LOCUS       NM_001271195            5095 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus follistatin-like 5 (Fstl5), mRNA.
ACCESSION   NM_001271195 XM_003753598
VERSION     NM_001271195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5095)
  AUTHORS   Khanshour,A.M., Kidane,Y.H., Kozlitina,J., Cornelia,R., Rafipay,A.,
            De Mello,V., Weston,M., Paria,N., Khalid,A., Hecht,J.T.,
            Dobbs,M.B., Richards,B.S., Vargesson,N., Hamra,F.K., Wilson,M.,
            Wise,C., Gurnett,C.A. and Rios,J.J.
  TITLE     Genetic association and characterization of FSTL5 in isolated
            clubfoot
  JOURNAL   Hum Mol Genet 29 (22), 3717-3728 (2021)
   PUBMED   33105483
  REMARK    GeneRIF: Genetic association and characterization of FSTL5 in
            isolated clubfoot.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Sep 6, 2012 this sequence version replaced XM_003753598.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.348702.1,
                                           SRR22582416.1259057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-704               JAXUCZ010000002.1  163156576-163157279
            705-846             JAXUCZ010000002.1  163207648-163207789
            847-880             JAXUCZ010000002.1  163288472-163288505
            881-1129            JAXUCZ010000002.1  163388187-163388435
            1130-1326           JAXUCZ010000002.1  163492704-163492900
            1327-1447           JAXUCZ010000002.1  163515087-163515207
            1448-1614           JAXUCZ010000002.1  163587436-163587602
            1615-1735           JAXUCZ010000002.1  163654717-163654837
            1736-1897           JAXUCZ010000002.1  163697934-163698095
            1898-2032           JAXUCZ010000002.1  163701690-163701824
            2033-2059           JAXUCZ010000002.1  163717607-163717633
            2060-2178           JAXUCZ010000002.1  163724367-163724485
            2179-2328           JAXUCZ010000002.1  163747137-163747286
            2329-2436           JAXUCZ010000002.1  163777776-163777883
            2437-2561           JAXUCZ010000002.1  163780104-163780228
            2562-5095           JAXUCZ010000002.1  163822607-163825140
FEATURES             Location/Qualifiers
     source          1..5095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..5095
                     /gene="Fstl5"
                     /note="follistatin-like 5"
                     /db_xref="GeneID:365823"
                     /db_xref="RGD:1306858"
     exon            1..704
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..846
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             721..3264
                     /gene="Fstl5"
                     /note="follistatin-related protein 5; ollistatin-like 5"
                     /codon_start=1
                     /product="follistatin-related protein 5 precursor"
                     /protein_id="NP_001258124.1"
                     /db_xref="GeneID:365823"
                     /db_xref="RGD:1306858"
                     /translation="MFKCWSAVLILGFIFLASEGRPTKESGYGLKYYQPLTRLRHKQE
                     KSQESSRIKEFLIHDGPFGSCENKYCGLGRHCVISRETRHAECTCMDLCKQHYKPVCG
                     SDGEFYENHCEVHRAACLKKQKITIVHNEDCFFKGDNCMTTEYSKMKSMLLDLQNQKY
                     ITQENENPNSDDISRKKTLVDQMFKYFDADSNGLVDINELTQVIKQEELNKDLSDCTL
                     YDLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQRVSITAATVGQSAVLSCAVVGTL
                     RPPIIWKRNNIVLNNLDLEDINDFGDDGSLYITKVTTVHMGNYTCYADGYEDVHQTHI
                     FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPDPQLGWLKNGIDITPKLSKQLTLQ
                     ANGSEVHISNVRYEDTGAYTCIARNEAGVDEDISSLFVEDSARKTLANILWREEGLGI
                     GNMFYVFYDDGVKVIQPTECEFQRHIKPSEKLLGFQDEVCPKDEEDEVQRCVWASAVN
                     VKDKFIYVAQPTLDRILIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGSMEK
                     TSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTPTLIITHMRFGFILHKDES
                     ALHKIDLETMSYIKTISLKDSKCIPLSLAYSHLGGYYFISCKPDITGAIPPQLVVDSV
                     TDSIIGSNSDVTGTPYVSPDGHYLVSVNDVKGLVRVQYITIRGEILDAFDIHTNLHIS
                     DLAFQPSFTEAHQYNIYGSSSQQTDVLFVELSTGKVKMIKSLKEPLKTEDWPWSPKNR
                     HIQGSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVQKGNTVVWVGDA"
     exon            847..880
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1129
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1326
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1447
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1614
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1735
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1897
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2032
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2059
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2178
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2328
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2436
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2561
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..5095
                     /gene="Fstl5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatccgcg gtcccagcga aggaggaggc gcagacacag ccgcagcctt tagtttctgc
       61 tgggctccgc gaatcgagca taaagtccga caatgcccac gccgccgatt ttaatccgga
      121 atctggtcct cgggattgcg gtggctgaac ccatcagaag cccagtcaag gggccgcccc
      181 tcacctcccg gagagttaat atgcaaaaca gttacgtcag atgtgggggc ggggcacacc
      241 ggggttgaca ggcagcctgg ctcttgccga gggaggaggc gcgagaatca gcttggttca
      301 gtgactgaga ctaactggac gtgagcggag ctggtgctgt ccacagtgtg tcggtgctga
      361 acgccgggtg tgagggatcg cctgcttggg cacctggagg caacgcccac tggaacactc
      421 tgtgcccagt gggacccgct tcaccagcag gacccaattt aacttgacaa aggagtgcga
      481 ctcggacgtg ggagagactc ctatgtttgc aatctgggcg cccactcagg cgtgactttg
      541 gagatttctg tagttttaac tcaaactatt ttgatttttt tccaacctaa gaggaccttt
      601 tcatcgttat tatttttctt ttttcttttt tatactgcga cttatatttc cacatcattt
      661 agaaatcttt ttggaggact tttttttttt ttacttaaaa taaggtgaaa atcaataaag
      721 atgtttaagt gctggtcagc cgttttgatt cttggattca tcttcctggc ttctgaaggg
      781 aggccaacaa aagaatcagg atatggcctt aaatactatc aacctctcac aagattacga
      841 cataagcagg aaaaaagtca agaaagttca agaatcaaag aatttctaat tcacgatgga
      901 ccttttggat cttgtgaaaa taagtactgt ggcttgggga ggcactgtgt tatcagcaga
      961 gagacaaggc acgctgagtg tacgtgcatg gacctctgca aacagcacta caaacctgtg
     1021 tgtggatctg atggggaatt ctatgagaac cactgtgaag tgcacagagc tgcctgcctg
     1081 aaaaagcaaa agatcaccat tgttcacaac gaagactgct tctttaaagg agacaactgc
     1141 atgacaactg aatacagcaa aatgaaaagt atgcttttag acttacaaaa tcaaaagtac
     1201 attacacaag aaaatgagaa tcccaacagc gatgacattt ctaggaagaa gacgttggtg
     1261 gatcaaatgt tcaagtattt tgatgcagac agtaatggac ttgtagatat taatgaacta
     1321 actcaggtga ttaaacagga ggaactgaac aaagacctgt ctgactgtac gttgtatgat
     1381 ctgctcaagt atgatgattt caatgctgac aagcacctgg ctcttgaaga attctacaga
     1441 gcatttcagg tgatccagtt gagtctgccc gaagatcaga gagtaagcat taccgcagcc
     1501 accgtgggac agagtgctgt tctgagctgt gccgttgtgg gaacactgag accccctatc
     1561 atatggaaga ggaacaacat tgttctaaat aatttagatt tggaagacat caatgacttt
     1621 ggcgatgatg ggtccttata tatcaccaag gttaccacag ttcatatggg aaattatacc
     1681 tgctatgcag atggctatga agatgtccat cagacacaca tcttccaagt gaatgtccct
     1741 ccagtcatcc gagtgtatcc agagagtcag gccagagaac ctggggtaac tgcaagcctg
     1801 aggtgccatg cagagggcat accggaccct cagcttgggt ggttgaagaa tggaatcgat
     1861 attacaccaa agctctccaa acagctcacg cttcaagcaa atggcagtga ggtccacata
     1921 agcaatgtgc gttatgaaga tacaggagca tacacgtgca ttgctaggaa tgaagccggt
     1981 gtggatgaag acatctcttc tctttttgtg gaagattctg ctagaaagac actagctaac
     2041 atattatgga gagaagaagg tctgggaatt gggaacatgt tctatgtgtt ttatgacgac
     2101 ggagtcaaag tgatacaacc cacggaatgt gaatttcaga ggcacattaa gcccagtgaa
     2161 aagctccttg gatttcagga tgaagtctgt cccaaagatg aagaggatga agtgcagaga
     2221 tgtgtttggg cttcggctgt taatgtcaaa gacaagttca tttatgttgc tcagccaact
     2281 ttggatagaa tcttgattgt tgatgtgcag tcccaaaaag ttgttcaggc agtgagtaca
     2341 gaccctgtac cagttaaatt acactacgac aagtcacatg accaggtctg ggtgctgagc
     2401 tggggcagca tggagaagac atcgccaact ttacaggtga tcactctggc cagcgggaat
     2461 gtgcctcacc acaccatcca cacacagcct gtcgggaaac agtttgacag agtggatgac
     2521 tttttcattc ccaccccaac acttattatt actcacatga gatttggatt tattcttcat
     2581 aaagatgaat ctgcactaca caaaattgat ctcgaaacca tgtcctacat caaaacaatt
     2641 agcctgaagg actcaaagtg cattcctctg tccttggcat acagccatct gggaggatac
     2701 tacttcatta gctgcaagcc tgacatcact ggagccattc caccacagct tgtggtggac
     2761 agtgtgactg attctatcat tggctccaac agtgatgtga caggcactcc ttacgtctct
     2821 ccagacggac actatcttgt cagtgttaat gatgtgaaag gtcttgtcag agtccaatat
     2881 atcaccatcc gaggagaaat cctggatgcc tttgacatcc acaccaacct gcacatatct
     2941 gacctggcct tccagccatc cttcacagaa gcccaccagt acaacatcta cggcagttca
     3001 agccaacaaa cagatgtgct ctttgtggag ctgtccactg ggaaggtcaa gatgatcaaa
     3061 agtctcaaag aacctctcaa gacagaagac tggccctgga gtccgaaaaa caggcacatc
     3121 caaggcagtg gcctgtttgg acagtacctg atgaccccct ccaaagattc tctcttcatc
     3181 ctggatggtc gccttaataa gttaaactgt gagatcactg aggttcagaa aggaaataca
     3241 gttgtttggg ttggcgatgc ctaaggagcc ctatcaccta tttatggagg aaaagtttta
     3301 cagtacattg cacttgatcc atatttaaat tacaacttaa cttttccaag tttatatcct
     3361 agataaaacc ccctttgttt gttacaaaaa aaaaagctag attttttttt aaatatattg
     3421 gctggttaga aacatttcat acaatattta attagaaatt acagcaattg caagaatcaa
     3481 acatgtagct atattttaaa cgagtaaaat gatattaaaa tcttttaaaa aatacactgc
     3541 agggaatttc agatgatcta aacatcatgt cactctttaa gatatttttt cttgtcattt
     3601 tgctatgctt taatcagaaa taaaaggtcg tgtcaaacct taaaattctt aattcaaaat
     3661 actctgtccc gtccactgtt taaaatcttt tgtgccttga aggaaatgtc atggaagaaa
     3721 aaaggaaggc taaactctgc atattggaca acctcatagc aatgactcta ctgtcattaa
     3781 gaaatgttta tatcttgcac caaatcctgc cttcaggcat ttgtttgacc ttcaatgaaa
     3841 tgtcatgtga agtcataatt tggccttggg ctgtatacag atgagaaact atcaaatatt
     3901 cactgtacta tgtgcatcgt gctttagaaa atggacagga agggagaaaa atatgtatgg
     3961 taaaaatgtt ggcaatgtat tgtgtacctg ttttgctttc attcactaga gtgcattata
     4021 ttattggtgt acatttatct gggaattcaa gtgcttacag aagatttcct tcttagtatc
     4081 aggattaata tttttatgta gcctagtgtt ccataagtca ggaactttct cagttttgga
     4141 caaggaacat gactgcatct gcacagaaag aaccacttgt agggagattg acagtgagac
     4201 aaagctggaa ccactctctg tagctcagtg gcttatatcc tcttcagaca acattcattg
     4261 attggtccaa agaagatgaa cggtttttta gcagaaaatg gtaagatgaa cccacagtgg
     4321 agagtagaag gtgagctcca ctgcttttgc tatttagata ttatctagta atcaagccca
     4381 tcctttatca atggccaaga tgacttctac tccagcatat tctaaagcat cttctaactc
     4441 tatgctctag ctgtgaccca acagagtctc ttgggatata gtagagaagt aaaatgtctg
     4501 cctttatcct ttttcctaaa agagaaaata gaaagcctgt agaaataaat taataccaat
     4561 aagttgggtt attgaaaaac ggacaaaaca atccaggtgt aagggaatag tgtacatggt
     4621 ttgagaatct tttctactta tttttcttct tcttgttgct aacactggtg atgagctatt
     4681 gaagtgatgt ccatttgctg aaggtaatcc aataagatct ttttttaaat acaaatttta
     4741 ctcaagttta aattgtgtaa aactgcatag aaacttggaa ttttatagtg tgcattctct
     4801 tatgtgtata tagcaccatg ggctgtgtga taatagattt cttcttagcg taagagacat
     4861 taagggaact agatttaata aacaacaaaa atcagcctat gtttttatgg attgaatctg
     4921 tttcactctt tagtaacttt ctccctggga aacatgaatc atgcagtgtc tgtgttgatg
     4981 atttggtgta agtctctcct tatcctgtac atgtagatct tcttttagaa gcttttacca
     5041 tgtggatgct gtctgttgtc attgcttgat aaaagaataa acctcttatg tttta
//
