LOCUS       NM_053629               1895 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus follistatin like 3 (Fstl3), mRNA.
ACCESSION   NM_053629
VERSION     NM_053629.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1895)
  AUTHORS   McAleavy,M., Zhang,Q., Ehmann,P.J., Xu,J., Wipperman,M.F.,
            Ajithdoss,D., Pan,L., Wakai,M., Simonson,R., Gadi,A., Oyejide,A.,
            Hamon,S.C., Boyapati,A., Morton,L.G., Shavlakadze,T.,
            Kyratsous,C.A. and Glass,D.J.
  TITLE     The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in
            Hospitalized Patients
  JOURNAL   Mol Cell Biol 42 (1), e0046721 (2022)
   PUBMED   34723652
  REMARK    GeneRIF: The Activin/FLRG Pathway Associates with Poor COVID-19
            Outcomes in Hospitalized Patients.
REFERENCE   2  (bases 1 to 1895)
  AUTHORS   Nam,J., Perera,P., Gordon,R., Jeong,Y.H., Blazek,A.D., Kim,D.G.,
            Tee,B.C., Sun,Z., Eubank,T.D., Zhao,Y., Lablebecioglu,B., Liu,S.,
            Litsky,A., Weisleder,N.L., Lee,B.S., Butterfield,T., Schneyer,A.L.
            and Agarwal,S.
  TITLE     Follistatin-like 3 is a mediator of exercise-driven bone formation
            and strengthening
  JOURNAL   Bone 78, 62-70 (2015)
   PUBMED   25937185
  REMARK    GeneRIF: FSTL3 is a critical mediator of exercise-dependent bone
            formation
REFERENCE   3  (bases 1 to 1895)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1895)
  AUTHORS   Panse,K.D., Felkin,L.E., Lopez-Olaneta,M.M., Gomez-Salinero,J.,
            Villalba,M., Munoz,L., Nakamura,K., Shimano,M., Walsh,K.,
            Barton,P.J., Rosenthal,N. and Lara-Pezzi,E.
  TITLE     Follistatin-like 3 mediates paracrine fibroblast activation by
            cardiomyocytes
  JOURNAL   J Cardiovasc Transl Res 5 (6), 814-826 (2012)
   PUBMED   22915069
  REMARK    GeneRIF: Suggest FSTL3 has a role in paracrine communication
            between cardiomyocytes and fibroblasts.
REFERENCE   5  (bases 1 to 1895)
  AUTHORS   Shimano,M., Ouchi,N., Nakamura,K., Oshima,Y., Higuchi,A.,
            Pimentel,D.R., Panse,K.D., Lara-Pezzi,E., Lee,S.J., Sam,F. and
            Walsh,K.
  TITLE     Cardiac myocyte-specific ablation of follistatin-like 3 attenuates
            stress-induced myocardial hypertrophy
  JOURNAL   J Biol Chem 286 (11), 9840-9848 (2011)
   PUBMED   21245136
  REMARK    GeneRIF: Fstl3 as a stress-induced regulator of hypertrophy that
            controls myocyte size via regulation of Smad signaling.
REFERENCE   6  (bases 1 to 1895)
  AUTHORS   Schneyer,A., Schoen,A., Quigg,A. and Sidis,Y.
  TITLE     Differential binding and neutralization of activins A and B by
            follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)
  JOURNAL   Endocrinology 144 (5), 1671-1674 (2003)
   PUBMED   12697670
REFERENCE   7  (bases 1 to 1895)
  AUTHORS   Arai,K.Y., Tsuchida,K., Uehara,K., Taya,K. and Sugino,H.
  TITLE     Characterization of rat follistatin-related gene: effects of
            estrous cycle stage and pregnancy on its messenger RNA expression
            in rat reproductive tissues
  JOURNAL   Biol Reprod 68 (1), 199-206 (2003)
   PUBMED   12493714
REFERENCE   8  (bases 1 to 1895)
  AUTHORS   Bartholin,L., Maguer-Satta,V., Hayette,S., Martel,S., Gadoux,M.,
            Corbo,L., Magaud,J.P. and Rimokh,R.
  TITLE     Transcription activation of FLRG and follistatin by activin A,
            through Smad proteins, participates in a negative feedback loop to
            modulate activin A function
  JOURNAL   Oncogene 21 (14), 2227-2235 (2002)
   PUBMED   11948405
REFERENCE   9  (bases 1 to 1895)
  AUTHORS   Wankell,M., Kaesler,S., Zhang,Y.Q., Florence,C., Werner,S. and
            Duan,R.
  TITLE     The activin binding proteins follistatin and follistatin-related
            protein are differentially regulated in vitro and during cutaneous
            wound repair
  JOURNAL   J Endocrinol 171 (3), 385-395 (2001)
   PUBMED   11739004
REFERENCE   10 (bases 1 to 1895)
  AUTHORS   Tsuchida,K., Arai,K.Y., Kuramoto,Y., Yamakawa,N., Hasegawa,Y. and
            Sugino,H.
  TITLE     Identification and characterization of a novel follistatin-like
            protein as a binding protein for the TGF-beta family
  JOURNAL   J Biol Chem 275 (52), 40788-40796 (2000)
   PUBMED   11010968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 11, 2022 this sequence version replaced NM_053629.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB071603.1, SRR26643294.27684.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN16676784 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000007.1  10579720-10579844   c
            126-311             JAXUCZ010000007.1  10578367-10578552   c
            312-527             JAXUCZ010000007.1  10576713-10576928   c
            528-755             JAXUCZ010000007.1  10575420-10575647   c
            756-1895            JAXUCZ010000007.1  10574195-10575334   c
FEATURES             Location/Qualifiers
     source          1..1895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1895
                     /gene="Fstl3"
                     /gene_synonym="Flrg"
                     /note="follistatin like 3"
                     /db_xref="GeneID:114031"
                     /db_xref="RGD:621811"
     exon            1..125
                     /gene="Fstl3"
                     /gene_synonym="Flrg"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..799
                     /gene="Fstl3"
                     /gene_synonym="Flrg"
                     /note="follistatin-related protein 3; follistatin-related
                     gene protein; follistatin-like protein 3; follistatin-like
                     3 (secreted glycoprotein)"
                     /codon_start=1
                     /product="follistatin-related protein 3 precursor"
                     /protein_id="NP_446081.1"
                     /db_xref="GeneID:114031"
                     /db_xref="RGD:621811"
                     /translation="MRPGALWPLLWGALVWAVGSVGAVMGSGDSVPGGVCWLQQGKEA
                     TCSLVLKTQVSREECCASGNINTAWSNFTHPGNKISLLGFLGLVHCLPCKDSCDGVEC
                     GPGKACRMLGGRPHCECVSNCEGVPAGFQVCGSDGATYRDECELRTARCRGHPDLRVM
                     YRGRCQKSCAQVVCPRPQSCLVDQTGSAHCVVCRAAPCPVPPNPGQELCGNNNVTYIS
                     SCHLRQATCFLGRSIGVRHPGICTGGPKVPAEEEENFV"
     exon            126..311
                     /gene="Fstl3"
                     /gene_synonym="Flrg"
                     /inference="alignment:Splign:2.1.0"
     exon            312..527
                     /gene="Fstl3"
                     /gene_synonym="Flrg"
                     /inference="alignment:Splign:2.1.0"
     exon            528..755
                     /gene="Fstl3"
                     /gene_synonym="Flrg"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1895
                     /gene="Fstl3"
                     /gene_synonym="Flrg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtccccgc tgctgcccaa cactcgccat gcgtcctggg gcactgtggc cgctgctttg
       61 gggagccctg gtctgggcgg tgggatccgt gggcgccgtg atgggctcgg gggattctgt
      121 gccgggtggt gtgtgctggc tccagcaggg caaggaggcc acctgcagtc tggtgctgaa
      181 gacacaggtc agccgggagg agtgctgcgc ttccggcaac atcaacacag cctggtccaa
      241 cttcacccac ccgggcaata aaatcagcct gctaggattc ctgggccttg tccactgcct
      301 accatgcaaa gattcttgcg acggagtgga gtgcggcccc ggcaaggcgt gccgcatgtt
      361 ggggggccgt ccacactgcg agtgcgtgtc caactgcgag ggggttcccg cgggcttcca
      421 ggtctgcggc tctgatggcg ccacctaccg ggacgaatgc gaactgcgca ccgcgcgctg
      481 tcgcggacac ccagacctgc gcgtcatgta ccgcggccgc tgccaaaagt cctgcgctca
      541 ggtagtgtgc ccgcgccccc agtcgtgcct tgtggatcag actggcagcg cacactgcgt
      601 ggtgtgtcgc gctgcaccct gcccagtacc tcccaaccct ggccaagaac tctgcggcaa
      661 caacaacgtt acctacatct cgtcgtgtca cttgcgccag gccacttgct ttctgggccg
      721 ttccattgga gttcggcacc cgggcatctg cacaggtggc cccaaagtac cagcagagga
      781 ggaagagaac ttcgtgtgag ctgcagccac tgggcctggt atttaaggcc gtcctgattt
      841 ttatttatta ttacagaaaa tattctaatt tatgtcacat ggacattccc caaacctagc
      901 ctggaaccac ttggggatcc cctaggatcc tgagcacata tcacaggaac tgaaggaaga
      961 ttttgtaaga gttggtatat gccgtcaccg ggtactggga tccaagttag caccccagac
     1021 acctgctgcc cagggagggc tgcttcgtgg agaccccctg atttgatctc cccacctgct
     1081 ttctaggctg gcgctatctc aggccacagc tgacggtagt gtgtccacct caattggtgt
     1141 ttgcatgtgg ccggtctcag accagagcag gcagcatcgg gtcagagaaa cactgggttc
     1201 attcctgttc agtccacttg gggtgagacc tggtagaaac attgggttgt ggctgactcg
     1261 caagcccagg agaacctgtg gacaccagga ttcactctag caccaactgc cctgttccct
     1321 ggacacccac attagctttt acccagcccc acttgtcacc aagcacatgc tgttttgtct
     1381 cacccatcac cctgacagct gccactgaaa attacccacc cgtgccttca gggaaaccaa
     1441 agaggggagt gagagttcag taggtagagt gctttccaag cattcacaac gtcctgggct
     1501 ctgtccccag caccacataa aacagacatg ttgactcagg cctgttatcc cagcacttgg
     1561 aaagtagagg aaagaggatc aggagttcga gttcatcttt ggttacactg tgagttcaag
     1621 gccagcctga gctaccttat ctttgaaaaa agaaaaaaaa aaaaaaaccc ttaaaaagga
     1681 agacaagatg tcagaccaca acagaagacc ctgggaaggt gcacagccct ccagtttggg
     1741 ggcaaggagt tcccagagtc tttcttacca ctctccagtt ctcagctgtg cctttcttat
     1801 aatgttcccc aaagtgtcct tagcaggaag ctatggtagt ctctcctagc ctggagttct
     1861 gcctcaccaa ggaaataaaa gacaatagaa accac
//
