LOCUS       NM_001012014            2893 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus FtsJ RNA 2'-O-methyltransferase 3 (Ftsj3), mRNA.
ACCESSION   NM_001012014 XM_221038
VERSION     NM_001012014.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2893)
  AUTHORS   Ringeard,M., Marchand,V., Decroly,E., Motorin,Y. and Bennasser,Y.
  TITLE     FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid
            innate immune sensing
  JOURNAL   Nature 565 (7740), 500-504 (2019)
   PUBMED   30626973
REFERENCE   2  (bases 1 to 2893)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2893)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086512.1.
            
            On Feb 11, 2005 this sequence version replaced XM_221038.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2893
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2893
                     /gene="Ftsj3"
                     /note="FtsJ RNA 2'-O-methyltransferase 3"
                     /db_xref="GeneID:303608"
                     /db_xref="RGD:1307110"
     exon            1..37
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            38..130
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2553
                     /gene="Ftsj3"
                     /EC_number="2.1.1.-"
                     /note="rRNA (uridine-2'-O-)-methyltransferase 3; protein
                     ftsJ homolog 3; putative rRNA methyltransferase 3;
                     2'-O-ribose RNA methyltransferase SPB1 homolog; pre-rRNA
                     processing protein FTSJ3; FtsJ RNA methyltransferase
                     homolog 3; FtsJ homolog 3"
                     /codon_start=1
                     /product="pre-rRNA 2'-O-ribose RNA methyltransferase
                     FTSJ3"
                     /protein_id="NP_001012014.1"
                     /db_xref="GeneID:303608"
                     /db_xref="RGD:1307110"
                     /translation="MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQK
                     ARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQEDITTERCRQAL
                     RKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGCFITKVFR
                     SRDYQPLLWIFQQLFHRVQATKPQASRHESAEIFVVCQGFLAPDKVDAKFFDPKFAFK
                     EVEVQAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEISID
                     DKELAQHPATTEDIRACCQDIKVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISL
                     SSEEEGDEEESAAETKQASEEEEEREEEEQLNRTLAEMKAQEVAELKRKKKKLLREQR
                     KQRERVELKMDLPGVSIADEGETGMFSLRTIRGQQLLEEVTQGDMNAADTFLSDLPRD
                     DIYVSDAEDDDDTSLESDLDPEELAGVRTHSDQKEQKSLQFAQVDDSKEEEGENPLLV
                     PLEEKAVLQEEQASLWFSKDGFSGIDDDADEALEISQAQLLYKSRQKEQQPTDPPPPP
                     TNLKTEKKSSQCQNEVPKETEAITDTGGEDRDSSDSDSSSSEDEDDWKVSRGKKRSRG
                     SKADEDGFEVVPIEDPVKYRILDPEGLALGAVIASSKKAKRDLIDNSFNRYAFNEEEE
                     ELPEWFVQEEKQHRIRQLPLDKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKKL
                     EQTKKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRQVTYVVAKKGVGRKVRRPA
                     GVRGHFKVVDSRMKKDQRAQRKEQKRNHRRK"
     exon            131..236
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            237..283
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            284..363
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            364..463
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..658
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..774
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            775..879
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..980
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1061
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1208
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1344
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1526
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1644
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1898
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1984
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2084
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2268
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2363
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2871
                     /gene="Ftsj3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaaacctg cggagttaag ggctatctaa cgtctcgagt gagtgatact accccatccc
       61 gccatgggca agaaaggcaa agtaggcaag agccggcggg acaagttcta tcacttggcc
      121 aaggagaccg gttatcgttc gcgttctgcc ttcaaactga tccagctcaa tcgccgcttt
      181 cagttccttc agaaagcccg ggccttgctg gacctgtgtg ctgcacctgg aggatggctg
      241 caggtggctg ccaagtttat gcctgtatcc agtcttattg taggagtgga cctggttcca
      301 atcaagcctc tccccaatgt ggtgactctc caggaagata ttacaacaga acgctgtagg
      361 caggccctga ggaaggagct gaagacctgg aaagttgatg ttgtgctcaa tgatggggct
      421 cccaatgtgg gggctagttg ggtccatgat gcttactcac aagctcactt aactctgatg
      481 gctctgcgtt tggcctgtga ctttttggcc cgtggtggtt gtttcatcac gaaagtcttc
      541 cgctcccgag actatcagcc tctgctgtgg atcttccagc agctgttcca ccgtgtccag
      601 gccaccaagc cccaggcctc tcgtcacgaa tctgcagaaa tctttgtagt ctgccaagga
      661 ttcctggctc cggacaaggt tgatgctaaa ttcttcgatc ccaagtttgc ctttaaggaa
      721 gttgaagttc aggctaaaac tgtcactgag ttggtgacaa agaagaagcc aaaggctgaa
      781 ggctatgctg aaggtgacct cactctgtat caccgaacct cagtcactga cttcttgcga
      841 gctgccaatc ctgttgactt cctctccaag gccagcgaaa tctcaataga cgacaaagag
      901 ttggcacagc acccagctac cactgaagat atcagagcat gctgtcagga catcaaagtg
      961 ctggggcgca aggaacttag gtctctactg aattggagaa caaagcttcg gcgatatgtg
     1021 gccaagaagc tgaaagagca agccaaggca ctggacatca gcctcagctc ggaagaagaa
     1081 ggtgatgaag aagagtcagc agctgagaca aagcaggctt cagaggagga agaggagaga
     1141 gaggaggaag agcagcttaa ccggactctg gcagagatga aagcccaaga agtggcagaa
     1201 ctgaagagga agaagaagaa attgcttcgt gagcagagga agcagcggga gcgtgtagag
     1261 ctgaagatgg atctgcctgg ggtctccatt gcagatgagg gggagacagg catgttctcc
     1321 ctgcgaacca tccgtggtca gcagttgtta gaggaagtaa cacaaggaga catgaatgct
     1381 gcagacacct ttctgtctga tttgccaagg gatgacatct atgtgtcaga tgctgaggac
     1441 gatgatgata cttctctgga aagtgaccta gatccagaag agttggcagg agtcaggaca
     1501 cactcagatc agaaggagca gaagagcttg cagtttgctc aagtagatga cagcaaagag
     1561 gaagaaggag agaatccatt gcttgtacca ctagaagaaa aggcagtgct gcaggaagag
     1621 caagctagcc tgtggttctc caaggacggc ttcagtggga tagacgatga tgctgacgaa
     1681 gccctggaga tcagtcaggc acagctgctg tacaagagcc gtcagaagga gcagcagcca
     1741 acagatccac ctccaccacc tactaacttg aagactgaga agaaatcttc ccagtgccag
     1801 aatgaggtcc ctaaggagac agaggctatc actgacactg gaggggagga cagagacagc
     1861 tcggacagtg acagcagcag tagtgaggat gaagacgatt ggaaagtatc ccgtggtaag
     1921 aaacgaagcc gtggttctaa agcagacgag gatgggtttg aggtagtgcc tattgaggac
     1981 ccagtgaaat atcgaattct ggaccctgaa ggccttgctc taggtgctgt tattgcctct
     2041 tccaaaaagg caaagagaga ccttatagat aactcattca accggtatgc ttttaatgaa
     2101 gaggaggaag aacttccaga gtggtttgtg caggaagaaa agcagcatcg gatacgccag
     2161 ttacctcttg ataagaagga ggtggaacat taccgaaaac gctggcgtga aatcaacgca
     2221 cggcccatca agaaagtagc tgaggccaag gccagaaaga aacggaggat gctgaagaag
     2281 ctggagcaga ccaaaaagaa ggcggaagcc gtagtgaaca cagtggatat ctcagaacgg
     2341 gaaaaggtgg cacaactgcg aagtctctac aagaaggctg gacttggcaa ggagaaacgc
     2401 caggtcacct atgttgtagc caagaaaggt gtaggccgta aggtccggcg gccagctgga
     2461 gtcagaggcc atttcaaggt agtggactcc aggatgaaga aggaccaacg agcacagcga
     2521 aaggaacaga agagaaacca caggcgaaag tgagcagagt gctcgggggg tgacggccag
     2581 gaaggaaggc gcggcagtct ctctgtggtt gggagctgct gggcacccac agctcctctt
     2641 tgaagaatga tttaccatga aaggaccaag gaggttattt cttcatcgtg atagactgac
     2701 agtcacccac aatcttggcg tgtgatggaa cttggggatg ggaacaaatc tcttttataa
     2761 gccttcaggg gaattcagtg ttgctggcct tcgttggagg ccttatatta agcgtgtggt
     2821 tccttctgag tcccacccct ttccagtatt ttgaataaaa agataataga aaaaaaaaaa
     2881 aaaaaaaaaa aaa
//
