LOCUS       NP_001101517             457 aa            linear   ROD 27-MAR-2024
DEFINITION  forkhead box protein N3 [Rattus norvegicus].
ACCESSION   NP_001101517 XP_001065012 XP_001065063 XP_001065120 XP_234377
VERSION     NP_001101517.1
DBSOURCE    REFSEQ: accession NM_001108047.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 457)
  AUTHORS   Karanth,S., Zinkhan,E.K., Hill,J.T., Yost,H.J. and Schlegel,A.
  TITLE     FOXN3 Regulates Hepatic Glucose Utilization
  JOURNAL   Cell Rep 15 (12), 2745-2755 (2016)
   PUBMED   27292639
  REMARK    GeneRIF: the rs8004664 risk allele drives excessive expression of
            FOXN3 during fasting and that FOXN3 regulates fasting blood
            glucose.
REFERENCE   2  (residues 1 to 457)
  AUTHORS   Samaan,G., Yugo,D., Rajagopalan,S., Wall,J., Donnell,R.,
            Goldowitz,D., Gopalakrishnan,R. and Venkatachalam,S.
  TITLE     Foxn3 is essential for craniofacial development in mice and a
            putative candidate involved in human congenital craniofacial
            defects
  JOURNAL   Biochem Biophys Res Commun 400 (1), 60-65 (2010)
   PUBMED   20691664
REFERENCE   3  (residues 1 to 457)
  AUTHORS   Busygina,V., Kottemann,M.C., Scott,K.L., Plon,S.E. and Bale,A.E.
  TITLE     Multiple endocrine neoplasia type 1 interacts with forkhead
            transcription factor CHES1 in DNA damage response
  JOURNAL   Cancer Res 66 (17), 8397-8403 (2006)
   PUBMED   16951149
  REMARK    Erratum:[Cancer Res. 2006 Dec 15;66(24):12039]
REFERENCE   4  (residues 1 to 457)
  AUTHORS   Scott,K.L. and Plon,S.E.
  TITLE     CHES1/FOXN3 interacts with Ski-interacting protein and acts as a
            transcriptional repressor
  JOURNAL   Gene 359, 119-126 (2005)
   PUBMED   16102918
REFERENCE   5  (residues 1 to 457)
  AUTHORS   Pati,D., Keller,C., Groudine,M. and Plon,S.E.
  TITLE     Reconstitution of a MEC1-independent checkpoint in yeast by
            expression of a novel human fork head cDNA
  JOURNAL   Mol Cell Biol 17 (6), 3037-3046 (1997)
   PUBMED   9154802
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001065012.1, XP_001065063.1, XP_234377.4, XP_001065120.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.9192.1,
                                           SRR26643298.36743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     Protein         1..457
                     /product="forkhead box protein N3"
                     /note="checkpoint suppressor 1"
                     /calculated_mol_wt=50234
     Region          114..203
                     /region_name="FH_FOXN3"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     N3 (FOXN3); cd20059"
                     /db_xref="CDD:410833"
     Site            order(119,137..138,141,160..161,163..164,167,174,185..187,
                     189)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410833"
     CDS             1..457
                     /gene="Foxn3"
                     /gene_synonym="Ches1"
                     /coded_by="NM_001108047.2:219..1592"
                     /db_xref="GeneID:314374"
                     /db_xref="RGD:1305711"
ORIGIN      
        1 mgpvmpaskk pessgisvss glsqryrgsg fskalqeddd ldfplpdirl eegtmedeel
       61 tnlnwlhesk nllksfgesv lrsvspvqdl dddtppspah sdmpydarqn pnckppysfs
      121 clifmaieds ptkrlpvkdi ynwilehfpy fanaptgwkn svrhnlslnk cfkkvdkers
      181 qsigkgslwc idpeyrqnli qalkktpyhp pptpqayqst sgppiwpgst ffkrngallq
      241 vspgviqnga rvlsrglfpg arplpitpig mtaairnsit scrvrtesep pcgspvvsgd
      301 pkedhnyssa kssnarstsp tsdsisssss saddhyefat kgsqegsegs fqsheshsep
      361 eeddrkpsqk egkdalgdsg yasqhrkrqh lakarkvpsd tlplkkrrte kppesddeem
      421 keaagsllhl agirsclnni tnrtakgqke qketakn
//
