LOCUS       NM_001419637            6659 bp    mRNA    linear   ROD 19-FEB-2024
DEFINITION  Rattus norvegicus ferric-chelate reductase 1-like (Frrs1l), mRNA.
ACCESSION   NM_001419637 XM_345535
VERSION     NM_001419637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6659)
  AUTHORS   Brechet,A., Buchert,R., Schwenk,J., Boudkkazi,S., Zolles,G.,
            Siquier-Pernet,K., Schaber,I., Bildl,W., Saadi,A., Bole-Feysot,C.,
            Nitschke,P., Reis,A., Sticht,H., Al-Sanna'a,N., Rolfs,A., Kulik,A.,
            Schulte,U., Colleaux,L., Abou Jamra,R. and Fakler,B.
  TITLE     AMPA-receptor specific biogenesis complexes control synaptic
            transmission and intellectual ability
  JOURNAL   Nat Commun 8, 15910 (2017)
   PUBMED   28675162
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6659)
  AUTHORS   Madeo,M., Stewart,M., Sun,Y., Sahir,N., Wiethoff,S.,
            Chandrasekar,I., Yarrow,A., Rosenfeld,J.A., Yang,Y., Cordeiro,D.,
            McCormick,E.M., Muraresku,C.C., Jepperson,T.N., McBeth,L.J.,
            Seidahmed,M.Z., El Khashab,H.Y., Hamad,M., Azzedine,H., Clark,K.,
            Corrochano,S., Wells,S., Elting,M.W., Weiss,M.M., Burn,S.,
            Myers,A., Landsverk,M., Crotwell,P.L., Waisfisz,Q., Wolf,N.I.,
            Nolan,P.M., Padilla-Lopez,S., Houlden,H., Lifton,R., Mane,S.,
            Singh,B.B., Falk,M.J., Mercimek-Mahmutoglu,S., Bilguvar,K.,
            Salih,M.A., Acevedo-Arozena,A. and Kruer,M.C.
  TITLE     Loss-of-Function Mutations in FRRS1L Lead to an
            Epileptic-Dyskinetic Encephalopathy
  JOURNAL   Am J Hum Genet 98 (6), 1249-1255 (2016)
   PUBMED   27236917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001419637.2.
            
            On Apr 13, 2023 this sequence version replaced XM_345535.9.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               JACYVU010000161.1  47113886-47114260   c
            376-460             JACYVU010000161.1  47098878-47098962   c
            461-599             JACYVU010000161.1  47096076-47096214   c
            600-846             JACYVU010000161.1  47091620-47091866   c
            847-6659            JACYVU010000161.1  47080040-47085852   c
FEATURES             Location/Qualifiers
     source          1..6659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..6659
                     /gene="Frrs1l"
                     /gene_synonym="Epb4.1l4b"
                     /note="ferric-chelate reductase 1-like"
                     /db_xref="GeneID:366376"
                     /db_xref="RGD:1309978"
     exon            1..375
                     /gene="Frrs1l"
                     /gene_synonym="Epb4.1l4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1019
                     /gene="Frrs1l"
                     /gene_synonym="Epb4.1l4b"
                     /note="erythrocyte protein band 4.1-like 4b;
                     ferric-chelate reductase 1-like protein; DOMON
                     domain-containing protein FRRS1L"
                     /codon_start=1
                     /product="DOMON domain-containing protein FRRS1L
                     precursor"
                     /protein_id="NP_001406566.1"
                     /db_xref="GeneID:366376"
                     /db_xref="RGD:1309978"
                     /translation="MAGQSLRRSAWVPLLLRLLLAGIAACEASPADDGAGPGGRGPRG
                     RARGDAGADEAVPRHDSSYGTFAGEFYDLRYLSEEGYPFPTAPPVDPFAKIKVEDCGR
                     TKGCFRYGKPGCNAETCDYFLSYRMIGADVEFELSADTDGWVAVGFSSDKKMGGDDVM
                     ACVHDDNGRVRIQHFYNVGQWAKEVQRNPARDEEGVFENNRVTCRFKRPVNVPRDETI
                     VDLHLSWYYLFAWGPAIQGSITRHDIDSPPASERVVSIYKYEDIFMPSAAYQTFSSPF
                     CLLLIVALTFYLLMGTP"
     exon            376..460
                     /gene="Frrs1l"
                     /gene_synonym="Epb4.1l4b"
                     /inference="alignment:Splign:2.1.0"
     exon            461..599
                     /gene="Frrs1l"
                     /gene_synonym="Epb4.1l4b"
                     /inference="alignment:Splign:2.1.0"
     exon            600..846
                     /gene="Frrs1l"
                     /gene_synonym="Epb4.1l4b"
                     /inference="alignment:Splign:2.1.0"
     exon            847..6659
                     /gene="Frrs1l"
                     /gene_synonym="Epb4.1l4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgaggc agggaggcgg cgggtgcggg cgctccgcgg ctgcgcggcg cgtgctggcg
       61 gcggctcggt cccggcccgc gcccgccggg tccccgctgc ggccggagcg gcctggctgt
      121 gggatccgtg cgcagcgatg gcggggcaat ccctgcggcg ctcggcctgg gtaccactgc
      181 tcttgaggct gctgctggcg gggatcgctg cctgcgaagc cagtccggcg gacgacggcg
      241 cgggcccggg gggccgggga ccccggggac gcgcgcgagg ggacgcgggc gccgacgagg
      301 cagtgccgcg ccacgactcc tcctacggca ccttcgccgg cgagttctat gacctgcgct
      361 acctgtcaga ggagggatac ccttttccca ctgctcctcc tgtggaccca tttgccaaaa
      421 tcaaggtgga agactgcgga aggactaagg gatgcttcag gtatggaaag ccaggctgta
      481 atgcagaaac ctgcgactac ttcctcagct accggatgat aggcgccgat gtggagtttg
      541 agctgagtgc agacacagat ggttgggttg ccgttggatt ctcttcagac aaaaagatgg
      601 gtggtgatga tgtcatggcc tgcgtccatg atgacaatgg cagagtccga atacagcact
      661 tctataacgt ggggcagtgg gcaaaggagg ttcagagaaa tcctgcccga gacgaagaag
      721 gagtttttga gaacaaccgt gtcacctgta ggtttaagcg ccctgtgaat gttcccaggg
      781 atgaaacaat tgtggatctg cacttgagtt ggtactacct gtttgcctgg ggtccggcca
      841 ttcagggctc catcactcgt catgacatag actctccgcc ggcctcagag cgcgttgtca
      901 gtatttacaa gtacgaagac attttcatgc cgtcggctgc ctaccagacc ttctcctctc
      961 ctttttgtct gcttctcatt gttgccctga ccttctacct gctgatggga accccttaac
     1021 ctccgctgca agccacaggc tactgaagca ccttcagtat gtgtttttcc gcctgtataa
     1081 ctttagcttt tattatctaa aaacaagtca tgatttcaac attttttggg caaaaaaaaa
     1141 aaaaaaaaaa aaaagagcaa gtttagtttc tctcctactc agacagggtt gtcaaggcaa
     1201 ccctactttc aggaagtact taagacattt gcaaacactt ccagatacgt tttctatttg
     1261 agctttacaa tgtctgggca ttggcttcgt agaactgcgg gggctgtcat accgattggg
     1321 atttaaaccc agacaaaggg tgccttttgt tgacccacat gtctcacagc cttggctgac
     1381 gtgatcagat gacatacagg aaggtagagg aaactagacg tggaaagcgt acctcaaagc
     1441 agtctttact tttgagtcgt actgcacgag agggttactt agcacgttgt cgtggaggac
     1501 tttacgggac gtcgcggtgt gtcatcagcc tcttgagaac atttctgtgg cgcagaaatg
     1561 cttttagatt gtcacacagt tgatggggag tgtgggggag attctagtga taagccagtg
     1621 gtttgtcttt atctaaaata tatcctcaat tagtgtgtag ttatgagaaa acagttttat
     1681 atccctgcta ggaaagatta aaaacgtgaa tgttcctgaa gatgtaaaat tattttaatg
     1741 ataaaaatag gagaattctt agtagttaga attggctctc ttctgctact gtattccacc
     1801 agctaaggtg ttcgtgggcg gccaatggtg ttcagatcag cacacactga gtatgattaa
     1861 atatccatta caacagacaa gtcatcttat ggaaacaagg caatttaacc ataggtcagc
     1921 atttttaaag gctgtagaca ccaggagcaa aaatggggca ggggacccta aggtaaactt
     1981 cccaaaagtt tatgtgaaaa gtgttcaatt ccaagtttcc ttttgtcaaa tgaaccagat
     2041 actcttttag aggaaatacc taagttagca gccttcggag aggagagcct cggcgggcgc
     2101 ttacactgct gggtcggtcc catcatggca ttccagaatt cactgcttcc aagctggctc
     2161 ccactttata ggcgagcaat agcaggttat ggttaataag gtcatctccg agattcacgt
     2221 cggtggtgaa ggtcgcccca tgggaaagtg ttcggactca cctgggctag agccaaaaca
     2281 aagtaagtat tgctacttcc tgcccacacc acatttcaaa ctcaaggttc tagtcggagg
     2341 ccccacctca gtacaattat cttttcacca agccctctga tctttctttt ggctcaagca
     2401 tggcgggtac accagcttct cggcatgcga cgctggttga gaagcgaagg ttgggagcgt
     2461 acagagacac ctgtgttgta aataagaagc ccgatatttt tatatgccta tgtgcacaac
     2521 agtcgatcta tagctagcag agccagtaga gacagactcc agttgccagg aggagcagag
     2581 cgagtggtgt ctccctccca catacgtttc caatcaagta actgcttccc cgagtctttt
     2641 gactttggtg accagttttg tctatttttt tgctaggaac tttcagagtt atccttgccc
     2701 ttacagtaac atgcaactta ctctactaag cgtcggtctt ctctgcttca ggactgccac
     2761 ttgtcccaag tctgaggggc ctggagttct tccagcctgc tctcctctct cagctgtgct
     2821 gtcttccttc ctgtggatga tgacctcatg gaaaaggctc taacttaaac tctctcttcc
     2881 tccagtcctc tggactagtt ttaggacgta ctcaagtgct cctggatccc actgggcttc
     2941 ctcagcacac aggtcaagct ttagtgaaat tgcaggcttt ggctgctaac ccctcacgta
     3001 ggagctattt ctcaatgctc acccttatga cagacactac ctcttaggag gtatacatca
     3061 aactgatggg ccaagctaca agccgcctcg atgtcgtgag tttcttggag ccagaggaat
     3121 ctctatatat actttacctg actagctaat gtttttatgt ccctccttgt gatcaaaccg
     3181 tgtcttccaa aaacatacat gacagaatcc ttagtgaatg tgttggtttt acctttctgt
     3241 ggatatcagt tggaattttc aacaataaat catgggtcct ggaacaagaa tttacagact
     3301 agggatgtat cacaacagtt gaccgtcccg tcagagagct agccactgat agacctgttg
     3361 gagttaaagc cgtgtgaact caaactcctt tcattcttat ctaatgtaag agaaagatct
     3421 ttaccccctc cactcattcc ctctcttcca gcagggcctc acaggcctcc tcccagcctc
     3481 ccgactcccg gctgctgtta tctcaagcct acgccaccag atccgacagt tggttttcct
     3541 ttctaatata atgtctgtcc tgagggagac gcctgtcagt gctttttggt aaaaatgccc
     3601 aagtgaaata tgagtggcag ataaatgtac actagtttaa tgcacgtatc ttgcaagagg
     3661 cagcctgggc caagggtggg gatatgactc cacctcatgc agagtctttc gagctttcac
     3721 taaatagaac ctgctatcca ttctcaagtc aatggtgtgc cttcaaccgt ctcctagtac
     3781 tttacagcaa gcagaggact tcttacagct gtatttgagg aaaggaacac aacttttttt
     3841 aaaaaaaact ttttcttttt tatatttaag gtttatttta tgcatgtgag tgctctctgt
     3901 gcatgtacac ctgcgtgtca gaaaaggaca tcagatcccg tttagatagt tgtgagccac
     3961 catgtggttg ctgggaattg aactcaggac ctctggaaga gcagactgtg cacttaacca
     4021 ctgagccatc tctccagtcc ccacatttaa ctttattttt tgcttaaaaa cattttagta
     4081 cccccctgtc tctctccctc cccccctttc ttttcagcac tggggacata cccaaggcct
     4141 tgtatactga actacaaccc cagtttgttt taggaccatt aatgtttctc aaactaatgt
     4201 gtagactgga catgattgga agaatgcatt agttaatttt taaacatgac tttcttaaag
     4261 gcttggtcta tcttacgaca cggaacccca tatgcttttg ttgtcccact atagtcaaac
     4321 acccattcag agaacatttg gaagctgcat tcagttacct tgggttggtt tttgccctta
     4381 aacaaatgac aaggtttgac gcctgaggga tggatttccg tcccagcaga gttatacttt
     4441 cttgcaattc aagtgtgccg tctgtattcg ggattttatc ttacgtggca ttagcgctga
     4501 agttgaacag cgttttcagt tctagcccag gatcacttgt atcttcttct aaagggccag
     4561 gttgtataga ttttaacctt gaacttgtgt cgcagctgtt ctactctgcc acagacagct
     4621 ccaaaagaaa caagcatggc cgcacactag taaaacaact gaaattcgaa cttcatacac
     4681 tttgcaggta ccaaaatgat ctgttaagtt tcaaaaagcg attggaaaat gtaaaagaaa
     4741 aaatgttttt agtttacagg ctgaacagaa acaggaagta gactgggctg ggcttgtgga
     4801 ctctggtttt tcacagtggc tttagtcatg ggcatactat ttatctggtc agttgtaaac
     4861 cctatcagca gtaacttatt agctagtggt aaaactatta aagttgagga ataatttatt
     4921 taaaaatgat ttatagttgg ttttctgcta taaacaaata acatcgtagc atccttgtgc
     4981 attcatgcta taatgtgtct gctagagttg gcacggaaga ggaaacagtg aagaacccgt
     5041 ctgggtaggc cgcagctttg ttttgcctga ggtttgacag tcatgaacac gtctcactgc
     5101 tgaactactc ttttggcgaa cattcctatg ctttagagta atgtatttcc aagtagaaat
     5161 ttaaaaaaaa tatcattaag ggcacagagt gttttataca tgtgacgcct acatctcata
     5221 caataaaaca atgcgtgaga gccagcatac taggtcacgt gctgaggtga ctgtagttaa
     5281 ctattgtaca tccgtactct acaaacaact gcatatttag tagacaggtt gactattttc
     5341 agtgtgttta tatgtatata cactttgtac atatgtgaca gatgggagtg tatttataca
     5401 taaacatgca cttgagtgta tccctgtgag tgcatgtgta cacacacaca cacacacaca
     5461 cacacacaca cacacacacg cacaccacta aaggttattg tcagggttag ttctttttct
     5521 gatctcttgt atactttaaa acccagagat aaaacattac gtgttaaaag catacttacc
     5581 tgtgaatttt tggtaattta gtttatagaa aggatcccta gatcttttat taagccttga
     5641 ctcacatatt tagcattata taaagtatta ggagcatata tgcattgttg cttaatttaa
     5701 cttttctcta tgagtaactg gcatgttacg aggcagccta aacatgtttt aagttgcatt
     5761 agttctctcg ttctatttca ttattcagtg agcaacttga gtagtttcat gttggatttc
     5821 cttgtgtctt tatttaacag atgacttgca tataatttcc ttttcctgaa aatagtagtt
     5881 agggaaataa gagcttaaat atgcctggca atgggaaaac atatgtaaat ctagcctggg
     5941 ggagggggcg tgttctattt aagaatacac caatgactgg ggaatatttt cagttttctc
     6001 tcaaatattt gctattaggt gagagtaacc actcagtccg attcttctgg aatgtaatca
     6061 ttctctcagt ttgttgaatg ctcagtgggt gtggcactcg cccaggtcat tagactcttt
     6121 gctgcttcat cgaatgccct gggccctcag ccccggaaga gagaatgcag cttctccaca
     6181 tgccttattc cccctgaggc atcgacatgc tggaacagtc tgactccaag tactaataca
     6241 gtttttttga gactgtctac aaaatactat tttgttaaaa ctatgccttt aaatagacac
     6301 tgatgggtta tatttgtttt ataaaaagtt gtatacctaa tgttcaactg tggttgattt
     6361 tgagattata tataaatgta tatttataag cctgtcttat gtggattttt actctaagaa
     6421 gtgtggcgca ttactaataa agatatgggt ttctgtttct gtaaagtcat tgtagcaaca
     6481 ctcctaactg ctacctgaac gatgattcca ctcactggcc accatacata cttttatcta
     6541 tagaatatta agttatactc agaatgtatt aaccaggatg aaactttaag aacggaaact
     6601 ctcaacataa tttgaaattc ttcctgttga tgtaattaaa actagtttat aattcctta
//
