LOCUS       NM_001191787            4854 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus FAD-dependent oxidoreductase domain containing 2
            (Foxred2), mRNA.
ACCESSION   NM_001191787 XM_006241932 XM_235468
VERSION     NM_001191787.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4854)
  AUTHORS   Shim S, Lee W, Chung H and Jung YK.
  TITLE     Amyloid beta-induced FOXRED2 mediates neuronal cell death via
            inhibition of proteasome activity
  JOURNAL   Cell Mol Life Sci 68 (12), 2115-2127 (2011)
   PUBMED   20972601
  REMARK    GeneRIF: up-regulated FOXRED2 inhibits proteasome activity by
            interfering with 26S proteasome assembly to contribute to amyloid
            beta neurotoxicity via an endoplasmic reticulum stress response.
REFERENCE   2  (bases 1 to 4854)
  AUTHORS   Riemer J, Appenzeller-Herzog C, Johansson L, Bodenmiller B,
            Hartmann-Petersen R and Ellgaard L.
  TITLE     A luminal flavoprotein in endoplasmic reticulum-associated
            degradation
  JOURNAL   Proc Natl Acad Sci U S A 106 (35), 14831-14836 (2009)
   PUBMED   19706418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000186.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001191787.3.
            
            On or before Oct 12, 2022 this sequence version replaced
            XM_006241932.4, NM_001191787.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JACYVU010000186.1  2779971-2780172     c
            203-703             JACYVU010000186.1  2779082-2779582     c
            704-955             JACYVU010000186.1  2777099-2777350     c
            956-1222            JACYVU010000186.1  2775982-2776248     c
            1223-1389           JACYVU010000186.1  2775654-2775820     c
            1390-1555           JACYVU010000186.1  2772624-2772789     c
            1556-1797           JACYVU010000186.1  2771293-2771534     c
            1798-1968           JACYVU010000186.1  2769857-2770027     c
            1969-4854           JACYVU010000186.1  2764504-2767389     c
FEATURES             Location/Qualifiers
     source          1..4854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..4854
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /note="FAD-dependent oxidoreductase domain containing 2"
                     /db_xref="GeneID:315112"
                     /db_xref="RGD:1306763"
     exon            1..202
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
     exon            203..703
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2201
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /note="FAD-dependent oxidoreductase domain-containing
                     protein 2"
                     /codon_start=1
                     /product="FAD-dependent oxidoreductase domain-containing
                     protein 2 precursor"
                     /protein_id="NP_001178716.1"
                     /db_xref="GeneID:315112"
                     /db_xref="RGD:1306763"
                     /translation="MGPSGLLVALALHLAVCSRPHRDYCVLGAGPAGLQMAALLHRAG
                     RDYEVFERESAPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSDDPHLLF
                     RHYSQAYFPDASDMVRYLGDFAQRLGLRVLYNTNITHVTLDKDPQAWNGHYFILRDQK
                     GQVYQCSVLLVATGLAVPKLVDFPGSEYVEGYESVSVDPEDFVGQNVLILGHGNSAFE
                     TAENILGVTNFVHMLSRSRVRLSWATHYVGDVRAINNGLLDTYQLKSLDGLLESDLEY
                     LALVKDSKGKFHITLKFLLENSSNQSADSIPLPQDDNDNFAMRVAYDRVIRCLGWKFD
                     FSIFNQSLRLSSGTEFSKKYPLIKASYESKGSRGLFILGTASHSVDYRKSAGGFIHGF
                     RYTVRAVHRLLEHRHHGITWPSTQYPITQLTSSIIRRVNEASGLYQMFSVLADIILLK
                     ENATAFEYLEEFPIQMLAQLEMLTGRTARHGIFVINMEYGKNFSGPEKDVFYYDRSVA
                     HIEDAWMSNFLHPVIYYYRHLPTEQDMRFRPAQWPLPRPVAIHHIVEDFLTDWTAPVG
                     HILPLRRFLENCLDTDLRSFYAESCFLFTLTRQKLPPFCQQGYLRMQGLSSTKSLRQH
                     GVESRLLQDYTAMENSSRWLDDHSSAPGPLTQFLDSNREEL"
     exon            704..955
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1222
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1389
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1555
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1797
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1968
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..4854
                     /gene="Foxred2"
                     /gene_synonym="RGD1306763"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctaccgtga gagcatcgct gggccacggg cgtcggcagc gtgcggatcg gaagttcagc
       61 ctgggcaccg cgcacgcgcc agtagcagtg cgggatagcg gagaccgcgg caggtgtgcc
      121 ggggcatcct cacgtgatcc ggggggctgg ggaggggcct taaaggccac acctccttca
      181 ggtccccccc tgagggtgaa aggatgggtc cctcggggct gctggtggcc ctagccttgc
      241 acctggcagt gtgctcccgt ccgcaccggg actactgcgt gctgggcgct ggtcctgcgg
      301 gcctgcagat ggctgcactc ctgcatcgag ccggcaggga ctacgaggta ttcgaacgag
      361 agtccgcacc tggcagcttc ttcactcgct acccgcgcca ccgcaagctc atcagcatca
      421 acaagcggta cacaggcaag gccaacgcag agttcaacct tcgccacgac tggaactctc
      481 tcctcagcga cgacccacac ctgctcttca gacactactc ccaggcttac ttcccagacg
      541 ccagcgatat ggtgcgctac ctgggtgact tcgcacagcg cctagggctc cgtgtgttat
      601 acaacacaaa catcacccac gtgactctgg acaaggatcc acaagcctgg aacggccatt
      661 acttcattct gagggaccag aagggccagg tttaccaatg cagtgtcctg cttgtggcca
      721 ctggtttggc agtccccaaa ctggtcgact tccctggctc tgaatacgtg gaggggtacg
      781 agtctgtgtc tgtggaccct gaagactttg tgggtcagaa tgtgttgatc ctgggccatg
      841 ggaactcagc cttcgagaca gcagaaaaca tcttgggtgt cacaaacttt gttcacatgc
      901 tgagccgttc ccgagttcgg ctctcctggg ccacccacta tgttggagac gtcagagcca
      961 tcaacaatgg cctactggac acctaccagc tgaaatcgct agacggactc ctggaatcag
     1021 acctggagta tctagccctc gtgaaggaca gcaagggcaa gttccatatc accctgaagt
     1081 tcctcctgga gaacagcagc aaccagagtg ctgactccat tcccctcccc caggacgaca
     1141 atgacaactt tgccatgcgg gtggcctacg accgtgtcat ccgctgcctg ggctggaaat
     1201 ttgacttctc cattttcaac cagtccctca gactctcctc agggactgag ttcagcaaga
     1261 agtacccact gatcaaagcc agctatgaat ccaaagggag ccggggtctc tttatcctgg
     1321 ggaccgccag ccactcagtg gactaccgga agtctgctgg cggcttcatc cacggattcc
     1381 gatacacagt gcgtgctgtc caccggctgt tggagcatcg gcaccatggc atcacctggc
     1441 cgtccacaca gtaccccatc acacagctga ccagctccat cattcggcgt gtaaatgagg
     1501 cttcggggct gtaccaaatg ttcagcgtgc tggccgacat catcctgttg aaggagaacg
     1561 ctacagcatt tgagtacctg gaggagttcc ctatacagat gctggcccag ctggagatgc
     1621 tcacagggag gacagcaagg cacgggatct ttgtcatcaa catggaatat ggcaaaaact
     1681 tctctgggcc tgagaaggac gtcttctatt atgaccggtc cgtggcacac atagaagatg
     1741 cctggatgtc taacttcctc caccctgtca tctactacta cagacacctc cccaccgagc
     1801 aagacatgcg gttccgtcct gcacagtggc ccctgcctcg gcctgtggcc atccaccaca
     1861 tcgtggagga cttcctgact gactggacag cccccgtggg gcacatcctc ccactgaggc
     1921 gcttcctgga aaactgtctg gacacagatc tgcgtagctt ttatgcagag tcctgtttcc
     1981 tgttcactct cacacgccag aagctgccgc ccttttgcca gcagggatac ctaagaatgc
     2041 aggggctttc aagcaccaag agccttcgtc aacatggtgt ggaaagcagg ctcctgcagg
     2101 actacacggc catggagaac agcagcaggt ggcttgatga ccactcctca gctccagggc
     2161 ctctgactca attccttgac agcaacagag aggagctctg agcatcctct cccagactat
     2221 gatggcttgc acctctccag gaagcctttt cccagggaac ttctctccca cctttcaggc
     2281 ggctcaggac catcacagag gtcacagaca acaggacagc ctgtagagtg cagaaggctg
     2341 ggataaggtc acacagtgat gtcccttccc atgctggccc ctggtgctag atgcaaggtc
     2401 cagaggaggg tacctcctgt caggtatgag gtcccttcca catccagcta gtgttccact
     2461 tggaccatca ctaaacacca tgctggtctt gtgtgtctgt tctaggacca gccagtctcc
     2521 tttttcttcg ggttcactct cagatgggct cagctttacc tgggaacatc tcaaagcaga
     2581 cacccctcgt ttccatggtg ggcatgtgag ggtgaaggct tcagcagtgg ggtagacagt
     2641 ggggatcttc tagtgtcctc atccaggagg cctgccctat accacccttt ctttccacac
     2701 agtttcctct tccctggcac ttgctctcag caggagtcag cagcctctgt gtccctctcc
     2761 caccttgcta tctggcatcc tgagccatgt ctcccttgag acccgcctgg gcaggttttt
     2821 tttttttttt tttttttttt tttccggagc tggggaccaa acccagggcc ttgcgcttgc
     2881 taggcaagtg ctctaccgct gagctaaatc cccaacccct ccgcctgggc aggtttaaga
     2941 tattgctttg cctgctccct tgggcatgga aatgttgaca cttgcccagc tcctgatgct
     3001 cctctcctct tccttgcctt ccctccccag agtccatact cagccaacag attagcaaag
     3061 aagccatgag gaaagcatgg cccacaaggg catcatggtg atcacgtgat ttccatagcc
     3121 tcagagtgca ggtactgttt ttcaccagtg gccctctatc agccttcatg gaggccactc
     3181 aaacgcccag ggacacaacc caaagcccct tcctggggcc atcctcttct ccttgggaga
     3241 gtcttggctg ggtctacctg acctgcctgc agccaccttc ctttctggcc taccaagtcc
     3301 taacaggaca attcaacaac ttcatgtcac caggaggaac tgtgtacccc tgaacctact
     3361 tggtgtagta cgcacagagc caaaccttct aactaagtca tcatccaatc ccaggatgtc
     3421 agtgttgcca tatttcacac agattgattg gcaagccgaa cggggaccct gccatcccac
     3481 cctcttctcc acagcatttt caaatatgcc tttgatttag cactacgaca tcgaatcctg
     3541 ttccttacat ctccagtcat cgaggatggc tgagcacttg tttggtgcct tagcaagtag
     3601 ctggctgaca cccttgtata agacatctgc tgcttcctgt catctgccag atcgttgatt
     3661 ccgtcaaaat atcaggcagc cttatttgtt tttaacacgg agcatcctgt tcttgctcag
     3721 ttgactagag atgtcttcta cttcccccgc cccatagaga ttccatgtcc tgtggcctgg
     3781 tacttattat atagcccagc ctgcacttgg actcatggta attctcctgt ttcaacctcc
     3841 caagtattcg gattacaagc ttgaaccaca taaccttctt aagatttatt tcggggttgg
     3901 ggatttagct cagtggggtt ggggatttag ctcagtggta gagcgcttgc ctagcaaacg
     3961 caaggccctg ggttcggtcc ccagctctga aaaaagaaga aaaaaaaaga tttatttcta
     4021 cttatgtcta ctcatctgtg gacatgagtg caggtgccca gagaccagaa gagggtggca
     4081 gagcgcctgg aggctggagt tacaggaggt tgtgaaccac cgtgtgtgga tgctgggaac
     4141 tgagctcaaa tcctctgaaa cagccgtaag tgctgagaca attgctccag gacccctacc
     4201 tcataactat tttagagaaa agattaaaaa taaggcaagc tagatgtggc tcactccaat
     4261 atcctagcat tagggcagct aaggcaggag aattgaggtt taaagccagc ctgggctaca
     4321 tggagagttc ccgtatgggc aacttaataa gatcccatct caaaaaagaa attttaaaaa
     4381 ggcaaaaata actgggcatt gttgtttatg cctttaatct tagtatgccc aaagcacagg
     4441 gcggagaatc tcttgtgaat tcaaaaccag cctggttgac gaagtaaatt ccaggccagt
     4501 taaagctata taatgaaacc ttctctcaat caatcaatca atcaatcgga ataatcatgg
     4561 tgaaggaact ggttgaacta ggtgacaggc agggagagga gttacgtaac ttctcttgat
     4621 catctctgaa gagggtaggg aaggctgatg agtataccta tatatgtatg atgctgcatg
     4681 ggacatggcg ctgggtgagg gggcagcagc cgcttgtagc ggtgaccata ggaaaccgca
     4741 gtggctctgc tagggctgtg ggacgaggat cttcattcct cttctgatca aatttgtgtt
     4801 tatttttcaa atgtgattat aggctactga aataaaaata catttatttt caaa
//
