaa agtgagccat tcctatggct acgggctgtt ggatgcaggt
     1741 gccatggtgg ccctggccca gaactggaca acagtggccc cccagcggaa gtgcatcatt
     1801 gaaatcctgg cagagcccaa ggacattggc aaacggctag aggtgcgcaa gaccgtgaca
     1861 gcgtgcctgg gtgagcccaa ccacatctcc agactggaac acgttcaggc acggctcacc
     1921 ctgtcttaca atcgccgtgg tgacctggct atccacctca tcagccccat gggcacccgt
     1981 tccaccctat tagctgccag accacatgac tactctgctg atggatttaa tgactgggct
     2041 ttcatgacaa ctcattcctg ggatgaggac ccctctggcg agtgggtcct agagattgaa
     2101 aataccagcg aggccaacaa ctatgggacg ctgaccaagt tcactctcgt cctatatggc
     2161 acagcctctg agggtctctc tgcacctcca gagagcagcg gctgcaagac cctcacatcc
     2221 agccaggcct gcgtggtgtg tgaggaaggt ttctcactgc accagaaaag ctgtgtccag
     2281 cgttgcccac caggcttcac accccaagtc cttgatacac actacagcac tgagaatgat
     2341 gtggagatca tccgtgccag tgtctgcacc ccctgccacg cctcatgtgc cacttgccag
     2401 ggcccagctc ccacagactg cctcagctgc cccagccatg cctccctgga ccctgtggag
     2461 caaacctgct cccggcaaag ccagagcagc cgagagtccc gacctcagca gccacctccc
     2521 gcactgcgcc cagaggtgga agtggagccc cggttgcggg ctgggctggc ctctcacctg
     2581 ccggaggtcc tggccggcct cagctgcctt atcatcgctc tcatctttgg catcgtcttc
     2641 ctcttcctgc atcggtgttc aggcttcagc ttccggggag tgaaagtgta caccatggac
     2701 cgtggcctca tctcctacaa ggggctgcct cctgaggcct ggcaggagga gtgcccatct
     2761 gactcagaag aggatgaggg ccggggcgag aggaccgcct ttatcaaaga ccagagcgcc
     2821 ctttgatgag cccactgccc accctatcaa atcgatccct tcctcgggca ctttttaatt
     2881 caccaaagta tttttttatc ttgggactgg gtttggaccc tagctgggag gtgagagggg
     2941 cagagaccct tgggcctacc tgtttgcctg aggtggggtc ccgggagcct caccccccac
     3001 caaccctcca tgtggaggaa ggagtaaatc tttagggcag cttcctgcag agtgaagagg
     3061 ggcagccttt ctgagtccct ggccaggctg cagccttgcc cctcccctgc ccctcagaaa
     3121 gcaataatgg tccccatcca ggcaacaggg aggctggcca ggaggtactt gaagaaggtg
     3181 gccacctctc caagggcttt tgcatcccct gaccctctct ggctcaggat gagcctctga
     3241 agaagcttgc agtcacagga agggaccaaa gcaaagcagg cactctccag tgtgcctgca
     3301 ctcttgctct cagcctgcct ctgcactcca ggtctccacc tcagctggta gccaggctga
     3361 gctagaccag cacaggtcag gctctggggc cttatgctgg tgtcctgacc atcctctatg
     3421 gcaccctccc ccttgccagg gccttgtttt ctgagcccgg ggctgcctgg gcagttggcg
     3481 ctcacagtcc aggagcccct gggtgggtgg tggggaggga cggtggctcc tcccgcctcc
     3541 cacccgatgc tgctttcccc tgtggggatc tcaggagctg tttgaggata tattttcact
     3601 ttgtgattat tcactttaga tgctgatttt tttttttttt tgtattttta atgggggtag
     3661 cagctggacc attcaccttc tcctacccat gtccaccctg cctttcccat ggctgcccag
     3721 ctctgaggca gagggaatca ctaagcccca agtcctgaag aggcaggcca gccagctggg
     3781 ctccaggaaa gggggtcatg gtgggagggg taggctgaca tcatctgttt caaatggggt
     3841 tgtgccacag gcttttgggt tgctggctct ccaagtgcca ggggtgggca ggtggcacca
     3901 ccaagccctt tctaacactg tgccctggtg gagaaagcat tggcctatga tgccccccaa
     3961 accccctgtt ctgatgtgcc tttcgcaccc ctcccattag gacaatcagt cccctcccac
     4021 ttgggcctcc tcttttcttt ttcctagccc ttctcggtac ccaacctacc tgtccagggg
     4081 tgccccttgc tctcctgccc acccctagcg gccatccagg ctggttttgt aagatgctgg
     4141 gttggtgcac agtcattttt ttttccttgt aatttaaaca ggcctggcat tgttggttct
     4201 atttaatgga cacgagataa tgttagaggt tttaaagtga ttaaacgtgc agactatgca
     4261 aacc
//
