LOCUS       NM_001191846            2560 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus forkhead box O1 (Foxo1), mRNA.
ACCESSION   NM_001191846 XM_342244
VERSION     NM_001191846.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Wu,D., Lin,Y., Yang,M., Li,H., Wang,W., Wu,Q., Chen,M., Shao,N. and
            Deng,C.
  TITLE     Tissue factor regulates autophagy in pulmonary artery endothelial
            cells from chronic thromboembolic pulmonary hypertension rats via
            the p38 MAPK-FoxO1 pathway
  JOURNAL   Respir Res 25 (1), 261 (2024)
   PUBMED   38943142
  REMARK    GeneRIF: Tissue factor regulates autophagy in pulmonary artery
            endothelial cells from chronic thromboembolic pulmonary
            hypertension rats via the p38 MAPK-FoxO1 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Kamal,M.M., Ammar,R.A. and Kassem,D.H.
  TITLE     Silencing of forkhead box protein O-1 (FOXO-1) enhances
            insulin-producing cell generation from adipose mesenchymal stem
            cells for diabetes therapy
  JOURNAL   Life Sci 344, 122579 (2024)
   PUBMED   38518842
  REMARK    GeneRIF: Silencing of forkhead box protein O-1 (FOXO-1) enhances
            insulin-producing cell generation from adipose mesenchymal stem
            cells for diabetes therapy.
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Ma,Y.R., Gao,W., Wang,H.Q., Zhao,P.S., Zhang,Y.X., Wei,F.H.,
            Jiang,H., Zhang,J.B., Yuan,B. and Gao,F.
  TITLE     EGF-driven EGFR/miR-27b-3p/FOXO1 promotes rat FSH synthesis and
            secretion
  JOURNAL   FASEB J 38 (4), e23469 (2024)
   PUBMED   38358361
  REMARK    GeneRIF: EGF-driven EGFR/miR-27b-3p/FOXO1 promotes rat FSH
            synthesis and secretion.
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Fu,P., Zhu,R., Gao,W. and Gong,L.
  TITLE     Effects of resistance training on alleviating hypoxia-induced
            muscle atrophy: Focus on acetylation of FoxO1
  JOURNAL   J Cell Mol Med 28 (3), e18096 (2024)
   PUBMED   38149787
  REMARK    GeneRIF: Effects of resistance training on alleviating
            hypoxia-induced muscle atrophy: Focus on acetylation of FoxO1.
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Huang,X., Luo,X., Huang,S., Chen,X. and Qiu,L.
  TITLE     Inhibition of FoxO1 alleviates polycystic ovarian syndrome by
            reducing inflammation and the immune response
  JOURNAL   Funct Integr Genomics 24 (1), 6 (2024)
   PUBMED   38189995
  REMARK    GeneRIF: Inhibition of FoxO1 alleviates polycystic ovarian syndrome
            by reducing inflammation and the immune response.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Woods,Y.L., Rena,G., Morrice,N., Barthel,A., Becker,W., Guo,S.,
            Unterman,T.G. and Cohen,P.
  TITLE     The kinase DYRK1A phosphorylates the transcription factor FKHR at
            Ser329 in vitro, a novel in vivo phosphorylation site
  JOURNAL   Biochem J 355 (Pt 3), 597-607 (2001)
   PUBMED   11311120
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Rena,G., Prescott,A.R., Guo,S., Cohen,P. and Unterman,T.G.
  TITLE     Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation
            sites in regulating 14-3-3 binding, transactivation and nuclear
            targetting
  JOURNAL   Biochem J 354 (Pt 3), 605-612 (2001)
   PUBMED   11237865
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Schmoll,D., Walker,K.S., Alessi,D.R., Grempler,R., Burchell,A.,
            Guo,S., Walther,R. and Unterman,T.G.
  TITLE     Regulation of glucose-6-phosphatase gene expression by protein
            kinase Balpha and the forkhead transcription factor FKHR. Evidence
            for insulin response unit-dependent and -independent effects of
            insulin on promoter activity
  JOURNAL   J Biol Chem 275 (46), 36324-36333 (2000)
   PUBMED   10960473
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Margue,C.M., Bernasconi,M., Barr,F.G. and Schafer,B.W.
  TITLE     Transcriptional modulation of the anti-apoptotic protein BCL-XL by
            the paired box transcription factors PAX3 and PAX3/FKHR
  JOURNAL   Oncogene 19 (25), 2921-2929 (2000)
   PUBMED   10871843
REFERENCE   10 (bases 1 to 2560)
  AUTHORS   Fredericks,W.J., Galili,N., Mukhopadhyay,S., Rovera,G.,
            Bennicelli,J., Barr,F.G. and Rauscher,F.J. 3rd.
  TITLE     The PAX3-FKHR fusion protein created by the t(2;13) translocation
            in alveolar rhabdomyosarcomas is a more potent transcriptional
            activator than PAX3
  JOURNAL   Mol Cell Biol 15 (3), 1522-1535 (1995)
   PUBMED   7862145
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 3, 2021 this sequence version replaced NM_001191846.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.8908.1,
                                           SRR26643298.10907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-717               JAXUCZ010000002.1  138462974-138463690
            718-2069            JAXUCZ010000002.1  138536145-138537496
            2070-2560           JAXUCZ010000002.1  138538117-138538607
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..2560
                     /gene="Foxo1"
                     /gene_synonym="Fkhr; Foxo1a"
                     /note="forkhead box O1"
                     /db_xref="GeneID:84482"
                     /db_xref="RGD:620283"
     exon            1..717
                     /gene="Foxo1"
                     /gene_synonym="Fkhr; Foxo1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2055
                     /gene="Foxo1"
                     /gene_synonym="Fkhr; Foxo1a"
                     /note="forkhead box O1A (rhabdomyosarcoma); Forkhead box
                     protein O1A; Forkhead in rhabdomyosarcoma"
                     /codon_start=1
                     /product="forkhead box protein O1"
                     /protein_id="NP_001178775.1"
                     /db_xref="GeneID:84482"
                     /db_xref="RGD:620283"
                     /translation="MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAP
                     SGSTAANPDATASLASASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAASRGLCG
                     DFQGPEAGCVHSAPPQPPPTGPLSQPPPVPPAAAGPLAGQPRKTSSSRRNAWGNLSYA
                     DLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFI
                     RVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQE
                     GPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGD
                     GDVHSLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGSM
                     MQQTPCYSFAPPNTSLNSPSPNYAKYTYGQSSMSPVPQMPMQTLQDSKSSYGGLNQYN
                     CAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVLMGPNSVMPAYGSQAPHN
                     KMMNPSSHTHPGHAQQTSSVNGRALPHVVNTMPHTSAMNRLTPVKTPLQVPLSHPMQM
                     SALGNYSSVSSCNGYGRMGVLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDF
                     NFDNVLPNQSFPHSVKTTTHSWVSG"
     exon            718..2069
                     /gene="Foxo1"
                     /gene_synonym="Fkhr; Foxo1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2560
                     /gene="Foxo1"
                     /gene_synonym="Fkhr; Foxo1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgcggccc ccaatctcgg agcgacactc cgagcgccgg ctccgcgccc ccggtggccg
       61 cgtctcctgg tactctctgc tggtggggga ggggcggggg gcaccatggc cgaagcgcct
      121 caggtggtgg agaccgaccc ggacttcgag ccgctgcctc ggcagcgctc ctgcacctgg
      181 ccgctgccca ggccggagtt taaccagtcc aactcgacca cctccagccc ggcgccgtcg
      241 ggcagcacgg ccgccaaccc cgacgccacg gcgagcctgg cctcggcgtc cgctgtcagc
      301 accgacttta tgagcaacct gagcctgcta gaagagagcg aggacttcgc gcgggcaccg
      361 ggttgcgtgg ccgtggcggc cgcagctgcc gccagtaggg gcctgtgcgg ggacttccag
      421 ggcccggagg cgggctgcgt gcactcggcg ccgccgcagc ccccaccgac cgggccgctg
      481 tcgcagcccc caccggtgcc tccagccgcc gcggggccac tcgctgggca gccgcgcaag
      541 accagttcgt cgcgccgcaa cgcgtggggc aacctgtcgt acgccgacct catcaccaag
      601 gccatcgaga gctcggcgga gaagaggctc accctgtcgc agatctacga gtggatggtg
      661 aagagtgtgc cctacttcaa ggataagggc gacagcaaca gctcggcggg ctggaagaat
      721 tcaattcgcc acaatctgtc cctacacagc aagtttattc gagtacagaa tgaaggaact
      781 gggaaaagtt cttggtggat gctcaatcca gagggaggca agagtgggaa atcaccccgg
      841 agaagagctg catccatgga caacaacagt aaatttgcta agagccgagg acgggctgct
      901 aagaaaaaag catctctcca gtccgggcaa gagggtcctg gagatagccc tgggtctcag
      961 ttttctaaat ggcctgcaag ccctgggtcc cacagcaatg atgactttga taactggagt
     1021 acatttcgtc ctcgaaccag ctcaaacgct agcaccatca gtgggagact ttctcccatc
     1081 atgacagagc aggatgacct gggggatggg gatgtgcatt ccctggtgta tccaccctct
     1141 gctgccaaga tggcgtctac actgcccagt ctgtctgaaa tcagcaatcc agaaaacatg
     1201 gagaaccttc tggataatct caatcttctc tcatccccaa catctttaac tgtgtcaacc
     1261 cagtcctcgc ctggcagcat gatgcagcag acaccttgct attcatttgc accgccaaac
     1321 accagtctaa attcccccag ccccaactac gcaaagtaca cgtacggcca atccagcatg
     1381 agccctgtgc cccagatgcc tatgcagaca cttcaggaca gcaaatcaag ttatggagga
     1441 ttgaaccagt ataactgtgc cccaggactc ttgaaagagt tgctgacttc tgactctcct
     1501 ccccacaatg atattatgtc accagtcgat cctggagtgg ctcaacccaa cagtcgggtc
     1561 ctgggccaaa atgtactgat gggccctaac tcagtcatgc cagcctatgg cagccaggca
     1621 cctcataaca aaatgatgaa ccccagttcc cacacccacc ctggacatgc acagcaaact
     1681 tcttcagtca atggccgtgc cctgccccat gtggtgaaca ccatgcctca cacatctgcc
     1741 atgaaccgct tgaccccagt gaagacacct ttacaagtgc ctctgtccca ccccatgcag
     1801 atgagtgccc tgggcaacta ctcctctgtg agcagctgca atggctatgg taggatgggt
     1861 gtcctccacc aggagaagct cccaagtgac ttggatggca tgtttattga gcgcttggac
     1921 tgtgacatgg agtccatcat tcggaacgac ctcatggacg gagatacctt ggattttaac
     1981 tttgataatg tgttgcccaa ccaaagcttc ccgcacagtg tcaagactac aacacacagc
     2041 tgggtgtcag gctaggagtt agtgagcagg caacatttaa aagtccttca gattgtctga
     2101 caccgggaac tgaggagcag tccaaagatg cccttcaccc ctccttttag ttttcttgat
     2161 taaaaaaaaa aaatcctttt tcctttcgtc agacttggca gcagaaacac gttcctgtgc
     2221 aggatgtttg cccagcaccc acaggttatg tgctcctgta gataaggact gtgccattgg
     2281 gaatcatgac agcaaagtgc caaactcact acaccactta actgcagaaa agactttccg
     2341 atcctggcgt gctttcaagt cttgtatata tgcagtagat acagaaccgt atctgtgtgt
     2401 gtgtgtgtgt tttttaaatc tactcggccc aaggaaagtt tatactcttt tgtaatactg
     2461 tgatggtctc atgtcttgat ggacttggct gtgtactgcc tgtgctctgc taaggtgatg
     2521 aatcatgaac tgagatctcc attctgcacc tctgctgaat
//
