LOCUS       NM_001108097            6477 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor receptor substrate 2
            (Frs2), mRNA.
ACCESSION   NM_001108097 XM_001080960 XM_006241381 XM_235164
VERSION     NM_001108097.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6477)
  AUTHORS   Chen,J., Cui,X., Li,L., Qu,J., Raj,J.U. and Gou,D.
  TITLE     MiR-339 inhibits proliferation of pulmonary artery smooth muscle
            cell by targeting FGF signaling
  JOURNAL   Physiol Rep 5 (18) (2017)
   PUBMED   28947594
REFERENCE   2  (bases 1 to 6477)
  AUTHORS   Ho,T.H., Liu,X.D., Huang,Y., Warneke,C.L., Johnson,M.M., Hoang,A.,
            Tamboli,P., Wang,F. and Jonasch,E.
  TITLE     The impact of FGFR1 and FRS2alpha expression on sorafenib treatment
            in metastatic renal cell carcinoma
  JOURNAL   BMC Cancer 15, 304 (2015)
   PUBMED   25900027
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6477)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6477)
  AUTHORS   Lu,T.Y., Lin,B., Li,Y., Arora,A., Han,L., Cui,C., Coronnello,C.,
            Sheng,Y., Benos,P.V. and Yang,L.
  TITLE     Overexpression of microRNA-1 promotes cardiomyocyte commitment from
            human cardiovascular progenitors via suppressing WNT and FGF
            signaling pathways
  JOURNAL   J Mol Cell Cardiol 63, 146-154 (2013)
   PUBMED   23939491
REFERENCE   5  (bases 1 to 6477)
  AUTHORS   Xu,B., Yang,L. and Hinton,B.T.
  TITLE     The Role of fibroblast growth factor receptor substrate 2 (FRS2) in
            the regulation of two activity levels of the components of the
            extracellular signal-regulated kinase (ERK) pathway in the mouse
            epididymis
  JOURNAL   Biol Reprod 89 (2), 48 (2013)
   PUBMED   23782834
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6477)
  AUTHORS   Gotoh,N., Ito,M., Yamamoto,S., Yoshino,I., Song,N., Wang,Y.,
            Lax,I., Schlessinger,J., Shibuya,M. and Lang,R.A.
  TITLE     Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2
            recruitment are critical for induction of lens and retina
  JOURNAL   Proc Natl Acad Sci U S A 101 (49), 17144-17149 (2004)
   PUBMED   15569927
REFERENCE   7  (bases 1 to 6477)
  AUTHORS   Tacconelli,A., Farina,A.R., Cappabianca,L., Desantis,G.,
            Tessitore,A., Vetuschi,A., Sferra,R., Rucci,N., Argenti,B.,
            Screpanti,I., Gulino,A. and Mackay,A.R.
  TITLE     TrkA alternative splicing: a regulated tumor-promoting switch in
            human neuroblastoma
  JOURNAL   Cancer Cell 6 (4), 347-360 (2004)
   PUBMED   15488758
REFERENCE   8  (bases 1 to 6477)
  AUTHORS   Gross,I., Bassit,B., Benezra,M. and Licht,J.D.
  TITLE     Mammalian sprouty proteins inhibit cell growth and differentiation
            by preventing ras activation
  JOURNAL   J Biol Chem 276 (49), 46460-46468 (2001)
   PUBMED   11585837
REFERENCE   9  (bases 1 to 6477)
  AUTHORS   Xu,H., Lee,K.W. and Goldfarb,M.
  TITLE     Novel recognition motif on fibroblast growth factor receptor
            mediates direct association and activation of SNT adapter proteins
  JOURNAL   J Biol Chem 273 (29), 17987-17990 (1998)
   PUBMED   9660748
REFERENCE   10 (bases 1 to 6477)
  AUTHORS   Kouhara,H., Hadari,Y.R., Spivak-Kroizman,T., Schilling,J.,
            Bar-Sagi,D., Lax,I. and Schlessinger,J.
  TITLE     A lipid-anchored Grb2-binding protein that links FGF-receptor
            activation to the Ras/MAPK signaling pathway
  JOURNAL   Cell 89 (5), 693-702 (1997)
   PUBMED   9182757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Jul 20, 2021 this sequence version replaced
            XM_006241381.4, NM_001108097.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.30701.1,
                                           SRR26360172.831610.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000007.1  54678512-54678656   c
            146-246             JAXUCZ010000007.1  54633597-54633697   c
            247-338             JAXUCZ010000007.1  54612912-54613003   c
            339-430             JAXUCZ010000007.1  54609026-54609117   c
            431-617             JAXUCZ010000007.1  54606734-54606920   c
            618-776             JAXUCZ010000007.1  54605121-54605279   c
            777-940             JAXUCZ010000007.1  54604525-54604688   c
            941-6477            JAXUCZ010000007.1  54597182-54602718   c
FEATURES             Location/Qualifiers
     source          1..6477
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..6477
                     /gene="Frs2"
                     /note="fibroblast growth factor receptor substrate 2"
                     /db_xref="GeneID:314850"
                     /db_xref="RGD:1308201"
     exon            1..145
                     /gene="Frs2"
                     /inference="alignment:Splign:2.1.0"
     exon            146..246
                     /gene="Frs2"
                     /inference="alignment:Splign:2.1.0"
     exon            247..338
                     /gene="Frs2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..430
                     /gene="Frs2"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1891
                     /gene="Frs2"
                     /codon_start=1
                     /product="fibroblast growth factor receptor substrate 2"
                     /protein_id="NP_001101567.2"
                     /db_xref="GeneID:314850"
                     /db_xref="RGD:1308201"
                     /translation="MGSCCSCPEKDTVPDNHRNKFKVINVDDDGNELGSGVMELTDTE
                     LILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQ
                     EIMQNNSINVVEEPVVERNSHQTELEVPRTPRTPTTPGLGAQSLPNGYPRYPSFGDAS
                     SHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRASVHIPPEA
                     RVSNAESNTPKEEPSNTEDRDPHVLLKPEGVKFVLGPTPVQKQLMEKEKLEQLGKDQV
                     SGSGASSTEWDTGYDSDERRDVPPVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQ
                     NINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNY
                     VNTENVTVPASAHKIDCSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNP
                     QTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
                     "
     exon            431..617
                     /gene="Frs2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..776
                     /gene="Frs2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..940
                     /gene="Frs2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..6477
                     /gene="Frs2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgcctag ggttcgggct ggagaaaggc ctggtagata caggcgccga ggctccgtcg
       61 gctcggagta gggggtcggg tcgcggagag agtgaggagc tctgcggccg ctaccccgcg
      121 ccctcgcagc gccttcgcgc cgacgaaatg gctaccaaga agtagatgcc caggcgtaat
      181 ggtgaggaaa tccacggtac tccacgtgcc atgaagtaag atgcagcata gcatccatcc
      241 agattagtta aggtaacaaa cagggacatc gtgttttgaa atatgattaa cctcctgatg
      301 cagcttcaga ggctaacaac attaatggcc agatctagtg ctcacatggt cttctgaaga
      361 agccatgggt agctgttgta gctgtccaga gaaagacact gtcccagata accatcggaa
      421 caagtttaag gtcattaatg tggatgacga tgggaatgag ctaggctctg gtgtaatgga
      481 gctcacagac acggagctga ttctgtatac ccggaaacgc gactcggtga agtggcacta
      541 cctctgccta cgacgatatg gctatgactc aaatctattt tcttttgaaa gtggtcgaag
      601 gtgtcaaact ggacaaggaa tttttgcttt taaatgtgcc cgtgcagaag aattatttaa
      661 catgttgcaa gagattatgc aaaataatag tataaatgtg gtggaagagc ccgttgtaga
      721 aaggaatagt catcagacag aattggaagt ccctagaaca cctcgaacac ctacaactcc
      781 agggcttggt gctcagagcc tacctaatgg gtatcctcga tacccctcgt tcggagacgc
      841 ttcatcccac ccctcaagcc ggcatccttc tgtgggaagt gcccgcttac cttcagtcgg
      901 cgaagagtcc acacaccctt tgctggtggc tgaggaacaa gtacatactt atgtaaacac
      961 tacaggtgta caagaagaac ggaaaaaccg tgccagtgtg cacattcccc cagaggcaag
     1021 agtttctaat gccgaaagca acacaccaaa agaagagcca agtaatactg aagacaggga
     1081 cccgcacgtg cttcttaagc ctgaaggcgt caagtttgtt ttaggaccaa cccctgttca
     1141 gaagcagtta atggaaaagg agaaactgga gcagcttgga aaagaccaag tcagtgggag
     1201 tggtgcgagt agcacggaat gggacactgg ctatgacagc gatgaacgca gagatgtgcc
     1261 ccctgttaac aaactggtgt atgaaaatat aaacgggctg tctatcccta gtgcctcagg
     1321 ggtcaggaga ggtcgtctga catctaccag cacctcagac acccagaata tcaacaactc
     1381 agcgcagaga agacctgcac tattaaacta tgaaaattta ccatctttgc ctcctgtgtg
     1441 ggaagcccgc aagctcagta gggatgaaga cgacaattta ggaccaaaga ccccatctct
     1501 aaatggctac cataataatc tagatccaat gcataactat gttaatacag agaatgtaac
     1561 agtgccggca agtgctcaca aaatagactg ttcaaggcgt agggattgca cacccacagt
     1621 ctttaacttt gatatcaggc gccctagttt agaacacagg caactcaatt atatacaggt
     1681 ggacttggaa gggggcagtg actctgacaa ccctcagacc ccaaaaacac cgaccactcc
     1741 cctcccacag acccccaccc ggcgcacaga gctgtatgcc gtgatagaca ttgagagaac
     1801 tgctgctatg tccaacttgc agaaagcgct gcctcgggat gacggcacgt ccaggaagac
     1861 tagacacaat agtactgacc tgcccatgtg agccggacac attatgtcgg cgtctgcacc
     1921 ttcgcgagct ttccaccagg aagaggcagc gcttgttctc ctttctacac taactccttt
     1981 tgtagactga tctgttttcc ctgagtattt cctgtgcatc tttaaaggga attaatgcag
     2041 agcaggtact tcactaattc atgatgttgt gctcatcgct gtacagcagc gtcctcgttt
     2101 ttacagtgcc tatttaccat gagaagggaa gggagtgcat actggctgac gtagactcag
     2161 tgttctgggt gtgtgcatct ttcatgttga agttgtggtt gcatttgaac cttttataaa
     2221 gtctcttgac agtgcacatc gctaacataa cgctaggccc tgagaggaat cctgtaggtc
     2281 actgttcaca ggttatggtc tccagcatgc aaggtgagga tttatttcat cagttaaagg
     2341 ctttttgacc tgggccacac ttgtgtaaaa gaaacaaaga gagccacact tccttctgtg
     2401 ccagttagtt cctctgtcct cactgtcact agaaagaacc cagtctagtt gtgtatcgga
     2461 aggcagaagg gagacagcgc cgtgttctcg cctcctggtg tcatttgaag gcagatagca
     2521 tctaactcag agttacaatg ggtttaggaa tcagtctcag gtcactttac ccaaaaacat
     2581 ttgaaagtct acaccatgat ctattggtgt ttctttgtga taggttattg acacattgtt
     2641 tctggagaca tctgtgccat tgaatcccac gagcttcagt tttagcccct tccatcttgc
     2701 agctgtcttg ccttgttata gaatatcttt tagttacaac acaatgtttg tgcaccattt
     2761 tggaatggga ttgtgtgttt gctctcacta cttagtctga attttcagtt atggtcttga
     2821 aggtccattt ggagctgttc tctgacaggg ttacccttgt ccagtattta ttcatctgct
     2881 gtttactttc caagttgctg acaaaagcat catttggatt ttgaatttca tttgtgtcca
     2941 tgggtaatct ctttagtagc tgagaagaaa aggaagatac tcttaaaggt ttgggtcccc
     3001 accaagggtc ctgtcctctc tgggataccc tgtgcagcat gttagcaggg gttgtcccag
     3061 ctccacggcc gcagtcccac tctgccggct ctgctgtcct ctcatgtggg gctgggctct
     3121 tcttatccat gatgttggcg agctgataat gttgccagca cagcaggtac agggaagtct
     3181 tgaagcagtt cgattatatc ataatcgtga atgtgaaatg aataaagttt atataaactg
     3241 atgtgatccc agattttgaa ctcttggaaa tcaagaacac tcccaaacca ctgtatagta
     3301 aatggaaggt taggcagcct tatgaaatag tttacttgtt ttctctaaag ttgaggacgt
     3361 ttcgtgttat gatctggtta taccagatgt gactgaaaaa aaggtttcag tcatccgacg
     3421 ttcagtatat ttaggaactc agcacagaac agtgcctgga ttagcagaat aggactgagg
     3481 ccatgagaag cgaattacat gtgctcatct ttagtgccat tggtttatag catagcaggc
     3541 gtttcctttt ccttttccct ctgtgaacta aaatgttgac tgttctcttc aagagagtag
     3601 tggctacatg tgctgtttcc atggttaata cactgttccc cactcgtcct tctcctgagt
     3661 agtttgtcct tctcctgagt agtttgctag ttgtgccaaa tttcactggt ggttttggtg
     3721 gcgtggggta aggacactga cgggaacagc gtacgacttc ctctgtaacg agcagccaga
     3781 caggagtaac tctccacctc agaggactct tatctctggg ctggatgctc tgttcttcct
     3841 ttgtgctcct ggcttccctt ccgattgaac ttagagtcat agtttttagc tgaccaatac
     3901 caccattaca acttgtgctt caagtagtat atggcctaag agtgcaaatg ggaccgcttc
     3961 atctgctaag aatttgattt tagggtacag catgaatatt aggaagaggt aaacagggat
     4021 gttaatttct agatgtcttc tggaaaccac ctttgtttct gtttagtcag tcatgcagaa
     4081 tacctgtatc ctttacagtc gtctcacagt gacattgagc tcggccctgg aagaatgtac
     4141 ctgctactat ttggtaaact ttagagtgag acatttcact ggcatgtatt tgtagccata
     4201 tgtctcagat tttctgaagc aaacctaatt ttagataatt ggttttgttg attagatcat
     4261 gtgaccccac tttttggttt tggaaataaa atccctgctc ccttttttct ccccatataa
     4321 aatccttttt tagtccatat agatcttaac atttcttttc cagaccaggg ctggaaactg
     4381 atgggtatca ctagtgtttt ctgaatgttg tgtttcccag tttcatcttc ctttgaaaag
     4441 tgaaaatatg gtgcctttcc tcctttcctc cttcctccct tcctccctct ctccaagaag
     4501 attggaaagc cgttccttta tctcctgctg ctgtggaggt gatgagacat gcactttact
     4561 cttgaagact cagcaaatgc taagcttttc acttctcagt atctccacaa taggctgcat
     4621 ttccgactta gggcatttgc caggcaatct ttgccattac agatattaat gctgccccct
     4681 ccactgtgca ctgtgttata agtcaaacgt gtttgtttat gctcccactg cacccacccg
     4741 aatctgtggc acagcgtata aaatgtacct cactaaagtt ctgttaaaaa tgggacaggg
     4801 gccttacgtt ctcataactc ccagcaatgt gccaccatgt atttgcctca aggcagaggt
     4861 ttaacgagct aacaagtact tcccagctcc catgtgctgt cttctaccca caatacccaa
     4921 gtgtttgtgc aatgtgtagt gcgtatgtat aaatatatac atattatata tatatattct
     4981 ttagagacac cattcagaag taatgtattg gcatctcatt catatttctg atgtgaaata
     5041 tatggtacta tttacttttt ccttaatgtt tgccaaattt gaatcaaggc attggtacaa
     5101 aatttcagca tgtgtaggaa acattttggc ttgaaaagtt agcagatcct ttcaccctgt
     5161 cagtgtgctc cgcgcagacc agcgccctgc cgtctcgctg cccagttccc atccctgtgt
     5221 ccttgatttt cagggtgtaa cacaattctt tcatagcatc ctgttgttga aattctctgg
     5281 caattggaca atgacaatgt ggaaacaggc tggtatagat agtacagtag tcaccaggtg
     5341 ccgcatttgc attagtaaat gcaaaataga tgttttataa aggacagact ttgtgttatg
     5401 tttctatttt cattacattg tataataatg taagattatt gtatgttcta atttgcatta
     5461 taaatgtttt tttcctacat aaaggcataa atatagcaac tttgtataaa ggtagcttat
     5521 tagatttaaa tttttctttt ataaaagttg tctacagtgg gactaccatt gccaaattgt
     5581 atatgagata caaatcttcc cctatggtta atttcttttc taaacattcc atatttctct
     5641 aatgaaagac gtgatactgt actatgcata aattgtgttt tagtgctgtt gtatatcagc
     5701 agtttaattt tgggttggca aacgtaacca ctgttaatta caataaaacc ttgtgtgtat
     5761 aacggcgtcg ctggccctct cacccctgtc cttgttctca ctcccccatc agtgccaatg
     5821 tcagacgttc tgtagcatgg caataaagca gaccttttac actgaggcag agcgtggctc
     5881 tgttcagggc acgggggtgg gaggcccgcc tgcccaccca tagccgtcgt cccggtgtgg
     5941 ggctcttttg ccatataagc catgttgtca ggcgtgagaa gttatatatg atgtaaacat
     6001 gctctaagga caagtgtggc tgtgctcgaa agctttgttc ttgatgtaac agttataact
     6061 agtttttaat ctttggaaaa atcaaagtcc ttgaagtaca atcaagactt tattaactgg
     6121 agtacttaaa gaataagcta gtgatgggat tttgttcaac aagggctaag caacacttta
     6181 aaatgttctt atttattgtc ttagtatact tcactatcct gaaattacaa tgtgtaaact
     6241 gtggtttcat cttggactat gtagcatcat gcagtgccat actgttacca ttctggcata
     6301 aatacccatg atgaggtact caagttgata ctggaagctg agctgaccat acactgacct
     6361 taagcattca tgaaaaactg ctttgttgaa taaaaatctg atgagttctt atggtcactt
     6421 tccccttatt gccaaaagta gattgcaata aaacccaaat aaaagtttga atactta
//
