LOCUS       NM_012562               1515 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus alpha-L-fucosidase 1 (Fuca1), mRNA.
ACCESSION   NM_012562
VERSION     NM_012562.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Liu,T.W., Ho,C.W., Huang,H.H., Chang,S.M., Popat,S.D., Wang,Y.T.,
            Wu,M.S., Chen,Y.J. and Lin,C.H.
  TITLE     Role for alpha-L-fucosidase in the control of Helicobacter
            pylori-infected gastric cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (34), 14581-14586 (2009)
   PUBMED   19666478
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Komosinska-Vassev,K., Olczyk,K., Kozma,E.M., Olczyk,P., Wisowski,G.
            and Winsz-Szczotka,K.
  TITLE     Alterations of glycosaminoglycan metabolism in the development of
            diabetic complications in relation to metabolic control
  JOURNAL   Clin Chem Lab Med 43 (9), 924-929 (2005)
   PUBMED   16176171
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Rellier,N., Ruggiero-Lopez,D., Lecomte,M., Lagarde,M. and
            Wiernsperger,N.
  TITLE     In vitro and in vivo alterations of enzymatic glycosylation in
            diabetes
  JOURNAL   Life Sci 64 (17), 1571-1583 (1999)
   PUBMED   10353622
REFERENCE   6  (bases 1 to 1515)
  AUTHORS   Waters,P.J., Flynn,M.D., Corrall,R.J. and Pennock,C.A.
  TITLE     Increases in plasma lysosomal enzymes in type 1 (insulin-dependent)
            diabetes mellitus: relationship to diabetic complications and
            glycaemic control
  JOURNAL   Diabetologia 35 (10), 991-995 (1992)
   PUBMED   1451959
REFERENCE   7  (bases 1 to 1515)
  AUTHORS   Fisher,K.J. and Aronson,N.N. Jr.
  TITLE     Isolation and sequence analysis of a cDNA encoding rat liver
            alpha-L-fucosidase
  JOURNAL   Biochem J 264 (3), 695-701 (1989)
   PUBMED   2482732
REFERENCE   8  (bases 1 to 1515)
  AUTHORS   Kretz,K.A., Darby,J.K., Willems,P.J. and O'Brien,J.S.
  TITLE     Characterization of EcoRI mutation in fucosidosis patients: a stop
            codon in the open reading frame
  JOURNAL   J Mol Neurosci 1 (3), 177-180 (1989)
   PUBMED   2642067
REFERENCE   9  (bases 1 to 1515)
  AUTHORS   Leoncini,G., Balestrero,F., Maresca,M., Armani,U., Piana,A. and
            Metzger,R.P.
  TITLE     Effect of diabetes mellitus on selected acid hydrolase activities
            in human platelets
  JOURNAL   Diabete Metab 13 (3), 198-204 (1987)
   PUBMED   3609421
REFERENCE   10 (bases 1 to 1515)
  AUTHORS   Goi,G., Fabi,A., Lorenzi,R., Lombardo,A., Tettamanti,G.,
            Burlina,A.B., Pinelli,L. and Gaburro,D.
  TITLE     Serum enzymes of lysosomal origin as indicators of the metabolic
            control in diabetes: comparison with glycated hemoglobin and
            albumin
  JOURNAL   Acta Diabetol Lat 23 (2), 117-125 (1986)
   PUBMED   3751446
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081844.1.
            
            On Oct 12, 2007 this sequence version replaced NM_012562.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081844.1, X16145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1515
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /note="alpha-L-fucosidase 1"
                     /db_xref="GeneID:24375"
                     /db_xref="RGD:2636"
     exon            1..398
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1410
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /EC_number="3.2.1.51"
                     /note="tissue alpha-L-fucosidase; fucosidase, alpha-L- 1,
                     tissue; alpha-L-fucosidase I; alpha-L-fucoside
                     fucohydrolase 1; Fucosidase, alpha-L-1, tissue"
                     /codon_start=1
                     /product="tissue alpha-L-fucosidase precursor"
                     /protein_id="NP_036694.2"
                     /db_xref="GeneID:24375"
                     /db_xref="RGD:2636"
                     /translation="MWELKSEWWAVGFGLLLLLAASAQAGGLAPHHYTPDWPSLDSRP
                     LPRWFDEAKFGLFVHWGVYSVPAWGSEWFWWHWQGEQSSAYVRFMKENYPPGFSYADF
                     APQFTARFFHPEEWADLFQAAGAKYVVLTAKHHEGFTNWPSAVSWNWNSKDVGPHRDL
                     VGELGAAVRKRNIRYGLYHSLFEWFHPLYLLDKKNGLKTQHFVSTKTMPELYDLVNRY
                     KPDLIWSDGEWECPDSYWNSTEFLAWLYNESPVKDQVVVNDRWGQNCSCRHGGYYNCE
                     DKYRPHSLPDHKWEMCTSVDKASWGYRRDMSMSTIVDENEIIEELVQTISLGGNYLLN
                     IGPNKDGVIVPIFQERLLAVGKWLQINGEAIYASKPWRVQSEKNKTVVWYTTKDSAVY
                     ATFLHWPEDGVVNLQSPKMTSATKITMLGMEGELHWTQDPLEGVLITLPQLPPGTFPV
                     ESAWTLKLTKVN"
     exon            399..533
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            534..671
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            672..777
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            778..978
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1169
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1269
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1489
                     /gene="Fuca1"
                     /gene_synonym="Fuca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttcggtcc cggaagcagg gatgtgggag ctgaaaagtg agtggtgggc ggtgggcttc
       61 gggcttctgc tgctactggc agcttcggcc caggcagggg gcttggctcc gcaccactac
      121 actccggact ggccgagctt ggactcgcga ccactgccga gatggttcga cgaggccaag
      181 ttcgggttgt tcgtgcattg gggggtgtac tcggtgcccg cctggggcag cgagtggttc
      241 tggtggcact ggcagggcga gcagtcgtcg gcgtacgtgc gcttcatgaa agaaaactac
      301 ccgcccggct tcagctacgc cgactttgca ccgcagttta cagcgcgctt cttccatccg
      361 gaggagtggg cagacctctt ccaggctgcc ggggccaagt atgtcgtcct gaccgcaaag
      421 catcacgaag gcttcacaaa ctggccaagc gccgtgtctt ggaactggaa ctcgaaggac
      481 gtggggcccc accgtgattt ggtcggtgag ttgggagcag ctgtgcggaa gaggaacata
      541 cgatacggcc tctaccactc gctctttgag tggttccatc cactctacct actagataag
      601 aaaaatggcc tcaagactca gcatttcgtc agtacaaaaa caatgccaga gctgtacgac
      661 ctcgtgaata ggtacaagcc tgacctaatc tggtctgatg gggagtggga gtgtcccgat
      721 tcgtactgga actccacgga gttccttgct tggctctaca atgaaagccc ggtcaaggat
      781 caggtggtag tgaatgaccg gtggggtcag aactgctcct gtcgtcacgg agggtactac
      841 aactgtgaag acaaatacag accacacagc ctgccagacc acaagtggga gatgtgcacc
      901 agcgtggaca aggcgtcctg gggctatcgg agagacatga gcatgtctac catcgtcgac
      961 gaaaatgaaa tcattgagga attggttcag acaataagtc tgggaggcaa ctatcttctc
     1021 aacatcggac cgaataaaga cggcgtgatc gtccccatct tccaggaaag gctccttgct
     1081 gttggcaagt ggctgcagat caacggggag gccatctatg cctccaaacc atggagggtg
     1141 cagtctgaaa agaacaagac agttgtgtgg tacaccacta aagactcggc tgtttatgcc
     1201 acttttctgc actggccaga agatggagtg gtaaacctcc aatctcccaa aatgacatcg
     1261 gccacaaaga taacgatgct aggaatggaa ggagaactgc actggaccca ggacccactg
     1321 gaaggcgtcc tcatcactct gccccagttg ccaccaggca ctttcccagt ggagtctgcc
     1381 tggactctaa agctgacaaa agtgaactga tcgcaggagc tcaaggatag agggcccagt
     1441 gtgctgctgt ctcttaagga ttatcgtgaa taaagtagct tcctttccaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaaa
//
