LOCUS       NM_001100648            4151 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus forkhead box N1 (Foxn1), mRNA.
ACCESSION   NM_001100648 XM_001080864 XM_220632
VERSION     NM_001100648.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4151)
  AUTHORS   Goto,T., Yogo,K., Hochi,S. and Hirabayashi,M.
  TITLE     Characterization of homozygous Foxn1 mutations induced in rat
            embryos by different delivery forms of Cas9 nuclease
  JOURNAL   Mol Biol Rep 50 (2), 1231-1239 (2023)
   PUBMED   36441374
  REMARK    GeneRIF: Characterization of homozygous Foxn1 mutations induced in
            rat embryos by different delivery forms of Cas9 nuclease.
REFERENCE   2  (bases 1 to 4151)
  AUTHORS   Goto,T., Hara,H., Nakauchi,H., Hochi,S. and Hirabayashi,M.
  TITLE     Hypomorphic phenotype of Foxn1 gene-modified rats by CRISPR/Cas9
            system
  JOURNAL   Transgenic Res 25 (4), 533-544 (2016)
   PUBMED   26931321
REFERENCE   3  (bases 1 to 4151)
  AUTHORS   Kushwaha,R., Thodima,V., Tomishima,M.J., Bosl,G.J. and
            Chaganti,R.S.
  TITLE     miR-18b and miR-518b Target FOXN1 during epithelial lineage
            differentiation in pluripotent cells
  JOURNAL   Stem Cells Dev 23 (10), 1149-1156 (2014)
   PUBMED   24383669
REFERENCE   4  (bases 1 to 4151)
  AUTHORS   Zook,E.C., Zhang,S., Gerstein,R.M., Witte,P.L. and Le,P.T.
  TITLE     Enhancing T lineage production in aged mice: a novel function of
            Foxn1 in the bone marrow niche
  JOURNAL   J Immunol 191 (11), 5583-5593 (2013)
   PUBMED   24184560
REFERENCE   5  (bases 1 to 4151)
  AUTHORS   Nowell,C.S., Bredenkamp,N., Tetelin,S., Jin,X., Tischner,C.,
            Vaidya,H., Sheridan,J.M., Stenhouse,F.H., Heussen,R., Smith,A.J.
            and Blackburn,C.C.
  TITLE     Foxn1 regulates lineage progression in cortical and medullary
            thymic epithelial cells but is dispensable for medullary sublineage
            divergence
  JOURNAL   PLoS Genet 7 (11), e1002348 (2011)
   PUBMED   22072979
REFERENCE   6  (bases 1 to 4151)
  AUTHORS   Schlake,T., Schorpp,M., Nehls,M. and Boehm,T.
  TITLE     The nude gene encodes a sequence-specific DNA binding protein with
            homologs in organisms that lack an anticipatory immune system
  JOURNAL   Proc Natl Acad Sci U S A 94 (8), 3842-3847 (1997)
   PUBMED   9108066
REFERENCE   7  (bases 1 to 4151)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,S., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in
            proliferating epithelial and mesenchymal cells of embryonic and
            adult tissues
  JOURNAL   Mol Cell Biol 17 (3), 1626-1641 (1997)
   PUBMED   9032290
REFERENCE   8  (bases 1 to 4151)
  AUTHORS   Schuddekopf,K., Schorpp,M. and Boehm,T.
  TITLE     The whn transcription factor encoded by the nude locus contains an
            evolutionarily conserved and functionally indispensable activation
            domain
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9661-9664 (1996)
   PUBMED   8790387
REFERENCE   9  (bases 1 to 4151)
  AUTHORS   Segre,J.A., Nemhauser,J.L., Taylor,B.A., Nadeau,J.H. and
            Lander,E.S.
  TITLE     Positional cloning of the nude locus: genetic, physical, and
            transcription maps of the region and mutations in the mouse and rat
  JOURNAL   Genomics 28 (3), 549-559 (1995)
   PUBMED   7490093
REFERENCE   10 (bases 1 to 4151)
  AUTHORS   Long,G.M. and May,P.A.
  TITLE     Dynamic visual acuity and contrast sensitivity for static and
            flickered gratings in a college sample
  JOURNAL   Optom Vis Sci 69 (12), 915-922 (1992)
   PUBMED   1300512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 25, 2020 this sequence version replaced NM_001100648.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1054              JAXUCZ010000010.1  63770718-63771771   c
            1055-1206           JAXUCZ010000010.1  63763586-63763737   c
            1207-1668           JAXUCZ010000010.1  63762721-63763182   c
            1669-1782           JAXUCZ010000010.1  63760659-63760772   c
            1783-1913           JAXUCZ010000010.1  63758813-63758943   c
            1914-2010           JAXUCZ010000010.1  63757852-63757948   c
            2011-2218           JAXUCZ010000010.1  63753494-63753701   c
            2219-2710           JAXUCZ010000010.1  63752862-63753353   c
            2711-4151           JAXUCZ010000010.1  63749461-63750901   c
FEATURES             Location/Qualifiers
     source          1..4151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..4151
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /note="forkhead box N1"
                     /db_xref="GeneID:287469"
                     /db_xref="RGD:3970"
     exon            1..1054
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1206
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
     CDS             1084..3030
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /note="winged-helix nude"
                     /codon_start=1
                     /product="forkhead box protein N1"
                     /protein_id="NP_001094118.2"
                     /db_xref="GeneID:287469"
                     /db_xref="RGD:3970"
                     /translation="MVSLLPPHSDVTLPGSTRLEGEPQGDLMQAPGLPGSPAPQNKHA
                     NFSCSSFVPDGPPERAPSLPPHSPSVASPGPEQIQSHCTAGPGPGSFRLSPSDKYPGF
                     GFEEGPAGSPGRFLRGNHMPFHPYKGHFHEDIFSEAQTAMALDGHSFKTQGALEAFEE
                     IPVDVGDAEAFLPSFPAEAWCNGLPYPSQEHNQVLQGSEVKVKPQALDNGPGMYCYQP
                     PLQHVYCSSQPTFHQYSPGGGSYPVPYLGSTHYPYQRIAPQANADGHQPLFPKPIYSY
                     SILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVEN
                     KSGSSSRKGCLWALNPSKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKL
                     GSPLLGCPPPGLAGPGPIRPLAPSAGLTQPLHPMHPAPGPMPGKNPLQDLLGGHAPSC
                     YGQTYPHLSPSLAPSGHQQPLFSQPDGHLDLQAQPGTPQDSPLPAHTPPSHGAKLLAE
                     PSSARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSP
                     TSSSMLPPPPAAHCFPPGPCLAETGNEAGELAPPGSGGSGALGDMHLSTLYSAFVELE
                     PTPSSAAASTAVYLSPGSKPMALA"
     exon            1207..1668
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1782
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1913
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2010
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2218
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2710
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..4151
                     /gene="Foxn1"
                     /gene_synonym="Rnu; RONU; Whn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggattaa aggccttcac cactaaccac tgcctgtcct ttaccttttt tccttgtgtg
       61 tgtgtgtgtg tgtgtgtgtg tgcacgtgat atgggggtct cacaaatgca gcctaggctg
      121 accttaaatt tgtcatcctc ctgcctctgc ctcccagatt acacactatt agctcaacta
      181 ggaaagagtt ctgtctccaa attctttgtc aggtctatcc ccaccactca gggcttcaaa
      241 attcccctcg aaaggtggag ttaggggctt ttccctttct ggctatccaa aggtgtcatg
      301 ttcttgaata tgagaatgcc tactaacctt gaaggggaag ccaccttgct cctagaaaca
      361 agatctgggg gtaggctctt ggtcttggag catgggtgcc agcagaagca ggtaggcaga
      421 agggaggaaa aggcagatca taaatgactc ccaagaagaa aagcaagcat tactgtggat
      481 gaggtctcgg gtggacacga gaggtcccta gagagagatc tctaaggagg gagagtacag
      541 gagggccaat ttcttaagct aggtgtccat agcaagggag aagagaggcc taaaacaatt
      601 ctaggagtag agggtagctt tgagaaccag cctttctttt tttctttcaa atctctttct
      661 gaccatttac aagacaggca tccataggta tgtcaaagac atccatccat ccacctgtct
      721 atccatggcc catctatctg ttcatctgta agtcattcat ctatctcttc atccatcctc
      781 tgtctgtcta tccatcttcc atccaaccac ccacccaact atccatccac ctgtctagag
      841 aggtcagggc tactgggaag ggcctgtggt cctgtggcat ttatggggca tgtgacttgc
      901 ctgcttggcc cggggaggca gtcccacccc tgccctgggg cagggggccg gtcctgacat
      961 gtgggcgtat ttatacctgg atggaggctc ccctgaagct gaaagctgga tgactcccca
     1021 aagccgggat ggtgtcctcg gcccagagcc cactctggct ttcttcgagg ccaggactgg
     1081 gtgatggtgt cgctactccc tccgcactct gacgtcacac ttccaggctc cacccgactg
     1141 gagggcgaac cccaagggga cctcatgcag gctccgggcc tcccaggctc ccctgcccca
     1201 cagaacaagc acgccaactt cagctgctca tcatttgtgc ctgatggccc tccagagagg
     1261 gccccctcgc tgccccccca cagcccaagc gtcgcatctc caggcccaga gcagatccag
     1321 agccactgca cagctggacc tggcccaggc tccttccgcc tttctccctc agacaagtat
     1381 cctggctttg gctttgagga gggcccagca ggcagcccag ggcgcttcct caggggcaac
     1441 cacatgcctt tccaccctta caaggggcac ttccatgaag acatcttctc tgaggcccag
     1501 acggccatgg cgcttgatgg acactccttt aagactcagg gggcactgga agcctttgag
     1561 gagatccctg tggatgtggg ggatgctgag gcctttctgc ctagcttccc agcagaggct
     1621 tggtgcaatg gactccctta ccccagccag gaacacaacc aagttctgca ggggtcagag
     1681 gtcaaggtca agccccaagc tttggacaat ggtcctggga tgtactgcta ccagcctccc
     1741 ttgcagcatg tgtactgttc ttctcagccc acctttcatc agtactcccc gggtggaggc
     1801 agctaccctg tgccctacct gggctccact cactacccct atcagaggat tgcgccccag
     1861 gccaacgcag acggtcacca gccactcttc ccaaagccca tctactccta cagcatcctc
     1921 atcttcatgg cccttaagaa cagcaagacc ggaagccttc cagtcagtga aatctacaat
     1981 ttcatgacgg agcacttccc ttatttcaag actgcgcctg atggctggaa gaattctgtt
     2041 cgccataacc tgtctctcaa caagtgcttt gagaaggtag agaataaatc cggaagttcc
     2101 tcccgaaagg gctgtctgtg ggccctcaat ccttccaaaa tcgacaagat gcaggaagag
     2161 ctgcagaagt ggaagaggaa agaccccatt gctgtgcgca aaagcatggc caaaccagaa
     2221 gagctggaca gcctcatcgg agacaaaagg gagaaactgg gttctcctct gctaggatgt
     2281 ccaccacctg ggctggcagg cccaggtccc atccggcccc tggcaccttc agctggtctt
     2341 acccagcctc tacacccaat gcatccagct ccaggtccca tgcctggcaa gaaccccctg
     2401 caggacctac tgggtggcca tgcaccctcc tgctacgggc agacctaccc acacctttct
     2461 cccagcctgg ccccttctgg acaccagcag ccattgtttt cacagccaga tgggcatctt
     2521 gatctgcagg cccagccagg caccccccag gactcacctc tacctgccca cacaccaccc
     2581 agccacggtg ccaagctgct ggctgagcct tcctcagcca ggaccatgca cgatactctg
     2641 ctaccagacg gagaccttgg cactgacctg gacgccatca acccctctct cactgacttc
     2701 gacttccagg gaaatctgtg ggagcagctg aaggatgaca gcttggccct ggaccccctc
     2761 gtactggtga cctcatcccc aacgtcatcc tccatgttgc cccctccacc agcggcccat
     2821 tgcttccctc cagggccttg tctggcagaa acaggcaatg aggcaggtga actggcacct
     2881 ccaggcagcg gtggctccgg tgctctggga gacatgcacc tcagcaccct ctactcggcc
     2941 tttgtggaac tggaacccac gccctcctca gcagctgcca gcactgccgt gtacctcagt
     3001 cccggctcga agccaatggc tctggcttga gctgtgccca acatcagctc agtgcctagc
     3061 tggctgccca tatagggctc accttaaagg tcaaagaagg aaaacactac ttgtctccta
     3121 tgtcactcag ccaacttatt tgttagccag aagctagggg atccacctag gatgctaccg
     3181 ggtgacgcgc tccacacgcg ggctccagca aggaaagtgt cggaaaagtg acagcgcgcc
     3241 ccctagtgcc aggtcactcg aacttcagct ctcgagtgtc actcaagctc aacccacctg
     3301 ctcatttgat ttctggggca gctgagcgct aaaagcttta gttagcaaag ctcagggcca
     3361 gtgtgacagg tcaaagatca acccccccaa acctcatcat aatccccatt tgctctacag
     3421 gtgtgaccca cttcagtcat attctctccc agaaatctct atttattctc ctatcttaca
     3481 cccttatagc ctacagggtc tcctcccacg tgacctgtga accccttagg gagacagcta
     3541 cttcatagga cttatctatt catcctgagt atatactctg gctggccacc tccagggtga
     3601 cacacagaag ggggcagcat ctaccctggg accaaactga gcccaaatcc aacacaaagt
     3661 gtttggaaag aactcttgtc ctcagaaact tgaacttgtc cccctctctt agtctcagcc
     3721 acaggaaagg ccccttccaa gtggccaagt ctcattcctt ctcaaagagt ggtttcctac
     3781 acttcagacc ccagcttacg agatgctgtc aactgtttca agcatcctgg gtaactagag
     3841 tttgtagccc gccacaggat gtggtgtgtg tgattcacac acacacacac acacacacac
     3901 acacacacac acacacacac acacacacac acctgcatag cagacttggg actcccaggg
     3961 agccggcaga gctgtgattc aaatgcccac catgacccac caagtgggat tctcagcctt
     4021 ccctgggcct gagggcaata agtacctcca taggttgtcc ccaagctcac acaagggtgg
     4081 acggatccct cagtcgtcac ctatcatcat cccctgcctg gaacaataaa gtaagtgcct
     4141 gatggttgca a
//
