LOCUS       NM_001401121            2330 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus FRAT regulator of WNT signaling pathway 2
            (Frat2), mRNA.
ACCESSION   NM_001401121 XM_017590381
VERSION     NM_001401121.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2330)
  AUTHORS   Walf-Vorderwulbecke,V., de Boer,J., Horton,S.J., van Amerongen,R.,
            Proost,N., Berns,A. and Williams,O.
  TITLE     Frat2 mediates the oncogenic activation of Rac by MLL fusions
  JOURNAL   Blood 120 (24), 4819-4828 (2012)
   PUBMED   23074275
REFERENCE   2  (bases 1 to 2330)
  AUTHORS   van Amerongen,R., Nawijn,M., Franca-Koh,J., Zevenhoven,J., van der
            Gulden,H., Jonkers,J. and Berns,A.
  TITLE     Frat is dispensable for canonical Wnt signaling in mammals
  JOURNAL   Genes Dev 19 (4), 425-430 (2005)
   PUBMED   15681612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 2, 2022 this sequence version replaced XM_017590381.2.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2330              JAXUCZ010000001.1  250603450-250605779 c
FEATURES             Location/Qualifiers
     source          1..2330
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2330
                     /gene="Frat2"
                     /note="FRAT regulator of WNT signaling pathway 2"
                     /db_xref="GeneID:679110"
                     /db_xref="RGD:1591882"
     exon            1..2330
                     /gene="Frat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1088
                     /gene="Frat2"
                     /note="frequently rearranged in advanced T-cell lymphomas
                     2; FRAT2, WNT signaling pathway regulator"
                     /codon_start=1
                     /product="GSK-3-binding protein FRAT2"
                     /protein_id="NP_001388050.1"
                     /db_xref="GeneID:679110"
                     /db_xref="RGD:1591882"
                     /translation="MPCRREEEEEEAGDEAEGEEDDDSFLLLQQSVTLGGSTDVDRLI
                     AQIGETLQLDAAHDSPASPCAAPGPPPAPPVLAALPADKVGGPARLLRPAASAEAGDP
                     APPGAVRCVLGERGRVRGRAAPYCVAEIAPGASALPRPGRRGWLPGALASRRIQQRRC
                     TASGSRAADDDPHRLLQQLVLSGNLIKEAVRRLQRAVAAVAATSPASAPGSGGGRSGP
                     DSVTLQPSGSWL"
ORIGIN      
        1 cgaaggcggt gcccggacac gggagtcgct tgcaagcata aaaactagca ctgggccgag
       61 agctgggcag cggtctcgca cagtgcgtgc ggtcccgcgc ccctaagtct tctagtgaac
      121 ctatcccccc acggccgcgc gcggtggtag gagccgcgcg acgtcaccca ttgtttacaa
      181 atcaagccga gccggtagcg ttccggctcc cgcggctcta aggcgcgcgg tgccactgcc
      241 cggtggtccc ggcttcttcg gtcccaggct cggcacccgc ccagcccggg cctccgcccc
      301 gctcccgccc ccgccccagc cgcggcccga cgagcccgcg gccaaccaag cggccagaga
      361 cgcccgcaca gccgcggggg cccgggcggg gggccatgcc gtgccggagg gaggaggagg
      421 aggaggaagc cggcgacgag gcggaggggg aggaggacga cgacagcttc ctcctgctgc
      481 agcagtcggt gactctgggc ggctcgaccg acgtggaccg gctcatcgcc cagatcggcg
      541 agacgctgca gctggacgcg gcgcacgata gtccggcctc gccgtgtgcc gccccgggtc
      601 ccccacccgc gcccccggtc ctggcggcgc tgccggcgga caaggtcggg ggcccagcga
      661 ggctgctgcg gccggcagca tcagcggagg ccggagaccc tgcgcccccg ggggcggtgc
      721 gctgcgtgct gggggagcgc gggcgggtgc ggggccgggc ggcgccctac tgcgtggcag
      781 agatcgcccc gggcgccagc gcgctgcccc ggcctgggcg gcgagggtgg ctccccggcg
      841 ccttggcttc tcggagaatc cagcagcggc ggtgtaccgc aagcggatcg cgcgcagcgg
      901 acgacgaccc tcaccggctc ctgcagcagc tcgtgctctc cggaaacctc atcaaggagg
      961 cggtgcgcag gctccagcga gcggtcgccg cggttgcggc cacgagcccc gcgagcgccc
     1021 cgggttccgg gggtggccga agtggaccgg actcagtcac cctgcagccc tcgggctcct
     1081 ggctctgacc cggggtctct ggaggaggaa gaggacgcga ctacgcggtt ccaacagtgt
     1141 cttgcccggg acagtatgga gatgaagctg tcgtccatcc ctcgggttac agcctcaaag
     1201 ttaccggccg tgagaggctg ttagagaaaa cggactcgac tgagcagcac cggcagccga
     1261 gaacctggga tctaccggga gaactgtggc agctacttga tccacttgga actgacttag
     1321 cccttgggca tcgtgtgctt ggattgttta tagatgtgtc tcgcaggggc gggaattggg
     1381 agggcttcta acaatacttg aaaaccaaaa gtaggcatat atgatctcgt tattttcggg
     1441 tagagaagct ttctgaatat ggtgctacaa ttgcagacta gagagggtct agggtgaaga
     1501 acataaaaag ttggcagatg ggtgggttgg caacgcttgc tttctcctgc ttaatttgtg
     1561 gttgtgaagg tgggcgatgg aacctagttg gtgaattccc aaaggtgggg agagatgagt
     1621 ttaagtgcaa atgacttgac cttgccagct tggactcaag gtcaggttga ttgagtcggg
     1681 tgttgaggga ttcttgggag cactaaccca gtgtcttttt ctggatccaa tcacagacct
     1741 aagtgtcgct ttgccaccgc ttggagtctc ccgaggactc agaggccgac agggctgtgt
     1801 agggagagtt atttgcgttt tctgtgcttt tctttcccag aactcctcct cctgctaggc
     1861 cactcttggc catagcacca gctttctcag aaatggtcat aaacaactcc tgacctccct
     1921 gcacccgccg cctgatgtgt ttgtggtgtg tgtggattgg gatgaaccca gtgggtacac
     1981 ttttctgttc ctttggccct ctgcagagtt ggtgggagtc tcccgctttc ctcacctgtc
     2041 agttcttggt gactgaaact gtttttttaa aaatatgatt ccgggaggag aaagtgctgg
     2101 cttttcccct tgtgaaaccc aagggcaccg ttttctgagg tgccacccca aactttaagg
     2161 tagctaaact tttttttttt ttttttttaa gattcaatgg cttgttcatc ctccagatgt
     2221 ggctgttgat gtagacttcg caacggagtg tctgaaattg tggtggtcct gatttaaagg
     2281 attcataatt aaaatgtctg ctgaataaac ttggtttttg ttttggaaaa
//
