LOCUS       NM_001100806            2657 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus fascin actin-bundling protein 1 (Fscn1), mRNA.
ACCESSION   NM_001100806 XM_001064232 XM_001064289
VERSION     NM_001100806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Wu,M., Hao,Y., Wu,X., Zhu,M., Chen,X., Qi,J., Yu,Z. and Xu,H.
  TITLE     SirT7-mediated transcription of fascin in hyperglycemic glomerular
            endothelial cells contributes to EndMT in diabetic nephropathy
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (4), 586-596 (2024)
   PUBMED   38449390
  REMARK    GeneRIF: SirT7-mediated transcription of fascin in hyperglycemic
            glomerular endothelial cells contributes to EndMT in diabetic
            nephropathy.
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Wang,B., Fan,B., Dai,Q., Xu,X., Jiang,P., Zhu,L., Dai,H., Yao,Z.,
            Xu,Z. and Liu,X.
  TITLE     Fascin-1 Contributes to Neuropathic Pain by Promoting Inflammation
            in Rat Spinal Cord
  JOURNAL   Neurochem Res 43 (2), 287-296 (2018)
   PUBMED   29052088
  REMARK    GeneRIF: that Fascin-1 increased rapidly in dorsal root ganglions
            and spinal cord after chronic constriction injury
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Aramaki,S., Mayanagi,K., Jin,M., Aoyama,K. and Yasunaga,T.
  TITLE     Filopodia formation by crosslinking of F-actin with fascin in two
            different binding manners
  JOURNAL   Cytoskeleton (Hoboken) 73 (7), 365-374 (2016)
   PUBMED   27169557
  REMARK    GeneRIF: Filopodia formation by crosslinking of F-actin with fascin
            in two different binding manners
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Gungor-Ordueri,N.E., Celik-Ozenci,C. and Cheng,C.Y.
  TITLE     Fascin 1 is an actin filament-bundling protein that regulates
            ectoplasmic specialization dynamics in the rat testis
  JOURNAL   Am J Physiol Endocrinol Metab 307 (9), E738-E753 (2014)
   PUBMED   25159326
  REMARK    GeneRIF: Data suggest that fascin 1 is involved in localization of
            actin-bundling proteins paladin and Eps8 (EGF receptor pathway
            substrate 8) during spermatogenesis; thus, fascin 1 regulates
            cytoskeletal filaments in Sertoli cells and in spermatid polarity.
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Sasaki,Y., Hayashi,K., Shirao,T., Ishikawa,R. and Kohama,K.
  TITLE     Inhibition by drebrin of the actin-bundling activity of brain
            fascin, a protein localized in filopodia of growth cones
  JOURNAL   J Neurochem 66 (3), 980-988 (1996)
   PUBMED   8769857
REFERENCE   7  (bases 1 to 2657)
  AUTHORS   Edwards,R.A., Herrera-Sosa,H., Otto,J. and Bryan,J.
  TITLE     Cloning and expression of a murine fascin homolog from mouse brain
  JOURNAL   J Biol Chem 270 (18), 10764-10770 (1995)
   PUBMED   7738015
REFERENCE   8  (bases 1 to 2657)
  AUTHORS   Adams,J.C.
  TITLE     Formation of stable microspikes containing actin and the 55 kDa
            actin bundling protein, fascin, is a consequence of cell adhesion
            to thrombospondin-1: implications for the anti-adhesive activities
            of thrombospondin-1
  JOURNAL   J Cell Sci 108 (Pt 5), 1977-1990 (1995)
   PUBMED   7657718
REFERENCE   9  (bases 1 to 2657)
  AUTHORS   Mosialos,G., Yamashiro,S., Baughman,R.W., Matsudaira,P., Vara,L.,
            Matsumura,F., Kieff,E. and Birkenbach,M.
  TITLE     Epstein-Barr virus infection induces expression in B lymphocytes of
            a novel gene encoding an evolutionarily conserved 55-kilodalton
            actin-bundling protein
  JOURNAL   J Virol 68 (11), 7320-7328 (1994)
   PUBMED   7933116
REFERENCE   10 (bases 1 to 2657)
  AUTHORS   Yamashiro-Matsumura,S. and Matsumura,F.
  TITLE     Intracellular localization of the 55-kD actin-bundling protein in
            cultured cells: spatial relationships with actin, alpha-actinin,
            tropomyosin, and fimbrin
  JOURNAL   J Cell Biol 103 (2), 631-640 (1986)
   PUBMED   3525578
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001100806.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168678.1, SRR26643299.49634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-912               JAXUCZ010000012.1  16722823-16723734   c
            913-1069            JAXUCZ010000012.1  16714248-16714404   c
            1070-1191           JAXUCZ010000012.1  16713987-16714108   c
            1192-1359           JAXUCZ010000012.1  16713593-16713760   c
            1360-2657           JAXUCZ010000012.1  16710601-16711898   c
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2657
                     /gene="Fscn1"
                     /gene_synonym="Fascin"
                     /note="fascin actin-bundling protein 1"
                     /db_xref="GeneID:683788"
                     /db_xref="RGD:1583309"
     exon            1..912
                     /gene="Fscn1"
                     /gene_synonym="Fascin"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1562
                     /gene="Fscn1"
                     /gene_synonym="Fascin"
                     /note="fascin homolog 1, actin bundling protein"
                     /codon_start=1
                     /product="fascin"
                     /protein_id="NP_001094276.2"
                     /db_xref="GeneID:683788"
                     /db_xref="RGD:1583309"
                     /translation="MTANGTAEAVQIQFGLISCGNKYLTAEAFGFKVNASASSLKKKQ
                     IWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPDGDCRFLVVAHDDGRWS
                     LQSEAHRRYFGGTEDRLSCFAQSVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPA
                     DEIAVDRDVPWGVDSLITLAFQDQRYSVQTSDHRFLRHDGRLVARPEPATGFTLEFRS
                     GKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTR
                     QGMDLSANQDEETDQETFQLEIDRDTRKCAFRTHTGKYWTLTATGGVQSTASTKNASC
                     YFDIEWCERRITLRASNGKFVTAKKNGQLAATVETAGDSELFLMKLINRPIIVFRGEH
                     GFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSSVTSSSDTPVD
                     FFLEFCDYNKVALKVGGRYLKGDHAGVLKACAETIDPATLWEY"
     exon            913..1069
                     /gene="Fscn1"
                     /gene_synonym="Fascin"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1191
                     /gene="Fscn1"
                     /gene_synonym="Fascin"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1359
                     /gene="Fscn1"
                     /gene_synonym="Fascin"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..2657
                     /gene="Fscn1"
                     /gene_synonym="Fascin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggactaag cggtgcttaa caaaggaggt ccggaacagc cacccaagct ccccgggcta
       61 ccgggccgcc ctccgccacc atgaccgcca acggcacggc cgaggctgtg cagatccagt
      121 tcgggctcat cagctgcggc aacaagtacc tgacagccga ggcgttcggg ttcaaggtga
      181 acgcatccgc tagtagcttg aagaagaagc agatctggac gctggagcaa cctcccgatg
      241 aggcgggcag cgcggccgtg tgtctgcgca gccacctggg tcgctacctg gccgccgaca
      301 aggacggcaa tgtgacctgc gagcgcgagg tacctgacgg cgactgccgc ttcctcgtcg
      361 tggcacacga cgacggccgc tggtcgctgc agtccgaggc gcaccggcgc tacttcggcg
      421 gcaccgagga ccgcctgtcc tgcttcgcgc agagcgtgtc gccggccgag aagtggagcg
      481 tgcacatcgc catgcacccg caggtcaaca tctacagcgt cacccgcaag cgctacgctc
      541 atctgagcgc gcgaccggcc gacgagatcg cggtagaccg cgacgtgcct tggggcgtcg
      601 actcgctcat caccttggcc ttccaggacc agcgctacag cgtgcagacg tcggaccacc
      661 gcttcctgcg ccacgacggg cgccttgtgg cgcggcctga gcccgccacg ggcttcacac
      721 tggagttccg ctccggcaag gtggcctttc gcgactgcga aggtcgctac ctggctccgt
      781 ccgggcccag cggcaccctc aaggctggca aggccaccaa ggtgggcaaa gatgagctct
      841 tcgccctgga acagagctgc gctcaggtgg tgctgcaggc agccaacgag aggaacgtgt
      901 ccacgcgcca gggaatggac ctgtcagcca atcaggatga agagacggat caggagacct
      961 tccagctgga gatcgaccgg gacacaagaa agtgtgcctt ccgcacccac acgggcaagt
     1021 actggacgct gacagcgact ggaggtgtgc agtccactgc atccactaag aatgccagct
     1081 gctactttga cattgagtgg tgtgagcggc ggatcactct gagagcgtcc aacggcaagt
     1141 ttgtgaccgc caagaaaaac ggccaactgg ctgccactgt ggagacagca ggggactcgg
     1201 aactcttcct catgaagctg attaaccgcc ccatcatcgt gttccgtggg gagcacgggt
     1261 tcattggctg ccgcaaggtc acgggcaccc tggacgccaa tcgctccagt tacgacgtct
     1321 ttcagctgga gttcaatgat ggcgcctaca acatcaaaga ctccacgggc aagtactgga
     1381 cggtgggtag cgactcctcg gtcaccagca gcagcgacac ccccgtggat ttcttccttg
     1441 agttctgtga ctacaataag gtggctctca aggtgggcgg tcgctacctg aagggggacc
     1501 acgccggggt cctgaaggcc tgcgcggaga ctatcgaccc cgccacactc tgggagtact
     1561 agggccacct gccctctgca ggccgctgtc cagtccctcc tgttatcctt actcaccgag
     1621 tggccctgca gcaggtggca agcccttgcc tttcaaactg gaaacccgag agaaagcggt
     1681 gcccttgccc gtcgccctct gtggacccct tctccctaac tctctgctcc ccatgggtcg
     1741 gtggctgcag actgtccccg ggagggactc tggttccctc tgtacccttc ttttcatggg
     1801 gcactctggc acctttcttc tgacctcagt caactctgag ccttatttcc cccaggaagt
     1861 ggcctaggag aagctacagg gcctagggag ctgccctgag cttgtaactg gaagaacccc
     1921 acccccaacc cccaccctca cctctctggt gcacctactc tggccccagc atctggaggc
     1981 gagcctttgg gagggactaa ggcccgcatg gtctgccttg ccccaagtgt ttttctggat
     2041 catggctgga agtcagtccc atcctgcagc attcaggcct ggctcttaga ctcaaagcta
     2101 gctaggtgac actgccaggt tgcttctgcg tattctggag ggtgcggggc tctccacatc
     2161 gtgagggggc ggggctctcc ccgcctcatt ccctttcccc tggcctgact ggaagcagaa
     2221 aaatgaccaa atcagtattt tttttttttt aaggaaatgt tactgttgaa agggccctag
     2281 gcaagcctgc cctattggtt gtagccgtga gtggtcttgg ggggagatgc ttggcacctc
     2341 tccctgcctc cccagagggt tccttccctc cctccctcct gcctgtccac ccagccctgg
     2401 ctctgtgatt ggtgctcccc gtcttcccag acacctcggg gctcctgggc gggagaaagc
     2461 cagatgtgtc cctccctggg agccctgcag taaacctcag ggggcccttt cccagatacc
     2521 ccattccacc gactccccca caccatgcat ctcactctgg gtgtctctgt cttttatttt
     2581 ttgtaactgt catttgtata actctgaaaa cccatgatag tagctttgaa ctggaaaata
     2641 aagtaacacc aagtctg
//
