LOCUS       NM_001398971            6391 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus ferric-chelate reductase 1 (Frrs1), mRNA.
ACCESSION   NM_001398971 XM_039103830
VERSION     NM_001398971.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6391)
  AUTHORS   Vargas JD, Herpers B, McKie AT, Gledhill S, McDonnell J, van den
            Heuvel M, Davies KE and Ponting CP.
  TITLE     Stromal cell-derived receptor 2 and cytochrome b561 are functional
            ferric reductases
  JOURNAL   Biochim Biophys Acta 1651 (1-2), 116-123 (2003)
   PUBMED   14499595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000078.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001398971.2.
            
            On Dec 29, 2021 this sequence version replaced XM_039103830.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132273, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JACYVU010000078.1  3488615-3488657
            44-101              JACYVU010000078.1  3490216-3490273
            102-189             JACYVU010000078.1  3492930-3493017
            190-413             JACYVU010000078.1  3505014-3505237
            414-550             JACYVU010000078.1  3508626-3508762
            551-645             JACYVU010000078.1  3509693-3509787
            646-793             JACYVU010000078.1  3511448-3511595
            794-976             JACYVU010000078.1  3514131-3514313
            977-1075            JACYVU010000078.1  3529240-3529338
            1076-1223           JACYVU010000078.1  3530971-3531118
            1224-1337           JACYVU010000078.1  3534413-3534526
            1338-1453           JACYVU010000078.1  3535822-3535937
            1454-1540           JACYVU010000078.1  3538464-3538550
            1541-1638           JACYVU010000078.1  3539786-3539883
            1639-1697           JACYVU010000078.1  3540132-3540190
            1698-1841           JACYVU010000078.1  3541839-3541982
            1842-1903           JACYVU010000078.1  3542469-3542530
            1904-6391           JACYVU010000078.1  3542608-3547095
FEATURES             Location/Qualifiers
     source          1..6391
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..6391
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /note="ferric-chelate reductase 1"
                     /db_xref="GeneID:310810"
                     /db_xref="RGD:1306883"
     exon            1..43
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            44..101
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            102..189
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            190..413
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1996
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /note="stromal cell derived factor receptor 2"
                     /codon_start=1
                     /product="ferric-chelate reductase 1 precursor"
                     /protein_id="NP_001385900.1"
                     /db_xref="GeneID:310810"
                     /db_xref="RGD:1306883"
                     /translation="MAAPQFTLSVLVCALLICSVTAYPNGRVARSCAGMIPQHNHSPQ
                     SDPVHKITVSQMKFKPGDQIKVTLSGPPFRGFLLEARNAEDLSGPPIGTFTLIDSDSS
                     QILTCEDVQGFAVSHTSSSIKTEIKVYWNAPSSAPDHVQFLATVVQKYKIYWVKIPGP
                     VISQPSAPPFTTPEATTQPLTMAPSVSHLTKPFSASECGNKKFCVRSPLNCDPENEPA
                     CVFLSFTRENQSVMVEMSGPSDGYVSFAFSHDQWMGDDDAYLCIYEDQTVYIQPSYLT
                     GRSYPVMDSRGTLEDMAWRLADGVIQCSFRRNITLPEAKNRFVLNESYYIFYAEGAAH
                     DGRIFRHSQQPLITYEKYNVTGTPQNVGGSRSSALLKAHGALMFVAWVTTVSTGVLVA
                     RFFRSVWSKAFFFGQAAWFQVHRMLMLATSMLTCVAFVLPFVYRAGWSWRAGYHPYLG
                     CIVMTLAVLQPLLATFRPPLHDPRRQVFNWTHWSVGTAARIIAVAAMFLGMDLPGLDL
                     PSPQKTYAMMGFVVWHIGTEVILEIHAYLLSRKVEILDDDRIQILQSLTVAEAEGHVF
                     KKVVLAVYICGNVTFLMIFLSAISHV"
     exon            414..550
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..645
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..793
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..976
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1075
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1223
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1337
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1453
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1540
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1638
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1697
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1841
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1903
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..6391
                     /gene="Frrs1"
                     /gene_synonym="Sdfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccaagc cggaagttgg tcaggctgcc tctgctgctc aaggtgtcac tgtattcctg
       61 gagacccatc tgcctctgcc tcacaaggaa caggactaaa gagctcatgt atcacatagc
      121 ctaggctggc ccagatttgc cgtgtggctg aggatgagct tgagaatctg accttcccac
      181 cttcacttgg cgacgtgttc ttaatcatca cttggagatg gcggctcccc agttcaccct
      241 cagtgtcctc gtgtgtgcct tgctcatttg ctccgtgact gcttatccca atggaagagt
      301 agcaaggtcc tgtgctggga tgatccccca gcataaccac agccctcagt ctgatcctgt
      361 tcacaaaatc acagtgagtc agatgaagtt caaacctgga gaccagatca aagttacttt
      421 atcaggaccg ccatttagag gctttctttt agaagcccgg aacgctgagg atttgagcgg
      481 ccctcctatt ggcaccttca ccttgattga cagcgactcg tcacagattc tgacctgtga
      541 agatgtacag ggattcgctg tgagtcatac aagttcatcc ataaagacag aaattaaagt
      601 ctactggaat gctccaagca gtgccccgga tcacgtccaa tttctagcca cagttgttca
      661 gaaatataaa atctactggg tgaagattcc tggtcccgta atttcccaac cgagtgctcc
      721 tccctttacg acgcctgaag ctacaacaca acctttgaca atggcccctt ctgtctcgca
      781 cttaaccaaa ccattcagtg cctctgagtg tgggaacaag aagttctgcg tcaggagtcc
      841 gttgaactgt gacccagaga atgagcctgc ctgcgtcttc ttgtccttca ccagagaaaa
      901 ccagtcagtg atggttgaaa tgagcggacc cagtgatggc tacgtgtcct ttgcattttc
      961 tcatgaccaa tggatgggtg acgatgatgc ttacttatgt atttatgagg accagacagt
     1021 gtatatacag ccttcctact tgacagggag aagttatcct gtgatggact ccagggggac
     1081 tcttgaggat atggcttgga ggctggcaga cggcgtcata cagtgttcat tcagaagaaa
     1141 catcaccctt cctgaggcta agaacagatt tgtgctgaat gaaagctact acatattcta
     1201 cgcagaaggc gcggcccacg acggccgaat atttaggcac tctcagcaac ctttgataac
     1261 gtacgaaaaa tacaacgtga caggcactcc acagaacgta ggagggtccc gctcttcagc
     1321 ccttttgaaa gctcatggtg ccttaatgtt tgtggcatgg gtgaccacag tgagcacagg
     1381 agtcctggtt gcccggttct tcagatctgt ttggtcaaaa gctttcttct tcgggcaagc
     1441 agcttggttt caggtgcacc ggatgctcat gctcgctacc tctatgctca cctgcgtggc
     1501 ttttgttttg ccttttgtgt accgagcagg ctggagttgg cgcgcaggct accacccgta
     1561 cctcggttgt atagtgatga ccttagctgt ccttcagcct ctgctggcaa ccttcagacc
     1621 acctttacac gacccaagga ggcaagtgtt taactggact cactggagtg tggggacagc
     1681 tgctagaata atagcagtgg cagcaatgtt cctaggaatg gatttaccag gactggatct
     1741 ccccagtcca cagaagacct acgcaatgat ggggtttgtg gtctggcaca ttgggactga
     1801 ggtcattctg gagatacatg cttacctgct ctctagaaaa gttgaaatac tggatgacga
     1861 tagaattcag atccttcagt cactaaccgt tgctgaagca gagggtcatg tttttaagaa
     1921 ggtggtgttg gcggtttaca tatgtgggaa cgtgactttt ctcatgatat tcttgtctgc
     1981 aatcagccat gtttgagcac gaaaagactt gtttttttgt gggtcatgat gatcatcaaa
     2041 atgaggagag acctgatgcg tgtactgacc acctggcgca catactgatt cagaagaccc
     2101 ctgggcatcg ctctagagga attctgaagt ctggttttct tggctcacat tcaagtgggc
     2161 tatatgacac atgcattgat atcaatcaag gctttatgcg taattctgca ccttgaaggg
     2221 aacagtgtac ctgagatgac ctgactctaa acgtcccacg ccagatttaa aacaggaaac
     2281 tggaaaggaa gatagcaagt gaagacaatt atctcaggca aagaataagt ggagattgta
     2341 tccttaggaa tgagacaggt tttgtgtagc ccaggctggc ttctaactga ttgtataacc
     2401 aaagagaccc ggaacctgtg atcttcctgc ctgtgcttcc tgggtggcgg ggttacaggt
     2461 gtgcaccgct ctatctggtt ttaaggggac tgtaattttc atgctgctgc tgctgtggta
     2521 ctttaaagaa tacatttatg ttgattagtt tattttagag atttttatct tagatttttt
     2581 taaaaaaatt gctacatttt gtttttatac acatagatac acacacacac acacacacac
     2641 acacacacac acacacacac acacacacaa ataaataaaa cctacaagaa aaaacatgca
     2701 tgttttctga ccagcgactg ggactattct cttctgtttg tgttcagtac ttctggctaa
     2761 aggtggcacg gtggttgatt tattcagtgg gcatttcact aacatttaat tatgttatgg
     2821 atattatatt ctctctttag cagttaaatg caggtaggta tctcctgatt agagatttca
     2881 tttatttttt atctgtggag ctgaaccgac atcttatgta agatcagtcc ttataggagc
     2941 taagaacaaa gtcgtgaatt tcacagtggc taaacctcgc ccttgtgaac agatctagca
     3001 ggtgttcttg tctcttgtga aattaaacta acatggatgg gctcctttgg aagacagccc
     3061 tgtgctctag tgacttagag gcaatgcgtt ttcctctcct actaggtcat tttctatctc
     3121 aatgtttgct atgaggacct acagccagtg ggtggcgctg taataccgga ggactcattt
     3181 gttctgttcc cattgttttt atcatggggc tatttcctta caccctaccg ctctgttttt
     3241 tttttttttt tttttttttt ttgttttttt tttgtttttt tttttctttc ctttttggag
     3301 taataggtgc tagaaactta atgactggtg ttattacttt ctgacttatt tgttttcttt
     3361 gattatttat aatgagtgtt tgatattttc ttttatagtc ttctgaccct gtagcaaatg
     3421 aagataattt tgttaggcaa aggaaacagg taaagttgga catttaaaaa ataaaataat
     3481 tgggagggta tattttatgt ttttagatac tctttcggat gatttcggat ttctgcttgg
     3541 ctccagaacc ctattttcat ctctcagtaa ttaccccagt tcattgtttt tatttctaac
     3601 caataaagtg aaaacttttg gtttttctct acatagatct tagttaaaaa tagcttaggc
     3661 ttcggtagga atttcttgtg ctcatggtca atgaatgcca catttcggtt taaatatctc
     3721 ttgagaatgt ctttatttca agagaaaggg ctggggatgt agctcagagg caccgtgctt
     3781 gagtagtgag tgtgaagcca tgcttctgtc ctagcaccgg agaaatggca gagtaacaat
     3841 gtgaatctgt atgaaaaaat tttctttcag ttttacatta taagccacta aaggccaaaa
     3901 catatgtctt aataagtctt atttagtatc agacaaggaa aatcccttca ggaaaaggtg
     3961 gaatttgctt aggtttggtt tgcagatggg tgaacttctg gacttctgat gccaaggcca
     4021 atattgtaat gtatttttca aaagaaattt tttttattat ttctttaata cgtaggggca
     4081 ccctctcaga ggcgaaaggg aagtaggatg ggaggaggaa ccctgtgagg agaggcctgg
     4141 ggaggggagg ggaggtaaat atataaataa gttaagaaaa aagaacttta cataatgaca
     4201 ggtgggtgtg gtaccacagg cctctaattc cagtgggagg cagaggcagg cggatctctg
     4261 taagttcaag gccagcctgg tctataagag agttcaccag gacagccagg gtacacagag
     4321 aagccctgtc ttggaaaaca cacacacaca cacacacaca cacacacaca cacacacaca
     4381 cacacacatc tctcatatct catataatgt attttgatca tattcacctt agctcctccc
     4441 acatctccac taacttctct actcccaaac tgtatgtctt attattgttt gtttgcaata
     4501 atctgtgctg tctatatcct cctgggtttc tggctgccca ccaaagatcg aggtcaattt
     4561 ttcccaagcc acacccctaa agaaaactga ctcgctccca tgagaagcca tcaactgtag
     4621 gtcctcaggt agggatggac ttagggactc cttcccacct catgtggact ggcttgacct
     4681 tgcacaggag ttgtgcaggc aaccacagtg gttgtgaggt catgagtgag gtatcctgcc
     4741 agctcccgaa gacactgttt ccaccctgcg ccttccttcc cagcctctgg cacttgcagt
     4801 ctctgggact gctctgacgt ggtccctgag cgctgggaaa gggcgtgata tagatgctcc
     4861 acttgtgact catcgctccg cagatgcttt gaccagctgt gagtttctgc atagcatatt
     4921 ctttttcacg gagtggtgtt tgctcgggtt tactcctcca tcgagctgtg caaacaaatc
     4981 tgtgccactt aatcttagtg cgcccatttc ccttaggaac ggacgcgtta caacccttct
     5041 gctccctgtg cttggtctta gttttgcaat aaacaatctg ggtagatttt taaaaaaaaa
     5101 aaagtataca tatttttttt aaaaaaagaa aaactaaatg atttttctgt gtctaggcat
     5161 attgtcaaaa acagcaaaac catgttttct taaagaaggg ctattctgta aaatagagat
     5221 caatgttttc cacaaaataa aaaagaaata gtctagaaaa tcatggttaa gttagcatag
     5281 actgagtctg tgtttggcct tgtcagcttc tggtctgagg aggtcaagct ggggcacagc
     5341 ggcctgtaac tgtagtgaat atgtgactct cgttcctgtt agcgcttctc agtttgagga
     5401 ttccgggctg gaggtgaggt gatgcctcat cctccccaca tcctcccctc ccgcccagga
     5461 ggctgtagga aggcaagcac agcagatacc aactaggaag ccatgggggc cgtgtggctc
     5521 ttggctccaa gtctgtttat ctatgtattc tattgaagca agggggaaac ggggaacaaa
     5581 ggcccttgtt caagataatc cattattaat gggactggag aaacaattct tttatgttca
     5641 ttatgaactg gatcagcctt ctcatagctc ccacgtccgt ccttccttcc ctgtgtaacc
     5701 cctgacatac tcattcgtcg gcccacagtg tcggtgctca cccagccgca ctgcctttct
     5761 gtttccgtcc tagccagagc ctgcaggttc acgttttcca ttctttcatc ttcctggcac
     5821 ctccttgtcc tgttcccgac actgatccct ctttgtcagt gggtgctgag gtgggaggga
     5881 ggcctgagga gccacagtta ctcccgaatt ccatgtttgt ggcaatgggg tttgtctccc
     5941 gggagtcgtc tttgtcgtct tcaacaacct atctcattaa acttctgagt gaaatgacac
     6001 cagccaaagg tgcttgcttt gtacatgttg ctggtaaggc ctttgccact cgattacaat
     6061 gttaaacttt taacagtttt gcatctgaaa tgtggttttt ttttattatt ataagaatat
     6121 atgatgaaat agctcagaca cacctgacgg ttcttatctg attctcctgt tgtgcgaacc
     6181 agcaggatca aatgtgtgac gaactaaggt agaattcagg tcactgggtg ggggccgggt
     6241 agctaggggg tgggagttat tactaaggaa ggttaagttt gtgtcgggga agtgatgatt
     6301 gcacactgtt ctgaatgtgt tcaatgaact gaattctgca ctgagagatg attgacatgg
     6361 gaataaccca ataaaaactg agcaaaacgt t
//
