LOCUS       NM_053567               1866 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus formimidoyltransferase cyclodeaminase (Ftcd),
            mRNA.
ACCESSION   NM_053567
VERSION     NM_053567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Mertes,F., Martinez-Morales,J.R., Nolden,T., Sporle,R.,
            Wittbrodt,J., Lehrach,H. and Himmelbauer,H.
  TITLE     Cloning of mouse ojoplano, a reticular cytoplasmic protein
            expressed during embryonic development
  JOURNAL   Gene Expr Patterns 9 (8), 562-567 (2009)
   PUBMED   19766735
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Mao,Y., Vyas,N.K., Vyas,M.N., Chen,D.H., Ludtke,S.J., Chiu,W. and
            Quiocho,F.A.
  TITLE     Structure of the bifunctional and Golgi-associated
            formiminotransferase cyclodeaminase octamer
  JOURNAL   EMBO J 23 (15), 2963-2971 (2004)
   PUBMED   15272307
  REMARK    GeneRIF: Determination of the FTCD structure by X-ray
            crystallography and electron cryomicroscopy revealed that the eight
            subunits, each composed of distinct FT and CD domains, are arranged
            like a square doughnut
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Renous,R., Lapierre,P., Djilali-Saiah,I., Vitozzi,S. and Alvarez,F.
  TITLE     Characterization of the antigenicity of the
            formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis
  JOURNAL   Exp Cell Res 292 (2), 332-341 (2004)
   PUBMED   14697341
REFERENCE   5  (bases 1 to 1866)
  AUTHORS   Hilton,J.F., Christensen,K.E., Watkins,D., Raby,B.A., Renaud,Y., de
            la Luna,S., Estivill,X., MacKenzie,R.E., Hudson,T.J. and
            Rosenblatt,D.S.
  TITLE     The molecular basis of glutamate formiminotransferase deficiency
  JOURNAL   Hum Mutat 22 (1), 67-73 (2003)
   PUBMED   12815595
  REMARK    Erratum:[Hum Mutat. 2003 Nov;22(5):416]
REFERENCE   6  (bases 1 to 1866)
  AUTHORS   Gao,Y.S., Vrielink,A., MacKenzie,R. and Sztul,E.
  TITLE     A novel type of regulation of the vimentin intermediate filament
            cytoskeleton by a Golgi protein
  JOURNAL   Eur J Cell Biol 81 (7), 391-401 (2002)
   PUBMED   12160147
  REMARK    GeneRIF: FTCD is a potent modulator of the vimentin IF cytoskeleton
REFERENCE   7  (bases 1 to 1866)
  AUTHORS   Gao,Y.S., Alvarez,C., Nelson,D.S. and Sztul,E.
  TITLE     Molecular cloning, characterization, and dynamics of rat
            formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa
            protein
  JOURNAL   J Biol Chem 273 (50), 33825-33834 (1998)
   PUBMED   9837973
REFERENCE   8  (bases 1 to 1866)
  AUTHORS   Bashour,A.M. and Bloom,G.S.
  TITLE     58K, a microtubule-binding Golgi protein, is a formiminotransferase
            cyclodeaminase
  JOURNAL   J Biol Chem 273 (31), 19612-19617 (1998)
   PUBMED   9677387
REFERENCE   9  (bases 1 to 1866)
  AUTHORS   Findlay,W.A., Zarkadas,C.G. and MacKenzie,R.E.
  TITLE     An improved procedure for the purification of
            formiminotransferase-cyclodeaminase from pig liver. Kinetics of the
            transferase activity with tetrahydropteroylpolyglutamates
  JOURNAL   Biochim Biophys Acta 999 (1), 52-57 (1989)
   PUBMED   2572277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 2, 2020 this sequence version replaced NM_053567.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF079233.3, BC091134.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000020.1  12068151-12068219   c
            70-253              JAXUCZ010000020.1  12067211-12067394   c
            254-382             JAXUCZ010000020.1  12066369-12066497   c
            383-471             JAXUCZ010000020.1  12064770-12064858   c
            472-651             JAXUCZ010000020.1  12064469-12064648   c
            652-789             JAXUCZ010000020.1  12063244-12063381   c
            790-921             JAXUCZ010000020.1  12063036-12063167   c
            922-983             JAXUCZ010000020.1  12061337-12061398   c
            984-1113            JAXUCZ010000020.1  12060941-12061070   c
            1114-1275           JAXUCZ010000020.1  12060567-12060728   c
            1276-1319           JAXUCZ010000020.1  12057860-12057903   c
            1320-1458           JAXUCZ010000020.1  12057603-12057741   c
            1459-1554           JAXUCZ010000020.1  12056880-12056975   c
            1555-1866           JAXUCZ010000020.1  12054710-12055021   c
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1866
                     /gene="Ftcd"
                     /note="formimidoyltransferase cyclodeaminase"
                     /db_xref="GeneID:89833"
                     /db_xref="RGD:70915"
     exon            1..69
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1641
                     /gene="Ftcd"
                     /EC_number="2.1.2.5"
                     /EC_number="4.3.1.4"
                     /note="58 kDa microtubule-binding protein;
                     formiminotransferase cyclodeaminase"
                     /codon_start=1
                     /product="formimidoyltransferase-cyclodeaminase"
                     /protein_id="NP_446019.1"
                     /db_xref="GeneID:89833"
                     /db_xref="RGD:70915"
                     /translation="MSQLVECVPNFSEGNNQEVIDAISQAISQTPGCVLLDVDAGPST
                     NRTVYTFVGQPECVVEGALSAARTASQLIDMRKHKGEHPRMGALDVCPFIPVRGVSMD
                     ECVLCAKAFGQRLAEELNVPVYLYGEAAQMPSRQTLPAIRAGEYEALPEKLKQAEWVP
                     DFGPSSFVPSWGATVTGARKFLIAFNINLLSTKEQAHRIALNLREQGRGKDQPGRLKK
                     VQGIGWYLEEKNLAQVSTNLLDFEVTALHTVYEEARREAQELNLPVVGSQLVGLVPLK
                     ALLDAAAFYCDKEKLFVLEEEHRIRLVVNRLGLDSLAPFDPKERIIEYLVPDSGPEQS
                     LLDASLRAFVREVGARSAAPGGGSVAAAVAALGAALASMVGQMTYGRRQFDHLDSTMR
                     RLIPPFHAASAQLTSLVDADARAFAACLGAIKLPKNTPEERDRRTCALQEGLRQAVAV
                     PLKLAETVSQLWPALQELAQCGNLSCLSDLQVAAKALETGVFGAYFNVLINLKDMTDD
                     VFKEKTRHRISSLLQEAKTQAALVLGSLEARKE"
     exon            70..253
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            254..382
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            383..471
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            472..651
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            652..789
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            790..921
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            922..983
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1113
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1275
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1319
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1458
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1554
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1866
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcaggtgc tggccatgtc ccagttggtg gaatgtgtcc ccaacttctc agaggggaac
       61 aaccaggagg tgatcgatgc catttctcaa gccatctccc agaccccagg ttgtgtgctg
      121 ttggacgttg atgctggacc ctccaccaac cgcactgtct acacttttgt ggggcagccg
      181 gagtgtgtgg tcgagggagc cctcagtgct gcgcgaacag cctcacagct catcgacatg
      241 aggaagcaca agggagagca ccctcgaatg ggtgctctgg atgtgtgtcc cttcatcccg
      301 gtgaggggcg tcagcatgga cgagtgtgtg ctctgtgcca aggcatttgg gcagcggctg
      361 gcagaggaac tgaatgtacc agtgtacctc tatggtgagg cggctcagat gcccagtcgt
      421 cagaccctgc cagccatccg ggctggagag tatgaggccc tgcctgagaa gctcaaacag
      481 gccgagtggg tgcccgactt tggccctagc tcctttgtcc ccagttgggg tgccactgtc
      541 acgggtgcac ggaaattcct cattgcgttc aatatcaatc tgctaagcac caaggaacag
      601 gcccaccgta tcgctctcaa cctgcgggag cagggccgag ggaaagacca gccgggacgt
      661 ctgaaaaagg ttcagggcat cggctggtac ctagaagaga agaacctggc tcaggtgtcc
      721 accaacctcc tggattttga ggtcacggct ctgcacacag tgtacgagga ggcccgccga
      781 gaggctcagg agctgaatct cccagtggtg ggctcacagc tggtgggcct ggtgcctctg
      841 aaggccttac tggatgccgc agccttctac tgtgacaagg agaagctgtt tgttctggag
      901 gaggagcacc ggattcgact ggtggtgaac cggctgggtc tggattccct ggcgcccttc
      961 gacccaaagg agcggatcat cgagtacctg gtcccggata gtggaccaga acagagcctg
     1021 ctggacgcat cactgcgtgc ttttgttcgg gaggtgggag cccgctctgc tgccccagga
     1081 ggcggttccg tagccgcagc tgttgcagct ctgggtgcag ccctggcttc tatggtgggc
     1141 cagatgacct atggccggcg ccagtttgat cacctggatt ccacaatgcg acgcttgatc
     1201 ccacccttcc atgcagcctc cgcccagctg acttcattgg tggacgctga cgcgcgggct
     1261 tttgctgcct gtttgggggc aataaagctg cccaagaata cgcctgaaga gagggacagg
     1321 cgcacatgtg ctctgcaaga ggggctgaga caggcggtcg ctgtgccact gaaactggct
     1381 gagacggtgt cccagctatg gccggcgctg caggagctgg cccaatgtgg caacctctct
     1441 tgcttgtctg acctgcaggt ggcagccaaa gccttggaga caggtgtgtt tggtgcgtac
     1501 ttcaatgtgc tcatcaacct gaaggacatg acggatgatg tatttaaaga gaagacacgc
     1561 catcgaatct ccagccttct gcaggaagcc aagacccagg ctgcactggt gctgggtagc
     1621 ctagaagctc ggaaggagtg aagagatcgc tcctcagtga atggtccaac ttccagaatt
     1681 ccttacctat cttgcttggg gagaagactc agccatgata tcagcagggt caggttgggg
     1741 ctctatagac agctgtagga tcagaagacc caacagaggt ggtttggggt agggtatggt
     1801 agggcctgat tgggggtggt atcccgacac tctctgttat ctgtggcttc tagtaaaatt
     1861 tgaaca
//
