LOCUS       NM_199237               2364 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus follicle stimulating hormone receptor (Fshr),
            mRNA.
ACCESSION   NM_199237 XM_345635
VERSION     NM_199237.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2364)
  AUTHORS   Weng,X., Ma,X., Wang,Q., Xu,K., Hu,X., Liu,W. and Zhang,C.
  TITLE     Effect of hypothyroidism on CYP51 and FSHR expression in rat ovary
  JOURNAL   Theriogenology 138, 145-151 (2019)
   PUBMED   31352176
  REMARK    GeneRIF: Hypothyroidism changes CYP51 and FSHR expression in ovary,
            which are regulated by gonadotropin. Moreover, genes changes in
            ovary are at least partially attributed to steroids biosynthesis.
REFERENCE   2  (bases 1 to 2364)
  AUTHORS   Gulappa,T., Menon,B. and Menon,K.M.J.
  TITLE     LHCGR Expression During Follicle Stimulating Hormone-Induced
            Follicle Growth Is Negatively Regulated by Eukaryotic Initiation
            Factor 5A
  JOURNAL   Endocrinology 158 (8), 2672-2679 (2017)
   PUBMED   28605466
  REMARK    GeneRIF: The results of this study support the notion that by
            inhibiting eIF5A hypusination, FSH reduces the expression of an
            LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR
            mRNA expression by abrogating the inhibitory action of LRBP.
REFERENCE   3  (bases 1 to 2364)
  AUTHORS   Lee,J.H., Lee,M., Ahn,C., Kang,H.Y., Tran,D.N. and Jeung,E.B.
  TITLE     Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene
            Diepoxide-Induced Ovarian Failure Model
  JOURNAL   Int J Environ Res Public Health 14 (2), 161 (2017)
   PUBMED   28208728
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2364)
  AUTHORS   Jiang,X., Fischer,D., Chen,X., McKenna,S.D., Liu,H., Sriraman,V.,
            Yu,H.N., Goutopoulos,A., Arkinstall,S. and He,X.
  TITLE     Evidence for Follicle-stimulating Hormone Receptor as a Functional
            Trimer
  JOURNAL   J Biol Chem 289 (20), 14273-14282 (2014)
   PUBMED   24692546
REFERENCE   5  (bases 1 to 2364)
  AUTHORS   Uchida,S., Uchida,H., Maruyama,T., Kajitani,T., Oda,H.,
            Miyazaki,K., Kagami,M. and Yoshimura,Y.
  TITLE     Molecular analysis of a mutated FSH receptor detected in a patient
            with spontaneous ovarian hyperstimulation syndrome
  JOURNAL   PLoS One 8 (9), e75478 (2013)
   PUBMED   24058690
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2364)
  AUTHORS   Kotlar,T.J., Young,R.H., Albanese,C., Crowley,W.F. Jr., Scully,R.E.
            and Jameson,J.L.
  TITLE     A mutation in the follicle-stimulating hormone receptor occurs
            frequently in human ovarian sex cord tumors
  JOURNAL   J Clin Endocrinol Metab 82 (4), 1020-1026 (1997)
   PUBMED   9100567
REFERENCE   7  (bases 1 to 2364)
  AUTHORS   Aittomaki,K., Lucena,J.L., Pakarinen,P., Sistonen,P.,
            Tapanainen,J., Gromoll,J., Kaskikari,R., Sankila,E.M.,
            Lehvaslaiho,H., Engel,A.R., Nieschlag,E., Huhtaniemi,I. and de la
            Chapelle,A.
  TITLE     Mutation in the follicle-stimulating hormone receptor gene causes
            hereditary hypergonadotropic ovarian failure
  JOURNAL   Cell 82 (6), 959-968 (1995)
   PUBMED   7553856
REFERENCE   8  (bases 1 to 2364)
  AUTHORS   Davis,D., Liu,X. and Segaloff,D.L.
  TITLE     Identification of the sites of N-linked glycosylation on the
            follicle-stimulating hormone (FSH) receptor and assessment of their
            role in FSH receptor function
  JOURNAL   Mol Endocrinol 9 (2), 159-170 (1995)
   PUBMED   7776966
REFERENCE   9  (bases 1 to 2364)
  AUTHORS   Heckert,L.L., Daley,I.J. and Griswold,M.D.
  TITLE     Structural organization of the follicle-stimulating hormone
            receptor gene
  JOURNAL   Mol Endocrinol 6 (1), 70-80 (1992)
   PUBMED   1738373
REFERENCE   10 (bases 1 to 2364)
  AUTHORS   Sprengel,R., Braun,T., Nikolics,K., Segaloff,D.L. and Seeburg,P.H.
  TITLE     The testicular receptor for follicle stimulating hormone: structure
            and functional expression of cloned cDNA
  JOURNAL   Mol Endocrinol 4 (4), 525-530 (1990)
   PUBMED   2126341
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_199237.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.33395.1,
                                           SRR26360186.2175711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000006.1  10952329-10952550
            223-294             JAXUCZ010000006.1  11058861-11058932
            295-369             JAXUCZ010000006.1  11098478-11098552
            370-444             JAXUCZ010000006.1  11101062-11101136
            445-516             JAXUCZ010000006.1  11125329-11125400
            517-594             JAXUCZ010000006.1  11127126-11127203
            595-663             JAXUCZ010000006.1  11138531-11138599
            664-738             JAXUCZ010000006.1  11138709-11138783
            739-924             JAXUCZ010000006.1  11155764-11155949
            925-2364            JAXUCZ010000006.1  11158849-11160288
FEATURES             Location/Qualifiers
     source          1..2364
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2364
                     /gene="Fshr"
                     /note="follicle stimulating hormone receptor"
                     /db_xref="GeneID:25449"
                     /db_xref="RGD:2632"
     exon            1..222
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2149
                     /gene="Fshr"
                     /note="FSH-R; follitropin receptor"
                     /codon_start=1
                     /product="follicle-stimulating hormone receptor precursor"
                     /protein_id="NP_954707.1"
                     /db_xref="GeneID:25449"
                     /db_xref="RGD:2632"
                     /translation="MALLLVSLLAFLGTGSGCHHWLCHCSNRVFLCQDSKVTEIPTDL
                     PRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRI
                     EKANNLLYINPEAFQNLPSLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHIV
                     ARNSFMGLSFESVILWLSKNGIEEIHNCAFNGTQLDELNLSDNNNLEELPNDVFQGAS
                     GPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLPNLDKFVTLMEASLTYPSHCC
                     AFANLKRQISELHPICNKSILRQDIDDMTQIGDQRVSLIDDEPSYGKGSDMMYNEFDY
                     DLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYK
                     LTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVF
                     ASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAFAAALFPIFGIS
                     SYMKVSICLPMDIDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNPTIVSSSSD
                     TKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFL
                     YAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSATHNFHARKSHCSSAPRVTNSYV
                     LVPLNHSSQN"
     exon            223..294
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            295..369
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            370..444
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            445..516
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            517..594
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            595..663
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            664..738
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            739..924
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
     exon            925..2364
                     /gene="Fshr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagcctgg ggaatctgtg gaagttttcg cgctgatgca gaaagaaagt cggtgaatgg
       61 ataaataagg atggccttgc tcctggtctc cttgctggca ttcttgggca cgggatctgg
      121 atgtcatcac tggctgtgtc attgctctaa tagggtcttt ctctgccaag acagcaaggt
      181 gacagagatt ccgaccgacc tcccccggaa cgccattgaa ctgaggtttg tgctcaccaa
      241 gcttcgagtc atcccgaaag gatcatttgc tggatttgga gacctggaga aaatagagat
      301 ctctcagaat gatgtcttgg aagtaataga ggcagatgtg ttctccaacc tacccaagtt
      361 gcatgaaatt aggattgaaa aggccaacaa tcttctgtac atcaacccgg aggccttcca
      421 gaatctcccc agtctcagat atctgttaat atccaacaca ggcattaagc acttgccagc
      481 tgttcacaag atccagtctc tccaaaaggt tctactagac attcaagata acataaacat
      541 ccacatcgtt gccaggaact ccttcatggg actgagtttt gaaagtgtga ttttatggct
      601 gagtaagaat gggattgaag aaatacacaa ctgtgcattc aacggaactc agctagatga
      661 actgaatcta agcgataaca ataatttgga agaattgcct aatgacgttt tccagggagc
      721 ctctgggcca gtcattttag atatctcaag gacaaaggtc cattccttac caaaccatgg
      781 cttagaaaat ctgaagaagc tgagggccag gtcaacatac cgcttgaaaa agctccctaa
      841 tctggacaag tttgtcaccc tcatggaggc cagcctcacc taccccagcc actgctgtgc
      901 ttttgcaaac ttgaagcggc aaatctctga acttcatcca atttgcaaca agtctatttt
      961 aaggcaagat attgatgata tgactcaaat tggggatcag agagtctctc tgatagatga
     1021 tgaacccagt tatggaaaag gatctgacat gatgtacaat gaatttgatt atgacttatg
     1081 taatgaagtt gttgatgtga cctgctcacc aaagccagat gcatttaatc catgtgaaga
     1141 tatcatgggg tacaacatcc tcagggtctt gatatggttt attagcatcc tggccattac
     1201 tgggaacacc acagtgctgg tggtcctgac cacaagccaa tacaaactaa ctgtgccccg
     1261 gtttcttatg tgtaacctcg ccttcgctga tctctgcata ggcatctact tgctacttat
     1321 agcatcagtt gacatccata ccaagagcca gtaccacaac tatgccattg actggcaaac
     1381 aggagcaggc tgtgatgctg ctggcttttt cactgtcttt gccagtgaac tgtcagtcta
     1441 cacattgaca gccatcaccc tagaaagatg gcataccatc acacatgcta tgcaactgga
     1501 atgcaaggtg cagctccggc atgctgccag cgtcatggta ttgggctgga cttttgcctt
     1561 cgcagctgct ctcttcccca tctttggcat cagtagctac atgaaagtga gcatctgcct
     1621 gcccatggat atcgacagcc ctttgtcaca gctgtatgtt atggccctcc ttgtcctcaa
     1681 tgtcctggcc tttgtggtca tctgtggctg ctatacccac atctacctca cagtgaggaa
     1741 tcctaccatt gtgtcctcat caagcgacac caagattgcc aagcgcatgg ccacactcat
     1801 cttcacagac tttctctgca tggcccccat ttcattcttt gccatttctg cctccctcaa
     1861 ggtgccgctc atcactgtgt ccaaggccaa gattctccta gttctgttct accccatcaa
     1921 ttcttgtgcc aatcctttcc tctacgccat tttcaccaag aacttccgca gggacttctt
     1981 catcctgctg agcaagtttg gctgttatga aatgcaagcc cagatttaca ggacagaaac
     2041 ctcatccgct acccacaact tccatgcccg aaagagccac tgctcctcag ctcccagagt
     2101 caccaatagt tacgtgcttg tccctcttaa tcattcatcc cagaactaaa aatcaatgtg
     2161 aaaatggatc ctcaccttga aagacaatta tgactccttc tgaagagcag gccatggact
     2221 aagtggcagt gttactgcac atctcatcta atttaatctc tctgggtgtg tgcatggcag
     2281 actgatcagg gaccattaat gtcccatgtg gctcatctaa gaactgaatt attggtaaca
     2341 gcaattaaaa caatgcaata ccgc
//
