LOCUS       NM_001108047            3666 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus forkhead box N3 (Foxn3), mRNA.
ACCESSION   NM_001108047 XM_001065012 XM_001065063 XM_001065120 XM_234377
VERSION     NM_001108047.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3666)
  AUTHORS   Karanth,S., Zinkhan,E.K., Hill,J.T., Yost,H.J. and Schlegel,A.
  TITLE     FOXN3 Regulates Hepatic Glucose Utilization
  JOURNAL   Cell Rep 15 (12), 2745-2755 (2016)
   PUBMED   27292639
  REMARK    GeneRIF: the rs8004664 risk allele drives excessive expression of
            FOXN3 during fasting and that FOXN3 regulates fasting blood
            glucose.
REFERENCE   2  (bases 1 to 3666)
  AUTHORS   Samaan,G., Yugo,D., Rajagopalan,S., Wall,J., Donnell,R.,
            Goldowitz,D., Gopalakrishnan,R. and Venkatachalam,S.
  TITLE     Foxn3 is essential for craniofacial development in mice and a
            putative candidate involved in human congenital craniofacial
            defects
  JOURNAL   Biochem Biophys Res Commun 400 (1), 60-65 (2010)
   PUBMED   20691664
REFERENCE   3  (bases 1 to 3666)
  AUTHORS   Busygina,V., Kottemann,M.C., Scott,K.L., Plon,S.E. and Bale,A.E.
  TITLE     Multiple endocrine neoplasia type 1 interacts with forkhead
            transcription factor CHES1 in DNA damage response
  JOURNAL   Cancer Res 66 (17), 8397-8403 (2006)
   PUBMED   16951149
  REMARK    Erratum:[Cancer Res. 2006 Dec 15;66(24):12039]
REFERENCE   4  (bases 1 to 3666)
  AUTHORS   Scott,K.L. and Plon,S.E.
  TITLE     CHES1/FOXN3 interacts with Ski-interacting protein and acts as a
            transcriptional repressor
  JOURNAL   Gene 359, 119-126 (2005)
   PUBMED   16102918
REFERENCE   5  (bases 1 to 3666)
  AUTHORS   Pati,D., Keller,C., Groudine,M. and Plon,S.E.
  TITLE     Reconstitution of a MEC1-independent checkpoint in yeast by
            expression of a novel human fork head cDNA
  JOURNAL   Mol Cell Biol 17 (6), 3037-3046 (1997)
   PUBMED   9154802
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001108047.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.9192.1,
                                           SRR26643298.36743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000006.1  124571931-124572040 c
            111-204             JAXUCZ010000006.1  124464533-124464626 c
            205-761             JAXUCZ010000006.1  124400080-124400636 c
            762-874             JAXUCZ010000006.1  124351766-124351878 c
            875-939             JAXUCZ010000006.1  124297525-124297589 c
            940-1045            JAXUCZ010000006.1  124217330-124217435 c
            1046-3666           JAXUCZ010000006.1  124195701-124198321 c
FEATURES             Location/Qualifiers
     source          1..3666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..3666
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /note="forkhead box N3"
                     /db_xref="GeneID:314374"
                     /db_xref="RGD:1305711"
     exon            1..110
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..204
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /inference="alignment:Splign:2.1.0"
     exon            205..761
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1592
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /note="checkpoint suppressor 1"
                     /codon_start=1
                     /product="forkhead box protein N3"
                     /protein_id="NP_001101517.1"
                     /db_xref="GeneID:314374"
                     /db_xref="RGD:1305711"
                     /translation="MGPVMPASKKPESSGISVSSGLSQRYRGSGFSKALQEDDDLDFP
                     LPDIRLEEGTMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSD
                     MPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKN
                     SVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPPPTPQAYQ
                     STSGPPIWPGSTFFKRNGALLQVSPGVIQNGARVLSRGLFPGARPLPITPIGMTAAIR
                     NSITSCRVRTESEPPCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADD
                     HYEFATKGSQEGSEGSFQSHESHSEPEEDDRKPSQKEGKDALGDSGYASQHRKRQHLA
                     KARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKE
                     QKETAKN"
     exon            762..874
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..939
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1045
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..3666
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcggctg ggagacggcg cgagccggcg gcggggcccc ccgcgagtcc agcgccgctg
       61 cagcccccca atgcggccgc gagaagcagc tggggggcag gcgatcgaag cagcctctag
      121 aagtgtcgtc tagtgattat gaaggcacct ttgtcctttc tggagagatg ctgacctccg
      181 tttcctggac ccattctgac tcaggagcct tcacgtaaat gggtccagtc atgcctgcca
      241 gtaagaagcc cgagagctca ggaatcagtg tgtccagtgg actgagtcag cggtaccggg
      301 gcagtggttt ctccaaggcc ctccaggaag atgatgatct cgacttccct ctgcctgaca
      361 tcagattaga agaggggacc atggaagatg aagagctgac caacctgaac tggttgcacg
      421 agagcaaaaa cttactgaag agctttgggg agtcggtcct gaggagtgtc agtcccgtgc
      481 aggacctgga cgatgatacc ccgccgtccc ccgcccactc ggacatgccc tacgatgcca
      541 ggcagaaccc caactgcaag cccccctact cttttagctg cctcatattc atggccattg
      601 aggactctcc aaccaagcgc ctgccagtga aggatatcta caactggatc ttagaacatt
      661 tcccgtattt tgcaaatgca cctactgggt ggaagaactc agtgagacat aatttgtccc
      721 tgaataagtg tttcaagaaa gtggacaaag agaggagtca gagtattggg aaaggatcat
      781 tgtggtgcat agacccagag tatagacaaa atctaattca ggctttgaaa aagacaccgt
      841 accacccacc tcctactcct caggcttatc aaagcacatc aggtccaccc atctggccgg
      901 gtagtacctt cttcaagaga aatggagccc ttctgcaagt ttctccagga gtgatacaaa
      961 atggagcgag ggttctgagc cgagggctgt ttcctggtgc ccgcccgttg ccaatcactc
     1021 ccattgggat gacggcagcc ataaggaata gcatcaccag ttgccgggtg cggactgaga
     1081 gcgagccgcc atgtggctcc ccagtggtca gtggggaccc caaggaggac cacaactaca
     1141 gtagtgccaa gtcctccaat gcccggagca cctctcccac cagcgactcc atctcctcct
     1201 cctcctcctc agccgacgac cactacgagt ttgccacgaa ggggagccag gagggcagtg
     1261 agggaagctt ccagagccat gagagccaca gcgaaccaga ggaggacgac aggaaaccca
     1321 gccagaagga gggcaaggac gccctggggg acagcggata cgcatcccag cacaggaagc
     1381 gccagcactt ggccaaggcc aggaaagtcc ccagcgacac actgcccctc aaaaagagac
     1441 gcacggagaa gccgcccgag agcgacgatg aggagatgaa ggaggcggcc ggttcgctcc
     1501 tgcacttggc agggattcgg tcctgtttga acaacatcac caatcggacg gccaaggggc
     1561 agaaagaaca aaaggaaacc gcaaaaaatt gaaacaagtc tctgatttgt tttgaactta
     1621 cggccatttg gtttcagcat gtcaggagat ttctaatgat ttgtggcaat atcagcaatt
     1681 tttttctttt tcttttttcc ttttgttggt ttggttttct ttactttctt tccttttttt
     1741 tttttaattt gccccccact cctttgtttt tggaccctta agaattttct gtttaaagga
     1801 gattgaagcc atagaaactc atatcgacac tcagccgttt tacaaaagct tttctttatc
     1861 tgaacacaaa aaccgaaaaa caaaaagcca aaattaacca ttgcttcctg cagcctgtca
     1921 gacctgtgct taaacccaca gggatgttcg tgtcaatgcc acaggaacga ggcacgcaat
     1981 caccaccgct cagcccaacc cttaggttta acaagtcagt tgagcttgga gtgaggctga
     2041 gaagcatttg cagagactga agagcccagg tcccctagaa acagattatc cccaggctct
     2101 ggccctggca tcccacctta ccagaagcgc catcgccatt gccctgtggc aagccggggg
     2161 cctgcctgcc cgtcctctgc acttcccagc cttgagcctg gtaacatctc ccaggttgga
     2221 caccagactg ttcagctgga ttaggtgtca gtgactggaa agggaaagca gggattgtta
     2281 gagccatcga taaccactga gttctgctct atgttaaatc aagaagacgt tccaaaagcc
     2341 ataagcctga aggttggtcc tgtgtacaca cacacacaca cacacacaca cacacacaca
     2401 cacacgactt aaggtgatgt agaaaacacg ctgtgccctc ttaactgcac aaggaaaagc
     2461 aatcgggccc aagaaatgac agtagctgtt aagaaaggaa aatggtgcag attttttcct
     2521 tctatataat ctgatccaag ttgggggtgg ggggtgctac agaaactgcc attagtatta
     2581 tggtgtcttt tcttgaggtt aaaggcacgt ttggtggact caaaaaacaa aaacatggca
     2641 acaatacaac tcctgcactg tcctcaaaaa ttaatatcag tactcatttt tgcaacaaaa
     2701 aagaccagtg attttcacat tcagccagtg tagccagcag aaatttctga tccacaatgc
     2761 atggattcct ttgaagaaac gaaaaaagga aaaaaaaaga aaaagaaaaa aaaatcacaa
     2821 aaacaaactt ttttttattc agaaataaca aagttcttgt aaggtaaatg atgtatttag
     2881 catgaagcat gaattatttt catataaata tagagaatag agagaagact atgcctctaa
     2941 tttttaagcc cttaagctta gaggcccttt gttctttttt ttttcctccc tttttctttc
     3001 ttttttttcc ccctttttct ttctttcttt cttctttttt tgttgtcgtt attattttgt
     3061 ttggtttttt gaagcaggtg tttaaggttt aaccttcttc agggacaaat tctgactgat
     3121 ggggagctta ctctgcaata tcaactatct tcatgctctg gtaggggctt gggtggctga
     3181 gctctatact gccttgtcta cactcagccc cgacccctct gattctctac tgaagagtgt
     3241 gtccttccct ttgtctgtat gtgtttaaca tgacgcaata attcgagggc aaacttagtg
     3301 tgtacgatag aatcaagaga gttgtgggac gcttacttga ggaaaatcat taccgtgatt
     3361 tggttctagg aaaaaggcag tgaataatta tgcaaattcg ccagaggaag gggaaacatg
     3421 ctaatgggcc ttactgggtg agggtaagag atgggtactt gggtaggagg aagtaagtga
     3481 tcgaggggtt ggatggagca gccctgagcc ttccacagcg acggtctgat gtcgcagcaa
     3541 gacgggggct ggccatctct gccacttcaa cacagtgacc accttgggac taagaccacc
     3601 taaatagtga gagctgagta acaaccaaac cacgtcacag aagccagaaa cttcagttac
     3661 ctttgc
//
