LOCUS       NM_001399214            3039 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus forkhead box O6 (Foxo6), mRNA.
ACCESSION   NM_001399214 XM_001057233
VERSION     NM_001399214.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3039)
  AUTHORS   Kim,D.H., Lee,S., Noh,S.G., Lee,J. and Chung,H.Y.
  TITLE     FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and
            hyperlipidemia in aged rats fed a high-fat diet
  JOURNAL   Aging (Albany NY) 16 (5), 4095-4115 (2024)
   PUBMED   38441531
  REMARK    GeneRIF: FoxO6-mediated ApoC3 upregulation promotes hepatic
            steatosis and hyperlipidemia in aged rats fed a high-fat diet.
REFERENCE   2  (bases 1 to 3039)
  AUTHORS   Salih,D.A., Rashid,A.J., Colas,D., de la Torre-Ubieta,L., Zhu,R.P.,
            Morgan,A.A., Santo,E.E., Ucar,D., Devarajan,K., Cole,C.J.,
            Madison,D.V., Shamloo,M., Butte,A.J., Bonni,A., Josselyn,S.A. and
            Brunet,A.
  TITLE     FoxO6 regulates memory consolidation and synaptic function
  JOURNAL   Genes Dev 26 (24), 2780-2801 (2012)
   PUBMED   23222102
REFERENCE   3  (bases 1 to 3039)
  AUTHORS   Wen,Q., Duan,X., Liao,R., Little,P., Gao,G., Jiang,H., Lalit,S.,
            Quirion,R. and Zheng,W.
  TITLE     Characterization of intracellular translocation of Forkhead
            transcription factor O (FoxO) members induced by NGF in PC12 cells
  JOURNAL   Neurosci Lett 498 (1), 31-36 (2011)
   PUBMED   21549807
  REMARK    GeneRIF: nerve growth factor could induce the nuclear exclusion of
            FoxO1-GFP and FoxO3a-GFP in PC12 cells with different properties,
            but had no effect on FoxO6-GFP's nuclear localization
REFERENCE   4  (bases 1 to 3039)
  AUTHORS   Jacobs,F.M., van der Heide,L.P., Wijchers,P.J., Burbach,J.P.,
            Hoekman,M.F. and Smidt,M.P.
  TITLE     FoxO6, a novel member of the FoxO class of transcription factors
            with distinct shuttling dynamics
  JOURNAL   J Biol Chem 278 (38), 35959-35967 (2003)
   PUBMED   12857750
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000005.1.
            
            On Jan 4, 2022 this sequence version replaced XM_001057233.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840114
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-917               JAXUCZ010000005.1  139160713-139161629 c
            918-3039            JAXUCZ010000005.1  139141330-139143451 c
FEATURES             Location/Qualifiers
     source          1..3039
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3039
                     /gene="Foxo6"
                     /note="forkhead box O6"
                     /db_xref="GeneID:313558"
                     /db_xref="RGD:1595858"
     exon            1..917
                     /gene="Foxo6"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..2183
                     /gene="Foxo6"
                     /codon_start=1
                     /product="forkhead box protein O6"
                     /protein_id="NP_001386143.1"
                     /db_xref="GeneID:313558"
                     /db_xref="RGD:1595858"
                     /translation="MAAKLRAHQVDVDPDFAPQSRPRSCTWPLPQPDLAGDEDGALGA
                     GVAEGSEDCGPERRATAPAMAPAPPLGAEVGPLRKAKSSRRNAWGNLSYADLITKAIE
                     SAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTG
                     KSSWWMLNPEGGKTGKTPRRRAVSMDNGAKFLRIKGKASKKKQLHLPERSPDDSPPGA
                     PAPGPMSASAKWAASPASHASDDYEAWADFRGSGRPLLGEAAELEDDEALEALAPSSP
                     LMYPSPASALSPALGARCPGELPRLAELGGPLGLHGGGVAGLPDALLDGAQDAYGPRA
                     RAGTPSYFGGCKASAYGGGGGFGPPALGSLRRLPMQTIQENKQASFAPAAAPFRPGAL
                     PALLPPPPPAPRPGPLLGAPGELALAGAAAAYPGKGAAPYAPPAPSRSALAHPISLMT
                     LPGEAGAAGLAPPAHATAFGGPPGGLLLDALPGPYAAAAAGPLGAGPDRFPADLDLDM
                     FSGSLECDVESIILNDFMDSDEMDFNFDSALPPPPPGLAGAPPPNQSWVPG"
     exon            918..3039
                     /gene="Foxo6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtgcagc cggcgctgag cgcggcaggc gcgggagctg gcgctggagc cggagcggcg
       61 gcggcggcgg cggcggcggc attcaccggg cggcggcgcg ggctctggca cgggcttggg
      121 ctccggcatg gtgcaagcga gcctcgtccc gggagagcgg ggcccgcgcg cgggaccggc
      181 gcccgcggag cggcggcagc ggcagtggcg gtggtggctg cgggcacaga caggcggcag
      241 gtgctagaag ctgggctggg cgaggtgtat gcccgctggg ctcccgggcc gccgccccct
      301 cactgcctga gtctttgcct ccctccgtgc tcgccagttc gtccagcccg ctgcctccgc
      361 gccccggccc atggcgcccc gtggttgagt cggcgccgcc agggacccct cccgcgggcc
      421 tccccggggc gcgcagatct cagagccgcg cgcccaccct ccgcggagcc tccctccctg
      481 cctcgcccga gccgggcggg accatggctg cgaagctgcg agcgcatcag gtggacgtgg
      541 acccggactt cgcgccgcag agccggccgc gctcctgtac ctggcctctg ccgcagccgg
      601 acttggccgg cgacgaggac ggggcgctgg gcgcaggagt ggccgagggc tccgaggact
      661 gcgggccgga acgcagggcg acggccccag cgatggcccc agcgccgccg ctgggcgcgg
      721 aggtcggacc gttgcggaaa gcgaagagct cccgacggaa cgcgtggggg aacctttcct
      781 acgccgacct catcaccaaa gccatcgaga gcgccccgga caagagactc acgctctcgc
      841 agatctacga ctggatggtc cgctacgtgc cctacttcaa ggataaaggc gacagcaaca
      901 gctcggccgg ctggaagaac tccatccggc acaacctgtc gctgcacacc cggttcatcc
      961 gcgtgcagaa tgaggggact ggcaaaagtt catggtggat gctgaacccc gagggcggaa
     1021 agacgggcaa gaccccgagg cgccgggccg tgtccatgga caacggggcc aagttcctgc
     1081 gcatcaaggg caaggcgagc aagaagaagc agctgcacct gccagagcgg agcccggacg
     1141 acagccctcc gggcgcaccg gctccagggc ccatgtcagc ctccgccaag tgggccgcca
     1201 gcccggcctc gcatgccagc gacgactacg aggcgtgggc tgacttccgc ggcagcggga
     1261 gacccctgct cggggaggcg gccgagctgg aggacgacga ggccctggag gccctggcac
     1321 cctcctcgcc actcatgtac ccaagccccg cgagcgcgct gtcgcccgcc ctgggcgcgc
     1381 gctgcccggg cgagctgccg cgtctagccg agctgggagg tccgctgggc ctgcacggtg
     1441 gtggcgtggc cgggctgccc gacgccctgc tggacggcgc gcaggacgcg tacgggccgc
     1501 gggcacgcgc cgggaccccc tcctactttg gcggctgcaa ggcgagcgcc tacggcgggg
     1561 gcgggggctt cgggccgcct gctctgggct cgctgcgccg cctgcccatg cagaccatcc
     1621 aggagaacaa gcaggccagc ttcgcgccgg ccgccgcgcc cttccgcccc ggggcgctgc
     1681 ccgcgctgct gccgccgcct ccgcccgcgc cgaggcccgg tccgctgctg ggcgcgcccg
     1741 gggagctggc gctggccggc gcggccgccg cttacccagg caagggagcg gccccgtacg
     1801 cgccgccggc gccctcgcgc agtgccttag cccaccccat cagccttatg acgctgcccg
     1861 gcgaggcggg cgccgccggc ttggccccgc cggcccacgc cacagccttc gggggtccgc
     1921 ctggcggcct cctgctggac gcgctgcctg ggccctacgc ggccgcagca gccgggcctc
     1981 tgggtgcagg accggaccgc ttcccggccg acctggacct cgacatgttc agcgggagcc
     2041 tagagtgtga cgtcgagtcc atcatcctca acgacttcat ggacagcgac gaaatggact
     2101 tcaacttcga ctcagccctg cctccgcctc ccccaggcct ggctggggcg ccgcccccta
     2161 accagagctg ggtgccgggc tgagggccgc cctgcgtggc ctgggtgccc cggtcccgtt
     2221 cccatggggc ctctgtcttc ccatcccgac ccccgggttc ccactccccc gacccagctc
     2281 cactggagga tccaggaggc aaccccagcc cagctggaga catccctccg agctgagcgc
     2341 agagggaggt gggaaggagc ggctgggaca ccttgccagt cctgtccgaa ctcctaagac
     2401 ctcctgctgg ggctggaggc ctgggagaga tggctgaggt ccggctaggt gggagtgggg
     2461 aagatcaagg cggatggccc actgtggatg cttaccctgg aagcccccta cgaagtgggg
     2521 aaagggcatt tctgaacctt cagttcctat tgctgggtcc tttgtgacgc ttaggccacc
     2581 caactccaat ctgattctca aatgacactt tccctcactg gccatagacc caccacacga
     2641 agccagcaac cctctcgttc acacctatct tggtcatcca ttccgctcag tcctctggtc
     2701 ctcagctacc ctctggttca gtctcccatc ttaaccagtc ctggcacctc ctctctcctg
     2761 tcagccaacc ccacactcct tcagtactgg tcacagcctc tccagcgggc ctcagttcca
     2821 gatccatccc ccaattcgac acccctagtc ctggcccttc tctcccatat ttataagtgt
     2881 ccggtcgggg cgggcggtgg gcgcggcgtc cccggcgcat atcgtaggca gtgtactgtg
     2941 gccgtgccgt cagcgtgtgc gtgtgcgtgt gtgccgtgtc gaggccgtgt agagtgcatt
     3001 gtacagcata ttttcatgaa taaaattgtt ttaaatatt
//
