LOCUS       NM_001100527            2764 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus frizzled-related protein (Frzb), mRNA.
ACCESSION   NM_001100527 XM_001063215 XM_215757
VERSION     NM_001100527.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2764)
  AUTHORS   Schlensog,M., Magnus,L., Heide,T., Eschenbruch,J., Steib,F.,
            Tator,M., Kloten,V., Rose,M., Noetzel,E., Gaisa,N.T., Knuchel,R.
            and Dahl,E.
  TITLE     Epigenetic loss of putative tumor suppressor SFRP3 correlates with
            poor prognosis of lung adenocarcinoma patients
  JOURNAL   Epigenetics 13 (3), 214-227 (2018)
   PUBMED   27623992
REFERENCE   2  (bases 1 to 2764)
  AUTHORS   Pachori,A.S., Madan,M., Nunez Lopez,Y.O., Yi,F., Meyer,C. and
            Seyhan,A.A.
  TITLE     Reduced skeletal muscle secreted frizzled-related protein 3 is
            associated with inflammation and insulin resistance
  JOURNAL   Obesity (Silver Spring) 25 (4), 697-703 (2017)
   PUBMED   28240822
REFERENCE   3  (bases 1 to 2764)
  AUTHORS   Partl,J.Z., Fabijanovic,D., Skrtic,A., Vranic,S., Martic,T.N. and
            Serman,L.
  TITLE     Immunohistochemical expression of SFRP1 and SFRP3 proteins in
            normal and malignant reproductive tissues of rats and humans
  JOURNAL   Appl Immunohistochem Mol Morphol 22 (9), 681-687 (2014)
   PUBMED   25046226
  REMARK    GeneRIF: study indicates that increased expression of both SFRP1
            and SFRP3 may contribute to the pathogenesis of IUGR placental
            dysfunction, whereas the loss of these proteins may be involved in
            the development of human trophoblastic tumors.
REFERENCE   4  (bases 1 to 2764)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 2764)
  AUTHORS   Cruciat,C.M. and Niehrs,C.
  TITLE     Secreted and transmembrane wnt inhibitors and activators
  JOURNAL   Cold Spring Harb Perspect Biol 5 (3), a015081 (2013)
   PUBMED   23085770
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2764)
  AUTHORS   Wawrzak,D., Metioui,M., Willems,E., Hendrickx,M., de Genst,E. and
            Leyns,L.
  TITLE     Wnt3a binds to several sFRPs in the nanomolar range
  JOURNAL   Biochem Biophys Res Commun 357 (4), 1119-1123 (2007)
   PUBMED   17462603
REFERENCE   7  (bases 1 to 2764)
  AUTHORS   Qian,D., Jones,C., Rzadzinska,A., Mark,S., Zhang,X., Steel,K.P.,
            Dai,X. and Chen,P.
  TITLE     Wnt5a functions in planar cell polarity regulation in mice
  JOURNAL   Dev Biol 306 (1), 121-133 (2007)
   PUBMED   17433286
REFERENCE   8  (bases 1 to 2764)
  AUTHORS   Bennett,C.N., Ross,S.E., Longo,K.A., Bajnok,L., Hemati,N.,
            Johnson,K.W., Harrison,S.D. and MacDougald,O.A.
  TITLE     Regulation of Wnt signaling during adipogenesis
  JOURNAL   J Biol Chem 277 (34), 30998-31004 (2002)
   PUBMED   12055200
REFERENCE   9  (bases 1 to 2764)
  AUTHORS   Lee,C.S., Buttitta,L.A., May,N.R., Kispert,A. and Fan,C.M.
  TITLE     SHH-N upregulates Sfrp2 to mediate its competitive interaction with
            WNT1 and WNT4 in the somitic mesoderm
  JOURNAL   Development 127 (1), 109-118 (2000)
   PUBMED   10654605
REFERENCE   10 (bases 1 to 2764)
  AUTHORS   Mayr,T., Deutsch,U., Kuhl,M., Drexler,H.C., Lottspeich,F.,
            Deutzmann,R., Wedlich,D. and Risau,W.
  TITLE     Fritz: a secreted frizzled-related protein that inhibits Wnt
            activity
  JOURNAL   Mech Dev 63 (1), 109-125 (1997)
   PUBMED   9178261
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166428.1.
            
            On or before Aug 29, 2008 this sequence version replaced
            XM_001063215.1, XM_215757.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166428.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2764
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2764
                     /gene="Frzb"
                     /note="frizzled-related protein"
                     /db_xref="GeneID:295691"
                     /db_xref="RGD:1311315"
     exon            1..119
                     /gene="Frzb"
                     /inference="alignment:Splign:2.1.0"
     exon            120..860
                     /gene="Frzb"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..1354
                     /gene="Frzb"
                     /note="secreted frizzled-related protein 3"
                     /codon_start=1
                     /product="secreted frizzled-related protein 3 precursor"
                     /protein_id="NP_001093997.1"
                     /db_xref="GeneID:295691"
                     /db_xref="RGD:1311315"
                     /translation="MVCRGPGRMLLGWAGLLVLAALCLLQVPGAQAAACEPVRIPLCK
                     SLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQH
                     EPIKPCKSVCERARQGCEPILIKYRHSWPESLACEELPVYDRGVCISPEAIVTADGAD
                     FPMDSSTGHCRGTSSERCKCKPVRATQKTYFRNNYNYVIRAKVKEVKMKCHDVTAIVE
                     VKEILKASLVNIPRDTVNLYSTSGCLCPPLSVNEEYVIMGYEDEERSRLLLVEGSIAE
                     KWKDRLGKKVKRWDMKLRHLGLGKTDASDSTQNQKSGRNANPRPARS"
     exon            861..908
                     /gene="Frzb"
                     /inference="alignment:Splign:2.1.0"
     exon            909..974
                     /gene="Frzb"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1179
                     /gene="Frzb"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1243
                     /gene="Frzb"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..2740
                     /gene="Frzb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcattaact ctcgctggat agggccctgc cattgctctc aagaggctgt ggtgtctgcg
       61 acgtagacat ttaaagtgac tttgctccag cctcccagcc cgactttctg caggcggagg
      121 ctgatgtctc tgccagagcg agaggaataa atagatgctg cctcgtctag aggcttagac
      181 tctcgggaag agcagccagc ggagcaaggc accgagctcc gccaggctcc tggaccggac
      241 ctgggaggac ttggatccaa gagtactgtg gttgtcccgg ggaacggctg ttcacccctc
      301 cggaccgcag gaggagaatc cagaacgcgc ctctccggtc catcgcccgg ctgcgccctg
      361 ccccatccat cctgctggga ccatggtctg ccgcggcccg ggacggatgc tgctaggatg
      421 ggccgggctg ttggtcctgg ctgctctctg cctgctccag gtacccggag cccaggcagc
      481 agcctgcgag cctgtccgca tccccctgtg caagtcccta ccctggaaca tgaccaagat
      541 gcccaaccac ctgcaccaca gtacccaggc taacgccatc ctggccatcg aacaattcga
      601 agggctgctg ggcacccact gcagcccgga tcttctcttc ttcctctgtg ccatgtacgc
      661 acccatttgc accatcgact tccagcacga gcccatcaag ccctgcaagt ccgtgtgtga
      721 gcgcgcccga cagggctgcg agcccatcct catcaagtac cgccactcgt ggccggaaag
      781 cttggcctgc gaagagctgc cggtgtacga ccgcggcgtg tgcatctctc cggaggccat
      841 cgtcaccgcg gacggagccg attttcctat ggattcgagc actggacact gcagagggac
      901 aagcagtgaa cgttgcaaat gtaagcctgt cagagctaca cagaagacct atttccggaa
      961 caattacaac tatgtcatcc gggctaaagt taaagaggta aagatgaaat gtcatgacgt
     1021 gaccgccatt gtggaggtga aggaaattct aaaggcatca ctggtaaaca ttccaaggga
     1081 taccgtcaac ctgtacagca cctctggctg cctctgccct cccctcagtg ttaatgagga
     1141 gtatgtcatc atggggtatg aagatgaaga gcgctccagg ttactcttgg tagaaggctc
     1201 tatcgctgag aagtggaagg atcggcttgg taagaaagtc aagcgctggg atatgaaact
     1261 ccgtcatctt ggactgggta aaactgatgc cagcgattcc actcagaatc agaagtctgg
     1321 caggaacgct aatccccggc cagcgcgcag ctgaatcctg aaatgtaaaa ggccacaccc
     1381 acggactccc tcctaagact ggcgctgctg gactagcaaa ggaacaccgc acggttgcac
     1441 tcgcgacctc ctgtttacca cagacaccgc gtgccaactg atgttacttc tggttccttt
     1501 tctcctgctt cttaatagcc tggggttaga ttcttctata tgttctatat cctgtttcac
     1561 caaccatgtg ggaactgttc ttttgcaacc agaataataa attaaatatg ttgatgctaa
     1621 ggtctctgtc ctggagtccc gggttttaat ttggtgttct gtaccccgat tgagatgcag
     1681 tatttgatgt aaagagagaa ttctggtaat atctcaagaa ctagatattg ctgtaaagca
     1741 gactctgcgg ctatccttga agccttgtgt ttgtatgcct ttgggcattt ccctcatgct
     1801 gtgaaagttc taaatgttta taaaggtaga atggcagatt gaaatcagac actgcacaag
     1861 cggagcgggg caacaccggg aagcatttat gaggaaatgc cacacagcat gaattatttt
     1921 caagattggc aggcagcaaa ataaatagtg ttaggagcca agaaaagaat attttgcctg
     1981 gttaaggggc acactggagt cagtagccct tgagccactg acaacagtgc tcttctggca
     2041 aagtcttttg atttgttcat aaatgtatta acggacatta gagaaaagct tatagctaga
     2101 cttctgttgt tatcactgta gctctgcttc cttctaaata aagctcattg ttggacgccc
     2161 cacctccatt cagaaataaa tttggctcgc tgtattgacc aggaaaagaa agcactgaag
     2221 tatgcatgtg tgcaccaggg tgttatttta aagagatgtg taactctata aaagactata
     2281 gtttacagga cagtgaaatg tgcacatttg ttttcttttt tattcttctt tttgctttgg
     2341 gcttgtgatt ttggtttttg gtgtgtctgt atttttgggg gtgggtggtt taagccattg
     2401 cacatccaag tcgaactaga tgagtagact aggctcatgg cctagacctt atgaattgaa
     2461 tttgtgctgt ttaatgctcc gtcaaaatgt ctaataaaag gaattatggt tgtcgggaga
     2521 gacaacaaca acaaaaatgt ttttcttact caagctgcag tgaaaccccc gatggcccat
     2581 ggggaactca tggtgccttt tcttccttcc tgcagtgggg atctttagag catgtgccaa
     2641 tcacctaaaa gtctcattcc ttgcagctta cgcatgtggt agtagtggat ccaaattcct
     2701 aagctatggt gtgctgaaaa taaagcatgt atgaagcaaa aaaaaaaaaa aaaaaaaaaa
     2761 aaaa
//
