LOCUS       NM_001007597            1655 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus follicle stimulating hormone subunit beta (Fshb),
            mRNA.
ACCESSION   NM_001007597 XM_006234672 XM_342485
VERSION     NM_001007597.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1655)
  AUTHORS   Han,D.X., Xiao,Y., Wang,C.J., Jiang,H., Gao,Y., Yuan,B. and
            Zhang,J.B.
  TITLE     Regulation of FSH expression by differentially expressed miR-186-5p
            in rat anterior adenohypophyseal cells
  JOURNAL   PLoS One 13 (3), e0194300 (2018)
   PUBMED   29534107
  REMARK    GeneRIF: Study in primary rat pituitary cells demonstrates that
            miR-186-5p regulates FSH secretion by directly targeting the FSHb
            3' UTR.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1655)
  AUTHORS   Han,D.X., Sun,X.L., Xu,M.Q., Chen,C.Z., Jiang,H., Gao,Y., Yuan,B.
            and Zhang,J.B.
  TITLE     Roles of differential expression of microRNA-21-3p and microRNA-433
            in FSH regulation in rat anterior pituitary cells
  JOURNAL   Oncotarget 8 (22), 36553-36565 (2017)
   PUBMED   28402262
  REMARK    GeneRIF: our results indicate that miR-21-3p and miR-433 can
            down-regulate the expression of FSHb by directly targeting the FSHb
            3'UTR in rat primary pituitary cells.
REFERENCE   3  (bases 1 to 1655)
  AUTHORS   Moriyama,R., Yamazaki,T., Kato,T. and Kato,Y.
  TITLE     Long-chain unsaturated fatty acids reduce the transcriptional
            activity of the rat follicle-stimulating hormone beta-subunit gene
  JOURNAL   J Reprod Dev 62 (2), 195-199 (2016)
   PUBMED   26853521
  REMARK    GeneRIF: the upstream region of Fshb is susceptible to unsaturated
            long-chain fatty acids
REFERENCE   4  (bases 1 to 1655)
  AUTHORS   Garrel,G., Racine,C., L'Hote,D., Denoyelle,C., Guigon,C.J., di
            Clemente,N. and Cohen-Tannoudji,J.
  TITLE     Anti-Mullerian hormone: a new actor of sexual dimorphism in
            pituitary gonadotrope activity before puberty
  JOURNAL   Sci Rep 6, 23790 (2016)
   PUBMED   27030385
  REMARK    GeneRIF: The study uncovers a new role for AMH in regulating
            gonadotrope function and suggests that AMH participates in the
            postnatal elevation of FSH secretion in females.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1655)
  AUTHORS   Lannes,J., L'Hote,D., Garrel,G., Laverriere,J.N.,
            Cohen-Tannoudji,J. and Querat,B.
  TITLE     Rapid communication: A microRNA-132/212 pathway mediates GnRH
            activation of FSH expression
  JOURNAL   Mol Endocrinol 29 (3), 364-372 (2015)
   PUBMED   25635942
  REMARK    GeneRIF: GnRH stimulation of Fshb expression is dependent on
            miR-132/212 and involves a SIRT1-FOXO1 pathway.
REFERENCE   6  (bases 1 to 1655)
  AUTHORS   Kumar,T.R., Wang,Y., Lu,N. and Matzuk,M.M.
  TITLE     Follicle stimulating hormone is required for ovarian follicle
            maturation but not male fertility
  JOURNAL   Nat Genet 15 (2), 201-204 (1997)
   PUBMED   9020850
REFERENCE   7  (bases 1 to 1655)
  AUTHORS   Matthews,C.H., Borgato,S., Beck-Peccoz,P., Adams,M., Tone,Y.,
            Gambino,G., Casagrande,S., Tedeschini,G., Benedetti,A. and
            Chatterjee,V.K.
  TITLE     Primary amenorrhoea and infertility due to a mutation in the
            beta-subunit of follicle-stimulating hormone
  JOURNAL   Nat Genet 5 (1), 83-86 (1993)
   PUBMED   8220432
REFERENCE   8  (bases 1 to 1655)
  AUTHORS   Gharib,S.D., Roy,A., Wierman,M.E. and Chin,W.W.
  TITLE     Isolation and characterization of the gene encoding the
            beta-subunit of rat follicle-stimulating hormone
  JOURNAL   DNA 8 (5), 339-349 (1989)
   PUBMED   2504572
REFERENCE   9  (bases 1 to 1655)
  AUTHORS   Keene,J.L., Matzuk,M.M., Otani,T., Fauser,B.C., Galway,A.B.,
            Hsueh,A.J. and Boime,I.
  TITLE     Expression of biologically active human follitropin in Chinese
            hamster ovary cells
  JOURNAL   J Biol Chem 264 (9), 4769-4775 (1989)
   PUBMED   2494176
REFERENCE   10 (bases 1 to 1655)
  AUTHORS   Maurer,R.A.
  TITLE     Molecular cloning and nucleotide sequence analysis of complementary
            deoxyribonucleic acid for the beta-subunit of rat follicle
            stimulating hormone
  JOURNAL   Mol Endocrinol 1 (10), 717-723 (1987)
   PUBMED   3155259
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Apr 13, 2016 this sequence version replaced
            XM_006234672.2, NM_001007597.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168724.1, CB315892.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000003.1  114007036-114007072 c
            38-224              JAXUCZ010000003.1  114006211-114006397 c
            225-1655            JAXUCZ010000003.1  114003262-114004692 c
FEATURES             Location/Qualifiers
     source          1..1655
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q33"
     gene            1..1655
                     /gene="Fshb"
                     /gene_synonym="FSH-B; FSH-beta"
                     /note="follicle stimulating hormone subunit beta"
                     /db_xref="GeneID:25447"
                     /db_xref="RGD:2630"
     exon            1..37
                     /gene="Fshb"
                     /gene_synonym="FSH-B; FSH-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            38..224
                     /gene="Fshb"
                     /gene_synonym="FSH-B; FSH-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..455
                     /gene="Fshb"
                     /gene_synonym="FSH-B; FSH-beta"
                     /note="follitropin subunit beta; follitropin beta chain;
                     follicle stimulating hormone, beta polypeptide; follicle -
                     stimulating hormone subunit beta; follicle stimulating
                     hormone beta subunit"
                     /codon_start=1
                     /product="follitropin subunit beta precursor"
                     /protein_id="NP_001007598.1"
                     /db_xref="GeneID:25447"
                     /db_xref="RGD:2630"
                     /translation="MMKSIQLCILLWCLRAVCCHSCELTNITISVEKEECRFCISINT
                     TWCEGYCYTRDLVYKDPARPNTQKVCTFKELVYETIRLPGCARHSDSLYTYPVATECH
                     CGKCDSDSTDCTVRGLGPSYCSFGEMKE"
     exon            225..1655
                     /gene="Fshb"
                     /gene_synonym="FSH-B; FSH-beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcagcttt ccccaggaga gatagccaac tgcacaggac atagctgttg acttacctgg
       61 ccatgatgaa gtcgatccag ctttgcatcc tactctggtg cttgagagca gtctgctgcc
      121 atagctgtga actgaccaac atcaccatct cagtagagaa ggaagagtgc cgtttctgca
      181 taagcatcaa taccacttgg tgtgagggct actgctacac cagggatctg gtgtataagg
      241 acccagctag accaaacacc cagaaagtat gcaccttcaa ggagctggtg tacgagacca
      301 taagattgcc tggctgtgcc cgccactcag actccctcta cacatatcca gtagccactg
      361 aatgccactg tggcaagtgt gatagtgaca gcaccgactg cactgtaaga ggcctgggac
      421 ccagctactg ctccttcggt gaaatgaaag aataaggaac aatggacatt gccattcacc
      481 cacccttgtc ttgaaggacc atgatatcca aaatgtctgg gtctgctctg cactggggct
      541 gtaaaccact gccttaggga ccatcggctc cactattgtc cactgtactg acaggtagtg
      601 aggaggagct caggactggg agtgccaggg ccaggactct ataccactca tctttccctc
      661 catccacact gttgattatc taagtcattc actctcaact cacagcttgg ggcggggggg
      721 ttggaggctt taattttcag caatcttagg aatcttctag agcaaccctt tcctttagac
      781 aaagggatgc atgagtccag agggaggaaa ggaaagtgga aatctgtgaa agaactaaac
      841 ctagcataac catctgcttt tcagagccat cagactttta aagactccag catgattgca
      901 agcgaaaggt ctaaagtctg catggaattc aatgagaaac tcaatggttt ccttaaggaa
      961 aagaaaggca agtcttgcca catatgccag gaaatgctga cgtagctggc tgaggaaagc
     1021 tgtcctccac aaggttagga tactcaactc ttccaaagca tgtggagtat tgagacaggg
     1081 ttgaacattt gtggattgtt ctatgcagat gaagacagag gaagtaacca agctcagaat
     1141 ttccaaggta ttgccaccaa gttctttagt taaaggaaaa gaaaaaaatt aatttggaac
     1201 tgtgaatata gtctacattt attcattact ttaagaaatg atcaaatgct gctaggattc
     1261 tgcaaaactc ccttggaatc aaagaaaaca acagtgaaag tgtttgatag gtgatctaac
     1321 cagctttctc tcccatgcag tgagagaagg gtttgaagtg ggtttcaaag aagtttcagt
     1381 gattaattaa atacatttaa cttgcctaca aatacacctg tataaattaa tggttatata
     1441 aaattaaccg tgagggaaaa ctgctgtttt ctaggacccc ctgcttctct tttacctatc
     1501 cacattctcc ttaatctttt gttcctttca aatacatcat gagtcaaatt cttttaaagc
     1561 tgttaactct tttcatcatg tacctatttc acagttatga tgtttgatta atttatttaa
     1621 atcttatttt tttaataaaa gtgctactga tgaaa
//
