LOCUS       NM_024369               2283 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus follistatin-like 1 (Fstl1), mRNA.
ACCESSION   NM_024369
VERSION     NM_024369.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Xu,H., Guo,H., Tang,Z., Hao,R., Wang,S. and Jin,P.
  TITLE     Follistatin-like 1 protects against doxorubicin-induced
            cardiotoxicity by preventing mitochondrial dysfunction through the
            SIRT6/Nrf2 signaling pathway
  JOURNAL   Cell Biol Int 48 (6), 795-807 (2024)
   PUBMED   38436106
  REMARK    GeneRIF: Follistatin-like 1 protects against doxorubicin-induced
            cardiotoxicity by preventing mitochondrial dysfunction through the
            SIRT6/Nrf2 signaling pathway.
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Zhang,Z., He,J. and Wang,B.
  TITLE     Circ_TLK1 knockdown alleviates oxygen-glucose
            deprivation/reoxygenation-induced PC12 cell injury by regulating
            microRNA-136-5p/follistatin like-1 axis
  JOURNAL   Eur J Neurosci 56 (4), 4304-4316 (2022)
   PUBMED   35766911
  REMARK    GeneRIF: Circ_TLK1 knockdown alleviates oxygen-glucose
            deprivation/reoxygenation-induced PC12 cell injury by regulating
            microRNA-136-5p/follistatin like-1 axis.
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Inoue,K., Fujie,S., Horii,N., Yamazaki,H., Uchida,M. and Iemitsu,M.
  TITLE     Aerobic exercise training-induced follistatin-like 1 secretion in
            the skeletal muscle is related to arterial stiffness via arterial
            NO production in obese rats
  JOURNAL   Physiol Rep 10 (10), e15300 (2022)
   PUBMED   35585770
  REMARK    GeneRIF: Aerobic exercise training-induced follistatin-like 1
            secretion in the skeletal muscle is related to arterial stiffness
            via arterial NO production in obese rats.
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Yang,W., Duan,Q., Zhu,X., Tao,K. and Dong,A.
  TITLE     Follistatin-Like 1 Attenuates Ischemia/Reperfusion Injury in
            Cardiomyocytes via Regulation of Autophagy
  JOURNAL   Biomed Res Int 2019, 9537382 (2019)
   PUBMED   31139662
  REMARK    GeneRIF: FSTL1 plays a protective role in myocardial IRI by
            regulating autophagy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Takahashi,T., Zimmer,J., Friedmacher,F. and Puri,P.
  TITLE     Follistatin-like 1 expression is decreased in the alveolar
            epithelium of hypoplastic rat lungs with nitrofen-induced
            congenital diaphragmatic hernia
  JOURNAL   J Pediatr Surg 52 (5), 706-709 (2017)
   PUBMED   28188034
  REMARK    GeneRIF: Decreased expression of Fstl1 in alveolar epithelium may
            disrupt alveolarization and pulmonary surfactant production, thus
            contributing to the development of pulmonary hypertension in the
            nitrofen-induced rat congenital diaphragmatic hernia model.
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Zhang,G., Ohsawa,Y., Kametaka,S., Shibata,M., Waguri,S. and
            Uchiyama,Y.
  TITLE     Regulation of FLRG expression in rat primary astroglial cells and
            injured brain tissue by transforming growth factor-beta 1 (TGF-beta
            1)
  JOURNAL   J Neurosci Res 72 (1), 33-45 (2003)
   PUBMED   12645077
  REMARK    GeneRIF: Expression levels of FLRG protein are significantly
            increased in brain damaged regions after penetrating injury;
            specifically, FLRG protein is colocalized in glial fibrillary
            acidic protein-positive reactive astroglial cells.
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Malik-Hall,M., Poon,W.Y., Baker,M.D., Wood,J.N. and Okuse,K.
  TITLE     Sensory neuron proteins interact with the intracellular domains of
            sodium channel NaV1.8
  JOURNAL   Brain Res Mol Brain Res 110 (2), 298-304 (2003)
   PUBMED   12591166
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Arai,K.Y., Tsuchida,K., Uehara,K., Taya,K. and Sugino,H.
  TITLE     Characterization of rat follistatin-related gene: effects of
            estrous cycle stage and pregnancy on its messenger RNA expression
            in rat reproductive tissues
  JOURNAL   Biol Reprod 68 (1), 199-206 (2003)
   PUBMED   12493714
  REMARK    GeneRIF: Characterization of follistatin-related gene: effects of
            estrous cycle stage and pregnancy on its messenger RNA expression
            in reproductive tissues.
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Remmers,E.F., Griffiths,M.M., Longman,R.E., Gulko,P.S.,
            Kawahito,Y., Chen,S., Chang,L., Shepard,J., Ge,L., Dracheva,S.,
            Wang,J.P., Joe,B., Cannon,G.W. and Wilder,R.L.
  TITLE     An integrated rat genetic map: analysis of linkage conservation
            with the mouse and human maps
  JOURNAL   Transplant Proc 31 (3), 1549-1554 (1999)
   PUBMED   10330996
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   Zwijsen,A., Blockx,H., Van Arnhem,W., Willems,J., Fransen,L.,
            Devos,K., Raymackers,J., Van de Voorde,A. and Slegers,H.
  TITLE     Characterization of a rat C6 glioma-secreted follistatin-related
            protein (FRP). Cloning and sequence of the human homologue
  JOURNAL   Eur J Biochem 225 (3), 937-946 (1994)
   PUBMED   7957230
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087014.1.
            
            On Dec 26, 2004 this sequence version replaced NM_024369.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087014.1, U06864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2283
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /note="follistatin-like 1"
                     /db_xref="GeneID:79210"
                     /db_xref="RGD:68955"
     exon            1..88
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1009
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /note="follistatin-related protein 1; follistatin-like
                     protein 1"
                     /codon_start=1
                     /product="follistatin-related protein 1 precursor"
                     /protein_id="NP_077345.1"
                     /db_xref="GeneID:79210"
                     /db_xref="RGD:68955"
                     /translation="MWKRWLALALVTIALVHGEEEQRSKSKICANVFCGAGRECAVTE
                     KGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSV
                     SPSASPVVCYQANRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKSFDNGDSH
                     LDSSEFLKFVEQNETAVNITAYPNQENNKLLRGLCVDALIELSDENADWKLSFQEFLK
                     CLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCSCGHWVCTAMTCDGKNQKGVQTH
                     TEEEMTRYAQELQKHQGTAEKTKKVNTKEI"
     exon            89..145
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            146..250
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            251..380
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            381..413
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            414..544
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            545..663
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            664..776
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            777..887
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            888..964
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
     exon            965..2274
                     /gene="Fstl1"
                     /gene_synonym="Frp; Fstl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggtgatc ggcgacgctc ccaccttcgc ctccaactca ctgcttccat cctgcccagt
       61 gtcctctcga gtcccggacc cgagcacgat gtggaaacgc tggctggcgc tcgcgctggt
      121 gaccatcgcc ctggtccacg gcgaggagga acaaagaagc aaatccaaga tctgcgccaa
      181 tgtgttttgt ggagctggcc gggaatgcgc cgtcacggag aagggggagc caacgtgcct
      241 ctgcattgag caatgcaaac ctcacaagag gcctgtgtgt ggcagtaatg gcaagaccta
      301 cctcaaccat tgtgaacttc acagagacgc ctgcctcact ggatccaaga tccaggttga
      361 ttatgatggg cactgcaaag aaaagaagtc tgtgagtcca tccgccagcc ccgttgtctg
      421 ctatcaggct aaccgtgatg agctgcggcg ccggatcatc cagtggctgg aagccgagat
      481 cattccagat ggctggttct ctaaaggcag taactacagt gagatcctag acaagtactt
      541 taagagcttt gataatggtg actctcacct ggactccagc gaattcctga aattcgtgga
      601 gcagaatgaa acagccgtca acatcaccgc ttaccccaat caggagaaca acaaactgct
      661 cagaggcctc tgtgttgatg ccctcattga actgtccgat gagaacgctg actggaaact
      721 cagcttccaa gagttcctca agtgcctcaa cccatccttc aaccctcctg agaagaagtg
      781 cgccctggag gacgaaacct atgcagatgg agctgagacc gaggtggact gcaatcgctg
      841 tgtctgttcc tgtggacact gggtctgcac agcgatgacc tgtgatggaa agaatcagaa
      901 gggggtccag acccacacag aggaggagat gacgagatat gcccaggaac tccagaagca
      961 ccagggaaca gcagaaaaga ccaagaaggt gaacaccaaa gagatctaag aagaggcacg
     1021 tagcacctca tctggaaccc agcacctcct cttcagcgct aagtccagta tacagcgtct
     1081 gtggcaatca ccgaatcacc agtatttgct tgtacggcag caaatcttat tctgtttgtt
     1141 ttgcaataaa ggaagtgagg gtggctggct agccagggca ggcaggccac aactttcact
     1201 tctaggaatg ctttaagaga cactaaaggg caccttgggg caggaggcga gtatccggtt
     1261 ggcagaggag cagaggcagg tctgaatgaa acctttctgg ggtcagctgt gaggatacaa
     1321 caggaaaagc atgtgatgtt agggggaaca ctgagctggc cctgctggag gaaatagggg
     1381 gagcttggtg gggaggaacc ctgctgcttt gacccttgtc accactgtca tcatcccaga
     1441 tctgcagcaa atctgcttct ccttttgatc cccacagtca cctgcataca cagtcgcccc
     1501 attagttagc tgtgtccctc aaacttggag tttcctgaag agtgggtttg aatgatgcaa
     1561 atacttacgg acttcaagcg ccatggagac ctaaccaaaa ttttaaatac atttcccttc
     1621 tttttttttt tttttttacc aaaggtgcta tttctctgta aaacactttt tctttttcgc
     1681 aagctgactt cattcctcag ttattaccat tatattattg ttgtttttta atatttcatc
     1741 ttttgactag atattacgct tttgtgatta ttttttttca ttagtcttac catttcagaa
     1801 gtgaaggtga aaggggtttg ggtgtttctc caggtacagg gaactctaac acagatgacc
     1861 ccttgccctg ccacatccta gactgaacgc agtccagagc tactgcaccc ccacccatgg
     1921 ctcccacatg atcggctggg tgccacaaag cacaagaggt ccctcagaca gaagccatgg
     1981 gaaaaaagca tcttcataga cagttgagat ccaaagagtt gatttggttt catttcttgt
     2041 gagaagttcc aaggacggga tcccaggcca tggcagcctg ccgtcatctg tggctaacgg
     2101 gcagagcgag tcactgcggt cctagctctc ctatttctgg gtgtccgttt ccttagagaa
     2161 ctgattagga ggcatcttga gatttaatca atggtagttt gtggtttagg caatcctcaa
     2221 gcccctttgt tgtcctgttt tatgtgcatt ggacgtaaca aaaaaaaaaa aaaaaaaaaa
     2281 aaa
//
