LOCUS       NM_001106136            1250 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus ferritin mitochondrial (Ftmt), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_001106136 XM_001057384 XM_225772
VERSION     NM_001106136.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1250)
  AUTHORS   Xu,C.Z., Gao,Q.Y., Gao,G.H., Chen,Z.T., Wu,M.X., Liao,G.H.,
            Cai,Y.W., Chen,N., Wang,J.F. and Zhang,H.F.
  TITLE     FTMT-dependent mitophagy is crucial for ferroptosis resistance in
            cardiac fibroblast
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119825 (2024)
   PUBMED   39168410
  REMARK    GeneRIF: FTMT-dependent mitophagy is crucial for ferroptosis
            resistance in cardiac fibroblast.
REFERENCE   2  (bases 1 to 1250)
  AUTHORS   Wang,X., Ma,H., Sun,J., Zheng,T., Zhao,P., Li,H. and Yang,M.
  TITLE     Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis
            Via Mitophagy in Type 2 Diabetic Osteoporosis
  JOURNAL   Biol Trace Elem Res 200 (1), 298-307 (2022)
   PUBMED   33594527
  REMARK    GeneRIF: Mitochondrial Ferritin Deficiency Promotes Osteoblastic
            Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis.
REFERENCE   3  (bases 1 to 1250)
  AUTHORS   Lane,D.J., Merlot,A.M., Huang,M.L., Bae,D.H., Jansson,P.J.,
            Sahni,S., Kalinowski,D.S. and Richardson,D.R.
  TITLE     Cellular iron uptake, trafficking and metabolism: Key molecules and
            mechanisms and their roles in disease
  JOURNAL   Biochim Biophys Acta 1853 (5), 1130-1144 (2015)
   PUBMED   25661197
  REMARK    Review article
REFERENCE   4  (bases 1 to 1250)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1250)
  AUTHORS   Bresgen,N., Ohlenschlager,I., Wacht,N., Afazel,S., Ladurner,G. and
            Eckl,P.M.
  TITLE     Ferritin and FasL (CD95L) mediate density dependent apoptosis in
            primary rat hepatocytes
  JOURNAL   J Cell Physiol 217 (3), 800-808 (2008)
   PUBMED   18726999
  REMARK    GeneRIF: Ferritin contributes to apoptosis in primary epatocytes in
            an autocrine, density dependent mode, involving Fas stimulation and
            proapoptotic mitochondrial signalling.
REFERENCE   6  (bases 1 to 1250)
  AUTHORS   Zanella,I., Derosas,M., Corrado,M., Cocco,E., Cavadini,P.,
            Biasiotto,G., Poli,M., Verardi,R. and Arosio,P.
  TITLE     The effects of frataxin silencing in HeLa cells are rescued by the
            expression of human mitochondrial ferritin
  JOURNAL   Biochim Biophys Acta 1782 (2), 90-98 (2008)
   PUBMED   18160053
REFERENCE   7  (bases 1 to 1250)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473971.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057384.1, XM_225772.4.
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..1250
                     /gene="Ftmt"
                     /note="ferritin mitochondrial"
                     /db_xref="GeneID:291470"
                     /db_xref="RGD:1306563"
     exon            1..1250
                     /gene="Ftmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..793
                     /gene="Ftmt"
                     /EC_number="1.16.3.1"
                     /codon_start=1
                     /product="ferritin, mitochondrial"
                     /protein_id="NP_001099606.1"
                     /db_xref="GeneID:291470"
                     /db_xref="RGD:1306563"
                     /translation="MLSCFWFFSKHIGPALMSLPCVLHRFTAPRCLASRYPLSPLLAS
                     PRRLLASVASSQGSTGPARVRQNFHPDSEAAINRQINMELYASYVYLSMAYYFSRDDV
                     ALYNFSKYFLRQSLEEREHAEKLMRLQNQRGGRICLQDIKKPDKDDWECGLRAMECAL
                     LLEKSVNQSLLDLHTLASEKGDPHLCDFLETHYLHEQVKSIKELGDHVHNLVTMGAPA
                     AGLAEYLFDKHTLGSESKH"
ORIGIN      
        1 catttagacc tgacgctcag cagcagacct tgtgctgagc ttgtctgacc tcagtttccc
       61 ctactttcaa ataggagtca tgctgtcctg cttttggttc ttctccaagc acatcggccc
      121 tgcactgatg tccctgccct gtgtgttaca cagattcact gccccacggt gcttggcctc
      181 caggtatcct ttaagtcccc tactggcctc ccctcgacgc ctcctggcct cggtggcttc
      241 ctcccagggc tccactgggc ctgccagagt gcgccagaac tttcacccag actccgaggc
      301 tgccatcaac cgccaaatca acatggagct ttacgcatcc tacgtgtacc tgtccatggc
      361 ttactacttc tccagggatg atgtggcctt gtacaacttc tccaagtatt tccttcgcca
      421 gtccctggag gagagggagc atgcagagaa gcttatgaga ctgcagaacc agcgaggagg
      481 ccggatctgc ctccaggaca tcaagaagcc agacaaagat gactgggaat gcggactgcg
      541 ggccatggaa tgtgccttgc tcttagaaaa gagtgtaaac cagtccctcc tggacttgca
      601 tactctggcc tcagaaaaag gagatcctca tttgtgtgac tttctggaaa ctcactacct
      661 gcatgagcaa gtgaagtcta tcaaagaatt aggtgaccac gtgcacaact tagtcactat
      721 gggggctcca gccgctggcc tagcggagta tcttttcgac aagcacacgc ttggaagcga
      781 gagcaagcac taagacagag gctgcctacc ggatacccca gtgggtccca agacctggat
      841 ggagttagag atctcctgtt tcttgccctt aaaacttgac tccaacttta cattctcctc
      901 cctttttgga ctgttctgct aatgttttgt agagaaaata tgcttagccc tgtgttcacc
      961 acagctttct accaacacca aaatactaat attttcccag cctgaaagat agcccagaat
     1021 actctggtat gaaagggatg ggagacaaaa cacttaaatt agatacaaga gtgtgttctt
     1081 tgaatattat tagcaaatgt tgttcctaac cataaaccta aactgaactt ccatgatctt
     1141 tccaattcaa caatctatac tgtcttcaaa atcttatgca aagtggtcgg tgagagaaat
     1201 gtataatata tcattgtagg acagagaaga tatagagtac ttagaaaatc
//
