LOCUS       NM_001039713            1571 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus FTO, alpha-ketoglutarate dependent dioxygenase
            (Fto), mRNA.
ACCESSION   NM_001039713 XM_214652
VERSION     NM_001039713.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Song,M., Yi,F., Zeng,F., Zheng,L., Huang,L., Sun,X., Huang,Q.,
            Deng,J., Wang,H. and Gu,W.
  TITLE     USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic
            Stroke Through Repressing m6A Modification of SIRT6
  JOURNAL   Mol Neurobiol 61 (9), 6658-6674 (2024)
   PUBMED   38340205
  REMARK    GeneRIF: USP18 Stabilized FTO Protein to Activate Mitophagy in
            Ischemic Stroke Through Repressing m6A Modification of SIRT6.
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Zhao,T., Tao,Z., Zhang,G., Zhu,J., Du,M., Hua,F. and He,H.
  TITLE     Fat mass and obesity-associated protein (FTO) affects midpalatal
            suture bone remodeling during rapid maxillary expansion
  JOURNAL   Eur J Orthod 46 (2) (2024)
   PUBMED   38376496
  REMARK    GeneRIF: Fat mass and obesity-associated protein (FTO) affects
            midpalatal suture bone remodeling during rapid maxillary expansion.
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Song,M., Lv,K., Xu,Z., Li,J., Sun,J., Shi,J. and Xu,Y.
  TITLE     N6 methyladenosine eraser FTO suppresses Staphylococcus
            aureus-induced ferroptosis of bone marrow mesenchymal stem cells to
            ameliorate osteomyelitis through regulating the MDM2/TLR4/SLC7A11
            signaling pathway
  JOURNAL   Cell Biol Int 48 (4), 450-460 (2024)
   PUBMED   38165230
  REMARK    GeneRIF: N6 methyladenosine eraser FTO suppresses Staphylococcus
            aureus-induced ferroptosis of bone marrow mesenchymal stem cells to
            ameliorate osteomyelitis through regulating the MDM2/TLR4/SLC7A11
            signaling pathway.
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Zang,S., Yin,X. and Li,P.
  TITLE     FTO-mediated m6A demethylation regulates GnRH expression in the
            hypothalamus via the PLCbeta3/Ca2+/CAMK signalling pathway
  JOURNAL   Commun Biol 6 (1), 1297 (2023)
   PUBMED   38129517
  REMARK    GeneRIF: FTO-mediated m[6]A demethylation regulates GnRH expression
            in the hypothalamus via the PLCbeta3/Ca[2+]/CAMK signalling
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Deng,J., Liao,Y., Chen,J., Chen,A., Wu,S., Huang,Y., Qian,H.,
            Gao,F., Wu,G., Chen,Y., Chen,X. and Zheng,X.
  TITLE     N6-methyladenosine demethylase FTO regulates synaptic and cognitive
            impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal
            rats
  JOURNAL   Cell Death Dis 14 (12), 820 (2023)
   PUBMED   38092760
  REMARK    GeneRIF: N6-methyladenosine demethylase FTO regulates synaptic and
            cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic
            neonatal rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   Lim,L.S., Tai,E.S., Aung,T., Tay,W.T., Saw,S.M., Seielstad,M. and
            Wong,T.Y.
  TITLE     Relation of age-related cataract with obesity and obesity genes in
            an Asian population
  JOURNAL   Am J Epidemiol 169 (10), 1267-1274 (2009)
   PUBMED   19329528
REFERENCE   7  (bases 1 to 1571)
  AUTHORS   Fischer,J., Koch,L., Emmerling,C., Vierkotten,J., Peters,T.,
            Bruning,J.C. and Ruther,U.
  TITLE     Inactivation of the Fto gene protects from obesity
  JOURNAL   Nature 458 (7240), 894-898 (2009)
   PUBMED   19234441
REFERENCE   8  (bases 1 to 1571)
  AUTHORS   Jia,G., Yang,C.G., Yang,S., Jian,X., Yi,C., Zhou,Z. and He,C.
  TITLE     Oxidative demethylation of 3-methylthymine and 3-methyluracil in
            single-stranded DNA and RNA by mouse and human FTO
  JOURNAL   FEBS Lett 582 (23-24), 3313-3319 (2008)
   PUBMED   18775698
REFERENCE   9  (bases 1 to 1571)
  AUTHORS   Fredriksson,R., Hagglund,M., Olszewski,P.K., Stephansson,O.,
            Jacobsson,J.A., Olszewska,A.M., Levine,A.S., Lindblom,J. and
            Schioth,H.B.
  TITLE     The obesity gene, FTO, is of ancient origin, up-regulated during
            food deprivation and expressed in neurons of feeding-related nuclei
            of the brain
  JOURNAL   Endocrinology 149 (5), 2062-2071 (2008)
   PUBMED   18218688
  REMARK    GeneRIF: FTO could participate in the central control of energy
            homeostasis.
REFERENCE   10 (bases 1 to 1571)
  AUTHORS   Gerken,T., Girard,C.A., Tung,Y.C., Webby,C.J., Saudek,V.,
            Hewitson,K.S., Yeo,G.S., McDonough,M.A., Cunliffe,S., McNeill,L.A.,
            Galvanovskis,J., Rorsman,P., Robins,P., Prieur,X., Coll,A.P.,
            Ma,M., Jovanovic,Z., Farooqi,I.S., Sedgwick,B., Barroso,I.,
            Lindahl,T., Ponting,C.P., Ashcroft,F.M., O'Rahilly,S. and
            Schofield,C.J.
  TITLE     The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent
            nucleic acid demethylase
  JOURNAL   Science 318 (5855), 1469-1472 (2007)
   PUBMED   17991826
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AM233906.1.
            
            On Mar 16, 2006 this sequence version replaced XM_214652.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM233906.1, BC168239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1571
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /note="FTO, alpha-ketoglutarate dependent dioxygenase"
                     /db_xref="GeneID:291905"
                     /db_xref="RGD:1305121"
     CDS             1..1509
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /EC_number="1.14.11.53"
                     /function="nuclear protein"
                     /note="protein fto; m6A(m)-demethylase FTO; fat mass and
                     obesity-associated protein; fat mass and obesity
                     associated; tRNA N1-methyl adenine demethylase FTO; mRNA
                     N(6)-methyladenosine demethylase FTO; mRNA
                     (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small
                     nuclear RNA N(6)-methyladenosine-demethylase FTO; U6 small
                     nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO"
                     /codon_start=1
                     /product="alpha-ketoglutarate-dependent dioxygenase FTO"
                     /protein_id="NP_001034802.1"
                     /db_xref="GeneID:291905"
                     /db_xref="RGD:1305121"
                     /translation="MKRVQTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQL
                     KYPKLVFREAGSIPEELHKEVPEAFLTLHKHGCLFRDLVRIQGKDVLTPVSRILIGDP
                     GCTYKYLNTRLFTVPWPVKGCTINYTEAEIAAACQTFLKLNDYLQVETIQALEELAIK
                     EKANEDAVPLCMAEFPRAGVGPSCDDEVDLKSRAAYNVTLLNFMDPQKMPYLKEEPYF
                     GMGKMAVSWHHDENLVDRSAVAVYSYSCEGSEDESDDESSFEGRDPDTWHVGFKISWD
                     IETPGLTIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQR
                     CQLALQNVLNDSDNGDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYKICTDW
                     WCEPMTQLEGLWKKMESVTNAVLREVKREGLSVEQRSEILSAVLIPLTMRQNLRKEWH
                     ARCQARVVRTLPAQQKPDCRPYWEKDDPSMPLPFDLTDVVSEIRSQLLEARS"
     exon            1..45
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
     exon            46..123
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
     exon            124..742
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
     exon            743..886
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
     exon            887..966
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1110
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1230
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1355
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1571
                     /gene="Fto"
                     /gene_synonym="RGD1305121"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagcgcg tccagaccgc ggaggaacgg gagcgggaag ctaagaaact gaggctcctc
       61 gaggagcttg aagacacttg gcttccttac ctgaccccca aagatgacga gttctatcag
      121 cagtggcagc tgaaatatcc taaactggtt ttccgagagg ctggcagcat acccgaggag
      181 ctgcacaaag aggtccccga ggcctttctc acactgcaca agcatggctg cttgtttcgg
      241 gacctggtga ggatccaagg caaagacgtg ctcaccccgg tgtctcgcat cctcattggg
      301 gaccccggct gcacctacaa gtacttgaac accaggctct tcaccgtgcc ctggccagtg
      361 aagggctgca ccatcaatta cacagaggcc gagattgccg ccgcatgtca gaccttcctc
      421 aagctcaatg actacctaca ggtcgagacc atccaggcct tggaagaact ggctatcaaa
      481 gagaaggcca atgaagacgc tgtgccgttg tgcatggcag agttccccag ggctggcgtg
      541 ggaccgtcct gcgatgatga agtggacctt aagagcagag cagcctacaa cgtgactttg
      601 ctaaacttca tggatcctca gaaaatgccg tacttgaaag aggagcccta tttcggcatg
      661 gggaagatgg cggtgagctg gcaccatgac gagaacttgg tggacaggtc agccgtggcg
      721 gtgtacagct atagctgtga aggctccgag gatgaaagcg atgacgagtc cagcttcgaa
      781 ggcagagatc ccgatacgtg gcatgttggt tttaagatct catgggacat cgagacgcca
      841 ggcttgacaa ttcctcttca ccagggagac tgctatttca tgctggatga cctcaatgcc
      901 acccaccagc actgtgtttt ggctggctca cagcctcggt ttagctccac ccaccgcgtg
      961 gcagagtgct caacaggcac cttggattat atcttacaac gctgccagtt ggcactgcag
     1021 aatgttctca atgactcgga caatggcgac gtctcgctga agtccttcga gcctgcagtt
     1081 ctgaaacaag gagaagagat ccacaacgag gtcgagtttg agtggctgag gcagttctgg
     1141 tttcaaggaa atcgatacaa aatttgcact gattggtggt gtgagcccat gactcagctg
     1201 gaggggctgt ggaagaagat ggagagtgtg acaaatgccg tgcttcgtga agttaagaga
     1261 gaggggctct ccgtggaaca aaggagtgaa attctgtctg ccgtcctgat cccactcacc
     1321 atgcgccaga atctgaggaa agaatggcac gccaggtgcc aggcccgagt tgtccgaact
     1381 ctaccagcac agcagaaacc agactgccgg ccatattggg agaaggatga cccttctatg
     1441 cctctgccct ttgacctcac agatgtggtc tctgagatca gaagccagct tctggaagca
     1501 agatcctaga ggatgcacca gtcctaggtg gagaaggaaa agatgtcctt ggcttttctc
     1561 cccagtcctt g
//
