LOCUS       NP_001386143             559 aa            linear   ROD 29-MAR-2024
DEFINITION  forkhead box protein O6 [Rattus norvegicus].
ACCESSION   NP_001386143 XP_001057233
VERSION     NP_001386143.1
DBSOURCE    REFSEQ: accession NM_001399214.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 559)
  AUTHORS   Kim,D.H., Lee,S., Noh,S.G., Lee,J. and Chung,H.Y.
  TITLE     FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and
            hyperlipidemia in aged rats fed a high-fat diet
  JOURNAL   Aging (Albany NY) 16 (5), 4095-4115 (2024)
   PUBMED   38441531
  REMARK    GeneRIF: FoxO6-mediated ApoC3 upregulation promotes hepatic
            steatosis and hyperlipidemia in aged rats fed a high-fat diet.
REFERENCE   2  (residues 1 to 559)
  AUTHORS   Salih,D.A., Rashid,A.J., Colas,D., de la Torre-Ubieta,L., Zhu,R.P.,
            Morgan,A.A., Santo,E.E., Ucar,D., Devarajan,K., Cole,C.J.,
            Madison,D.V., Shamloo,M., Butte,A.J., Bonni,A., Josselyn,S.A. and
            Brunet,A.
  TITLE     FoxO6 regulates memory consolidation and synaptic function
  JOURNAL   Genes Dev 26 (24), 2780-2801 (2012)
   PUBMED   23222102
REFERENCE   3  (residues 1 to 559)
  AUTHORS   Wen,Q., Duan,X., Liao,R., Little,P., Gao,G., Jiang,H., Lalit,S.,
            Quirion,R. and Zheng,W.
  TITLE     Characterization of intracellular translocation of Forkhead
            transcription factor O (FoxO) members induced by NGF in PC12 cells
  JOURNAL   Neurosci Lett 498 (1), 31-36 (2011)
   PUBMED   21549807
  REMARK    GeneRIF: nerve growth factor could induce the nuclear exclusion of
            FoxO1-GFP and FoxO3a-GFP in PC12 cells with different properties,
            but had no effect on FoxO6-GFP's nuclear localization
REFERENCE   4  (residues 1 to 559)
  AUTHORS   Jacobs,F.M., van der Heide,L.P., Wijchers,P.J., Burbach,J.P.,
            Hoekman,M.F. and Smidt,M.P.
  TITLE     FoxO6, a novel member of the FoxO class of transcription factors
            with distinct shuttling dynamics
  JOURNAL   J Biol Chem 278 (38), 35959-35967 (2003)
   PUBMED   12857750
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000005.1.
            
            On Jan 4, 2022 this sequence version replaced XP_001057233.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840114
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..559
                     /product="forkhead box protein O6"
                     /calculated_mol_wt=57296
     Region          89..176
                     /region_name="FH_FOXO6"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     O6 (FOXO6) and similar proteins; cd20063"
                     /db_xref="CDD:410837"
     Site            order(92..93,111,115,139..140,142..143,146,153,162..163,
                     165)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410837"
     Region          358..>377
                     /region_name="FOXO_KIX_bdg"
                     /note="KIX-binding domain of forkhead box O, CR2;
                     pfam16675"
                     /db_xref="CDD:465228"
     Region          499..537
                     /region_name="FOXO-TAD"
                     /note="Transactivation domain of FOXO protein family;
                     pfam16676"
                     /db_xref="CDD:435506"
     CDS             1..559
                     /gene="Foxo6"
                     /coded_by="NM_001399214.1:504..2183"
                     /db_xref="GeneID:313558"
                     /db_xref="RGD:1595858"
ORIGIN      
        1 maaklrahqv dvdpdfapqs rprsctwplp qpdlagdedg algagvaegs edcgperrat
       61 apamapappl gaevgplrka kssrrnawgn lsyadlitka iesapdkrlt lsqiydwmvr
      121 yvpyfkdkgd snssagwkns irhnlslhtr firvqnegtg ksswwmlnpe ggktgktprr
      181 ravsmdngak flrikgkask kkqlhlpers pddsppgapa pgpmsasakw aaspashasd
      241 dyeawadfrg sgrpllgeaa eleddealea lapssplmyp spasalspal garcpgelpr
      301 laelggplgl hgggvaglpd alldgaqday gpraragtps yfggckasay gggggfgppa
      361 lgslrrlpmq tiqenkqasf apaaapfrpg alpallpppp paprpgpllg apgelalaga
      421 aaaypgkgaa pyappapsrs alahpislmt lpgeagaagl appahatafg gppgglllda
      481 lpgpyaaaaa gplgagpdrf padldldmfs gslecdvesi ilndfmdsde mdfnfdsalp
      541 ppppglagap ppnqswvpg
//
