LOCUS       NP_001029303             711 aa            linear   ROD 24-JUN-2024
DEFINITION  forkhead box protein P1 [Rattus norvegicus].
ACCESSION   NP_001029303 XP_216227
VERSION     NP_001029303.1
DBSOURCE    REFSEQ: accession NM_001034131.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 711)
  AUTHORS   Li,C., Pu,Y., Wang,D., Cheng,R., Xu,R., Gong,Q., Jiang,Y., Zhang,C.
            and Chen,Y.
  TITLE     MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1 to
            Suppress Angiogenesis
  JOURNAL   Int Heart J 65 (2), 300-307 (2024)
   PUBMED   38556338
  REMARK    GeneRIF: MiR-522-3p Attenuates Cardiac Recovery by Targeting FOXP1
            to Suppress Angiogenesis.
REFERENCE   2  (residues 1 to 711)
  AUTHORS   Liu,X., Yang,Y., Song,J., Li,D., Liu,X., Li,C., Ma,Z., Zhong,J. and
            Wang,L.
  TITLE     Knockdown of forkhead box protein P1 alleviates hypoxia
            reoxygenation injury in H9c2 cells through regulating
            Pik3ip1/Akt/eNOS and ROS/mPTP pathway
  JOURNAL   Bioengineered 13 (1), 1320-1334 (2022)
   PUBMED   35000528
  REMARK    GeneRIF: Knockdown of forkhead box protein P1 alleviates hypoxia
            reoxygenation injury in H9c2 cells through regulating
            Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
REFERENCE   3  (residues 1 to 711)
  AUTHORS   Li,Y., Li,X., Wang,L., Han,N. and Yin,G.
  TITLE     miR-375-3p contributes to hypoxia-induced apoptosis by targeting
            forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat
            cardiomyocyte h9c2 cells
  JOURNAL   Biotechnol Lett 43 (2), 353-367 (2021)
   PUBMED   33128129
  REMARK    GeneRIF: miR-375-3p contributes to hypoxia-induced apoptosis by
            targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2)
            in rat cardiomyocyte h9c2 cells.
REFERENCE   4  (residues 1 to 711)
  AUTHORS   Smith,R.J., Vento,P.J., Chao,Y.S., Good,C.H. and Jhou,T.C.
  TITLE     Gene expression and neurochemical characterization of the
            rostromedial tegmental nucleus (RMTg) in rats and mice
  JOURNAL   Brain Struct Funct 224 (1), 219-238 (2019)
   PUBMED   30302539
  REMARK    GeneRIF: Both Pnoc and FoxP1 were expressed at high levels in the
            rostromedial tegmental nucleus and colocalized strongly with
            previously established RMTg markers. FoxP1 was particularly
            selective for RMTg neurons, as it was absent in most adjacent brain
            regions.
REFERENCE   5  (residues 1 to 711)
  AUTHORS   Xu,H. and Liu,F.
  TITLE     Downregulation of FOXP1 correlates with tendon stem/progenitor
            cells aging
  JOURNAL   Biochem Biophys Res Commun 504 (1), 96-102 (2018)
   PUBMED   30170733
  REMARK    GeneRIF: The results indicate that FOXP1 plays a crucial role in
            tendon-derived stem/progenitor cell aging.
REFERENCE   6  (residues 1 to 711)
  AUTHORS   Wang,B., Weidenfeld,J., Lu,M.M., Maika,S., Kuziel,W.A.,
            Morrisey,E.E. and Tucker,P.W.
  TITLE     Foxp1 regulates cardiac outflow tract, endocardial cushion
            morphogenesis and myocyte proliferation and maturation
  JOURNAL   Development 131 (18), 4477-4487 (2004)
   PUBMED   15342473
REFERENCE   7  (residues 1 to 711)
  AUTHORS   Shi,C., Zhang,X., Chen,Z., Sulaiman,K., Feinberg,M.W.,
            Ballantyne,C.M., Jain,M.K. and Simon,D.I.
  TITLE     Integrin engagement regulates monocyte differentiation through the
            forkhead transcription factor Foxp1
  JOURNAL   J Clin Invest 114 (3), 408-418 (2004)
   PUBMED   15286807
REFERENCE   8  (residues 1 to 711)
  AUTHORS   Li,S., Weidenfeld,J. and Morrisey,E.E.
  TITLE     Transcriptional and DNA binding activity of the Foxp1/2/4 family is
            modulated by heterotypic and homotypic protein interactions
  JOURNAL   Mol Cell Biol 24 (2), 809-822 (2004)
   PUBMED   14701752
REFERENCE   9  (residues 1 to 711)
  AUTHORS   Takahashi,K., Liu,F.C., Hirokawa,K. and Takahashi,H.
  TITLE     Expression of Foxp2, a gene involved in speech and language, in the
            developing and adult striatum
  JOURNAL   J Neurosci Res 73 (1), 61-72 (2003)
   PUBMED   12815709
REFERENCE   10 (residues 1 to 711)
  AUTHORS   Shu,W., Yang,H., Zhang,L., Lu,M.M. and Morrisey,E.E.
  TITLE     Characterization of a new subfamily of winged-helix/forkhead (Fox)
            genes that are expressed in the lung and act as transcriptional
            repressors
  JOURNAL   J Biol Chem 276 (29), 27488-27497 (2001)
   PUBMED   11358962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 14, 2005 this sequence version replaced XP_216227.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100267.1, SRR21887622.3650210.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     Protein         1..711
                     /product="forkhead box protein P1"
                     /calculated_mol_wt=79455
     Region          1..41
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q498D1.1)"
     Site            115
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H334; propagated from
                     UniProtKB/Swiss-Prot (Q498D1.1)"
     Region          273..292
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q498D1.1)"
     Region          305..332
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q498D1.1)"
     Region          336..403
                     /region_name="FOXP-CC"
                     /note="FOXP coiled-coil domain; pfam16159"
                     /db_xref="CDD:465036"
     Region          382..403
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q498D1.1)"
     Region          416..420
                     /region_name="CTBP1-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q498D1.1)"
     Region          424..456
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q498D1.1)"
     Region          471..>685
                     /region_name="COG5025"
                     /note="Transcription factor of the Forkhead/HNF3 family
                     [Transcription]"
                     /db_xref="CDD:227358"
     Region          498..579
                     /region_name="FH_FOXP2"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     P2 (FOXP2); cd20065"
                     /db_xref="CDD:410839"
     Site            order(503..510,512,514,518..522,526,528..530,532..533,
                     535..536,538,543..544,546..548,550..551,557,560,566..570,
                     572,575)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:410839"
     Site            order(535,538,542,545,548..549,552,577..578)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410839"
     Region          645..711
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q498D1.1)"
     Site            687
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H334; propagated from
                     UniProtKB/Swiss-Prot (Q498D1.1)"
     Site            692
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H334; propagated from
                     UniProtKB/Swiss-Prot (Q498D1.1)"
     CDS             1..711
                     /gene="Foxp1"
                     /coded_by="NM_001034131.2:14..2149"
                     /db_xref="GeneID:297480"
                     /db_xref="RGD:1308669"
ORIGIN      
        1 mmqesgseak sngstiqngs sggnhllecg tlrdtrsnge apavdlgaad lahvqqqqqq
       61 alqvarqlll qqqqqqqqqq qqqqqqqqqq qqqqqqqqqq qqqqqqqqqv sglkspkrnd
      121 kqpalqvpvs vammtpqvit pqqmqqilqq qvlspqqlqv llqqqqalml qqqqlqefyk
      181 kqqeqlqlql lqqqhagkqp keqqqqqvat qqlafqqqll qmqqlqqqhl lslqrqgllt
      241 iqpgqpalpl qplaqgmipt elqqlwkevt sahtaeettg snhssldlts tcvsssapsk
      301 tslimnphas tngqlsvhtp kreslsheeh phshplyghg vckwpgceav cddfpaflkh
      361 lnsehalddr staqcrvqmq vvqqlelqla kdkerlqamm thlhvkstep kaapqplnlv
      421 ssvtlsksas easpqslpht pttptapltp vtqgpsvitt tsmhtvgpir rrysdkynvp
      481 issadiaqnq efyknaevrp pftyaslirq ailespekql tlneiynwft rmfayfrrna
      541 atwknavrhn lslhkcfvrv envkgavwtv devefqkrrp qkisgnpsli knmqsghayc
      601 tplnaalqas maensiplyt tasmgnptlg slasaireel ngamehtnsn esdsspgrsp
      661 mqavhpihvk eepldpeeae gplslvttan hspdfdhdrd yedepvnedm e
//
