LOCUS       NM_001106960            5123 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus FERM and PDZ domain containing 4 (Frmpd4), mRNA.
ACCESSION   NM_001106960 XM_001065707 XM_228906
VERSION     NM_001106960.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5123)
  AUTHORS   Chen,R., Qian,L., Fu,J., Qin,J., Chen,X. and Xu,X.
  TITLE     Downregulation of Preso protects against
            ischemic/reperfusion-mediated neuronal injury through regulating
            PSD95-nNOS/YAP pathways
  JOURNAL   Neurochem Int 169, 105586 (2023)
   PUBMED   37442439
  REMARK    GeneRIF: Downregulation of Preso protects against
            ischemic/reperfusion-mediated neuronal injury through regulating
            PSD95-nNOS/YAP pathways.
REFERENCE   2  (bases 1 to 5123)
  AUTHORS   Hu,J.H., Yang,L., Kammermeier,P.J., Moore,C.G., Brakeman,P.R.,
            Tu,J., Yu,S., Petralia,R.S., Li,Z., Zhang,P.W., Park,J.M., Dong,X.,
            Xiao,B. and Worley,P.F.
  TITLE     Preso1 dynamically regulates group I metabotropic glutamate
            receptors
  JOURNAL   Nat Neurosci 15 (6), 836-844 (2012)
   PUBMED   22561452
  REMARK    GeneRIF: We identified and cloned a full-length gene determined to
            be homologous to human FRMPD4 and is here termed Preso1.
REFERENCE   3  (bases 1 to 5123)
  AUTHORS   Yuzawa,S., Kamakura,S., Iwakiri,Y., Hayase,J. and Sumimoto,H.
  TITLE     Structural basis for interaction between the conserved cell
            polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched
            protein (LGN)
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19210-19215 (2011)
   PUBMED   22074847
REFERENCE   4  (bases 1 to 5123)
  AUTHORS   Lee,H.W., Choi,J., Shin,H., Kim,K., Yang,J., Na,M., Choi,S.Y.,
            Kang,G.B., Eom,S.H., Kim,H. and Kim,E.
  TITLE     Preso, a novel PSD-95-interacting FERM and PDZ domain protein that
            regulates dendritic spine morphogenesis
  JOURNAL   J Neurosci 28 (53), 14546-14556 (2008)
   PUBMED   19118189
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474014.2.
            
            [WARNING] On Oct 17, 2024 this sequence was replaced by
            NM_001106960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001065707.1, XM_228906.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5123
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..5123
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /note="FERM and PDZ domain containing 4"
                     /db_xref="GeneID:302656"
                     /db_xref="RGD:1566031"
     exon            1..162
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..5123
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /codon_start=1
                     /product="FERM and PDZ domain-containing protein 4"
                     /protein_id="NP_001100430.1"
                     /db_xref="GeneID:302656"
                     /db_xref="RGD:1566031"
                     /translation="MTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKP
                     VVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILFTVIQPYP
                     SPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQ
                     TKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQV
                     TQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIA
                     LRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVK
                     ANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYG
                     ISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNL
                     ACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGTENKGKHNLLGPDWNCMPQMTTFIG
                     EGEQEAQITYIDSKQKAVEMTDSTLCPKEHRHLYIDNTYSSDELSQPLTQPGDAPCEA
                     DYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTLGYERMLDEN
                     PEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLL
                     HDICYAENTDDAEDEDEVSCEEDLVVSEINQPAILDLSGSSDDIIDLTTLPPPEGDDN
                     EDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHENKEQGSSLQNEEIPVSLIDA
                     VPTSAEGKCEKGLDPTVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETN
                     SSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKTPSVGLPPKSSHG
                     LAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRK
                     SKLAEGEGKCPLSGNVPGKKQQGTKIAETEEDTKGKVGTVSSRDNPHLSTFNLERTAF
                     RKDSQRWYVASDGGVVEKSGVEAPAMKAFPRGPGLGNREAEGKEDGTMEGEADDASGL
                     GQGERFLSDMACVASAKDLDNPEDTDSPTCDHATKLPEAEDNVARLCDYHLAKRMSSL
                     QSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHLIPDASGKGGSYIS
                     PEERVAGHPNHGATFKELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIK
                     ETTALTEPGKERQGGMPSAWSPHPEADPILLPSNIHLESKVPSPNQDPNDFSQGNQAF
                     GEAVSWRPADLRGGSLRTPPSQRALRHSSSILSGPVGLETFQEGTKGVVSLKYPGITE
                     AQEASSERRAELPLGKKLTKSFSQSSMHFISEGKFHKRSPMSHKDSKVYRTLPLRKLE
                     SSNWRCRGPFSYCFLNQGQDEDGDEDEEGEATLQVSCLYRPHITQGMPETSNSSLAVG
                     LQKQGEELSRGTVLKDWTEDPDGPDDLDFSSLAFDARIARINALKANTYGMPDGFLEA
                     QNDANELLCLVRATKAKREESRPEAYDLTLSQYKQLLSIESRQLGSACRKMAMAEKSP
                     EEMLLAMSSSFQVLCCLTEACMRLVKVVNSETQRQEIVEKIDEVVINYICLLKAAEAA
                     TGKTTGDPSIGLSMRHSTTMAALVSTLTRSLKMLLNK"
     exon            163..265
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            266..311
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            312..416
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            417..524
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            525..656
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            657..776
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            777..913
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1040
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1130
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1313
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1452
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..2511
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..3801
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..5123
                     /gene="Frmpd4"
                     /gene_synonym="RGD1566031"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcacatgac acaggcaatc ccatttgatg accctcggtt tgacagctgc caaatcattc
       61 ccccagctcc acggaaggtg gagatgagga gggaccctgt gctgggcttt gggttcgtgg
      121 cagggagtga aaagccagtg gtcgttcgat cggtaacacc aggtggcccc tcagaaggca
      181 agctgatccc gggagatcaa attgtaatga ttaatgatga accagtcagc gctgcgccaa
      241 gagagagggt catcgacctg gtcaggagct gcaaagaatc gattctgttc actgtcatcc
      301 agccttatcc ttctcccaaa tcagcattta ttagtgctgc taaaaaggca agattgaagt
      361 ccaatccagt caaagtacgc ttttccgaag aggtcatcat caatggtcag gtgtcggaaa
      421 ctgttaaaga caattcactt ctttttatgc caaatgtttt gaaagtctac ttggaaaatg
      481 gacagaccaa atcctttcgc tttgactgca gcacttccat taaggatgtc atcttaactc
      541 tgcaagagaa gctgtctatc aaaggcattg agcacttctc tctcatgctg gagcagagaa
      601 ctgaaggggc cggcaccaag ctgctcttac ttcatgaaca ggagacactc actcaggtga
      661 cacagaggcc gagttcccat aagatgaggt gtcttttccg aatcagtttt gttcccaagg
      721 atcccattga cctgttaagg agagatccag ttgctttcga gtatctctat gttcagagct
      781 gtaacgatgt cgttcaggag cgatttggac cagagctgaa atacgacatt gccttgcggc
      841 tggccgcttt acaaatgtac attgctactg tcaccaccaa acagacgcag aaaatctccc
      901 tcaagtacat tgagaaagaa tggggactag agactttcct tccatctgct gtacttcaga
      961 gcatgaaaga gaagaacatc aagaaagcgc tctcccacct tgtcaaagca aatcaaaact
     1021 tggtaccacc gggtaaaaag ctctctgcac tacaagctaa ggtccactat ctcaagttcc
     1081 tcagtgacct gcgactatac gggggccgtg tgttcaaggc aacattagtg caggcagaga
     1141 agcgctcaga agtgactctt ctggtgggtc cccggtatgg cataagccat gtcataaaca
     1201 ccaaaaccaa cctggtggct cttttagctg acttcagcca tgtcaacagg attgaaatgt
     1261 ttactgaaga ggagagtttg gtgagggtgg agttgcatgt gctcgatgtg aagcccatta
     1321 cactccttat ggagtcatca gatgccatga acctggcctg tctgacagct ggatactacc
     1381 ggttgctcgt ggactccagg aggtcaatat ttaacatggc caacaagaaa aatgcaggca
     1441 cacaggacac aggaacggaa aataaaggca agcataatct ccttggtcct gactggaact
     1501 gtatgcccca gatgacgacc ttcattggcg aaggggaaca agaagcccaa atcacttata
     1561 tagattctaa gcagaaggca gttgagatga cagacagcac cttgtgtccc aaagagcacc
     1621 ggcacttata tatcgacaac acatacagtt cagatgaact tagccagccg ctgactcagc
     1681 caggtgatgc accctgtgag gccgactata gaagcctagc tcagcggtcc cttttgaccc
     1741 tctcaggacc agacactctg aagaaagcac aggaatctcc gcgaggagct aaagtgtcct
     1801 ttatttttgg agatcttgcc ttagatgatg gcatgagtcc accaactcta ggctatgaaa
     1861 gaatgttaga tgagaatcca gaaatgctgg agaagcagag gaatctctac atcagcagtg
     1921 ccaatgatat gaaaaacctg gacctcactc cagacacaga cagcatccag tttgtggcaa
     1981 attcagtata tgcaaacata ggtgatgtga agaactttga agcccctgag ggaatagagg
     2041 agcccctctt acatgacatc tgttatgctg aaaacacaga tgatgcagaa gatgaagatg
     2101 aggtgagctg cgaggaggat ctcgtggtga gtgaaatcaa ccaaccagcc atccttgacc
     2161 tgtctgggtc aagtgatgat attattgacc ttacaacact gcctcctcca gaaggagatg
     2221 acaatgagga tgacttcctc ctgcgttctc tgaacatggc cattgctgct cccccacctg
     2281 gttttagaga cagttctgat gaagaggaca ctcagagcca ggcaacatcc ttccatgaga
     2341 acaaagaaca aggcagcagc ctgcagaatg aggagatccc tgtgtccctc attgatgctg
     2401 tgcccaccag tgcagagggc aagtgtgaga agggactgga ccctaccgtc gtttccacac
     2461 tagaagccct agaagctctt tcagaagaac agcagaagag tgaaaattca ggtgtagcca
     2521 tcttgcgggc ttatagtccc gagtcttcct cagactcggg caatgagact aactcttctg
     2581 aaatgacaga gggttctgaa ctagctgcag cacagaagca gtcggaaagc ctctcccgca
     2641 tgttcttggc cactcatgaa ggttatcacc ctctggcaga agaacagaca gagttcccca
     2701 cctccaaaac cccctctgtg ggcttgcctc caaagtcctc tcatggcctg gctgctcgcc
     2761 cagcgaccga cctcccaccc aaagttgtgc cttccaagca gatccttcac tcagatcaca
     2821 tggaaatgga gccagaaacc atggagacca agtcagtcac tgactatttt agcaaactgc
     2881 acatggggtc agtggcatat tcctgtacca gcaaaaggaa aagcaagctt gctgagggag
     2941 aggggaaatg ccccctgagt gggaatgtac cagggaaaaa acagcaagga accaaaatag
     3001 cagagacgga ggaggacacc aaaggcaaag ttggcactgt atcttcaaga gacaatccac
     3061 acctcagcac ttttaacctg gagagaactg cctttcgcaa ggacagccaa agatggtatg
     3121 tggcctctga tggtggggtg gtagagaaaa gtggagtgga agcaccagcc atgaaagcct
     3181 ttcccagagg tcctggtctg gggaacagag aggctgaagg gaaagaggat ggcactatgg
     3241 aaggagaggc tgatgatgct tcaggacttg gtcaagggga acgcttcctg tcagatatgg
     3301 cctgtgtagc ctcagccaaa gacttagaca accctgaaga cactgactct cccacttgtg
     3361 accatgccac taagcttcct gaggctgaag acaatgtggc ccgcctttgt gactaccatt
     3421 tggccaagcg aatgtcatcc ctgcagagtg agggccattt ttctctacag agctctcaag
     3481 gctcttcagt ggacacaggc tgtggcccag gcagcagtag cagtgcctgt gccactcctg
     3541 tggaatcgcc cctctgccca tccatgggaa agcacctgat tccagatgct tctgggaaag
     3601 gtgggagtta catttcacca gaggagagag tcgctggtca tcccaaccat ggagccacct
     3661 tcaaggaact gcacccacag acagaaggga tgtgtccacg catgacagtg cctgctctgc
     3721 acacagccat taatgccgac cccctgtttg gcactttgag agatggatgc catcgactgc
     3781 ccaagattaa ggaaaccaca gctttaacag agcctgggaa ggagagacaa ggaggcatgc
     3841 cttcagcttg gtctccacat cctgaagctg atcccatcct gctaccatca aatattcact
     3901 tggaatcaaa ggtgccaagc ccaaatcaag accctaatga tttctcccaa ggaaaccagg
     3961 cattcggaga ggctgtgagc tggcgaccag cagatctgag agggggaagc ctcaggacac
     4021 cacccagcca gagggctctc agacatagca gcagtatcct ctcaggaccc gtaggtttgg
     4081 agaccttcca agaaggaaca aagggtgtag tcagcttgaa gtatccaggt atcacagaag
     4141 cacaggaggc cagttcagaa agaagagcag aactccctct ggggaagaag ctcaccaaaa
     4201 gtttttccca aagctcaatg cactttatct ctgagggaaa gtttcacaaa aggtccccca
     4261 tgtctcataa agactccaag gtgtatagga ccctaccctt acggaagctg gaaagcagca
     4321 actggagatg ccgaggaccc ttcagctact gttttctaaa ccaagggcag gatgaagatg
     4381 gggatgagga tgaagaagga gaggccaccc ttcaggtctc ttgtctctat cgaccacaca
     4441 taacccaagg catgccagaa acaagtaact catccctggc tgttggattg cagaagcaag
     4501 gggaagaact gtccagaggg acagtgctga aggactggac agaagaccca gatggtccag
     4561 atgatttgga cttcagcagt ctggcttttg atgcccggat tgcaagaata aacgctctaa
     4621 aggcaaacac gtatggaatg cccgatgggt ttctcgaagc ccagaatgat gccaatgagc
     4681 tgctctgcct tgtgagggca accaaggcaa aaagggagga gtcgcgccct gaagcatatg
     4741 accttacact ttctcagtac aagcaactgt tatccattga gtccagacag ttgggaagtg
     4801 cctgtaggaa aatggcaatg gccgagaaaa gcccagaaga gatgctccta gctatgagtt
     4861 ccagttttca agtgctctgt tgtctaacag aagcttgcat gcggttagtg aaagtcgtga
     4921 actctgaaac acagcggcaa gaaattgtgg agaagattga tgaagtggtc ataaactata
     4981 tttgtcttct gaaagctgct gaggcagcca ctggcaagac cactggggat cctagtattg
     5041 gactatcaat gcgacattca accaccatgg ctgctcttgt aagcacacta acacgttctc
     5101 tcaagatgct tttaaataaa taa
//
