LOCUS       NM_001106216            1208 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus formyl peptide receptor 1 (Fpr1), mRNA.
ACCESSION   NM_001106216 XM_001057934 XM_218012
VERSION     NM_001106216.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1208)
  AUTHORS   Zhang,J., Ding,T., Tang,D., Wang,J. and Huang,P.
  TITLE     Formyl peptide receptor 1 promotes podocyte injury through
            regulation of mitogen-activated protein kinase pathways
  JOURNAL   Exp Biol Med (Maywood) 247 (2), 87-96 (2022)
   PUBMED   34565207
  REMARK    GeneRIF: Formyl peptide receptor 1 promotes podocyte injury through
            regulation of mitogen-activated protein kinase pathways.
REFERENCE   2  (bases 1 to 1208)
  AUTHORS   Liu,S., Gao,Y., Yu,X., Zhao,B., Liu,L., Zhao,Y., Luo,Z. and Shi,J.
  TITLE     Annexin-1 Mediates Microglial Activation and Migration via the CK2
            Pathway during Oxygen-Glucose Deprivation/Reperfusion
  JOURNAL   Int J Mol Sci 17 (10), 1770 (2016)
   PUBMED   27782092
  REMARK    GeneRIF: ANXA1 promotes microglial activation and migration during
            oxygen-glucose deprivation/reperfusion via FPR, and CK2 target
            alpha-E-catenin phosphorylation is involved in this process.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1208)
  AUTHORS   Wang,G., Zhang,L., Chen,X., Xue,X., Guo,Q., Liu,M. and Zhao,J.
  TITLE     Formylpeptide Receptors Promote the Migration and Differentiation
            of Rat Neural Stem Cells
  JOURNAL   Sci Rep 6, 25946 (2016)
   PUBMED   27173446
  REMARK    GeneRIF: Reports showed that both Fpr1 and Fpr2 are expressed on
            NSCs and both receptors mediate the migration of neural stem cells
            (NSCs) in vitro and in vivo, and promote the differentiation of
            NSCs to neuron through F-actin polymerization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1208)
  AUTHORS   Slowik,A., Merres,J., Elfgen,A., Jansen,S., Mohr,F., Wruck,C.J.,
            Pufe,T. and Brandenburg,L.O.
  TITLE     Involvement of formyl peptide receptors in receptor for advanced
            glycation end products (RAGE)--and amyloid beta 1-42-induced signal
            transduction in glial cells
  JOURNAL   Mol Neurodegener 7, 55 (2012)
   PUBMED   23164356
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1208)
  AUTHORS   Bufe,B., Schumann,T. and Zufall,F.
  TITLE     Formyl peptide receptors from immune and vomeronasal system exhibit
            distinct agonist properties
  JOURNAL   J Biol Chem 287 (40), 33644-33655 (2012)
   PUBMED   22859307
REFERENCE   6  (bases 1 to 1208)
  AUTHORS   Brandenburg,L.O., Konrad,M., Wruck,C.J., Koch,T., Lucius,R. and
            Pufe,T.
  TITLE     Functional and physical interactions between
            formyl-peptide-receptors and scavenger receptor MARCO and their
            involvement in amyloid beta 1-42-induced signal transduction in
            glial cells
  JOURNAL   J Neurochem 113 (3), 749-760 (2010)
   PUBMED   20141570
REFERENCE   7  (bases 1 to 1208)
  AUTHORS   Chen,J.H., Bian,X.W., Yao,X.H., Gong,W., Hu,J., Chen,K.,
            Iribarren,P., Zhao,W. and Zhou,X.D.
  TITLE     Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression
            of formylpeptide receptor and induces differentiation of malignant
            glioma cells
  JOURNAL   Biochem Biophys Res Commun 342 (4), 1368-1374 (2006)
   PUBMED   16516855
  REMARK    GeneRIF: Our results suggest that Nordy was capable of reducing the
            level of malignancy of glioma cells.
REFERENCE   8  (bases 1 to 1208)
  AUTHORS   Vaughn,M.W., Proske,R.J. and Haviland,D.L.
  TITLE     Identification, cloning, and functional characterization of a
            murine lipoxin A4 receptor homologue gene
  JOURNAL   J Immunol 169 (6), 3363-3369 (2002)
   PUBMED   12218158
REFERENCE   9  (bases 1 to 1208)
  AUTHORS   Lavigne,M.C., Murphy,P.M., Leto,T.L. and Gao,J.L.
  TITLE     The N-formylpeptide receptor (FPR) and a second G(i)-coupled
            receptor mediate fMet-Leu-Phe-stimulated activation of NADPH
            oxidase in murine neutrophils
  JOURNAL   Cell Immunol 218 (1-2), 7-12 (2002)
   PUBMED   12470609
REFERENCE   10 (bases 1 to 1208)
  AUTHORS   Bennett,T.A., Maestas,D.C. and Prossnitz,E.R.
  TITLE     Arrestin binding to the G protein-coupled N-formyl peptide receptor
            is regulated by the conserved 'DRY' sequence
  JOURNAL   J Biol Chem 275 (32), 24590-24594 (2000)
   PUBMED   10823817
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474033.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_218012.4, XM_001057934.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1208
                     /gene="Fpr1"
                     /note="formyl peptide receptor 1"
                     /db_xref="GeneID:292409"
                     /db_xref="RGD:1310883"
     exon            1..1208
                     /gene="Fpr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..1068
                     /gene="Fpr1"
                     /codon_start=1
                     /product="fMet-Leu-Phe receptor"
                     /protein_id="NP_001099686.1"
                     /db_xref="GeneID:292409"
                     /db_xref="RGD:1310883"
                     /translation="MNTNMSAVNFMNMSGSTRSVSAGYIVLDIFSYLIFALTFVLGVL
                     GNGLVIWVAGFRMKRTVTTISYLNLAIADFCFTSTLPFYIVSLVMGGIWPFGWFMCKF
                     IYTVIDINLFGSVFLIALIALDRCVCVLHPVWAQNHRTVTLAKKVIIVPWICAFLLTL
                     PVIIRVTTVPNRLGPGKTACALDFSPWTKDRAEKDKVAITMYTVRGIIRFILGFSTPM
                     SIVAICYGLIATKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVGLIRTIQIREHL
                     RNIPQSTLTAMKITSSLAFFNSCLNPILYVFMGQDFRQRLIHSLPASLERALSEDSAQ
                     TSDTGTNLGANSIPENPANAM"
ORIGIN      
        1 atgaacacca acatgtctgc agtgaacttc atgaatatgt ctgggagtac tcgatcagta
       61 tctgctggct acattgttct ggatatcttc tcatatttga tctttgcact cacctttgtg
      121 cttggagtct tgggcaacgg gctcgtgatc tgggtggccg gtttccgcat gaaacgcact
      181 gtcaccacca tctcttactt gaacttggcc attgctgact tttgcttcac ctccactttg
      241 ccattttaca tcgtcagcct ggtcatggga ggaatatggc catttggttg gttcatgtgc
      301 aagttcatat atactgtaat agacataaac ctatttggaa gtgtctttct gattgccctc
      361 atagcattgg atcgctgtgt ttgtgtcctg catccagtct gggctcagaa ccaccgcacc
      421 gtgaccctgg ccaagaaggt aatcattgta ccctggattt gtgcatttct ccttactttg
      481 ccagttatca ttcgtgtgac cacagtccct aatcgacttg gaccagggaa aacagcctgt
      541 gctttagact tctcaccctg gaccaaagat cgtgcagaaa aggataaagt agctatcacc
      601 atgtatactg tcagaggaat aatcaggttc atccttgggt tcagcactcc catgtccatt
      661 gtagctattt gttatgggtt aatagccact aaaatccaca ggcaaggtct tatcaaatcc
      721 agccgtccct tgcgagttct ctcttttgtt gtggctgcct ttttcctctg ctggtgccca
      781 tttcaagtag tgggcctcat acgcacaatc caaatccgtg aacacttgag gaacatacct
      841 caaagcactc taactgctat gaaaatcaca agctctttgg ctttcttcaa tagctgcctc
      901 aacccaatcc tttatgtctt catgggccag gacttcagac aaagactaat ccactcccta
      961 cctgccagtc tagagagggc cctgagtgag gactcagctc aaaccagtga cacaggcacc
     1021 aacttgggag ccaactctat tcctgaaaac ccagcaaatg caatgtaaaa acagggattt
     1081 agcttccaga ttcacatgct ttgagttcca ctgtgctata gtcactcctt gttgactttc
     1141 aggctacagg ctcattagga aaacttgaaa tgacctttta gacttttgta cctcaaccca
     1201 aggtggcc
//
