LOCUS       NM_012561               2203 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus follistatin (Fst), mRNA.
ACCESSION   NM_012561
VERSION     NM_012561.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Nagayama,I., Takayanagi,K., Hasegawa,H. and Maeshima,A.
  TITLE     Tubule-Derived Follistatin Is Increased in the Urine of Rats with
            Renal Ischemia and Reflects the Severity of Acute Tubular Damage
  JOURNAL   Cells 12 (5), 801 (2023)
   PUBMED   36899937
  REMARK    GeneRIF: Tubule-Derived Follistatin Is Increased in the Urine of
            Rats with Renal Ischemia and Reflects the Severity of Acute Tubular
            Damage.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Ogawa,C., Mikawa,S., Yamashita,K., Hayashi,Y., Masumoto,K.,
            Katou,F. and Sato,K.
  TITLE     Follistatin expression in the central nervous system of the adult
            rat
  JOURNAL   J Chem Neuroanat 105, 101753 (2020)
   PUBMED   32014555
  REMARK    GeneRIF: Follistatin expression in the central nervous system of
            the adult rat.
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Santamaria,C.G., Abud,J.E., Porporato,M.M., Meyer,N.,
            Zenclussen,A.C., Kass,L. and Rodriguez,H.A.
  TITLE     The UV filter benzophenone 3, alters early follicular assembly in
            rat whole ovary cultures
  JOURNAL   Toxicol Lett 303, 48-54 (2019)
   PUBMED   30599193
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Yang,C., Liu,J., Liu,K., Du,B., Shi,K., Ding,M., Li,B. and Yang,P.
  TITLE     Ghrelin suppresses cardiac fibrosis of post-myocardial infarction
            heart failure rats by adjusting the activin A-follistatin imbalance
  JOURNAL   Peptides 99, 27-35 (2018)
   PUBMED   29113826
  REMARK    GeneRIF: These data suggest that ghrelin inhibits myocardial
            fibrosis, attenuates left ventricular remodeling, and eventually
            improves cardiac function by adjusting Act A/FS imbalance.
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Salehi Jahromi,M., Ramezani Tehrani,F., Hill,J.W., Noroozzadeh,M.,
            Zarkesh,M., Ghasemi,A. and Zadeh-Vakili,A.
  TITLE     Alteration in follistatin gene expression detected in prenatally
            androgenized rats
  JOURNAL   Gynecol Endocrinol 33 (6), 433-437 (2017)
   PUBMED   28277126
  REMARK    GeneRIF: manifestation of polycystic ovarian syndrome-like
            phenotype following prenatal exposure to excess androgen is
            associated with irregularity in expression of the FST gene during
            the estrus cycle
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Urbanek,M., Legro,R.S., Driscoll,D.A., Azziz,R., Ehrmann,D.A.,
            Norman,R.J., Strauss,J.F. 3rd, Spielman,R.S. and Dunaif,A.
  TITLE     Thirty-seven candidate genes for polycystic ovary syndrome:
            strongest evidence for linkage is with follistatin
  JOURNAL   Proc Natl Acad Sci U S A 96 (15), 8573-8578 (1999)
   PUBMED   10411917
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Deng,A.Y., Jackson,C.M., Hoebee,B. and Rapp,J.P.
  TITLE     Mapping of rat chromosome 2 markers generated from
            chromosome-sorted DNA
  JOURNAL   Mamm Genome 8 (10), 731-735 (1997)
   PUBMED   9321465
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Matzuk,M.M., Lu,N., Vogel,H., Sellheyer,K., Roop,D.R. and
            Bradley,A.
  TITLE     Multiple defects and perinatal death in mice deficient in
            follistatin
  JOURNAL   Nature 374 (6520), 360-363 (1995)
   PUBMED   7885475
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Miyanaga,K. and Shimasaki,S.
  TITLE     Structural and functional characterization of the rat follistatin
            (activin-binding protein) gene promoter
  JOURNAL   Mol Cell Endocrinol 92 (1), 99-109 (1993)
   PUBMED   8472873
REFERENCE   10 (bases 1 to 2203)
  AUTHORS   Shimasaki,S., Koga,M., Buscaglia,M.L., Simmons,D.M., Bicsak,T.A.
            and Ling,N.
  TITLE     Follistatin gene expression in the ovary and extragonadal tissues
  JOURNAL   Mol Endocrinol 3 (4), 651-659 (1989)
   PUBMED   2725528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000065.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_012561.4.
            
            On Feb 10, 2021 this sequence version replaced NM_012561.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487230.17741.1,
                                           SRR8487231.45711.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JACYVU010000065.1  38635394-38635478   c
            86-277              JACYVU010000065.1  38633304-38633495   c
            278-496             JACYVU010000065.1  38632582-38632800   c
            497-721             JACYVU010000065.1  38632008-38632232   c
            722-952             JACYVU010000065.1  38630636-38630866   c
            953-2203            JACYVU010000065.1  38628530-38629780   c
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..2203
                     /gene="Fst"
                     /gene_synonym="FOL1; FS; Fst-288; RATFOL1"
                     /note="follistatin"
                     /db_xref="GeneID:24373"
                     /db_xref="RGD:2633"
     CDS             1..1035
                     /gene="Fst"
                     /gene_synonym="FOL1; FS; Fst-288; RATFOL1"
                     /note="activin-binding protein; follistatin-A"
                     /codon_start=1
                     /product="follistatin precursor"
                     /protein_id="NP_036693.1"
                     /db_xref="GeneID:24373"
                     /db_xref="RGD:2633"
                     /translation="MVCARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQV
                     LYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGP
                     GKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQY
                     QGKCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPSSSEQSLCGNDGVTYSSAC
                     HLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCGGGKKCLWDFKVGRGRCSLCDELCPD
                     SKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEETEEEEEEEDQDY
                     SFPISSTLEW"
     exon            1..85
                     /gene="Fst"
                     /gene_synonym="FOL1; FS; Fst-288; RATFOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..277
                     /gene="Fst"
                     /gene_synonym="FOL1; FS; Fst-288; RATFOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..496
                     /gene="Fst"
                     /gene_synonym="FOL1; FS; Fst-288; RATFOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..721
                     /gene="Fst"
                     /gene_synonym="FOL1; FS; Fst-288; RATFOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..952
                     /gene="Fst"
                     /gene_synonym="FOL1; FS; Fst-288; RATFOL1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..2203
                     /gene="Fst"
                     /gene_synonym="FOL1; FS; Fst-288; RATFOL1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtctgcg ccaggcacca gcccggcggg ctctgcctcc tgctgctgct actctgccaa
       61 ttcatggaag accgcagcgc ccaggctggg aattgctggc tccgccaagc caagaacggc
      121 cgctgccagg tcctgtataa gacagaactg agcaaggaag agtgttgcag caccggccgg
      181 ctgagcacct cgtggaccga ggaggatgtg aacgacaata ctctcttcaa gtggatgatt
      241 ttcaacgggg gcgcccccaa ctgcatccct tgtaaagaaa cgtgtgagaa tgtggactgt
      301 ggccccggga aaaagtgccg aatgaacaag aagaacaaac cccgctgcgt ctgtgcccca
      361 gactgttcca acatcacctg gaagggtcca gtgtgtgggc tcgatgggaa aacctaccgc
      421 aacgaatgtg cgctcctcaa ggccagatgt aaagagcagc cggaactgga agtccagtac
      481 cagggcaaat gtaaaaagac ttgcagggat gttttctgtc caggcagctc cacttgtgtg
      541 gtggatcaga ccaataatgc ctactgtgtg acctgtaatc ggatttgccc ggaaccctca
      601 tcttcagagc agtccctttg cgggaacgat ggtgtgactt actccagtgc ctgccacctg
      661 agaaaggcca cctgcttgct gggcagatcc attggattag cctatgaggg aaagtgtatc
      721 aaagcaaagt cttgtgaaga catccagtgc ggtggtggaa aaaaatgcct atgggatttc
      781 aaggttggca gaggtcgctg ctctctctgc gatgagctgt gcccggacag taagtcggat
      841 gagcccgtct gtgccagcga caatgccacg tacgccagcg agtgtgccat gaaggaagct
      901 gcctgctcct ccggcgtact gcttgaagtg aagcactccg gatcttgcaa ctccatctcg
      961 gaagaaacgg aggaagagga ggaagaggaa gaccaggact acagcttccc tatctcttcc
     1021 actctagagt ggtaaactgt ccagcagtgt gcagtgtgga cagagcctgt gggcaaaaca
     1081 aaacacagca gaaaaaaaaa aaaaaaaggc aagaaaaaaa agatagaaaa gaaaattaag
     1141 aaaaagaaaa aatatattgt tcataatgta aataagtgta tgcttattta tttgggggga
     1201 aaactataca ttaaaggacc tttgtcctga agctctctcc caggtcacat tgttactcac
     1261 tggccatgga gagatggtca ttttgtggtc tactggatga ggcctatagt tgaggctttg
     1321 tagacattta tttatactgt gtcatgtttt ataatttata cataaagtgt ctggttgact
     1381 gtacaccttg tttttgaaga aatttattcg tgaaaggaag agcagttgtt atttattgtg
     1441 aggtctcttg cttgtaaagt agaactgttt tgttttgttt tgtttttttt ttgccccctt
     1501 gtaaaccgtg taagttcatt cctcactatg cacacccacc tgtctccctc cccatttcac
     1561 tgttagattc ttctccacct tttaacaaat ttgcatgtca gttcctgtca cgtttattta
     1621 ttgggttctc ggctgcctaa cctgtacata cctgatccct cgggttttgt ttacaaggaa
     1681 tcttgactga ccaaaaggca ctgtaactct gcctcagata caaggtacag aggagatgcg
     1741 tctcggagga aacgtctgct tccgtcccct tgttctggtg aacgttggga gagagcatga
     1801 gagaagcatt aaaattctag agctgtgctt ttatgatcca aagacataga gtgatgtggg
     1861 tgtcagagac tgaagagagg tgaaagtcgc gctttcaacc tgtcattcag ggtttccttt
     1921 gagctagtcg gctgtacctt ttcaattagt tctctttttt ttttttcaac caacatgtca
     1981 ctaaaagttc catcaaagct ttatcagttc aagtttcttg cttttcataa tacttttttc
     2041 tgatgcaatt ttatattttc aaacatggca agttaaatat aaattcattt aaatatatag
     2101 ttttgtactt ttctaccatg taaatgtgca atgtatataa aagttataat gtgtatttgt
     2161 agataaatga tgagtgaaaa aataaaaaaa aatgtaaaag cca
//
