LOCUS       NM_001399291            4658 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus FERM domain containing 6 (Frmd6), transcript
            variant 1, mRNA.
ACCESSION   NM_001399291 XM_006240151
VERSION     NM_001399291.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4658)
  AUTHORS   Beck,J. and Kressel,M.
  TITLE     FERM domain-containing protein 6 identifies a subpopulation of
            varicose nerve fibers in different vertebrate species
  JOURNAL   Cell Tissue Res 381 (1), 13-24 (2020)
   PUBMED   32200438
  REMARK    GeneRIF: FERM domain-containing protein 6 identifies a
            subpopulation of varicose nerve fibers in different vertebrate
            species.
REFERENCE   2  (bases 1 to 4658)
  AUTHORS   Ishiuchi,T. and Takeichi,M.
  TITLE     Nectins localize Willin to cell-cell junctions
  JOURNAL   Genes Cells 17 (5), 387-397 (2012)
   PUBMED   22512338
REFERENCE   3  (bases 1 to 4658)
  AUTHORS   Ishiuchi,T. and Takeichi,M.
  TITLE     Willin and Par3 cooperatively regulate epithelial apical
            constriction through aPKC-mediated ROCK phosphorylation
  JOURNAL   Nat Cell Biol 13 (7), 860-866 (2011)
   PUBMED   21685893
  REMARK    GeneRIF: Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that
            controls epithelial apical morphology.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 6, 2022 this sequence version replaced XM_006240151.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.475120.1,
                                           SRR26360181.378526.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000006.1  95081986-95082091
            107-372             JAXUCZ010000006.1  95119472-95119737
            373-463             JAXUCZ010000006.1  95127785-95127875
            464-567             JAXUCZ010000006.1  95132283-95132386
            568-644             JAXUCZ010000006.1  95133522-95133598
            645-831             JAXUCZ010000006.1  95136685-95136871
            832-987             JAXUCZ010000006.1  95139229-95139384
            988-1053            JAXUCZ010000006.1  95140112-95140177
            1054-1122           JAXUCZ010000006.1  95140873-95140941
            1123-1297           JAXUCZ010000006.1  95142917-95143091
            1298-1633           JAXUCZ010000006.1  95146524-95146859
            1634-1765           JAXUCZ010000006.1  95147780-95147911
            1766-1857           JAXUCZ010000006.1  95150844-95150935
            1858-4658           JAXUCZ010000006.1  95152761-95155561
FEATURES             Location/Qualifiers
     source          1..4658
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..4658
                     /gene="Frmd6"
                     /note="FERM domain containing 6"
                     /db_xref="GeneID:257646"
                     /db_xref="RGD:727810"
     exon            1..106
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            107..372
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2142
                     /gene="Frmd6"
                     /note="isoform 1 is encoded by transcript variant 1; FERM
                     domain-containing protein 6; FERM domain-containing
                     protein 163SCII"
                     /codon_start=1
                     /product="FERM domain-containing protein 6 isoform 1"
                     /protein_id="NP_001386220.1"
                     /db_xref="GeneID:257646"
                     /db_xref="RGD:727810"
                     /translation="MNKLTFHNNKVMQDRRRVCIFLPNDKSVSIIINVKILCHQLLVQ
                     VCDLLRLKDSHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKEASKVRQYEVTWGIDQ
                     FGPPMIIHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHSQCVLREEAYFLLAAFAL
                     QADLGNFKRKVHHGDYFEPEAYFPAWVVSKRGKDYILKHIPNMHRDQFALTASEAYLK
                     YIKEAVRLDDVAIHYYRLYKDKREVEGSLTLGLTMRGIQIFQNLEEEKQLLYDFPWTN
                     VGKLVFVGKKFEILPDGLPSARKLVYYTGCPTRSRHLLQLLSNSHRLYMNLQPVLRHL
                     RKQEENEEKKQYRESYISDNLDLDMDPLEKRSRASGSSAGSMKHKRLSRHSTASHSSS
                     HTSGIETDTKPRDPGPEDGYSGSVMHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDS
                     QDDEIEMLVDDPRDLEPMTEESLEVSPEMCIYITQDMLLSRKLNGHSGLIVKEISSST
                     SSSSETVVKLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTA
                     QSYTFGCGHELDESGLYCDSCLAQQCVNMHDAFPVKRTSKYFSLDLTHDEVPEFLV"
     exon            373..463
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            464..567
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            568..644
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            645..831
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            832..987
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1053
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1122
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1297
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1633
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1765
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1857
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..4658
                     /gene="Frmd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtgggtct ggcggcagcg ggagagctgg gagctgcgag taggctcggc gccgctgtag
       61 cagacgccga ttctgagtcg gacgcctggc tctggcgact ttggaggtct cccagtggac
      121 tttctacagc gatgaaacct atgttgtggg gcaccacgat gcttctgtcg gccgtatgat
      181 gaggagggaa agttggcttt ggagcgctgg gagcctgaga agctgctgag aacccagcgc
      241 accctgcctg accactggcc agcccacaac acaatgaaca aactgacctt ccataacaac
      301 aaagtcatgc aggaccgccg cagagtgtgt attttcctcc ccaatgacaa gtctgtgagc
      361 atcatcataa atgttaaaat tctgtgtcac cagttgctgg tccaggtgtg tgacctgctc
      421 aggttgaagg atagtcacct ctttggtctc agtgttatac aaaataatga acacgtatat
      481 atggaattgt cacaaaagct ctataagtat tgtccaaaag aatggaaaaa ggaggccagc
      541 aaggtacgac aatacgaagt cacttggggc atcgaccagt ttgggcctcc catgatcatc
      601 catttccggg tgcagtacta tgtggagaac gggaagctga tcagtgaccg gattgcgaga
      661 tactattatt actggcacct aaggaaacag gtgctgcact ctcagtgtgt gctcagagag
      721 gaggcctact tcctgctggc agcctttgca ctgcaggctg acctcgggaa cttcaaaagg
      781 aaagtgcacc atggagacta ctttgagcca gaggcttact tcccagcatg ggtggtttcc
      841 aagcggggga aggactacat cctgaaacac attccaaaca tgcacagaga ccagtttgca
      901 ctgacagcct ccgaggcata tctaaagtac atcaaagagg ccgtccgact ggatgacgtc
      961 gccatccatt actacagact gtacaaggat aaaagagagg ttgaaggttc actgaccctg
     1021 ggactgacca tgcgagggat acagatcttt cagaatctag aagaagagaa acagttgctg
     1081 tatgatttcc cctggacaaa tgttgggaag ttggtgtttg tgggcaagaa gtttgagatt
     1141 ttgcccgatg gcctcccctc cgccaggaag ctggtctact acaccgggtg tcccacacgc
     1201 tcccggcatc tcctgcagct gctgagcaac agccaccggc tctacatgaa cctgcagccc
     1261 gtcctgcgcc acctccgcaa gcaggaggag aatgaagaga aaaagcagta ccgggaatcc
     1321 tacatcagtg acaacctgga ccttgacatg gacccgctgg aaaagcgatc ccgtgccagc
     1381 gggagcagcg ctggcagcat gaagcacaag cgtttgtccc gccactccac ggccagccac
     1441 agcagctccc acacgtcagg catcgagaca gacactaagc cccgggaccc agggccagaa
     1501 gatggctatt caggcagcgt catgcatcga aagctgaaga cctgtagctc catgaccagc
     1561 cacggcagct cccacacctc aggcgttgaa agtggaggca aagaccgcct ggaggaggac
     1621 tcgcaagatg atgaaataga gatgctggtt gatgaccccc gggacctgga gcccatgacc
     1681 gaagagtccc tggaagtgag cccagagatg tgtatctaca tcacacaaga catgctgctg
     1741 tccaggaagc tgaacgggca ctcagggtta attgtgaaag aaatcagttc ttccacctcc
     1801 agctcctcgg agacggttgt caagctgcgt ggacagagca ctgactctct tccacagacg
     1861 atatgtcgaa aaccaaagac ttccactgat cggcatagcc tgagccttga cgacatcaga
     1921 ctgtaccaga aagacttcct gcgcatcgca ggcctgtgtc aggacactgc tcagagctac
     1981 acgttcgggt gtggccatga actggatgag agcggtctct actgcgacag ctgcttggct
     2041 cagcagtgtg tcaacatgca tgacgctttc cccgtgaaga gaaccagcaa gtacttttct
     2101 ctggacctca ctcacgacga ggtcccagag ttccttgtct aagccccagt ggcagcgggc
     2161 agccctgcgg gcagctgctg tctgctggag gctgtggagt ccgagcgtct tcacacgttg
     2221 tttgtgccat aattttttca ccccaaactt agctctctct ttataatatt cgagatggaa
     2281 actaaagcct tggaacaatt gcactttaag tattatgcag aggtaaaaga aagccagaat
     2341 gtaagaggaa gacaagtgcc cagatgtcta tggccctttg gaagaagtgt gcttgctttc
     2401 ccgccttacc agacttccca cggttagact gcagtgtttg ttcatctcct gtttatcacg
     2461 tgacagacat tgggtttatc tgtttgctta tgagtttttt ttagccactc cctcatgaag
     2521 cgcttacggt ttgaggggga gggcagaggg aagttctctc ttcttttatg gagagccatt
     2581 cttagtacat agccattgct gcctcacgga ggttgaccca aaatgaaccc tgaagttggt
     2641 gggagtcaga cggttgtagc caaagatgcc tatgtgacgg aagcaccacg cagtcctgaa
     2701 gacgtgtgcc gggacacccg gggctccttc acgcgtggac agggcacgct gctgttttgt
     2761 tcttccagga gcttcccagg gagctctggg attcacttgc gcccgtggtt catttgcagt
     2821 ttacaaagct ggtatatgtt aagaaccagt ggaaatgtct cagaagacgt ttgtttggtt
     2881 gtgttttctt tgttggtttt taacggtggt gaacagatgg caatgcccgt ttctgcttta
     2941 acaagatacc ctaactgtac gtatatgttg tacatatcta gatacatggg actgtgtgtg
     3001 tctgtatgtg tttgaagctt cgtgactctt catttggact tccatgtatg tcttgcacac
     3061 atagaattcc ttgtttaatg tcgaggatac ttagccacag acaatcagtt gataaatgta
     3121 gaggtaagag tgactttttc cttgtgtgcc tttggccaag attctcaacc ctgattgcat
     3181 aacagactta tcaggggagc ttttaaaaca tgcctgggtc ccaccccggg ccggtttaaa
     3241 ccagtctcct ctgggtggga gattgattta cgttttccca ggtagagaca gtaatgcaca
     3301 agtaggactg gggaccacta atccgagtgt gtctttctat tcatttggaa gtaaaagtgt
     3361 acagaggaca ttggtgatgg agaacgggcc atttttaaga cagttactgg cctgctgctg
     3421 ttatagcgta taatgaaacc aagccaggag aacgagttta tcaacgttga agggtcgctc
     3481 gcccttcagg agagaacttc atagcacaat gtctttctag gagatgtttt taatgattta
     3541 gtattttaca acatttgttt accatatttt gatactccat ttttgctatc tgccaggttt
     3601 tattaaaaag aggactatgt attattttct aaagaaactc atatttttgt acaaaattat
     3661 gtttccaagt aaggaagaag tagatttagg gtaaggcaga acataagcag tgtttgcccg
     3721 tggatgggtc agtgttccaa agcccgtggt ggccacaggc gtgccccacc atactgccct
     3781 cctgtgctgg cacggcctca gcagcatctc acccagtaac tctcacctga cactttaaag
     3841 aaggaaaaag aagttctgtg gtcatgactt tattttgctt ttgtcgaacg cttttagaag
     3901 aaccaaagtt tcaaacgcca gaatgtctaa gtgtcttggt gtcctcacgg aaggtggaag
     3961 ggcgaagggg tcagtcacct gacggcttcc tttgcttccg agtcattaca caatcgcatc
     4021 ataacccaga cgcttagggc ccagaccctg ttaaggggcg tgccctccca agctctgatt
     4081 gtggagctgt gcgccccgca gccctcagcg tctcttgcag atgcaaagtg gtgaagttgc
     4141 ttaatcgaat aggttgtacc ttttcctctc tgctccagaa cccaggcttc agggctctgc
     4201 ccaggctgcc actcctcagc tgccctcctc caggccggca ggaacagtct tacagatttt
     4261 caaagacaaa gacagccagg gaacagtttc tagtttctga cccacggtag agtcacacag
     4321 acataggtgg agatccactc tgaagacctg acattttttg tattggggaa tcgtcatcaa
     4381 aaacaaaaag agggaagtag aaagctgtcg ctcacgctcg ctcgctagca cgcccgttgc
     4441 tgggggatgt gcctccctgc ctcttctgca tctgcatttg agctttgtat ctcagtaagc
     4501 tgcaaacagt cctttctgtg aaaggatcgt catgtcggga tgataactga aagtatgtta
     4561 aaaaaaagaa aagaaaagcg gtgttatttt gtaattattt cttataggtg tttcatggta
     4621 agatcaacag tcaataaagt taactttttt gcctttaa
//
