LOCUS       NP_001258033             710 aa            linear   ROD 24-JUN-2024
DEFINITION  forkhead box protein P2 [Rattus norvegicus].
ACCESSION   NP_001258033 XP_003749748
VERSION     NP_001258033.1
DBSOURCE    REFSEQ: accession NM_001271104.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 710)
  AUTHORS   De la Merced-Garcia,D.S., Sanchez-Barrera,A., Hernandez-Yonca,J.,
            Mancilla,I., Garcia-Lopez,G., Diaz,N.F., Terrazas,L.I. and
            Molina-Hernandez,A.
  TITLE     Increased Nuclear FOXP2 Is Related to Reduced Neural Stem Cell
            Number and Increased Neurogenesis in the Dorsal Telencephalon of
            Embryos of Diabetic Rats through Histamine H1 Receptors
  JOURNAL   Cells 12 (3), 510 (2023)
   PUBMED   36766852
  REMARK    GeneRIF: Increased Nuclear FOXP2 Is Related to Reduced Neural Stem
            Cell Number and Increased Neurogenesis in the Dorsal Telencephalon
            of Embryos of Diabetic Rats through Histamine H1 Receptors.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 710)
  AUTHORS   Jia,L., Wang,W., Liu,H., Zhu,F. and Huang,Y.
  TITLE     LncRNA TTN-AS1 exacerbates extracellular matrix accumulation via
            miR-493-3p/FOXP2 axis in diabetic nephropathy
  JOURNAL   J Genet 102 (2023)
   PUBMED   36722214
  REMARK    GeneRIF: LncRNA TTN-AS1 exacerbates extracellular matrix
            accumulation via miR-493-3p/FOXP2 axis in diabetic nephropathy.
REFERENCE   3  (residues 1 to 710)
  AUTHORS   Peng,H., Luo,Y. and Ying,Y.
  TITLE     lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by
            targeting the miR-122-5p/FOXP2 axis
  JOURNAL   Mol Cell Probes 50, 101500 (2020)
   PUBMED   31887421
  REMARK    GeneRIF: lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte
            injury by targeting the miR-122-5p/FOXP2 axis.
REFERENCE   4  (residues 1 to 710)
  AUTHORS   Liu,X., Zhang,R., Wu,Z., Si,W., Ren,Z., Zhang,S., Zhou,J. and
            Chen,D.
  TITLE     miR-134-5p/Foxp2/Syn1 is involved in cognitive impairment in an
            early vascular dementia rat model
  JOURNAL   Int J Mol Med 44 (5), 1729-1740 (2019)
   PUBMED   31545395
  REMARK    GeneRIF: The miR1345p/Foxp2/Syn1 axis was found to contribute to
            cognitive impairment in a chronic ischemiainduced early VD model,
            which may enable the development of new therapeutic strategies for
            the prevention and treatment of VD.
REFERENCE   5  (residues 1 to 710)
  AUTHORS   Stanic,D., Dhingra,R.R. and Dutschmann,M.
  TITLE     Expression of the transcription factor FOXP2 in brainstem
            respiratory circuits of adult rat is restricted to upper-airway
            pre-motor areas
  JOURNAL   Respir Physiol Neurobiol 250, 14-18 (2018)
   PUBMED   29414420
  REMARK    GeneRIF: The results of this study showed that FOXP2 expression in
            respiratory brainstem areas selectively delineates laryngeal and
            hypoglossal pre-motor neuron populations.
REFERENCE   6  (residues 1 to 710)
  AUTHORS   Gauthier,J., Joober,R., Mottron,L., Laurent,S., Fuchs,M., De
            Kimpe,V. and Rouleau,G.A.
  TITLE     Mutation screening of FOXP2 in individuals diagnosed with autistic
            disorder
  JOURNAL   Am J Med Genet A 118A (2), 172-175 (2003)
   PUBMED   12655497
REFERENCE   7  (residues 1 to 710)
  AUTHORS   Wassink,T.H., Piven,J., Vieland,V.J., Pietila,J., Goedken,R.J.,
            Folstein,S.E. and Sheffield,V.C.
  TITLE     Evaluation of FOXP2 as an autism susceptibility gene
  JOURNAL   Am J Med Genet 114 (5), 566-569 (2002)
   PUBMED   12116195
REFERENCE   8  (residues 1 to 710)
  AUTHORS   Watkins,K.E., Vargha-Khadem,F., Ashburner,J., Passingham,R.E.,
            Connelly,A., Friston,K.J., Frackowiak,R.S., Mishkin,M. and
            Gadian,D.G.
  TITLE     MRI analysis of an inherited speech and language disorder:
            structural brain abnormalities
  JOURNAL   Brain 125 (Pt 3), 465-478 (2002)
   PUBMED   11872605
REFERENCE   9  (residues 1 to 710)
  AUTHORS   Lai,C.S., Fisher,S.E., Hurst,J.A., Vargha-Khadem,F. and Monaco,A.P.
  TITLE     A forkhead-domain gene is mutated in a severe speech and language
            disorder
  JOURNAL   Nature 413 (6855), 519-523 (2001)
   PUBMED   11586359
REFERENCE   10 (residues 1 to 710)
  AUTHORS   Shu,W., Yang,H., Zhang,L., Lu,M.M. and Morrisey,E.E.
  TITLE     Characterization of a new subfamily of winged-helix/forkhead (Fox)
            genes that are expressed in the lung and act as transcriptional
            repressors
  JOURNAL   J Biol Chem 276 (29), 27488-27497 (2001)
   PUBMED   11358962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Aug 31, 2012 this sequence version replaced XP_003749748.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360176.2095161.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN14984027, SAMN14984033 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     Protein         1..710
                     /product="forkhead box protein P2"
                     /calculated_mol_wt=79106
     Region          1..44
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CF24.1)"
     Region          272..334
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CF24.1)"
     Region          337..404
                     /region_name="FOXP-CC"
                     /note="FOXP coiled-coil domain; pfam16159"
                     /db_xref="CDD:465036"
     Region          383..404
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CF24.1)"
     Region          417..421
                     /region_name="CTBP1-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CF24.1)"
     Region          433..460
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CF24.1)"
     Region          472..>703
                     /region_name="COG5025"
                     /note="Transcription factor of the Forkhead/HNF3 family
                     [Transcription]"
                     /db_xref="CDD:227358"
     Region          498..579
                     /region_name="FH_FOXP2"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     P2 (FOXP2); cd20065"
                     /db_xref="CDD:410839"
     Site            order(503..510,512,514,518..522,526,528..530,532..533,
                     535..536,538,543..544,546..548,550..551,557,560,566..570,
                     572,575)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:410839"
     Site            order(535,538,542,545,548..549,552,577..578)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410839"
     Region          644..663
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CF24.1)"
     Region          673..710
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CF24.1)"
     CDS             1..710
                     /gene="Foxp2"
                     /gene_synonym="RGD1559697"
                     /coded_by="NM_001271104.1:635..2767"
                     /db_xref="GeneID:500037"
                     /db_xref="RGD:1559697"
ORIGIN      
        1 mmqesateti snssmnqngm stlssqldag srdgrssgdt ssevstvell hlqqqqalqa
       61 arqlllqqqt sglkspkssd kqrplqvpvs vammtpqvit pqqmqqilqq qvlspqqlqa
      121 llqqqqavml qqqqlqefyk kqqeqlhlql lqqqqqqqqq qqqqqqqqqq qqqqqqqqqq
      181 qqqqqqqhpg kqakeqqqqq qqqqlaaqql vfqqqllqmq qlqqqqhlls lqcqglisip
      241 pgqaalpvqs lpqaglspae iqqlwkevtg vhsqedngik hggldlttnn sssttsstts
      301 kasppithhs ivngqssvln arrdssshee tgashtlygh gvckwpgces icedfgqflk
      361 hlnnehaldd rstaqcrvqm qvvqqleiql skererlqam mthlhmrpse pkpspkplnl
      421 vssvtmsknm letspqslpq tpttptapvt pitqgpsvit pasvpnvgai rrrhsdkyni
      481 pmsseiapny efyknadvrp pftyatlirq aimessdrql tlneiyswft rtfayfrrna
      541 atwknavrhn lslhkcfvrv envkgavwtv deveyqkrrs qkitgsptlv kniptslgyg
      601 aalnaslqaa laesslplls npglinnass gllqavhedl ngsldhidsn gnsspgcspq
      661 phihsihvke epviaededc pmslvttanh speleddrei eeeplsedle
//
