LOCUS       NM_001106943            3159 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus forkhead box O4 (Foxo4), mRNA.
ACCESSION   NM_001106943 XM_001069832 XM_228556
VERSION     NM_001106943.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3159)
  AUTHORS   Kozai,K., Moreno-Irusta,A., Iqbal,K., Winchester,M.L., Scott,R.L.,
            Simon,M.E., Muto,M., Parrish,M.R. and Soares,M.J.
  TITLE     The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation
  JOURNAL   Development 150 (2) (2023)
   PUBMED   36607602
  REMARK    GeneRIF: The AKT1-FOXO4 axis reciprocally regulates hemochorial
            placentation.
REFERENCE   2  (bases 1 to 3159)
  AUTHORS   Galley,J.C., Miller,M.P., Sanker,S., Liu,M., Sharina,I., Martin,E.,
            Gomez,D. and Straub,A.C.
  TITLE     FoxO4 controls sGCbeta transcription in vascular smooth muscle
  JOURNAL   Am J Physiol Heart Circ Physiol 322 (3), H417-H426 (2022)
   PUBMED   35089807
  REMARK    GeneRIF: FoxO4 controls sGCbeta transcription in vascular smooth
            muscle.
REFERENCE   3  (bases 1 to 3159)
  AUTHORS   Wu,J., Zhang,H., Deng,R., Xing,L., Hu,M. and Fu,X.
  TITLE     Interleukin-Ibeta promotes cartilage degeneration by regulating
            forkhead box protein O4 and type collagen
  JOURNAL   Mol Med Rep 24 (5) (2021)
   PUBMED   34549304
  REMARK    GeneRIF: InterleukinIbeta promotes cartilage degeneration by
            regulating forkhead box protein O4 and type collagen.
REFERENCE   4  (bases 1 to 3159)
  AUTHORS   Huang,J., Liu,Y., Wang,M., Wang,R., Ling,H. and Yang,Y.
  TITLE     FoxO4 negatively modulates USP10 transcription to aggravate the
            apoptosis and oxidative stress of hypoxia/reoxygenation-induced
            cardiomyocytes by regulating the Hippo/YAP pathway
  JOURNAL   J Bioenerg Biomembr 53 (5), 541-551 (2021)
   PUBMED   34251583
  REMARK    GeneRIF: FoxO4 negatively modulates USP10 transcription to
            aggravate the apoptosis and oxidative stress of
            hypoxia/reoxygenation-induced cardiomyocytes by regulating the
            Hippo/YAP pathway.
REFERENCE   5  (bases 1 to 3159)
  AUTHORS   Wang,J., Hao,D., Zeng,L., Zhang,Q. and Huang,W.
  TITLE     Neuropeptide Y mediates cardiac hypertrophy through
            microRNA-216b/FoxO4 signaling pathway
  JOURNAL   Int J Med Sci 18 (1), 18-28 (2021)
   PUBMED   33390770
  REMARK    GeneRIF: Neuropeptide Y mediates cardiac hypertrophy through
            microRNA-216b/FoxO4 signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3159)
  AUTHORS   Furukawa-Hibi,Y., Yoshida-Araki,K., Ohta,T., Ikeda,K. and
            Motoyama,N.
  TITLE     FOXO forkhead transcription factors induce G(2)-M checkpoint in
            response to oxidative stress
  JOURNAL   J Biol Chem 277 (30), 26729-26732 (2002)
   PUBMED   12048180
REFERENCE   7  (bases 1 to 3159)
  AUTHORS   De Ruiter,N.D., Burgering,B.M. and Bos,J.L.
  TITLE     Regulation of the Forkhead transcription factor AFX by
            Ral-dependent phosphorylation of threonines 447 and 451
  JOURNAL   Mol Cell Biol 21 (23), 8225-8235 (2001)
   PUBMED   11689711
REFERENCE   8  (bases 1 to 3159)
  AUTHORS   Biggs,W.H. 3rd, Cavenee,W.K. and Arden,K.C.
  TITLE     Identification and characterization of members of the FKHR (FOX O)
            subclass of winged-helix transcription factors in the mouse
  JOURNAL   Mamm Genome 12 (6), 416-425 (2001)
   PUBMED   11353388
REFERENCE   9  (bases 1 to 3159)
  AUTHORS   Medema,R.H., Kops,G.J., Bos,J.L. and Burgering,B.M.
  TITLE     AFX-like Forkhead transcription factors mediate cell-cycle
            regulation by Ras and PKB through p27kip1
  JOURNAL   Nature 404 (6779), 782-787 (2000)
   PUBMED   10783894
REFERENCE   10 (bases 1 to 3159)
  AUTHORS   Kops,G.J., de Ruiter,N.D., De Vries-Smits,A.M., Powell,D.R.,
            Bos,J.L. and Burgering,B.M.
  TITLE     Direct control of the Forkhead transcription factor AFX by protein
            kinase B
  JOURNAL   Nature 398 (6728), 630-634 (1999)
   PUBMED   10217147
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473966.2.
            
            [WARNING] On Oct 16, 2024 this sequence was replaced by
            NM_001106943.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001069832.1, XM_228556.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..3159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..3159
                     /gene="Foxo4"
                     /gene_synonym="RGD1561201"
                     /note="forkhead box O4"
                     /db_xref="GeneID:302415"
                     /db_xref="RGD:1561201"
     exon            1..46
                     /gene="Foxo4"
                     /gene_synonym="RGD1561201"
                     /inference="alignment:Splign:2.1.0"
     exon            47..595
                     /gene="Foxo4"
                     /gene_synonym="RGD1561201"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1660
                     /gene="Foxo4"
                     /gene_synonym="RGD1561201"
                     /codon_start=1
                     /product="forkhead box protein O4"
                     /protein_id="NP_001100413.1"
                     /db_xref="GeneID:302415"
                     /db_xref="RGD:1561201"
                     /translation="MEPENKKSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPELATEP
                     PEPSEVEPSLGQKVPTEGHSEPTLLPSRLPEPAGGPQPEILGAVTGPRKGGSRRNAWG
                     NQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSL
                     HSKFIKVHNEATGKSSWWMLNPDGGKGGKAPRRRAASMDSSSKLLRGRSKGPKKKPSV
                     LPAPPEGATPRSPLGHFAKWSSSPCPRNREEADVWTTFRPRSSSNASTVSTRLSPMRP
                     ESEVLAEEEMPASASSYAGGVPPTLSEDLELLDGLNLASPHSLLSRSNLSSFSLQHPG
                     LAGPLHSYGASLFGPIDGSLSAGEGCFSSSQSLEALLTSDTPPPPADVLMTQVDPILS
                     QAPTLLLLGGMPSSSKLATGVSLCPTPLEGPGPSNLVPTLSVMAPPPVMPGAPIPKVL
                     GTPVLASPTEDFSHDRMPQDLDLDMYMENLECDMDNIISDLMDGEGLDFNFEPDP"
     exon            596..1652
                     /gene="Foxo4"
                     /gene_synonym="RGD1561201"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..3159
                     /gene="Foxo4"
                     /gene_synonym="RGD1561201"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcaggtt taaaagagca ggaagctgag tgagagggtg cagaaaaact ggaaagaatg
       61 tgtttccccc cttgggggag gcatggtgag ggactgtggc aggctccact gaacgctgag
      121 ctgcagaggt tcgaccccac gtatggagcc agagaataag aagtcagcca cagaggctgc
      181 cgcgatcata gacctcgatc ccgacttcga accccagagc cgtccgcggt cctgcacctg
      241 gccccttcct cgaccagagc tcgctacgga gccacccgaa ccgtccgagg tggagcccag
      301 tctgggacag aaggtaccca cggagggaca ctccgaaccg accctgttgc cctctcggct
      361 cccagagccg gcagggggcc cccagccgga aatcctgggg gctgtaacag gtcctcggaa
      421 gggaggctcc cgccggaatg cctggggaaa tcagtcatat gcagaactca tcagccaggc
      481 cattgaaagc gccccggaga agcggctgac actcgcccag atatacgaat ggatggtccg
      541 cacggtgccc tacttcaagg acaagggtga cagcaacagc tcggcaggat ggaagaactc
      601 catccgtcac aacctgtctt tgcacagcaa gttcatcaag gtacataacg aggccaccgg
      661 caagagctct tggtggatgc tgaaccccga tggcggcaag ggtggcaagg caccccggcg
      721 cagggctgcc tccatggata gcagcagcaa gctgctccgg ggccgcagca aaggccccaa
      781 gaagaagcca tctgtcctgc cagctccacc tgaaggtgcc actccaagga gccctctggg
      841 ccactttgcc aagtggtcga gcagtccttg tcctcgaaat cgagaagaag ctgatgtgtg
      901 gaccactttc cgtccacgaa gcagttcaaa tgctagcact gtcagcactc ggctgtcccc
      961 aatgaggccg gagtctgagg tgctagcaga agaggaaatg ccagcctcag ccagcagcta
     1021 tgcagggggt gtccctccca ccctcagtga agatctagag ctgctggatg ggctcaatct
     1081 tgcatctccc cattccttgc tgtccaggag caatctctcc agcttctctt tgcagcatcc
     1141 tgggcttgct ggccccttac atagctatgg cgcctccctc tttggcccaa tagatgggtc
     1201 tttgtcagca ggagaagggt gcttctcgag ttcccagtct ctagaggctc tgctcacctc
     1261 tgatacacca ccacctcctg ctgatgttct catgacccag gtagatccta tcctgtctca
     1321 ggctcctaca cttctgttac tgggaggaat gccttcctct agcaagctgg ccacaggagt
     1381 cagcctgtgt cctacgccgc tagagggtcc tggtcccagc aacctggttc ccaccctttc
     1441 tgtgatggca ccacctccag tcatgccagg tgctcccatc cctaaggtcc tgggaacccc
     1501 tgtgcttgca tctcctactg aagatttcag ccatgacaga atgcctcagg atctggatct
     1561 tgatatgtac atggagaacc tggagtgtga catggataac atcatcagtg acctcatgga
     1621 tggtgaggga ctggacttca actttgagcc agatccctga gtcacagcaa gaagctttgt
     1681 cccctgcttc agaggtggag ccggagccga gcctgtcctt atccactttt cccccttgag
     1741 ccctccccag gagtctggga ccctacgtta gagctaggga taggtggtca cacactcaag
     1801 tgttgaggaa attataaaga tacatcaatg acagtaggga ttgtgaagga gggtgatggg
     1861 aggaaggagg gaaaggctta ttctcactgt gccaattagg gggtaattat ggtcctttct
     1921 caggggccac cattgatttc cccattacac ctcctaggcc ttgaagcagg ggccagcaat
     1981 gctgttggaa atgtgaagtc accagtggcc ttattaccct gcctttggga gcaggatcat
     2041 tattattatt attattattt ttggtagaga gagtcttact agagctgggc caggctgggt
     2101 tgagcctgga tttttatgca gtggggtggg tgggtggggg ttggggacct agaagggcca
     2161 agttttgagc actggagtgg ctcaccaggc caaatcactt ttgaaaggat gcagataaca
     2221 gacaggcttt ttataaactt ttaaagaaat ataaacacaa atatagagat ttttaacagt
     2281 ggtgaggtgc tagtgagggg gagaaggctt tttttctttc cgaaggcttt gtcatagtga
     2341 catgatacaa acactacaga ctcttacgga ggagacacag gaagctaggg aaaggtgggt
     2401 agcaagagtg actggaagga agcgttcccc cttggaccag gtctagaaaa agctctatac
     2461 atagttttaa gcacagaaac ctaagccagg tctctgcatt ctgtccacta gtgcctagaa
     2521 gagggtgctg ttgtggggca agcacactct tgtttcacca gtgcgggtta gtgctcccag
     2581 agagagcatc caaagcctga aattggcttg gggcctggga ggggcgtgaa agaaggaagg
     2641 atttagggta gtaaagttag gtacagagac ctccctgttc aaggcctggg acagctgtcc
     2701 ctgcccttct tcccagtcct ggtctgccag ggttatgtga agaccatagt ggcaggcagg
     2761 gttgtgggga ggaacaggga agggggagct tggggagttt ggctgagggt ctgggaaatg
     2821 agcagggatg gggggaatgt ggatcaggtt tactagcacc tgccagagag gccatctggg
     2881 gctcctccac cccagccccc aagcagcccc tcccccagcg ccctttgcat tgtcccctcc
     2941 cccactcctg ctgtgggttc ccatcatttc ctgtgtcagc gcctggccta cccagattgt
     3001 atcatgtgct agattggagt ggggaagtgt gtcaaatcaa taagtgagtt caataaatgt
     3061 ctataatcag atctggtttc tggtttctgc tgccttgctg cccccctcca atatggggga
     3121 gggagagagg cggaaagtcg aagggcagtt agttgactg
//
