LOCUS       NM_001008348            2903 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus FERM domain containing 8 (Frmd8), mRNA.
ACCESSION   NM_001008348 XM_219520
VERSION     NM_001008348.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2903)
  AUTHORS   Kunzel,U., Grieve,A.G., Meng,Y., Sieber,B., Cowley,S.A. and
            Freeman,M.
  TITLE     FRMD8 promotes inflammatory and growth factor signalling by
            stabilising the iRhom/ADAM17 sheddase complex
  JOURNAL   Elife 7, e35012 (2018)
   PUBMED   29897336
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2903)
  AUTHORS   Oikonomidi,I., Burbridge,E., Cavadas,M., Sullivan,G., Collis,B.,
            Naegele,H., Clancy,D., Brezinova,J., Hu,T., Bileck,A., Gerner,C.,
            Bolado,A., von Kriegsheim,A., Martin,S.J., Steinberg,F.,
            Strisovsky,K. and Adrain,C.
  TITLE     iTAP, a novel iRhom interactor, controls TNF secretion by policing
            the stability of iRhom/TACE
  JOURNAL   Elife 7, e35032 (2018)
   PUBMED   29897333
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085896.1.
            
            On Dec 16, 2004 this sequence version replaced XM_219520.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085896.1, FQ211651.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2903
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /note="FERM domain containing 8"
                     /db_xref="GeneID:309172"
                     /db_xref="RGD:1310323"
     exon            1..157
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1558
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /note="FKSG44 protein"
                     /codon_start=1
                     /product="FERM domain-containing protein 8"
                     /protein_id="NP_001008349.1"
                     /db_xref="GeneID:309172"
                     /db_xref="RGD:1310323"
                     /translation="MEGAEGNAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPL
                     AVENLSSISAHELHRAVREVLQLPDMALEAFALWLVSPLLEVQLKPKHQPYKLGRQWP
                     ELLLRFTDASDDDIAMDEPSLQFRRNVFFPKRRELQVHDEEVLRLLYEEAKGNVLTAR
                     YPCDLEDCEVLGGLVCRVQLGPYQPGQPAACTVREKLDSFLPAHLCKRGHGLFAAFRG
                     RGAKTGPCEQGLLNAYRQVKEMAGGDSERETTLGSHYRAYLLKCHELPFYGCAFFHGE
                     VDKPTQGFLHRGGRKPVTVAISLEGVHVIDNREKHVLLGLRFQELSWDHTSPEEEEPV
                     LWLEFDGDSEGTPVNKLLRIYSKQAELMSVLIEYCIELSQAAEPALPQESASGPQEAP
                     SPSSAPTQRPKLRRQGSVVCSRIQHLSTIDYVEDGSGIKRVKPKRTTSFFSRQLSSSH
                     GSYTVVQPNDNSPEQG"
     exon            158..242
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            243..410
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            411..512
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            513..571
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            572..738
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            739..963
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1087
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1231
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1436
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..2879
                     /gene="Frmd8"
                     /gene_synonym="RGD1310323"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcttcctc ccgcggcagc gtccgcggcg caacgcaagc aagtcgaccc tcagcgggac
       61 ctgagacccc gccggcgggc gtagtggtgg gtccagaact ggaggcctag tcgggtggca
      121 ttctggagtg aggcagcgga ctctgcgacc ctgggagatg gagggggcag aaggcaacgc
      181 ggggcagcct ggccctgcgg agcggtccca ccgaagtagc gtctcctcgg tgggtgcccg
      241 agcagctgat gtactggtgt acctggctga tgacacagta gtgcccctgg ctgtggagaa
      301 cctgtcctcg atcagtgccc atgagctgca ccgtgcagtc cgtgaagtcc tgcagctccc
      361 agacatggcc ctggaggcct ttgcactctg gcttgtctct cctctgctgg aggtacagtt
      421 gaaacccaag caccagccct acaaactggg ccgccagtgg ccagagctgc tgctgcggtt
      481 caccgatgcc tcggacgatg acatagccat ggatgagcct tcccttcagt tccgaaggaa
      541 tgtgtttttc ccaaagcgcc gagagctcca ggtccatgat gaggaggtct tgcggctgct
      601 ctatgaggaa gccaagggca atgtgctgac cgctcggtac ccttgtgact tggaggactg
      661 tgaggtgctg ggtggcctcg tgtgccgggt gcagcttggg ccctaccagc ctggccagcc
      721 tgctgcctgt acggtgagag agaagttgga ctccttcctc cctgcccacc tctgcaagcg
      781 aggccatggc ctctttgctg ccttccgggg ccgtggagcc aagactgggc catgtgagca
      841 aggcctgctg aatgcctacc gccaggtaaa ggaaatggca ggcggtgaca gtgagcgtga
      901 gaccaccttg ggctcccact atcgcgcata tctcctcaag tgccatgagc tgcccttcta
      961 cgggtgtgcc ttcttccatg gcgaggttga caagccaacc cagggcttct tgcatcgggg
     1021 tgggcgcaaa ccagtgaccg tggccatcag tctggagggt gtgcatgtca tcgacaacag
     1081 ggagaagcat gtgctgctgg gtctacgctt tcaggagctg tcatgggatc acacttcccc
     1141 tgaggaggag gagcctgtcc tgtggctgga gtttgatggt gacagtgagg gcacacctgt
     1201 caacaagcta ctgaggatct actccaagca ggctgagctg atgagtgttc tcattgagta
     1261 ttgcattgag ctgagccagg ccgctgagcc tgctctcccc caggagagtg catccggccc
     1321 tcaggaagct cccagcccct cttcagctcc cactcagcgc cccaagctgc gaaggcaggg
     1381 tagcgtggtg tgtagccgga ttcagcatct ctccaccatc gactacgtgg aagacggcag
     1441 cgggatcaag cgggtgaagc cgaagcgaac cacctccttc ttcagccgac agctctcctc
     1501 cagccacgga agctacaccg tggtacagcc caacgacaac agcccggagc agggctgaga
     1561 gaggccacag ctggcagcag gatgacatct gggtgccgtg gacatgacca ggcacagtcc
     1621 taggcaggac caagctacac tagtctcagg ctgtgggcct gggcgggtgc taggcagggt
     1681 ctgctggagt ttcagaccgt ggaaaagtga cacgcaaacc ttccgtgagt ctggcgtggg
     1741 cagagctgcc ctgcagccct ttctaccctc tttcctgaac tccaggccca gcagcccctt
     1801 ctgctcctcc ccaagtggac tgtgtctctc tggagggact gctggcagtt ccgatgtagg
     1861 taactgaaat caagttcagt gcttgcttct ggtcatgggt ccttggtgac ttctcttgca
     1921 ttccttctgc tgacattcca ccatgctgcc cagccaggct tccacccttt ctcctaaggt
     1981 atgctggaac tggagggtgc ctctgcaggc caacataagc tcatggctgg cttcttgttg
     2041 gcctttactg atgtctctgc tgaatggtag ctgtcctagg aactggatcc acactgcaca
     2101 caggaagccc ttacatgtcc ctgggctggc atggctgtcc cattccggcc agctcccttg
     2161 ttttcctgtg atctgggtct cagggttaaa ttttgccttg tttcctctgc tctgagctga
     2221 taaagcctag gacctggcaa ctcagaatta cactacactg tggattccct gaggccagcc
     2281 acagaggctc aagccacctc tggtctccta atgacactgt acaggaggcc tatcccagct
     2341 ctgcaccccg ggtatccttg attgctcctg agaggggctg gtccagggaa gggtgttttc
     2401 caggccctta agcccttggt actccctggg aatccccaca gagcccagag aacagctgtg
     2461 tcttctcagt ggaaagtccc agaaatgcaa acccctacat ttctgtaatg aaagcagttt
     2521 gcctgcccag tgaactccag aagtcttagc agcagagaga aaaggctggc ctcgcctatc
     2581 ctgtcgccta tcctgttgca atgtctgtaa gatgatgtca cctgccactt gtagttaacc
     2641 cttttggagt cacgtgtgtt ccctgagcta ccagcccact ctcggccacc ttctggtcat
     2701 tttgactgct gttgatggct ttaggtcatt atgtgagagg cacagatgtg tgtgtggaag
     2761 cacaaactct ggatttccac ttgtgcctta accctctagg acagagcact gttttactaa
     2821 ctgtcttgag tgttctcagt ctttcctatc atcggactta ataaaatcct cacctagcaa
     2881 aaaaaaaaaa aaaaaaaaaa aaa
//
