LOCUS       NM_001107072            1710 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus fascin actin-bundling protein 2, retinal (Fscn2),
            mRNA.
ACCESSION   NM_001107072 XM_001081803 XM_221196
VERSION     NM_001107072.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1710)
  AUTHORS   Wang,X., Nichols,L., Grunz-Borgmann,E.A., Sun,Z., Meininger,G.A.,
            Domeier,T.L., Baines,C.P. and Parrish,A.R.
  TITLE     Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells
  JOURNAL   Toxicol Lett 266, 56-64 (2017)
   PUBMED   27989596
  REMARK    GeneRIF: These data demonstrate that fascin2, a putative target of
            alpha(E)-catenin, may play important role in preventing
            cisplatin-induced acute kidney injury.
REFERENCE   2  (bases 1 to 1710)
  AUTHORS   Ramakrishnan,N.A., Drescher,M.J., Khan,K.M., Hatfield,J.S. and
            Drescher,D.G.
  TITLE     HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1
            can form a ternary complex with protocadherin 15 CD3 and
            F-actin-binding filamin A or can interact with HCN2
  JOURNAL   J Biol Chem 287 (45), 37628-37646 (2012)
   PUBMED   22948144
REFERENCE   3  (bases 1 to 1710)
  AUTHORS   Shin,J.B., Longo-Guess,C.M., Gagnon,L.H., Saylor,K.W., Dumont,R.A.,
            Spinelli,K.J., Pagana,J.M., Wilmarth,P.A., David,L.L.,
            Gillespie,P.G. and Johnson,K.R.
  TITLE     The R109H variant of fascin-2, a developmentally regulated actin
            crosslinker in hair-cell stereocilia, underlies early-onset hearing
            loss of DBA/2J mice
  JOURNAL   J Neurosci 30 (29), 9683-9694 (2010)
   PUBMED   20660251
REFERENCE   4  (bases 1 to 1710)
  AUTHORS   Yokokura,S., Wada,Y., Nakai,S., Sato,H., Yao,R., Yamanaka,H.,
            Ito,S., Sagara,Y., Takahashi,M., Nakamura,Y., Tamai,M. and Noda,T.
  TITLE     Targeted disruption of FSCN2 gene induces retinopathy in mice
  JOURNAL   Invest Ophthalmol Vis Sci 46 (8), 2905-2915 (2005)
   PUBMED   16043865
REFERENCE   5  (bases 1 to 1710)
  AUTHORS   Wada,Y., Abe,T., Takeshita,T., Sato,H., Yanashima,K. and Tamai,M.
  TITLE     Mutation of human retinal fascin gene (FSCN2) causes autosomal
            dominant retinitis pigmentosa
  JOURNAL   Invest Ophthalmol Vis Sci 42 (10), 2395-2400 (2001)
   PUBMED   11527955
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221196.3, XM_001081803.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1710
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1710
                     /gene="Fscn2"
                     /note="fascin actin-bundling protein 2, retinal"
                     /db_xref="GeneID:303741"
                     /db_xref="RGD:1308941"
     exon            1..994
                     /gene="Fscn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1647
                     /gene="Fscn2"
                     /note="fascin homolog 2, actin-bundling protein, retinal"
                     /codon_start=1
                     /product="fascin-2"
                     /protein_id="NP_001100542.1"
                     /db_xref="GeneID:303741"
                     /db_xref="RGD:1308941"
                     /translation="MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQ
                     IWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDHPGRDCRFLVLPQPDGRWVL
                     QSEPHGRFFGGVEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDE
                     MAADGDMPWGVDALLTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGK
                     LAFKDCDGRYLAPVGPAGTLKAGRNTRPGKDELFDLEQSHPQVVLVAANHRYVSVRQG
                     INVSANQDEELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMF
                     EIEWHGRRVALKASNGRYVCMKKNGQLAAISDFVGEDELFILKLINRPILVLRGLDGF
                     VCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFL
                     FEFRERGRLAIRALSGKYLRGGASGLLRADADLPTGEALWEY"
     exon            995..1151
                     /gene="Fscn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1273
                     /gene="Fscn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1441
                     /gene="Fscn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1710
                     /gene="Fscn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacaagacag agggagctga ctctgaggca gggagtgtcc atgttgctgg ctaggcttgg
       61 gagccaaggg ccagataaac agatctgggc ctcagggggg gctacaggcc ccctgaacac
      121 tcagagagag ctccctggac ccctgaagca acttggctag tctcaaagat gccaaccaac
      181 ggcttgcacc aggtgctgaa gatccagttt ggccttgtga acgatgccga ccgctacctc
      241 acggctgaga gctttggctt caaggtcaac gcttccgcag ccagcctcaa gaggaagcag
      301 atatgggtcc tggagcctga cccagggcag ggcactgctg tgctgtttcg cagcagccac
      361 ctaggccgct acctgtcggc agaagaagat gggcgcgtgg cctgtgagat ggatcacccg
      421 ggccgtgact gtcgcttctt ggtcttgccg cagcctgacg ggcgctgggt gctgcagtca
      481 gagccacacg gccgcttctt tggtggcgtt gaggaccgac tgtcctgctt tgctacggcc
      541 atctccccgg cagagctgtg gaccgtacac ctggccatcc acccacaggc tcacttgctg
      601 agtgtgagcc gccggcgcta cgtgcacctg tgccttcagg aggacgagat ggcggcagat
      661 ggtgacatgc cgtggggtgt ggacgcactg ctcaccctca ttttccagag caggcggtac
      721 tgcctcaagt cttatgacag ccgctacctt cgaagtgatg gccgccttgt ctgggagcct
      781 gaagcccatg cctgctacac actggagttc aaggcaggca agctggcctt caaggactgt
      841 gacggccgat acctggcacc tgtggggcct gccggcacgc ttaaggctgg ccgaaacacg
      901 aggcccggca aggatgaact cttcgacctg gagcagagtc acccacaggt ggtactggta
      961 gctgccaacc accgctacgt ctctgtgagg caaggaatca atgtctcagc caatcaggat
     1021 gaagaactgg accatgagac attcctaatg caaatcgacc aggagacaaa gaagtgtact
     1081 ttctattcca gcactggggg ctactggacc ttggtcactc acgggggcat tcaggccaca
     1141 gccacgcaag tttctgccaa caccatgttt gaaatagaat ggcacggccg gcgggtggca
     1201 cttaaagcca gcaatgggcg ttatgtgtgc atgaagaaga atgggcagct ggctgctatc
     1261 agtgactttg tgggtgagga cgagttattc atcctcaaac tcatcaaccg acccatcctg
     1321 gtgctccgtg gcctggatgg ctttgtgtgc caccgccgag gctccaacca gctggacacc
     1381 aaccgctcca cctacgatgt cttccacctg agcttcaggg atggcgccta tcaaatcaga
     1441 ggccgtggag gtgggttctg gtacactggg agccatggaa gtgtgtgcag cgatggtgac
     1501 ttggcggagg atttcctctt cgagttccga gagcgtggcc gtttggccat ccgtgccctc
     1561 agtggcaagt acctgcgtgg aggtgcctca gggctgctgc gtgctgacgc ggacctgcct
     1621 acgggggaag ctctctggga atattgagga ctcacagggg gtcaacccca gagccaacct
     1681 acccagcatt aaacctttgt tgcagagttg
//
