LOCUS       NM_012848                828 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ferritin heavy chain 1 (Fth1), mRNA.
ACCESSION   NM_012848
VERSION     NM_012848.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 828)
  AUTHORS   Irollo,E., Nash,B., Luchetta,J., Brandimarti,R. and Meucci,O.
  TITLE     The Endolysosomal Transporter DMT1 is Required for Morphine
            Regulation of Neuronal Ferritin Heavy Chain
  JOURNAL   J Neuroimmune Pharmacol 18 (3), 495-508 (2023)
   PUBMED   37661197
  REMARK    GeneRIF: The Endolysosomal Transporter DMT1 is Required for
            Morphine Regulation of Neuronal Ferritin Heavy Chain.
REFERENCE   2  (bases 1 to 828)
  AUTHORS   Tian,Y., Lu,J., Hao,X., Li,H., Zhang,G., Liu,X., Li,X., Zhao,C.,
            Kuang,W., Chen,D. and Zhu,M.
  TITLE     FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA
            Model of Parkinson's Disease
  JOURNAL   Neurotherapeutics 17 (4), 1796-1812 (2020)
   PUBMED   32959272
  REMARK    GeneRIF: FTH1 Inhibits Ferroptosis Through Ferritinophagy in the
            6-OHDA Model of Parkinson's Disease.
REFERENCE   3  (bases 1 to 828)
  AUTHORS   Zhang,Y., Li,H., Zhang,J., Cao,Y., Zhao,X., Yu,N., Gao,Y., Ma,J.,
            Zhang,H., Zhang,J., Guo,X. and Liu,X.
  TITLE     The clinical characteristics and outcomes of patients with diabetes
            and secondary hyperglycaemia with coronavirus disease 2019: A
            single-centre, retrospective, observational study in Wuhan
  JOURNAL   Diabetes Obes Metab 22 (8), 1443-1454 (2020)
   PUBMED   32406594
REFERENCE   4  (bases 1 to 828)
  AUTHORS   Hou,H., Zhang,B., Huang,H., Luo,Y., Wu,S., Tang,G., Liu,W., Mao,L.,
            Mao,L., Wang,F. and Sun,Z.
  TITLE     Using IL-2R/lymphocytes for predicting the clinical progression of
            patients with COVID-19
  JOURNAL   Clin Exp Immunol 201 (1), 76-84 (2020)
   PUBMED   32365221
REFERENCE   5  (bases 1 to 828)
  AUTHORS   Mu,T., Qin,Y., Liu,B., He,X., Liao,Y., Sun,J., Qiu,J., Li,X.,
            Zhong,Y. and Cai,J.
  TITLE     In Vitro Neural Differentiation of Bone Marrow Mesenchymal Stem
            Cells Carrying the FTH1 Reporter Gene and Detection with MRI
  JOURNAL   Biomed Res Int 2018, 1978602 (2018)
   PUBMED   30046590
  REMARK    GeneRIF: FTH1 gene expression did not affect mesenchymal stem cell
            differentiation into neurons and was not affected by neural
            differentiation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 828)
  AUTHORS   Wu,C.G., Groenink,M., Bosma,A., Reitsma,P.H., van Deventer,S.J. and
            Chamuleau,R.A.
  TITLE     Rat ferritin-H: cDNA cloning, differential expression and
            localization during hepatocarcinogenesis
  JOURNAL   Carcinogenesis 18 (1), 47-52 (1997)
   PUBMED   9054589
REFERENCE   7  (bases 1 to 828)
  AUTHORS   Ursini,M.V. and de Franciscis,V.
  TITLE     TSH regulation of ferritin H chain messenger RNA levels in the rat
            thyroids
  JOURNAL   Biochem Biophys Res Commun 150 (1), 287-295 (1988)
   PUBMED   2827671
REFERENCE   8  (bases 1 to 828)
  AUTHORS   Murray,M.T., White,K. and Munro,H.N.
  TITLE     Conservation of ferritin heavy subunit gene structure: implications
            for the regulation of ferritin gene expression
  JOURNAL   Proc Natl Acad Sci U S A 84 (21), 7438-7442 (1987)
   PUBMED   3478702
REFERENCE   9  (bases 1 to 828)
  AUTHORS   Krawetz,S.A., Connor,W., Cannon,P.D. and Dixon,G.H.
  TITLE     A vector-primer-cloner-sequencer plasmid for the construction of
            cDNA libraries: evidence for a rat glyceraldehyde-3-phosphate
            dehydrogenase-like mRNA and a ferritin mRNA within testis
  JOURNAL   DNA 5 (5), 427-435 (1986)
   PUBMED   3780374
  REMARK    Erratum:[DNA 1986 Oct;6(3):281]
REFERENCE   10 (bases 1 to 828)
  AUTHORS   Leibold,E.A., Aziz,N., Brown,A.J. and Munro,H.N.
  TITLE     Conservation in rat liver of light and heavy subunit sequences of
            mammalian ferritin. Presence of unique octopeptide in the light
            subunit
  JOURNAL   J Biol Chem 259 (7), 4327-4334 (1984)
   PUBMED   6546756
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U58829.1.
            
            On Aug 30, 2012 this sequence version replaced NM_012848.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U58829.1, FQ229789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-828               U58829.1           3-830
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..828
                     /gene="Fth1"
                     /gene_synonym="Fth"
                     /note="ferritin heavy chain 1"
                     /db_xref="GeneID:25319"
                     /db_xref="RGD:2635"
     exon            1..241
                     /gene="Fth1"
                     /gene_synonym="Fth"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..676
                     /gene="Fth1"
                     /gene_synonym="Fth"
                     /EC_number="1.16.3.1"
                     /note="ferritin H subunit; Ferritin subunit H; ferritin,
                     heavy polypeptide 1"
                     /codon_start=1
                     /product="ferritin heavy chain"
                     /protein_id="NP_036980.1"
                     /db_xref="GeneID:25319"
                     /db_xref="RGD:2635"
                     /translation="MTTASPSQVRQNYHQDSEAAINRQINLELYASYVYLSMSCYFDR
                     DDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAME
                     CALHLEKSVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKSIKELGDHVTNLRKMG
                     APESGMAEYLFDKHTLGHGDES"
     exon            242..388
                     /gene="Fth1"
                     /gene_synonym="Fth"
                     /inference="alignment:Splign:2.1.0"
     exon            389..514
                     /gene="Fth1"
                     /gene_synonym="Fth"
                     /inference="alignment:Splign:2.1.0"
     exon            515..828
                     /gene="Fth1"
                     /gene_synonym="Fth"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtgcttg aacggaaccc ggtgctcgac ccctccgacc cccgccggcc gctttgagcc
       61 tgagcccttt gcaacttcgt cgctccgccg ctccagcgtc gcctccgcgc ctcgcccagc
      121 cgccatcatg accaccgcgt ctccctcgca agtgcgccag aactaccacc aggactcgga
      181 ggctgccatc aaccgccaga tcaacctgga gttgtatgcc tcctacgtct atctgtccat
      241 gtcttgttat tttgaccggg atgatgtggc cctgaagaac tttgccaaat actttctcca
      301 tcaatctcat gaagagaggg aacatgctga gaaactgatg aagctgcaga accagcgagg
      361 tggacgaatc ttcctgcagg atataaagaa acctgaccgt gatgactggg agagcgggct
      421 gaatgcaatg gagtgtgcac tgcacttgga aaagagtgtg aatcagtcac tactggaact
      481 tcacaaactg gctactgaca agaatgatcc ccacttatgt gacttcattg agacgcatta
      541 cctgaatgag caggtgaaat ccattaaaga actgggtgac cacgtgacca acttacgcaa
      601 gatgggagcc cctgaatctg gcatggcaga atatctcttt gacaagcaca ccctgggaca
      661 cggtgatgag agctaagctg acgtccccaa ggccatgtga ctttactggt cactgaggca
      721 gtgcatgcat gtcaggctgc ctttatcttt tctataagtt gcaccaaaac atctgcttaa
      781 aagttcttta atttgtacca tttcttcaaa taaagaattt tggtaccc
//
