LOCUS       NM_001108250            3732 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus forkhead box P3 (Foxp3), mRNA.
ACCESSION   NM_001108250 XM_001064182 XM_228771
VERSION     NM_001108250.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3732)
  AUTHORS   Alfaar AS, Sturzbecher L, Diedrichs-Mohring M, Lam M, Roubeix C,
            Ritter J, Schumann K, Annamalai B, Pompos IM, Rohrer B, Sennlaub F,
            Reichhart N, Wildner G and Strauss O.
  TITLE     FoxP3 expression by retinal pigment epithelial cells: transcription
            factor with potential relevance for the pathology of age-related
            macular degeneration
  JOURNAL   J Neuroinflammation 19 (1), 260 (2022)
   PUBMED   36273134
  REMARK    GeneRIF: FoxP3 expression by retinal pigment epithelial cells:
            transcription factor with potential relevance for the pathology of
            age-related macular degeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3732)
  AUTHORS   Sawanobori Y, Kitazawa Y, Ueta H, Matsuno K and Tokuda N.
  TITLE     Selective involution of thymic medulla by cyclosporine A with a
            decrease of mature thymic epithelia, XCR1+ dendritic cells, and
            epithelium-free areas containing Foxp3+ thymic regulatory T cells
  JOURNAL   Histochem Cell Biol 156 (2), 133-146 (2021)
   PUBMED   33993340
  REMARK    GeneRIF: Selective involution of thymic medulla by cyclosporine A
            with a decrease of mature thymic epithelia, XCR1(+) dendritic
            cells, and epithelium-free areas containing Foxp3(+) thymic
            regulatory T cells.
REFERENCE   3  (bases 1 to 3732)
  AUTHORS   Taylor MR, Roby CR, Elziny S, Duricy E, Taylor TM and Bowers JM.
  TITLE     Age, but Not Sex, Modulates Foxp3 Expression in the Rat Brain
            across Development
  JOURNAL   Neuroscience 442, 87-99 (2020)
   PUBMED   32599120
  REMARK    GeneRIF: Age, but Not Sex, Modulates Foxp3 Expression in the Rat
            Brain across Development.
REFERENCE   4  (bases 1 to 3732)
  AUTHORS   Sun Z, Hu Y, Wang Y, Feng J and Dou Y.
  TITLE     Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal
            dysbiosis in rats through T helper 17/T regulatory cell signaling
            pathway
  JOURNAL   J Tradit Chin Med 40 (1), 38-48 (2020)
   PUBMED   32227764
REFERENCE   5  (bases 1 to 3732)
  AUTHORS   Putilin DA, Evchenko SY, Fedoniuk LY, Tokarskyy OS, Kamyshny OM,
            Migenko LM, Andreychyn SM, Hanberher II and Bezruk TO.
  TITLE     The Influence of Metformin to the Transcriptional Activity of the
            mTOR and FOX3 Genes in Parapancreatic Adipose Tissue of
            Streptozotocin-Induced Diabetic Rats
  JOURNAL   J Med Life 13 (1), 50-55 (2020)
   PUBMED   32341701
REFERENCE   6  (bases 1 to 3732)
  AUTHORS   Zahorsky-Reeves JL and Wilkinson JE.
  TITLE     The murine mutation scurfy (sf) results in an antigen-dependent
            lymphoproliferative disease with altered T cell sensitivity
  JOURNAL   Eur J Immunol 31 (1), 196-204 (2001)
   PUBMED   11265635
REFERENCE   7  (bases 1 to 3732)
  AUTHORS   Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N,
            Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne
            G, McEuen M, Proll S, Appleby M and Brunkow ME.
  TITLE     X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy
            syndrome is the human equivalent of mouse scurfy
  JOURNAL   Nat Genet 27 (1), 18-20 (2001)
   PUBMED   11137992
REFERENCE   8  (bases 1 to 3732)
  AUTHORS   Clark LB, Appleby MW, Brunkow ME, Wilkinson JE, Ziegler SF and
            Ramsdell F.
  TITLE     Cellular and molecular characterization of the scurfy mouse mutant
  JOURNAL   J Immunol 162 (5), 2546-2554 (1999)
   PUBMED   10072494
REFERENCE   9  (bases 1 to 3732)
  AUTHORS   Kanangat S, Blair P, Reddy R, Daheshia M, Godfrey V, Rouse BT and
            Wilkinson E.
  TITLE     Disease in the scurfy (sf) mouse is associated with overexpression
            of cytokine genes
  JOURNAL   Eur J Immunol 26 (1), 161-165 (1996)
   PUBMED   8566060
  REMARK    Erratum:[Eur J Immunol. 2003 Jul;33(7):2064. Deheshia M [corrected
            to Daheshia M]]
REFERENCE   10 (bases 1 to 3732)
  AUTHORS   Blair PJ, Bultman SJ, Haas JC, Rouse BT, Wilkinson JE and Godfrey
            VL.
  TITLE     CD4+CD8- T cells are the effector cells in disease pathogenesis in
            the scurfy (sf) mouse
  JOURNAL   J Immunol 153 (8), 3764-3774 (1994)
   PUBMED   7930593
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474078.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_001108250.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_228771.4, XM_001064182.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB232988.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3732
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..3732
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /note="forkhead box P3"
                     /db_xref="GeneID:317382"
                     /db_xref="RGD:1562112"
     exon            1..132
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            133..214
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            215..445
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1525
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /codon_start=1
                     /product="forkhead box protein P3"
                     /protein_id="NP_001101720.1"
                     /db_xref="GeneID:317382"
                     /db_xref="RGD:1562112"
                     /translation="MPNPRPAKPMAPSLAPGPSPGGLPSWKTAPKGSELLGTRGPGGP
                     FQGRDLRSGAHTSSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHF
                     MHQLSTVDAHGHTPVLQVRPLDNPAMIGLPPPTAATGVFSLKARPGLPPGINVASLEW
                     VSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKAFEEPGEFLKHC
                     QADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALTKAPPVASVD
                     KSSCCLVATSTQGSVLPAWSSPREASDSLFAVRRHLWGSHGNSTFPEFFHNMDYFKYH
                     NMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLH
                     KCFVRVESEKGAVWTVDEFEFRKKRSQRPSKCSNPCP"
     exon            446..550
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            551..689
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            690..777
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            778..882
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            883..970
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1051
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1202
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1279
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1381
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..3732
                     /gene="Foxp3"
                     /gene_synonym="RGD1562112"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgatccct ctctgtcagt ccacttcact caggtgagtg tccctgctct cccccaccag
       61 acacagctct gctggagaaa gtggcaggga aggagtgtca ggagccctcc agtacagccg
      121 gacacactgc agctccggca acttttcctg actctgcctt cacacgagac ttggaagtca
      181 gccacgtttc ggcagctcct ctgccgttat ccagcctgcc tcagacaaga acctgatgcc
      241 caacccaagg ccagctaagc ctatggctcc ttccttggcc cctggcccgt ccccaggagg
      301 cttgccaagc tggaagactg cgcccaaggg ctcagaactc ctagggacca ggggtcctgg
      361 gggacccttc caaggccggg acctgcgaag tggggcccac acctcctctt cttccttgaa
      421 ccccctgcca ccatcacagc tgcagctgcc tacagtgccc ctagtcatgg tggcaccctc
      481 tggggcccga ctaggcccct caccgcacct gcaggcactt ctccaggaca gaccacactt
      541 tatgcatcag ctctccactg tagacgcaca tggccacacc cctgtgctac aagtgcgccc
      601 actggacaac ccagcgatga tcggcctccc accgcctact gctgccactg gagtcttctc
      661 cctcaaggcc cggcctggcc tgccacctgg gatcaatgtg gccagtctgg aatgggtgtc
      721 cagggagccg gctctactct gcaccttccc acgctcaggt acacccagga aagacagcaa
      781 ccttctggct gcaccacaag gatcctaccc actgctggca aacggagtct gcaagtggcc
      841 gggttgtgag aaggccttcg aggagccggg agagtttctc aagcactgcc aagcagatca
      901 cctcttggat gagaagggca aggcccagtg cctcctccag agagaagtgg tgcagtctct
      961 ggagcagcag ctggagctgg aaaaggagaa gctgggagct atgcaggccc acctggctgg
     1021 gaagatggca ttgacaaaag ctccacctgt ggcctcagtg gacaagagct cctgctgcct
     1081 cgtagccacc agcacccagg gcagcgtcct cccggcctgg tctagtcccc gggaagcttc
     1141 agacagcttg tttgctgtgc ggagacacct ctggggaagc catggaaaca gcacctttcc
     1201 agagttcttc cacaacatgg actacttcaa gtaccataat atgcggcccc ctttcaccta
     1261 tgccaccctc atccgatggg ccatcctgga agctccagag aggcagagga cactcaatga
     1321 aatctaccat tggttcacac gcatgttcgc ctacttcaga aaccaccccg ccacctggaa
     1381 gaatgccatc cgccacaacc tgagcctgca caagtgcttt gtgcgagtgg agagtgagaa
     1441 gggagcagtg tggaccgtag atgaatttga gtttcgcaag aagaggagcc aacgccccag
     1501 caagtgctcc aacccctgcc cttgacctca aaaccaagaa aacatggacg ggggccaaaa
     1561 catgagactg aggctgtagg ggcaaggagg caagtcctgg acatacctat ggagaccagg
     1621 cagtgaggtt tctgccatct tgcctatcag ggcctccact ctctatctag ctgccctcct
     1681 gagaggggtg ccaatctcaa cctagcccct agccccaacc tacccccaag atgagctttc
     1741 cagccaaaca gccctcacaa ccagctatac atatatctgc cttggccact gccaagcaga
     1801 aaaatgacag acacagttcc taatactgtc ccttggactc aacccaaacc ctaaaacacg
     1861 aagagcctgc cttcgcacat tcatgggccc tcaaagttac aatcctgcaa ttgcacgtga
     1921 ctgcaatcct actgactcat agcccaacac tcacccacaa cgtctgcaac cacagacact
     1981 atgacacata gcaggggtgt agatgcagac cctcgtacag gagcagcgct ggaaccttca
     2041 gaattagcat cccagaaaac cacacaggca taactgatca tacgtagcct ctagtaatgc
     2101 ccaaaaaata tcaagtcaga cacagcttgt cagaacgcac acgtgtacat gtacacacat
     2161 gcagcccctc caccgtatct cctgagttcc atgaatacac accgactttc caaaatgtac
     2221 cccatgtatc acttgccact aaccccagtc ccctaccccc aagccccaat ccatgcctaa
     2281 gcgtggccca cagaagaact tctcttttat ttggaatcca aggcccctgg tccccagtgc
     2341 ccatccaata aactgtggtc aagctggaca atcaccctga tcagatatgg gaacagataa
     2401 gcagacagct gggtttaagg tcccaacagg agaaagtgga taccaaattg aagagagtgc
     2461 tagagccaag tgcttcagca cggtctccag tacccccaaa ttcctgcctg tgcttaggag
     2521 acatccatca gggctctaga cctctcggac ccggcccaag aggccagcat tctcctggcg
     2581 aagggctcgg tagtcctcac agatcttctc caggttgctc aaagtcttct tgcccatctc
     2641 tgtctcaatc taagaaaata ggatgcacac gtcttcagcg cctgctggct gtccctctcc
     2701 tgcactcctc cctgctcctc ccatacccta acagtggcct gttccttctc atcactggct
     2761 ttctgcgtat gtccttccct ccacctaaag caacagcttc taccacgggc tctgggaggc
     2821 ataagggggt tcaggctaaa agccagggct cagggtaggc agctggctag cctcaggtcg
     2881 caggcacatc aggcactaag gttaagcctg tatctgttgg ttttctggtt tcaaagactc
     2941 tcaacgcaaa acaaggaact gtctcctggc ctgtctccat tccccttccc attcccaggt
     3001 ctcacctgct cctcaagatc tcgaacttcc ctcatgatag tgcccgtgtc ctcaatggtc
     3061 tggatgagct ggctgcaatt ctggagacag caagagtaca aggcttgcac ccgtgctggc
     3121 cctctacagg cagcccagca ggcgcatggt tcccctcacc tcatgcagag cagctagata
     3181 tttgtaggct ttccgaacag catcatcctt cttagcatcc tgataagaca aaagggacct
     3241 cagagataac agcaagctat tgcccccttt tccactactc tatgcccctg taagaccacc
     3301 ctttactact atgccttcgc cctccgcaga gcaaagctag gcccaagcaa cagtgtacct
     3361 gaaggactca cagaggggca agctggccca taagcagatg ggcaggcaac agcccagccc
     3421 cacctcaacc ctccccaagg ccagcctgct tcataccttg aacacaagct catcagtcac
     3481 tgcaaatgtc cggtccagct tcccagagag agagttgatt tccttctgaa gttcctttgt
     3541 gtctgacaag atctggcaga aaccagagta actatcagtc cacatcttgg gcaaagtggc
     3601 tgagcaatga tagcactcat gagcctatag ctgacatcta gtcagggcct gtgtcactgt
     3661 gttggggtga ctattatgtg ttggggtgta cctgaacagc tctgcctagt ggtgagcatc
     3721 aagtccttgt gt
//
