LOCUS       NM_001401777            2549 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus FRAT regulator of WNT signaling pathway 1
            (Frat1), mRNA.
ACCESSION   NM_001401777 XM_017590485
VERSION     NM_001401777.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Bechard,M., Trost,R., Singh,A.M. and Dalton,S.
  TITLE     Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant
            of glycogen synthase kinase 3beta subcellular localization in
            pluripotent cells
  JOURNAL   Mol Cell Biol 32 (2), 288-296 (2012)
   PUBMED   22064483
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   van Amerongen,R., Nawijn,M., Franca-Koh,J., Zevenhoven,J., van der
            Gulden,H., Jonkers,J. and Berns,A.
  TITLE     Frat is dispensable for canonical Wnt signaling in mammals
  JOURNAL   Genes Dev 19 (4), 425-430 (2005)
   PUBMED   15681612
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Hino,S., Michiue,T., Asashima,M. and Kikuchi,A.
  TITLE     Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and
            is essential for Wnt-3a-induced accumulation of beta-catenin
  JOURNAL   J Biol Chem 278 (16), 14066-14073 (2003)
   PUBMED   12556519
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Jonkers,J., van Amerongen,R., van der Valk,M., Robanus-Maandag,E.,
            Molenaar,M., Destree,O. and Berns,A.
  TITLE     In vivo analysis of Frat1 deficiency suggests compensatory activity
            of Frat3
  JOURNAL   Mech Dev 88 (2), 183-194 (1999)
   PUBMED   10534617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 24, 2022 this sequence version replaced XM_017590485.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582416.390501.1,
                                        SRR22582424.1058444.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2549              JAXUCZ010000001.1  250587641-250590189
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2549
                     /gene="Frat1"
                     /note="FRAT regulator of WNT signaling pathway 1"
                     /db_xref="GeneID:103691373"
                     /db_xref="RGD:9147096"
     exon            1..2549
                     /gene="Frat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1013
                     /gene="Frat1"
                     /note="frequently rearranged in advanced T-cell lymphomas
                     1; FRAT1, WNT signaling pathway regulator"
                     /codon_start=1
                     /product="proto-oncogene FRAT1"
                     /protein_id="NP_001388706.1"
                     /db_xref="GeneID:103691373"
                     /db_xref="RGD:9147096"
                     /translation="MPCRREEEEEAGDEAEGEEDDDSFLLLQQSVTLGGSTDVDRLIA
                     QIGETLQLDAAHDGPASPRAAPGPPPAPPVLAALPADKAGAPARLLRPATSGEAGDPA
                     PPGAVRCVLGERGRVRGRAAPYCVAEIAPGASALPQQPGFDGPPGTGKLNTPQPLSGP
                     CRRGWLRNAAASRRLPQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRL
                     QLHAKLPAHPFLGPLSAPVHEPPSPQSPRAACSDPGACVRRAQLRTGDDLLVPGS"
ORIGIN      
        1 ggctcccgcg gctctcaggc gcgcggtgcc actgcccggt ggtcccggct tcctcggccc
       61 caggctcggc acccgcccag cccgggcctc cgccccgctc ccgcccccgc cccagccgcg
      121 gcccgccgag cccgcggcca accaagccgc cagagacgcc tgcacagccg cgggggcccg
      181 ggcggggggc catgccttgc cggagggagg aggaggagga agccggcgat gaggcggagg
      241 gggaggagga cgacgacagt ttcctcctgc tgcagcagtc ggtgactctg ggcggctcga
      301 ccgacgtgga ccggctcatc gcccagatcg gcgagacgct gcagctggac gcggcgcacg
      361 acggtccggc ctcgccgcgt gcggccccgg gtcccccgcc cgcgcccccg gtcctggcgg
      421 cgctgcccgc agacaaggcc ggggccccgg cgaggctgct gcggccggcg acatcagggg
      481 aggccggaga ccctgcgccc ccgggggcgg tgcgctgcgt gctgggggag cgcgggcgcg
      541 tgcggggccg ggcggcgccc tactgcgtgg cggagatcgc cccgggcgcc agcgctctgc
      601 cccagcagcc gggctttgac ggacccccag ggaccggcaa actaaacacc ccgcagccac
      661 tgtccggccc gtgccggcga ggttggctcc ggaacgcagc cgcgtcccgc cgcctgccac
      721 agcgacgcgg atctcagccg gagacccgca ccggcgacga cgacccgcac cgactcctgc
      781 agcagctcgt gctctcgggg aacctcatca aggaggcggt gcggagactt cattcgcgac
      841 ggctacagct acacgcaaag cttcccgcac acccgttcct cgggcccctg tcagccccgg
      901 tgcatgagcc gccttcgccc cagagccctc gcgcggcctg cagcgaccct ggcgcttgcg
      961 tgaggagggc gcagctcaga actggggacg accttcttgt ccctggcagc taacaaccta
     1021 ggtggccaca ccaccagcct gcagcggggg accgaggaat tcacccaggg cttcacccag
     1081 cctgagctgg tggaggactc gagcacttgg aaacgggaaa ttaagctaag gaagacagcc
     1141 aaaatatcgc agatattttc atggataact gaagttgaga gccccaaatt gtttgaaagc
     1201 caggactcag gtttgtttaa aggagattct atagagcgca ccgcaggctg tcagaaggac
     1261 tccttttttg gcgtgatcca acctggtcgc tgcaattccg cgcagactct cctggccaag
     1321 cgggcgacca cgtggccacg gtgcatgctc tcaggatcgg ctcagccagc tgtggaacga
     1381 aggacgatga tccccgttta ctcgctgtac ttttcagggc tggttcctga tccactttgg
     1441 gggaggggga aacaagaatg gacgtgattt cggggagctc cccaaaatgc cacacttgaa
     1501 cattttacga cagttaaaag gccatcatct catcttttgc ggtggtggtt tcaatgtaaa
     1561 acatgcggta ccacgggagg accctcttgg ggctgaatag aagtaaccgt tttctgtctg
     1621 tcccctcttt ttcaacgggt tgctgttaag agtgttgaag gggaaagctg taccccacga
     1681 gtggtaggag gcggcagtga gcggtgttgg gtgttggaag ggaatggcga agcacggagt
     1741 tgccttcgaa agtgttttta aaggagaccc atccctcttc gggttcaagg tcactgtctc
     1801 ctgagtgtgc accttgcagc tacactgaga ctaaccgtat taccttactg ggagaagagc
     1861 acactgtttt gcaaattcag gagtcctcta aggacactcc tgccacctcc cagaaggggt
     1921 ggcgatggcg ggtgcttgag agtctgtgct tctctccgga ggccaccgcc cctgcccctc
     1981 ctcccgactt gcaaacacac tgccttgaga cagtgaccga gtaccacctt tcccccttgg
     2041 ttctgctgcc ctactccagc agggtggctc tgatgacgct agatgccagg gacgttccac
     2101 ataatgggtg ctccagggac acagcttggg acatagtctc acacagccgc ttatcctggg
     2161 ctctcggggc catttgtaac agctgcagtt ccctggatag acagttgatt tcctcctcct
     2221 gaccctcccc cagctgtgcc agctcgcctt tgtaagtgaa ggaaatgtga aaatagtaga
     2281 aaatgtgacc ctccaaatgg gaaaactgca ggcttttttt tttttttttt gctatcgtga
     2341 ctgtgaagtg cttggaaata ctgtccactc tgagcgaccg tttcgtttta gattcatgga
     2401 gtcaatggct tgttcagcac ccagatgtgg ctattgacgt atctacactt cgcaccggag
     2461 tgactggaat tgtggctgtc ctgattatag gattttaact taactgaaat aactgttttt
     2521 gaataaatgt gttgggttcc ccaccacca
//
