LOCUS       NM_001034131            2214 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus forkhead box P1 (Foxp1), mRNA.
ACCESSION   NM_001034131 XM_216227
VERSION     NM_001034131.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2214)
  AUTHORS   Li,C., Pu,Y., Wang,D., Cheng,R., Xu,R., Gong,Q., Jiang,Y., Zhang,C.
            and Chen,Y.
  TITLE     MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to
            Suppress Angiogenesis
  JOURNAL   Int Heart J 65 (2), 300-307 (2024)
   PUBMED   38556338
  REMARK    GeneRIF: MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1
            to Suppress Angiogenesis.
REFERENCE   2  (bases 1 to 2214)
  AUTHORS   Liu,X., Yang,Y., Song,J., Li,D., Liu,X., Li,C., Ma,Z., Zhong,J. and
            Wang,L.
  TITLE     Knockdown of forkhead box protein P1 alleviates hypoxia
            reoxygenation injury in H9c2 cells through regulating
            Pik3ip1/Akt/eNOS and ROS/mPTP pathway
  JOURNAL   Bioengineered 13 (1), 1320-1334 (2022)
   PUBMED   35000528
  REMARK    GeneRIF: Knockdown of forkhead box protein P1 alleviates hypoxia
            reoxygenation injury in H9c2 cells through regulating
            Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
REFERENCE   3  (bases 1 to 2214)
  AUTHORS   Li,Y., Li,X., Wang,L., Han,N. and Yin,G.
  TITLE     miR-375-3p contributes to hypoxia-induced apoptosis by targeting
            forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat
            cardiomyocyte h9c2 cells
  JOURNAL   Biotechnol Lett 43 (2), 353-367 (2021)
   PUBMED   33128129
  REMARK    GeneRIF: miR-375-3p contributes to hypoxia-induced apoptosis by
            targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2)
            in rat cardiomyocyte h9c2 cells.
REFERENCE   4  (bases 1 to 2214)
  AUTHORS   Smith,R.J., Vento,P.J., Chao,Y.S., Good,C.H. and Jhou,T.C.
  TITLE     Gene expression and neurochemical characterization of the
            rostromedial tegmental nucleus (RMTg) in rats and mice
  JOURNAL   Brain Struct Funct 224 (1), 219-238 (2019)
   PUBMED   30302539
  REMARK    GeneRIF: Both Pnoc and FoxP1 were expressed at high levels in the
            rostromedial tegmental nucleus and colocalized strongly with
            previously established RMTg markers. FoxP1 was particularly
            selective for RMTg neurons, as it was absent in most adjacent brain
            regions.
REFERENCE   5  (bases 1 to 2214)
  AUTHORS   Xu,H. and Liu,F.
  TITLE     Downregulation of FOXP1 correlates with tendon stem/progenitor
            cells aging
  JOURNAL   Biochem Biophys Res Commun 504 (1), 96-102 (2018)
   PUBMED   30170733
  REMARK    GeneRIF: The results indicate that FOXP1 plays a crucial role in
            tendon-derived stem/progenitor cell aging.
REFERENCE   6  (bases 1 to 2214)
  AUTHORS   Wang,B., Weidenfeld,J., Lu,M.M., Maika,S., Kuziel,W.A.,
            Morrisey,E.E. and Tucker,P.W.
  TITLE     Foxp1 regulates cardiac outflow tract, endocardial cushion
            morphogenesis and myocyte proliferation and maturation
  JOURNAL   Development 131 (18), 4477-4487 (2004)
   PUBMED   15342473
REFERENCE   7  (bases 1 to 2214)
  AUTHORS   Shi,C., Zhang,X., Chen,Z., Sulaiman,K., Feinberg,M.W.,
            Ballantyne,C.M., Jain,M.K. and Simon,D.I.
  TITLE     Integrin engagement regulates monocyte differentiation through the
            forkhead transcription factor Foxp1
  JOURNAL   J Clin Invest 114 (3), 408-418 (2004)
   PUBMED   15286807
REFERENCE   8  (bases 1 to 2214)
  AUTHORS   Li,S., Weidenfeld,J. and Morrisey,E.E.
  TITLE     Transcriptional and DNA binding activity of the Foxp1/2/4 family is
            modulated by heterotypic and homotypic protein interactions
  JOURNAL   Mol Cell Biol 24 (2), 809-822 (2004)
   PUBMED   14701752
REFERENCE   9  (bases 1 to 2214)
  AUTHORS   Takahashi,K., Liu,F.C., Hirokawa,K. and Takahashi,H.
  TITLE     Expression of Foxp2, a gene involved in speech and language, in the
            developing and adult striatum
  JOURNAL   J Neurosci Res 73 (1), 61-72 (2003)
   PUBMED   12815709
REFERENCE   10 (bases 1 to 2214)
  AUTHORS   Shu,W., Yang,H., Zhang,L., Lu,M.M. and Morrisey,E.E.
  TITLE     Characterization of a new subfamily of winged-helix/forkhead (Fox)
            genes that are expressed in the lung and act as transcriptional
            repressors
  JOURNAL   J Biol Chem 276 (29), 27488-27497 (2001)
   PUBMED   11358962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001034131.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100267.1, SRR21887622.3650210.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000004.1  133353088-133353280 c
            194-391             JAXUCZ010000004.1  133266432-133266629 c
            392-529             JAXUCZ010000004.1  133208068-133208205 c
            530-619             JAXUCZ010000004.1  133206925-133207014 c
            620-779             JAXUCZ010000004.1  133201411-133201570 c
            780-984             JAXUCZ010000004.1  133194803-133195007 c
            985-1089            JAXUCZ010000004.1  133170579-133170683 c
            1090-1177           JAXUCZ010000004.1  133158541-133158628 c
            1178-1261           JAXUCZ010000004.1  133146715-133146798 c
            1262-1463           JAXUCZ010000004.1  133137935-133138136 c
            1464-1543           JAXUCZ010000004.1  133137748-133137827 c
            1544-1645           JAXUCZ010000004.1  133137013-133137114 c
            1646-1767           JAXUCZ010000004.1  133133907-133134028 c
            1768-1837           JAXUCZ010000004.1  133132079-133132148 c
            1838-2004           JAXUCZ010000004.1  133127447-133127613 c
            2005-2214           JAXUCZ010000004.1  133122046-133122255 c
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2214
                     /gene="Foxp1"
                     /note="forkhead box P1"
                     /db_xref="GeneID:297480"
                     /db_xref="RGD:1308669"
     exon            1..193
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..2149
                     /gene="Foxp1"
                     /codon_start=1
                     /product="forkhead box protein P1"
                     /protein_id="NP_001029303.1"
                     /db_xref="GeneID:297480"
                     /db_xref="RGD:1308669"
                     /translation="MMQESGSEAKSNGSTIQNGSSGGNHLLECGTLRDTRSNGEAPAV
                     DLGAADLAHVQQQQQQALQVARQLLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
                     QQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQV
                     LLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQQQQVATQQLAFQQQ
                     LLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAE
                     ETTGSNHSSLDLTSTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSH
                     PLYGHGVCKWPGCEAVCDDFPAFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKD
                     KERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTP
                     VTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLI
                     RQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGA
                     VWTVDEVEFQKRRPQKISGNPSLIKNMQSGHAYCTPLNAALQASMAENSIPLYTTASM
                     GNPTLGSLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPIHVKEEPLDPEEAEGP
                     LSLVTTANHSPDFDHDRDYEDEPVNEDME"
     exon            194..391
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..529
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..619
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..779
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..984
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1089
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1177
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1261
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1463
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1543
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1645
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1767
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1837
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2004
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2214
                     /gene="Foxp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtttttga gtcatgatgc aagaatctgg gtctgaggca aaaagtaacg gatcaaccat
       61 ccagaacggg tccagcggtg gcaaccactt actagagtgc gggacacttc gtgacactcg
      121 gtccaacgga gaggcaccag cggtggacct gggagcagcc gaccttgccc acgtccagca
      181 gcagcagcag caggccctgc aggtggcaag gcagctcctc cttcaacagc agcaacagca
      241 gcagcagcag cagcaacaac aacagcagca gcagcagcaa cagcagcagc agcagcagca
      301 gcagcagcag caacagcagc aacagcaaca acagcagcaa gttagtggat taaagtctcc
      361 gaagaggaat gacaagcaac cagctcttca ggttcccgtg tcagtggcta tgatgacacc
      421 tcaggttatc actcctcaac aaatgcagca gatcctccag cagcaagtgc tgagcccaca
      481 gcagctccag gttctcctcc agcaacagca ggccctcatg cttcaacagc agcagcttca
      541 agaattttac aagaaacaac aggaacagtt gcagcttcaa ctcctccaac agcaacatgc
      601 tggaaaacag ccgaaagagc agcagcagca gcaggtggct acccagcagt tggctttcca
      661 gcagcagctt cttcagatgc agcagctgca gcagcagcac ctcctgtctc tccagcggca
      721 aggccttcta acaattcagc ccgggcagcc tgcccttccc ctccaacctc ttgctcaagg
      781 catgattcca acggaactgc agcagctctg gaaagaagtg acaagtgccc acactgcaga
      841 ggaaaccaca ggcagcaacc acagcagcct agacctgacc agcacatgcg tctcgtcctc
      901 cgcaccttcc aagacctccc taatcatgaa cccacacgcc tctaccaatg gacagctctc
      961 ggtccacacc cccaaaaggg aaagcttgtc ccacgaggag cacccccaca gccaccctct
     1021 ctacggacat ggtgtctgca agtggccagg ctgtgaagca gtttgtgacg acttcccggc
     1081 ctttctaaaa catctcaaca gtgagcatgc gctggacgat agaagcacag ctcaatgtag
     1141 agtacaaatg caggttgtac agcagttaga gctacagctt gcaaaagaca aagagcgcct
     1201 gcaagccatg atgacccacc tgcatgtgaa gtctacagaa cccaaagctg cccctcagcc
     1261 cctgaatctg gtatcaagtg tcaccctctc caagtccgcc tcagaggctt ctccacagag
     1321 cttacctcat actccaacaa ccccaaccgc ccccctgact cccgtcaccc aaggcccctc
     1381 tgtcatcacc accaccagca tgcacacggt gggacctatc cgcaggcggt actcagacaa
     1441 atacaacgtg cccatttctt cagcagatat tgcgcagaac caagaatttt ataagaacgc
     1501 ggaagttaga ccaccattta catatgcatc tttaattagg caggccattc ttgaatctcc
     1561 agaaaagcag ctaacactaa acgaaatcta taactggttc acacgaatgt ttgcttactt
     1621 ccgacgcaat gcagccacgt ggaagaatgc agtgcgtcat aatcttagtc tccacaagtg
     1681 ttttgtgcga gtagagaacg ttaaaggggc agtatggaca gtggatgaag tagagttcca
     1741 aaaacggagg ccacaaaaga tcagtggtaa cccttccctt attaaaaaca tgcagagcgg
     1801 ccacgcctac tgcacacctc tcaatgcagc tttacaggct tccatggctg agaacagtat
     1861 acctctgtac actaccgcct ccatggggaa ccccacgctg ggcagcctgg ccagcgccat
     1921 ccgggaggag ctgaacgggg ccatggagca caccaacagc aacgagagtg acagcagtcc
     1981 aggcagatcc cctatgcaag ctgtgcaccc catacacgtc aaggaggaac ccctcgaccc
     2041 cgaggaagct gaagggcctc tgtccttagt gacaacagcc aaccacagtc cagattttga
     2101 ccacgacaga gattacgaag acgaacctgt aaacgaggac atggagtgaa cccttgggcg
     2161 ggccgacccc cgagaccgaa gattgggaaa gaagcaaaac aaattaaaaa aaaa
//
