LOCUS       NM_001106395            2885 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Rattus norvegicus forkhead box O3 (Foxo3), mRNA.
ACCESSION   NM_001106395 XM_001069121 XM_215421
VERSION     NM_001106395.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2885)
  AUTHORS   Zhang,P., Li,H., Zhang,A., Wang,X., Song,Q., Li,Z., Wang,W., Xu,J.,
            Hou,Y. and Zhang,Y.
  TITLE     Mechanism of myocardial fibrosis regulation by IGF-1R in atrial
            fibrillation through the PI3K/Akt/FoxO3a pathway
  JOURNAL   Biochem Cell Biol 101 (5), 432-442 (2023)
   PUBMED   37018819
  REMARK    GeneRIF: Mechanism of myocardial fibrosis regulation by IGF-1R in
            atrial fibrillation through the PI3K/Akt/FoxO3a pathway.
REFERENCE   2  (bases 1 to 2885)
  AUTHORS   Song,R., Wang,P., Yang,L., Liu,J., Chen,Z. and Ding,Y.
  TITLE     Association of FOXO3A with right ventricular myocardial fibrosis
            and its detection by speckle-tracking echocardiography in pulmonary
            hypertension
  JOURNAL   Echocardiography 40 (9), 958-968 (2023)
   PUBMED   37534549
  REMARK    GeneRIF: Association of FOXO3A with right ventricular myocardial
            fibrosis and its detection by speckle-tracking echocardiography in
            pulmonary hypertension.
REFERENCE   3  (bases 1 to 2885)
  AUTHORS   Findik,D.G., Kaplanoglu,G.T., Arik,G.N. and Alemari,N.B.A.
  TITLE     Decreased growth differentiation factor 9, bone morphogenetic
            protein 15, and forkhead box O3a expressions in the ovary via
            ulipristal acetate
  JOURNAL   Rev Assoc Med Bras (1992) 69 (8), e20230381 (2023)
   PUBMED   37585996
  REMARK    GeneRIF: Decreased growth differentiation factor 9, bone
            morphogenetic protein 15, and forkhead box O3a expressions in the
            ovary via ulipristal acetate.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2885)
  AUTHORS   Zhong,S., Chen,W., Wang,B., Gao,C., Liu,X., Song,Y., Qi,H., Liu,H.,
            Wu,T., Wang,R. and Chen,B.
  TITLE     Energy stress modulation of AMPK/FoxO3 signaling inhibits
            mitochondria-associated ferroptosis
  JOURNAL   Redox Biol 63, 102760 (2023)
   PUBMED   37267686
  REMARK    GeneRIF: Energy stress modulation of AMPK/FoxO3 signaling inhibits
            mitochondria-associated ferroptosis.
REFERENCE   5  (bases 1 to 2885)
  AUTHORS   Anamika, Roy,A. and Trigun,S.K.
  TITLE     Hippocampus mitochondrial MnSOD activation by a SIRT3 activator,
            honokiol, correlates with its deacetylation and upregulation of
            FoxO3a and PGC1alpha in a rat model of ammonia neurotoxicity
  JOURNAL   J Cell Biochem 124 (4), 606-618 (2023)
   PUBMED   36922709
  REMARK    GeneRIF: Hippocampus mitochondrial MnSOD activation by a SIRT3
            activator, honokiol, correlates with its deacetylation and
            upregulation of FoxO3a and PGC1alpha in a rat model of ammonia
            neurotoxicity.
REFERENCE   6  (bases 1 to 2885)
  AUTHORS   Nadal,A., Marrero,P.F. and Haro,D.
  TITLE     Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA
            synthase gene by insulin: the role of the forkhead transcription
            factor FKHRL1
  JOURNAL   Biochem J 366 (Pt 1), 289-297 (2002)
   PUBMED   12027802
  REMARK    GeneRIF: FKHRL1 role in downregulation of HMG-CoA synthase.
REFERENCE   7  (bases 1 to 2885)
  AUTHORS   Tran,H., Brunet,A., Grenier,J.M., Datta,S.R., Fornace,A.J. Jr.,
            DiStefano,P.S., Chiang,L.W. and Greenberg,M.E.
  TITLE     DNA repair pathway stimulated by the forkhead transcription factor
            FOXO3a through the Gadd45 protein
  JOURNAL   Science 296 (5567), 530-534 (2002)
   PUBMED   11964479
  REMARK    GeneRIF: role for FOXO3a in inducing a delay in the G2-M phase in
            response to stress stimuli during which it contributes to the
            repair of damaged DNA by a Gadd45a-dependent mechanism.
REFERENCE   8  (bases 1 to 2885)
  AUTHORS   Richards,J.S., Sharma,S.C., Falender,A.E. and Lo,Y.H.
  TITLE     Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary:
            evidence for regulation by IGF-I, estrogen, and the gonadotropins
  JOURNAL   Mol Endocrinol 16 (3), 580-599 (2002)
   PUBMED   11875118
  REMARK    GeneRIF: as a target of FSH, E2 and IGF-I signaling in granulosa
            cells, FKHR likely coordinates numerous cell survival mechanisms.
REFERENCE   9  (bases 1 to 2885)
  AUTHORS   Biggs,W.H. 3rd, Cavenee,W.K. and Arden,K.C.
  TITLE     Identification and characterization of members of the FKHR (FOX O)
            subclass of winged-helix transcription factors in the mouse
  JOURNAL   Mamm Genome 12 (6), 416-425 (2001)
   PUBMED   11353388
REFERENCE   10 (bases 1 to 2885)
  AUTHORS   Brunet,A., Bonni,A., Zigmond,M.J., Lin,M.Z., Juo,P., Hu,L.S.,
            Anderson,M.J., Arden,K.C., Blenis,J. and Greenberg,M.E.
  TITLE     Akt promotes cell survival by phosphorylating and inhibiting a
            Forkhead transcription factor
  JOURNAL   Cell 96 (6), 857-868 (1999)
   PUBMED   10102273
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474025.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215421.4, XM_001069121.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12-q13"
     gene            1..2885
                     /gene="Foxo3"
                     /gene_synonym="Fkhrl1; Foxo3a"
                     /note="forkhead box O3"
                     /db_xref="GeneID:294515"
                     /db_xref="RGD:1309196"
     exon            1..217
                     /gene="Foxo3"
                     /gene_synonym="Fkhrl1; Foxo3a"
                     /inference="alignment:Splign:2.1.0"
     exon            218..947
                     /gene="Foxo3"
                     /gene_synonym="Fkhrl1; Foxo3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..2348
                     /gene="Foxo3"
                     /gene_synonym="Fkhrl1; Foxo3a"
                     /note="forkhead box O3a"
                     /codon_start=1
                     /product="forkhead box protein O3"
                     /protein_id="NP_001099865.1"
                     /db_xref="GeneID:294515"
                     /db_xref="RGD:1309196"
                     /translation="MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
                     AKPSGETAADSMIPEEDDDEDDEDSGGRGSSAMVIGGGVSSALGSGLLLEDSARLLSP
                     GGQDLGTGPASSAGALSGGTQTQLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLS
                     YADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSR
                     FMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQAA
                     PESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPILASTELDD
                     VQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDLLDN
                     IALPPSQASPPGGLMQRSSSFPYTAKSSGLGSPTSSFNSTVFGPASLNSLRQSPMQTI
                     QENRPATFSSVSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNV
                     MLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGS
                     AKHQQQSPVSQSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDME
                     SIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG"
     exon            948..2383
                     /gene="Foxo3"
                     /gene_synonym="Fkhrl1; Foxo3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2885
                     /gene="Foxo3"
                     /gene_synonym="Fkhrl1; Foxo3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccctgcg agtgtctata actttgtgct gctgccgcgg ccgccctgct cgtggaaggg
       61 aggaggagga atgtggaagg cggcggcgca gcacaggctg acaggcggtt cctccggcgg
      121 gctgcggcgg cggcccgagc gtcccctcgt cgcggtgccc tgggctcgcg cggaatcgta
      181 cgccctcccg cctcgtccct gaagggaagg agccgaggta gctggagctc gagccttcgc
      241 ggcgccctgt ccctcccccg ccgcacccag cctgggcgcg agaggagaga gcaagagccc
      301 aagccgcggg cggcgggcag gcagcgaaga tggcagaggc accagcctcc ccggtcccgc
      361 tctctccgct cgaagtggag ctggacccag agttcgagcc acagagtcgg ccacgctcct
      421 gtacgtggcc cctgcagagg ccggagctgc aggcgagccc ggccaagccc tcgggggaga
      481 cggcggcaga ctccatgatc cccgaggagg acgacgatga agacgacgag gacagcggcg
      541 gccgaggcag ctcggccatg gtgatcggtg gcggcgtgag cagtgcgctg ggctccgggc
      601 tgctcctcga agattcggcc aggctgctgt ctcccggagg gcaggacctc gggacggggc
      661 cagcgtcctc cgcaggcgcg ctgagtgggg gcacgcagac gcagctgcag cctcagcagc
      721 cactgccacc gccgcagccg ggggcggctg ggggctctgg gcaaccgagg aaatgctcct
      781 cgcggcggaa tgcctggggg aacctgtcct acgctgacct gatcacccgc gccatcgaga
      841 gctccccgga caaacggctc actttgtccc agatctacga gtggatggtg cgctgtgtgc
      901 cctacttcaa ggataagggc gacagcaaca gctctgcggg ctggaagaac tccatccgcc
      961 acaacctgtc actgcacagc cgtttcatgc gggttcagaa cgaagggact ggcaagagct
     1021 cttggtggat catcaacccc gatgggggaa agagtgggaa ggctccccgg cggcgggccg
     1081 tctccatgga caacagcaac aagtacacca agagccgagg ccgggcagcc aagaagaagg
     1141 cggccctgca ggctgcccca gagtcggcag acgacagccc ttcccaactc tccaagtggc
     1201 cgggcagccc cacatcccgc agcagcgacg agctggacgc ctggaccgac ttccgctcgc
     1261 gcaccaattc caacgccagc accgtgagcg gccgcctgtc acccatcttg gcgagcacgg
     1321 agctggatga cgtccaggac gatgacgggc ccctctcccc catgctctac agcagctctg
     1381 ccagcctgtc gccttccgta agcaagccgt gtaccgtgga gctgccgcgg ctgactgaca
     1441 tggcgggcac catgaatctg aacgatgggc tggccgagaa cctcatggat gacctgctag
     1501 ataacatcgc gctcccgccc tcccaggcgt cgcctcctgg cgggcttatg cagcggagct
     1561 ccagcttccc gtacaccgcc aagagctccg gcctgggctc cccaaccagc tcctttaaca
     1621 gtaccgtgtt cggacctgcg tcactcaact ccctgcgcca gtcgcccatg cagaccatcc
     1681 aggagaacag accagccacc ttttcttccg tgtcgcacta cggcaaccag acactccaag
     1741 acctgctcac ttcggactcg ctcagccaca gcgatgtcat gatgacccag tcagacccct
     1801 tgatgtctca ggctagcacc gctgtgtccg cccagaacgc ccgccggaac gtgatgcttc
     1861 gcaacgaccc aatgatgtcc tttgccgccc agcctaccca ggggagtttg gtcaatcaga
     1921 acttgctcca ccaccagcac caaacccagg gcgctcttgg tggcagccgt gccttgtcaa
     1981 attctgtcag caacatgggc ttgagtgact ccagcagcct cggctcagcc aaacaccagc
     2041 agcagtctcc cgtcagccag tctatgcaaa ccctctcgga ctctctctca ggctcctcac
     2101 tgtattcagc cagtgcaaac cttcccgtca tgggtcacga caagttcccc agtgacttgg
     2161 acctggacat gttcaatggg agcttggagt gtgacatgga gtccatcatc cgtagcgaac
     2221 tcatggatgc cgatgggttg gattttaact ttgactccct catctccaca cagaacgttg
     2281 ttggtttgaa cgtggggaac ttcactggtg ctaagcaggc ctcatctcaa agctgggtgc
     2341 caggctgaag gatcactgag gaaaggggaa atgggcaaag cagaccctca aactgaccga
     2401 agacctacag agaaaaaaac cctttgccaa atctgctctc agccagtgga cagtgaaccc
     2461 cgtttacagc ttgacacctt tgtgactccc acgccatctt cctaacccag cagagactgt
     2521 tagcagccct ggccctgggt gaagcccttt cccgtggagc agaactctat aacgtatgca
     2581 aatctaactc atctgcaagt gacctgccat cgtggacagc acccatcagc atccctactc
     2641 cagagcacac cgggagcccc ggctgcggcg attccgtact gtttcaggat cgtgatggtt
     2701 taggggatat tttaagtgtc attttgtgtt tgtttccttt gaccctcttg agttttttta
     2761 cacacagtaa cctgcagtat ttttctgttg aaaacgttga ctgtcctttc cctagcacac
     2821 ttaaaaagca gaaggaaggt gttgtgtcag ttcccagtct gagcttttga gcctgtggaa
     2881 ctccg
//
