LOCUS       NM_001408783            1451 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus formyl peptide receptor 2 (Fpr2), mRNA.
ACCESSION   NM_001408783 XM_001073508
VERSION     NM_001408783.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1451)
  AUTHORS   Cao,Y., Chen,J., Liu,F., Qi,G., Zhao,Y., Xu,S., Wang,J., Zhu,T.,
            Zhang,Y. and Jia,Y.
  TITLE     Formyl peptide receptor 2 activation by mitochondrial formyl
            peptides stimulates the neutrophil proinflammatory response via the
            ERK pathway and exacerbates ischemia-reperfusion injury
  JOURNAL   Cell Mol Biol Lett 28 (1), 4 (2023)
   PUBMED   36658472
  REMARK    GeneRIF: Formyl peptide receptor 2 activation by mitochondrial
            formyl peptides stimulates the neutrophil proinflammatory response
            via the ERK pathway and exacerbates ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1451)
  AUTHORS   Flores,J.J., Ding,Y., Sherchan,P., Zhang,J.H. and Tang,J.
  TITLE     Annexin A1 upregulates hematoma resolution via the
            FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix
            hemorrhage
  JOURNAL   Exp Neurol 359, 114257 (2023)
   PUBMED   36279933
  REMARK    GeneRIF: Annexin A1 upregulates hematoma resolution via the
            FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix
            hemorrhage.
REFERENCE   3  (bases 1 to 1451)
  AUTHORS   Tylek,K., Trojan,E., Leskiewicz,M., Regulska,M., Bryniarska,N.,
            Curzytek,K., Lacivita,E., Leopoldo,M. and Basta-Kaim,A.
  TITLE     Time-Dependent Protective and Pro-Resolving Effects of FPR2
            Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve
            Inhibition of NF-kappaB and MAPKs Pathways
  JOURNAL   Cells 10 (9), 2373 (2021)
   PUBMED   34572022
  REMARK    GeneRIF: Time-Dependent Protective and Pro-Resolving Effects of
            FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve
            Inhibition of NF-kappaB and MAPKs Pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1451)
  AUTHORS   Niu,F., Xu,X., Zhang,R., Sun,L., Gan,N. and Wang,A.
  TITLE     Ursodeoxycholic acid stimulates alveolar fluid clearance in
            LPS-induced pulmonary edema via ALX/cAMP/PI3K pathway
  JOURNAL   J Cell Physiol 234 (11), 20057-20065 (2019)
   PUBMED   30972764
  REMARK    GeneRIF: The therapeutic efficacy of UDCA against LPS was mainly
            achieved through the ALX/cAMP/PI3K pathway.
REFERENCE   5  (bases 1 to 1451)
  AUTHORS   Gan,N., Zhang,R., Xu,X., Wang,Y., Qi,A., Zhang,Y. and Wang,A.
  TITLE     Effects of the ALX/FPR2 receptors of lipoxin A4 on lung injury
            induced by fat embolism syndrome in rats
  JOURNAL   Biomed Pharmacother 112, 108595 (2019)
   PUBMED   30784911
  REMARK    GeneRIF: The inflammatory response plays an important role in fat
            embolism syndrome and the activation of FPR2 receptor can decrease
            the inflammatory response.
REFERENCE   6  (bases 1 to 1451)
  AUTHORS   Chiang,N., Takano,T., Arita,M., Watanabe,S. and Serhan,C.N.
  TITLE     A novel rat lipoxin A4 receptor that is conserved in structure and
            function
  JOURNAL   Br J Pharmacol 139 (1), 89-98 (2003)
   PUBMED   12746227
  REMARK    GeneRIF: lipoxin A4 receptor conserved in both structure and
            function; plays key roles in regulating effector immune responses.
REFERENCE   7  (bases 1 to 1451)
  AUTHORS   Vaughn,M.W., Proske,R.J. and Haviland,D.L.
  TITLE     Identification, cloning, and functional characterization of a
            murine lipoxin A4 receptor homologue gene
  JOURNAL   J Immunol 169 (6), 3363-3369 (2002)
   PUBMED   12218158
REFERENCE   8  (bases 1 to 1451)
  AUTHORS   Yazawa,H., Yu,Z.X., Takeda, Le,Y., Gong,W., Ferrans,V.J.,
            Oppenheim,J.J., Li,C.C. and Wang,J.M.
  TITLE     Beta amyloid peptide (Abeta42) is internalized via the
            G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in
            macrophages
  JOURNAL   FASEB J 15 (13), 2454-2462 (2001)
   PUBMED   11689470
REFERENCE   9  (bases 1 to 1451)
  AUTHORS   Tiffany,H.L., Lavigne,M.C., Cui,Y.H., Wang,J.M., Leto,T.L.,
            Gao,J.L. and Murphy,P.M.
  TITLE     Amyloid-beta induces chemotaxis and oxidant stress by acting at
            formylpeptide receptor 2, a G protein-coupled receptor expressed in
            phagocytes and brain
  JOURNAL   J Biol Chem 276 (26), 23645-23652 (2001)
   PUBMED   11316806
REFERENCE   10 (bases 1 to 1451)
  AUTHORS   Le,Y., Gong,W., Tiffany,H.L., Tumanov,A., Nedospasov,S., Shen,W.,
            Dunlop,N.M., Gao,J.L., Murphy,P.M., Oppenheim,J.J. and Wang,J.M.
  TITLE     Amyloid (beta)42 activates a G-protein-coupled chemoattractant
            receptor, FPR-like-1
  JOURNAL   J Neurosci 21 (2), RC123 (2001)
   PUBMED   11160457
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 27, 2022 this sequence version replaced XM_001073508.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000001.1  67449637-67449839
            204-1451            JAXUCZ010000001.1  67457025-67458272
FEATURES             Location/Qualifiers
     source          1..1451
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1451
                     /gene="Fpr2"
                     /gene_synonym="Alx; Fpr-rs2; Fpr2l; Fprl1; Lxa4r"
                     /note="formyl peptide receptor 2"
                     /db_xref="GeneID:690158"
                     /db_xref="RGD:1584013"
     exon            1..203
                     /gene="Fpr2"
                     /gene_synonym="Alx; Fpr-rs2; Fpr2l; Fprl1; Lxa4r"
                     /inference="alignment:Splign:2.1.0"
     exon            204..1451
                     /gene="Fpr2"
                     /gene_synonym="Alx; Fpr-rs2; Fpr2l; Fprl1; Lxa4r"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1270
                     /gene="Fpr2"
                     /gene_synonym="Alx; Fpr-rs2; Fpr2l; Fprl1; Lxa4r"
                     /note="formyl peptide receptor-like 1; formyl peptide
                     receptor, related sequence 2-like; lipoxin A 4 receptor"
                     /codon_start=1
                     /product="formyl peptide receptor, related sequence 2"
                     /protein_id="NP_001395712.1"
                     /db_xref="GeneID:690158"
                     /db_xref="RGD:1584013"
                     /translation="MEANYSVPLNVSEVVVYDSTISRVLWILSMVVLSITFVLGVLGN
                     GLVIWVAGFRMVHTVTTTCYLNLALADFSFTATLPFFVISTAMKEKWPFGWFLCKLVH
                     IVVDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLARKVVVGPWILALILTLPI
                     FVFMTTVRVPGGNVYCTFNYASWGKTVEEVLDVANTCETVRGTIRFVIGFTMPMSIVA
                     ICYGLIAVKIHRRALVNSSRPLRVLTAVVVSFFICWFPFQLVALLGTIWFKELLFNTR
                     YGILKMWVNPTSSLAYFNSCLNPMLYVFMGQDFRERLIHSLPSSLERALSEDCGQTSD
                     TGTNSALPPADIEIKAI"
ORIGIN      
        1 attggagtga aacaaaatga ttccaatagc attacatttg catggctttt agcagtctta
       61 agaaacctca agtttgtatg acaagattga cttcagcttt cttgttcctc tcagagtttt
      121 cataagtctc tgctgagagc caagtacttc agttgcatca caggatccag gagtgagcca
      181 gaggaaggag acctcatctg gttgtgcaga caaaatggaa gccaactatt ccgtccctct
      241 gaatgtatca gaagtggtgg tctatgattc taccatctcc agagttctgt ggatcctctc
      301 aatggtggtt ctctccatta catttgtcct tggtgtgctg ggtaatggac tagtgatctg
      361 ggtagctgga ttccggatgg tacacactgt taccactact tgttatctga atttagcttt
      421 ggctgacttc tctttcacag caactctacc attctttgtc atctcaactg ctatgaaaga
      481 aaaatggcct tttggctggt ttctgtgtaa attagttcac attgtggtag acataaacct
      541 ctttggaagt gtcttcctga ttgctttaat tgccttggac cgctgcattt gtgtcctgca
      601 tccagtctgg gctcagaacc accgcactgt gagcctggct cggaaggtgg ttgttgggcc
      661 ctggatttta gctctgattc tcactttgcc catttttgtt ttcatgacta cagttagagt
      721 tcctggaggt aatgtgtact gtacattcaa ctatgcatcc tggggaaaaa ctgttgaaga
      781 agtgctggac gtagcaaaca cttgtgaaac agttagaggg accatcaggt tcgttattgg
      841 cttcacaatg cccatgtcca ttgtggccat ctgctatgga ctcatcgctg tcaagatcca
      901 cagaagagca cttgttaatt ccagtcgtcc cttacgagtc cttacagcag ttgtggtttc
      961 tttctttatc tgttggtttc cctttcaact ggtggccctt ttaggtacaa tctggttcaa
     1021 agagctattg tttaatactc gttacggaat tcttaagatg tgggttaacc caaccagctc
     1081 attggcctac ttcaatagtt gcctcaatcc aatgctctat gttttcatgg gccaggactt
     1141 ccgagagaga ctgattcatt ctctgccttc cagtttggag agagctctga gtgaggactg
     1201 tggccaaacc agtgatacag gcacaaattc tgctttacct cctgcagaca ttgagataaa
     1261 agcaatatga agattgggat gagggatttt ttttgtctta cctcagttga attccagttt
     1321 tgtcttacgt tatgttgtgc cctagagcaa ttttaaccta ataaaatact tctctgtctc
     1381 ctgactctgg gaaaagaatt aaaagtcaat atttaagtaa tctttcttgg gggaatcttt
     1441 atatgtatat a
//
