LOCUS       NM_022500                916 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ferritin light chain 1 (Ftl1), mRNA.
ACCESSION   NM_022500
VERSION     NM_022500.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 916)
  AUTHORS   Yang,X., Ding,Y., Sun,L., Shi,M., Zhang,P., Huang,Z., Wang,J.,
            He,A., Wang,J., Wei,J., Liu,M., Liu,J., Wang,G., Yang,X. and Li,R.
  TITLE     Ferritin light chain deficiency-induced ferroptosis is involved in
            preeclampsia pathophysiology by disturbing uterine spiral artery
            remodelling
  JOURNAL   Redox Biol 58, 102555 (2022)
   PUBMED   36446230
  REMARK    GeneRIF: Ferritin light chain deficiency-induced ferroptosis is
            involved in preeclampsia pathophysiology by disturbing uterine
            spiral artery remodelling.
REFERENCE   2  (bases 1 to 916)
  AUTHORS   Khodanovich,M.Y., Akulov,A.E., Anan'ina,T.V., Kudabaeva,M.S.,
            Pishchelko,A.O., Krutenkova,E.P., Nemirovich-Danchenko,N.M.,
            Svetlik,M.V., Tumentceva,Y.A., Van den Haute,C., Gijsbers,R.,
            Daniels,V., Thiry,I., Pershina,A.G., Shadrina,M.M. and Naumova,A.V.
  TITLE     Tissue-Specific Ferritin- and GFP-Based Genetic Vectors Visualize
            Neurons by MRI in the Intact and Post-Ischemic Rat Brain
  JOURNAL   Int J Mol Sci 21 (23), 8951 (2020)
   PUBMED   33255702
  REMARK    GeneRIF: Tissue-Specific Ferritin- and GFP-Based Genetic Vectors
            Visualize Neurons by MRI in the Intact and Post-Ischemic Rat Brain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 916)
  AUTHORS   Zhang,Y., Li,H., Zhang,J., Cao,Y., Zhao,X., Yu,N., Gao,Y., Ma,J.,
            Zhang,H., Zhang,J., Guo,X. and Liu,X.
  TITLE     The clinical characteristics and outcomes of patients with diabetes
            and secondary hyperglycaemia with coronavirus disease 2019: A
            single-centre, retrospective, observational study in Wuhan
  JOURNAL   Diabetes Obes Metab 22 (8), 1443-1454 (2020)
   PUBMED   32406594
REFERENCE   4  (bases 1 to 916)
  AUTHORS   Hou,H., Zhang,B., Huang,H., Luo,Y., Wu,S., Tang,G., Liu,W., Mao,L.,
            Mao,L., Wang,F. and Sun,Z.
  TITLE     Using IL-2R/lymphocytes for predicting the clinical progression of
            patients with COVID-19
  JOURNAL   Clin Exp Immunol 201 (1), 76-84 (2020)
   PUBMED   32365221
REFERENCE   5  (bases 1 to 916)
  AUTHORS   Wang,Q.P., Guo,L.Y., Lu,Z.Y. and Gu,J.W.
  TITLE     Reference intervals established using indirect method for serum
            ferritin assayed on Abbott Architect i2000SR analyzer in Chinese
            adults
  JOURNAL   J Clin Lab Anal 34 (3), e23083 (2020)
   PUBMED   31674712
  REMARK    GeneRIF: Reference intervals established using indirect method for
            serum ferritin assayed on Abbott Architect i2000SR analyzer in
            Chinese adults.
REFERENCE   6  (bases 1 to 916)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
REFERENCE   7  (bases 1 to 916)
  AUTHORS   Girelli,D., Corrocher,R., Bisceglia,L., Olivieri,O., Zelante,L.,
            Panozzo,G. and Gasparini,P.
  TITLE     Hereditary hyperferritinemia-cataract syndrome caused by a 29-base
            pair deletion in the iron responsive element of ferritin L-subunit
            gene
  JOURNAL   Blood 90 (5), 2084-2088 (1997)
   PUBMED   9292547
REFERENCE   8  (bases 1 to 916)
  AUTHORS   Denis,M.G., Chadeneau,C., Lustenberger,P., Le Mevel,B. and
            Meflah,K.
  TITLE     Isolation of cDNA clones corresponding to genes differentially
            expressed in two colon-carcinoma cell lines differing by their
            tumorigenicity
  JOURNAL   Int J Cancer 50 (6), 930-936 (1992)
   PUBMED   1555892
REFERENCE   9  (bases 1 to 916)
  AUTHORS   Leibold,E.A. and Munro,H.N.
  TITLE     Characterization and evolution of the expressed rat ferritin light
            subunit gene and its pseudogene family. Conservation of sequences
            within noncoding regions of ferritin genes
  JOURNAL   J Biol Chem 262 (15), 7335-7341 (1987)
   PUBMED   3584116
REFERENCE   10 (bases 1 to 916)
  AUTHORS   Leibold,E.A., Aziz,N., Brown,A.J. and Munro,H.N.
  TITLE     Conservation in rat liver of light and heavy subunit sequences of
            mammalian ferritin. Presence of unique octopeptide in the light
            subunit
  JOURNAL   J Biol Chem 259 (7), 4327-4334 (1984)
   PUBMED   6546756
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ220123.1 and JAXUCZ010000001.1.
            
            On Mar 8, 2021 this sequence version replaced NM_022500.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219809.1, FQ232031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               FQ220123.1         1-103
            104-270518283       JAXUCZ010000001.1  1-270518180
            270518284-270519095 FQ220123.1         105-916
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..916
                     /gene="Ftl1"
                     /gene_synonym="Ftl"
                     /note="ferritin light chain 1"
                     /db_xref="GeneID:29292"
                     /db_xref="RGD:61813"
     exon            1..307
                     /gene="Ftl1"
                     /gene_synonym="Ftl"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..757
                     /gene="Ftl1"
                     /gene_synonym="Ftl"
                     /note="ferritin L subunit 1; ferritin, light polypeptide"
                     /codon_start=1
                     /product="ferritin light chain 1"
                     /protein_id="NP_071945.3"
                     /db_xref="GeneID:29292"
                     /db_xref="RGD:61813"
                     /translation="MTSQIRQNYSTEVEAAVNRLVNLHLRASYTYLSLGFFFDRDDVA
                     LEGVGHFFRELAEEKREGAERLLKLQNERGGRALFQDVQKPSQDEWGKTLEAMEAALA
                     LEKNLNQALLDLHALGSARTDPHLCDFLESHFLDKEVKLIKKMGNHLTNLRRVAGPQP
                     AQTGVAQASLGEYLFERLTLKHD"
     exon            308..454
                     /gene="Ftl1"
                     /gene_synonym="Ftl"
                     /inference="alignment:Splign:2.1.0"
     exon            455..580
                     /gene="Ftl1"
                     /gene_synonym="Ftl"
                     /inference="alignment:Splign:2.1.0"
     exon            581..916
                     /gene="Ftl1"
                     /gene_synonym="Ftl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcagcgct ttggagatcc cgaggatctg tatcttgctt caacagtgtt tggacggaac
       61 agacccgggg actcccactt tattcacttc cagccgcctt acaagtctct ccagtcgcag
      121 cctccgggac catctccttg ccgccttcgg ctcctaggac cagccagccc cgtcttcgcg
      181 gttagctcca tactccggat cagccatgac ctctcagatt cgtcagaatt attccaccga
      241 agtggaagct gccgtgaacc gcctggtcaa cttgcacctg cgggcctctt acacctacct
      301 ctctctgggc ttcttttttg atcgggatga cgtggctttg gaaggcgtag gccacttctt
      361 ccgcgaattg gccgaggaga agcgcgaggg cgccgagcgt ctcctcaagt tgcagaacga
      421 acgcgggggc cgtgcactct tccaggatgt gcagaagcca tctcaagatg agtggggtaa
      481 aaccctggag gccatggaag ctgccttggc cctggagaag aacctgaacc aggccctctt
      541 ggatctgcac gccctgggct ctgcccgcac agaccctcac ctctgtgact tcttggaaag
      601 ccacttcctg gataaggagg tgaagctcat caagaagatg ggcaaccacc tgaccaacct
      661 ccgtagggtg gcagggccac aaccagcgca gactggcgtg gcccaggcat ctctgggcga
      721 gtatctcttt gagcgcctca ctctgaagca cgactaggcc tctgtgcctt ccaaggggct
      781 ccctcctctg ctctgcaccg accgcctcag cacctccacc cgaatgaacc tctaaagcca
      841 ctaggcagct ttgtaaccgc cctggagcct ctcccaagtc ttggaccaag taaaaataaa
      901 gctttttgaa acagca
//
