LOCUS       NM_024368               4577 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus fyn-related Src family tyrosine kinase (Frk),
            mRNA.
ACCESSION   NM_024368 XM_346605
VERSION     NM_024368.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4577)
  AUTHORS   Yim,E.K., Peng,G., Dai,H., Hu,R., Li,K., Lu,Y., Mills,G.B.,
            Meric-Bernstam,F., Hennessy,B.T., Craven,R.J. and Lin,S.Y.
  TITLE     Rak functions as a tumor suppressor by regulating PTEN protein
            stability and function
  JOURNAL   Cancer Cell 15 (4), 304-314 (2009)
   PUBMED   19345329
REFERENCE   2  (bases 1 to 4577)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 4577)
  AUTHORS   Ahn,M., Beacham,D., Westenbroek,R.E., Scheuer,T. and Catterall,W.A.
  TITLE     Regulation of Na(v)1.2 channels by brain-derived neurotrophic
            factor, TrkB, and associated Fyn kinase
  JOURNAL   J Neurosci 27 (43), 11533-11542 (2007)
   PUBMED   17959796
  REMARK    GeneRIF: Fyn kinase is associated with sodium channels in brain
            neurons and can modulate Na(v)1.2 channels by tyrosine
            phosphorylation after activation of TrkB/p75 neurotrophin receptor
            signaling by brain-derived neurotrophic factor (BDNF).
REFERENCE   4  (bases 1 to 4577)
  AUTHORS   Lin,S.Y. and Elledge,S.J.
  TITLE     Multiple tumor suppressor pathways negatively regulate telomerase
  JOURNAL   Cell 113 (7), 881-889 (2003)
   PUBMED   12837246
REFERENCE   5  (bases 1 to 4577)
  AUTHORS   Serfas,M.S. and Tyner,A.L.
  TITLE     Brk, Srm, Frk, and Src42A form a distinct family of intracellular
            Src-like tyrosine kinases
  JOURNAL   Oncol Res 13 (6-10), 409-419 (2003)
   PUBMED   12725532
  REMARK    GeneRIF: The tyrosine kinases Brk/PTK6/Sik, Srm,
            Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of
            sequence homology to other known kinases. The exon structure of
            these kinases, called the Brk family, is highly conserved and
            distinct.
            Review article
REFERENCE   6  (bases 1 to 4577)
  AUTHORS   Sunitha,I. and Avigan,M.I.
  TITLE     The apical membranes of maturing gut columnar epithelial cells
            contain the enzymatically active form of a newly identified
            fyn-related tyrosine kinase
  JOURNAL   Oncogene 13 (3), 547-559 (1996)
   PUBMED   8760296
REFERENCE   7  (bases 1 to 4577)
  AUTHORS   Sunitha,I. and Avigan,M.I.
  TITLE     A newly identified tyrosine kinase is preferentially expressed in
            the gastrointestinal tract
  JOURNAL   Biochim Biophys Acta 1221 (3), 348-352 (1994)
   PUBMED   8167158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_024368.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09583.1, SRR26360186.1171481.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-785               JAXUCZ010000020.1  39820441-39821225
            786-907             JAXUCZ010000020.1  39864139-39864260
            908-1071            JAXUCZ010000020.1  39899219-39899382
            1072-1240           JAXUCZ010000020.1  39901203-39901371
            1241-1399           JAXUCZ010000020.1  39906655-39906813
            1400-1581           JAXUCZ010000020.1  39920544-39920725
            1582-1747           JAXUCZ010000020.1  39922677-39922842
            1748-4577           JAXUCZ010000020.1  39923236-39926065
FEATURES             Location/Qualifiers
     source          1..4577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..4577
                     /gene="Frk"
                     /note="fyn-related Src family tyrosine kinase"
                     /db_xref="GeneID:79209"
                     /db_xref="RGD:621423"
     exon            1..785
                     /gene="Frk"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1959
                     /gene="Frk"
                     /EC_number="2.7.10.2"
                     /note="GTK; GASK; gastrointestinal-associated kinase;
                     gastrointestinal-associated tyrosine kinase; src related
                     tyrosine kinase; fyn-related kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase FRK"
                     /protein_id="NP_077344.1"
                     /db_xref="GeneID:79209"
                     /db_xref="RGD:621423"
                     /translation="MGSVCMRLWAYLQPFLPCWSQEADKSVVIENPGAYCPPEANRSQ
                     GQYFVALFDYEARTAEDLSFHAGDKLQVLDTSHEGWWLARHLEKKGPGLGQQLQGYIP
                     SNYVAEDRSLQAEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDE
                     GVVKHYRIRRLDEGGFFLTRRKTFSTLNEFVNYYTTTSDGLCVKLEKPCLKIQVPTPF
                     DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFL
                     REAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIRLTQQVD
                     MAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKH
                     EIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQN
                     YRLPQPSNCPEQFYSIMMECWNVEPKQRPTFETLHWKLEDYFEPDSSYSDTNNFIN"
     exon            786..907
                     /gene="Frk"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1071
                     /gene="Frk"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1240
                     /gene="Frk"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1399
                     /gene="Frk"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1581
                     /gene="Frk"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1747
                     /gene="Frk"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..4577
                     /gene="Frk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctgcagg tttgaagctg ggtgagagca gctgcagcag gccaggctgg gagctttcgc
       61 ctggagttag tctctccgta actttttcct gggacagagg gagaggtggc tgttctttgt
      121 tctcagatgt ccctctaaat aaaacctttt ttattttatt tattgttggg tgcccaggca
      181 gtcaggaaga agcactttcc cactggacct ccttctcagt ccccctcttg attttgcccc
      241 agggcagcag ctacaaacag aaagccagct gtgagtgtct tcttggccaa gcccagatct
      301 gcggagagat ccgaagcagg actttatagc tcttctcagt atggtgagtt gtagctgatt
      361 tggaagctgg tggaggagga cagtggctct gtacagtttg tggggatctc ccctgctact
      421 accaccagcc ggaacaccat gggcagcgtc tgtatgaggc tttgggcata ccttcagcct
      481 tttctcccct gctggtccca agaagcagac aaatcagtgg tgattgagaa tccaggggcc
      541 tactgtcctc cagaggccaa tcgaagccaa ggtcagtatt ttgtggctct gtttgattac
      601 gaagctcgta ctgcagagga cctgagcttc catgccggcg acaagctcca agtcttggac
      661 acttctcatg agggctggtg gttggccaga catttggaaa agaagggacc cggcttaggt
      721 cagcagctgc agggctacat tccttccaat tacgtggcag aggaccggag tctccaggca
      781 gaaccgtggt ttttcggagc aatcaaaaga gcagatgcag aaaagcaact tctgtattca
      841 gaaaaccaga cgggcgcctt tctaatcaga gagagtgaga gccagaaggg tgacttctcc
      901 ctctcagttt tagatgaagg tgttgtgaaa cactacagga taagaaggtt ggatgaaggt
      961 ggcttcttcc tcaccaggag aaaaactttt tcaaccttga atgaatttgt gaactactac
     1021 accacaacaa gtgatgggct gtgtgtcaag ctggagaagc catgcttaaa gattcaggta
     1081 ccgacccctt ttgatttgtc atataaaact gtggaccagt gggagataga ccgcaactcc
     1141 atacagcttc tcaagcgact gggatctggt cagtttggag aagtttggga aggtctgtgg
     1201 aataatacca ctccagtggc tgtgaaaacg ttaaaaccag gttcaatgga tccaaatgac
     1261 ttcctcaggg aggcacagat aatgaagagc ctaagacacc ccaagctcat ccagctctat
     1321 gctgtttgca cattagaaga tccaatttat attattacag aattgatgag acatggaagt
     1381 ctgcaagaat atctccaaaa tgatggtggg tcgaaaatcc gtttgactca acaggtggac
     1441 atggctgcac aggtagcttc tggaatggcc tatttggagt cccagaacta tatccacaga
     1501 gatctggctg caagaaatgt ccttgttggt gaacataata tctataaagt agcagatttt
     1561 ggacttgcaa gagtttttaa ggtggataat gaagacatct atgaatctaa acacgaaata
     1621 aagctgccag tgaagtggac tgcacccgaa gccattcgta ctaataaatt cagcattaag
     1681 tctgatgtgt ggtcttttgg aatcctgctt tatgaaatca ttacttatgg caaaatgcct
     1741 tacagcggga tgacaggtgc tcaagtaatt catatgttgg gtcaaaacta cagactacca
     1801 cagccatcta actgtccaga gcaattctat agcatcatga tggaatgctg gaatgtagag
     1861 cccaagcaac gaccaacgtt cgagaccctg cactggaaac ttgaagacta ctttgaacca
     1921 gactcttcct attctgatac aaacaacttc ataaactaaa caacaaggaa aaagaagaaa
     1981 tataattaag atgtgaaaac gcggaactca ccagtccaga aatatcgtct tctcaaccaa
     2041 ctgtgaaatc agcttatttt gacatattca ggtggtagga tgaactcaac catgcattct
     2101 gtatcaaaaa gatcatctgt gtattctatt gagtaggaaa cgctgcagga cagtataaga
     2161 tgatgtgtca tttttccctc actgcctggt aaaatcaatc acactaaatg aagttatttt
     2221 ttttcctttt aagaactcct cacatttcta tttattgttt gaaatgccga tcaagagaat
     2281 caacagatga cggtgtttac tctgttactg ttgtggcatt ttcctgttta ctgattagac
     2341 tggttattca ttattcctca aattgctgaa tcccatcagg ctgttattat gaaggaattt
     2401 gattgctttg ctgcacagca ggacctgtgc tttgagatat ttttttccct ctcttttaaa
     2461 atatcttgta actacaatga tggcaaagcc atgctaaatg actcgattgt acttgaagta
     2521 attgcacgta tttttcctgt gcataagaaa gcgaagcagc tgttgagaaa aagaattaaa
     2581 atcttcctca ttttgtagga ggaaatgatg gagtttgctc tatacctcag tatgtgtcat
     2641 cagagaatca tctgcattag ttttaatctc ttaatgtcag gaatcagatt gcaaagccga
     2701 tgaattgtta tgtgtgggaa tataagggaa ctaccacact gcctaccagg tctgagaaag
     2761 agatattaaa gtggcttagg gaagctaaca gagagctgga ggattgctgc agctttctaa
     2821 gtaataataa aaagttcctt tggcacactg gccgatttta aattggctgc aagacaggcc
     2881 aagccatgct tcagctcttg agactaggaa taatgtctaa acatggttat gaaatgtagc
     2941 tttcgtctgt taagactgga tgcttttagt ctcttcattt ttttctcacc ttggtaagaa
     3001 cttccctgtt ttcttaggca atgagtgtat cgaatgttct gcctcattgg atagttagca
     3061 atacttctct aaagtcagct ccatatattc catgatcttc taatgtgcag tgctgaatga
     3121 atgttccaaa aggaacattc atcctcctat aggacagaag agaatatcta gatggtcaca
     3181 aggatcccct gggaattgaa aaacatgtca gttctttcaa ctaggaacta ggaggcaagg
     3241 catcagggat taacttttac cagttcagtg atgtcaggac cctagctgca tttctgttgc
     3301 catggtgaaa atcctgacaa aaagcaactt agaagaggca aggtttattt tagcttacaa
     3361 tcccatgtca ttgtatcaca gcaggaagtc actgtgacaa gatcttgaag ctgattacac
     3421 cacatccaca ttctaagagg agagagacat tcacggatag cttgcttgct tcctgatttg
     3481 tgctcaggtc aatttctaca ctcttaaaaa gtttgggaca gctttgccta ggtaatagca
     3541 tgacacacaa taggctggac tttccaggat caattaacgt aattaagaca attctctaca
     3601 gacatgccaa aaggccagta taatatagag aatcattttc aactctttgc aactctcttt
     3661 ctgggttatt ctaggtactg acaaattgga tcacttaagc tagccattag accactaaga
     3721 ctcaaacttt cccatctata gcaagcattg tctgtgttca actggtcaca ggtaaccacc
     3781 agtggtaagt gaggctcctt gttcctttat attcaagaag ataaaatggg caacttcacc
     3841 cttagacatt atcctaagcc taaacacaca cacgcacgca cgcacgcacg cacgcacaca
     3901 cacacgcaca cgtgcatgca cacacactca cctcattccc attttggggg ataagcaggt
     3961 ggcaaacaca atcccgtgac cagtgaacaa caatcagcac agtgaatgta aatgcaaagt
     4021 gttgattggc ttggaagaaa gtctgcactg aagctgcgaa tataaacttc tccaagacaa
     4081 gtttcttatt tgaaaaaaaa aattagagat tagttcctga gttggtgtcc aatcacagaa
     4141 ctattaaaga tgaattaact gttggaatta atctatgtac atgtaagcat tcatttatca
     4201 tctcaaacat gtctgaactg acttgaatct gaatcatgtg tgaagaccac agagaaggaa
     4261 aagcatttgt aagataaagt cgccattaat attttaatca gttgacagag catggggtag
     4321 cttccgttgt ttatttcaga ttgcctggtc aaatgtaacc aaggagaaga cattcaacaa
     4381 ctaggtggct aaaatgaaat ttttaaaaaa ggactccttt tcctgagttc atttcttcag
     4441 gacagattct acttggggcg tatgtataaa ggaggagcac tagtctcatt tcattgtaca
     4501 aattcaaatg ctttgcactt ttatgtggta gctgataata ataaatttgt agtaagttct
     4561 ggctttgaaa tataaaa
//
