LOCUS       NM_031633               3393 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus forkhead box M1 (Foxm1), transcript variant 2,
            mRNA.
ACCESSION   NM_031633
VERSION     NM_031633.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3393)
  AUTHORS   Penailillo,R., Velasquez,V., Acuna-Gallardo,S., Garcia,F.,
            Sanchez,M., Nardocci,G., Illanes,S.E. and Monteiro,L.J.
  TITLE     FOXM1 Participates in Trophoblast Migration and Early Trophoblast
            Invasion: Potential Role in Blastocyst Implantation
  JOURNAL   Int J Mol Sci 25 (3), 1678 (2024)
   PUBMED   38338955
  REMARK    GeneRIF: FOXM1 Participates in Trophoblast Migration and Early
            Trophoblast Invasion: Potential Role in Blastocyst Implantation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3393)
  AUTHORS   Zhai,C., Zhang,N., Wang,J., Cao,M., Luan,J., Liu,H., Zhang,Q.,
            Zhu,Y., Xue,Y. and Li,S.
  TITLE     Activation of Autophagy Induces Monocrotaline-Induced Pulmonary
            Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation
  JOURNAL   Lung 200 (5), 619-631 (2022)
   PUBMED   36107242
  REMARK    GeneRIF: Activation of Autophagy Induces Monocrotaline-Induced
            Pulmonary Arterial Hypertension by FOXM1-Mediated FAK
            Phosphorylation.
REFERENCE   3  (bases 1 to 3393)
  AUTHORS   Monteiro,L.J., Cubillos,S., Sanchez,M., Acuna-Gallardo,S.,
            Venegas,P., Herrera,V., Lam,E.W., Varas-Godoy,M. and Illanes,S.E.
  TITLE     Reduced FOXM1 Expression Limits Trophoblast Migration and
            Angiogenesis and Is Associated With Preeclampsia
  JOURNAL   Reprod Sci 26 (5), 580-590 (2019)
   PUBMED   29848205
  REMARK    GeneRIF: Study shows that reduced FOXM1 expression limits
            Trophoblast migration and angiogenesis and is associated with
            preeclampsia.
REFERENCE   4  (bases 1 to 3393)
  AUTHORS   Zhu,H., Zhu,L.M., Jiang,Y.L., Hu,R.C. and Dai,A.G.
  TITLE     [Effect of HIF-2alpha mediated FoxM1 expression on proliferation of
            pulmonary artery smooth muscle cells in hypoxic rats]
  JOURNAL   Zhonghua Yi Xue Za Zhi 99 (2), 129-134 (2019)
   PUBMED   30669752
  REMARK    GeneRIF: HIF-2alpha up-regulates the expression of FoxM1 and
            promotes the proliferation of pulmonary artery smooth muscle cells
            in hypoxic rats
REFERENCE   5  (bases 1 to 3393)
  AUTHORS   Bourgeois,A., Lambert,C., Habbout,K., Ranchoux,B.,
            Paquet-Marceau,S., Trinh,I., Breuils-Bonnet,S., Paradis,R.,
            Nadeau,V., Paulin,R., Provencher,S., Bonnet,S. and Boucherat,O.
  TITLE     FOXM1 promotes pulmonary artery smooth muscle cell expansion in
            pulmonary arterial hypertension
  JOURNAL   J Mol Med (Berl) 96 (2), 223-235 (2018)
   PUBMED   29290032
  REMARK    GeneRIF: We show for the first time that FOXM1 is implicated in
            pulmonary arterial hypertension development and represents a new
            promising target.
REFERENCE   6  (bases 1 to 3393)
  AUTHORS   Krupczak-Hollis,K., Wang,X., Kalinichenko,V.V., Gusarova,G.A.,
            Wang,I.C., Dennewitz,M.B., Yoder,H.M., Kiyokawa,H., Kaestner,K.H.
            and Costa,R.H.
  TITLE     The mouse Forkhead Box m1 transcription factor is essential for
            hepatoblast mitosis and development of intrahepatic bile ducts and
            vessels during liver morphogenesis
  JOURNAL   Dev Biol 276 (1), 74-88 (2004)
   PUBMED   15531365
REFERENCE   7  (bases 1 to 3393)
  AUTHORS   Chaudhary,J., Mosher,R., Kim,G. and Skinner,M.K.
  TITLE     Role of winged helix transcription factor (WIN) in the regulation
            of Sertoli cell differentiated functions: WIN acts as an early
            event gene for follicle-stimulating hormone
  JOURNAL   Endocrinology 141 (8), 2758-2766 (2000)
   PUBMED   10919260
REFERENCE   8  (bases 1 to 3393)
  AUTHORS   Luscher-Firzlaff,J.M., Westendorf,J.M., Zwicker,J., Burkhardt,H.,
            Henriksson,M., Muller,R., Pirollet,F. and Luscher,B.
  TITLE     Interaction of the fork head domain transcription factor MPP2 with
            the human papilloma virus 16 E7 protein: enhancement of
            transformation and transactivation
  JOURNAL   Oncogene 18 (41), 5620-5630 (1999)
   PUBMED   10523841
REFERENCE   9  (bases 1 to 3393)
  AUTHORS   Yao,K.M., Sha,M., Lu,Z. and Wong,G.G.
  TITLE     Molecular analysis of a novel winged helix protein, WIN. Expression
            pattern, DNA binding property, and alternative splicing within the
            DNA binding domain
  JOURNAL   J Biol Chem 272 (32), 19827-19836 (1997)
   PUBMED   9242644
REFERENCE   10 (bases 1 to 3393)
  AUTHORS   Ye,H., Kelly,T.F., Samadani,U., Lim,L., Rubio,S., Overdier,D.G.,
            Roebuck,K.A. and Costa,R.H.
  TITLE     Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in
            proliferating epithelial and mesenchymal cells of embryonic and
            adult tissues
  JOURNAL   Mol Cell Biol 17 (3), 1626-1641 (1997)
   PUBMED   9032290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Sep 4, 2012 this sequence version replaced NM_031633.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U83112.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000004.1  163325750-163325789
            41-589              JAXUCZ010000004.1  163327831-163328379
            590-738             JAXUCZ010000004.1  163329202-163329350
            739-930             JAXUCZ010000004.1  163331182-163331373
            931-966             JAXUCZ010000004.1  163332113-163332148
            967-1095            JAXUCZ010000004.1  163332727-163332855
            1096-1140           JAXUCZ010000004.1  163333776-163333820
            1141-1210           JAXUCZ010000004.1  163334350-163334419
            1211-3393           JAXUCZ010000004.1  163334590-163336772
FEATURES             Location/Qualifiers
     source          1..3393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3393
                     /gene="Foxm1"
                     /note="forkhead box M1"
                     /db_xref="GeneID:58921"
                     /db_xref="RGD:61807"
     exon            1..40
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..589
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2403
                     /gene="Foxm1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     forkhead box protein M1; INS-1 winged helix; winged-helix
                     factor from INS-1 cells"
                     /codon_start=1
                     /product="forkhead box protein M1 isoform 2"
                     /protein_id="NP_113821.2"
                     /db_xref="GeneID:58921"
                     /db_xref="RGD:61807"
                     /translation="MRTSPRRPLILKRRRLPLPIQNAPSETSEEEAKRSPGQQEPTQA
                     QASQDVAESSSCKFPAGIKIINHPTMPNTQVVAIPNNADIQSIITALTAKGKESGSSG
                     PNKFILISSGGASSHPPDPQSQAQTSTDSKRTELITETLGPKPGAKGVPVPKPPGALP
                     RQRQESCGGEAAGCTLDNSLTNIQWLGKMSSDGLGRCSIKQELEEKENCHLEQNRVKV
                     EAPSRASVSWQDSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIA
                     KPGWKCWHQAYHKLGPQNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQV
                     FKPLEPGSPQSPEHLESQQKRPNPELRRNVTIKTELPLGARRKMKPLLPRVSSYLVPI
                     QFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIAPKVLLSNEGIAPLPATEPM
                     KEEKPLLGEGLLPLLPIQSIKEEVIQPGEDIPHLERPIKVESPPLEEWPSPCASVKEE
                     LSNSWEDSSCSPTPKPKKSYCGLKSPTRCVSEMLVTKRREKREVSRSRRKQHLQPPCL
                     DEPELFFSEDSSTFRPAMEILAESSEPAPQLSCPQEEGGPFKTPIKETLPVSSTPSKS
                     VLSRDPESWRLTPPAKVGGLDFSPVRTPQGAFGPLPDSLGLMELNTTPLKSVPLFDSP
                     RELLNSEAFDLASDPFSSSPPPHLEAKPGSPELQVPSLSANRSLTEGLVLDTMNDSLS
                     KILLDISFPGLEEDPLGPDNINWSQFIPELR"
     exon            590..738
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..930
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..966
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1095
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1140
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1210
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..3393
                     /gene="Foxm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctggctcg gccccgcgtg gagcagcggt ggcctgtgag ggtcaaagct tgtgattctc
       61 gatggagagt gaaagcacag cttcatgatg agaaccagcc cccggcggcc actgattctc
      121 aagagacgga ggctgcccct tcctattcaa aatgccccga gtgaaacctc agaggaagaa
      181 gcaaagagat cccctggaca gcaggagcct actcaagcac aggcctccca agatgtggca
      241 gagtccagct cttgcaaatt tccagctgga atcaagatta tcaaccaccc aaccatgccc
      301 aacacacaag tggtggctat ccccaacaac gcggacatcc agagcatcat cacagcgctg
      361 actgccaaag ggaaagagag tggcagcagt gggcccaaca agttcatcct catcagctct
      421 ggtggggcct catctcatcc tcctgatcct caatctcaag cccaaaccag cactgattcc
      481 aagagaacag aactgatcac cgagacgttg ggaccaaagc caggggctaa gggtgtgcct
      541 gttcccaagc cacctggagc tcttccaagg caaagacagg agagctgtgg tggtgaagcg
      601 gccggctgca cactggacaa cagcttaacc aatatccagt ggcttggaaa gatgagttct
      661 gatgggctgg gccgctgcag cattaagcag gaactggaag agaaggagaa ttgtcacctg
      721 gagcagaatc gggttaaggt tgaggcgccc tcaagagcat cagtgtcttg gcaggactct
      781 gtgtctgaga ggccacccta ctcctatatg gccatgatac agttcgcgat caacagcact
      841 gagaggaagc gtatgacctt gaaggatatc tacacttgga tcgaggacca cttcccttat
      901 tttaagcaca ttgccaagcc aggctggaag tgttggcacc aggcctacca caagctcggg
      961 ccacagaact ctattcgtca caacctttct ctccatgaca tgtttgttcg agaaacatct
     1021 gccaatggca aggtctcctt ctggaccatt cacccaagtg ctaatcgcta cttgacattg
     1081 gaccaagtgt ttaagccact ggaaccaggg tctccacaat cgcccgagca cttggaatca
     1141 cagcagaaac gacccaatcc tgagctccgt agaaatgtga ccatcaaaac tgaactccca
     1201 ctaggcgcac ggcgaaagat gaagccactg ctcccacggg ttagctcata cctggtgccc
     1261 atccagttcc cggtgaacca gtccctggtg ttacagccct cggtgaaggt tcccttgcct
     1321 ctggcagcat ctcttatgag ctcagagctt gcccgtcata gcaagcgagt ccgcattgca
     1381 cccaaggtgc tgctatccaa cgaagggata gccccacttc ctgccacaga acccatgaag
     1441 gaggagaaac ccctgcttgg agaagggcta ttgcctttgc ttcctattca gtccattaag
     1501 gaagaagtaa ttcagcctgg ggaggacata ccacacttag agaggcctat caaagtggag
     1561 agccctccct tggaagagtg gccctctccg tgtgcatcag tgaaagagga actgtccaac
     1621 tcctgggaag attcttcctg ctctcctacc ccaaagccca agaagtccta ttgtgggctt
     1681 aagtccccaa cacggtgtgt ctcagaaatg ctggtgacaa agcggagaga gaagagagag
     1741 gtgagccgat ctcggaggaa gcagcacctt cagccaccct gtctagatga gcctgaactc
     1801 ttcttctcag aggactccag cacatttcgg ccagccatgg agatcctggc agagtcttca
     1861 gagcctgcac cacagctcag ctgccctcag gaggagggag ggcccttcaa gacccccatc
     1921 aaggagacat tgcctgtctc ctccactcct agcaagtctg tgctctctag agaccctgag
     1981 tcctggaggc tcacaccccc agccaaagtt ggggggttag atttcagccc agtacgaacc
     2041 ccccagggtg cctttggccc tctgcctgac tcgctggggc ttatggagct gaataccaca
     2101 cctctgaaaa gtgttcccct cttcgactca ccccgggagc tccttaactc agaagccttt
     2161 gaccttgcct ctgatccctt tagcagttct ccaccaccac atttggaagc caagccaggc
     2221 tcccccgagc tgcaggtccc cagcctttca gccaaccgtt ctctcacaga aggccttgtc
     2281 ctggacacaa tgaatgatag cctcagcaag atccttctag acatcagttt ccctggcctg
     2341 gaggaggacc ctctgggccc tgacaacatc aactggtctc agttcatccc tgagctgcga
     2401 tagaggcagg gtcttaccct tgccactcaa gccaccagtt atcctggcac ttgtgtggct
     2461 ggatagtgca aggctcagtg taccccaaac cgtctgaggg agctagcagg caagggctga
     2521 gcggtgccct ttgacctaat tatgccaagg taaaagccac gtctaagcca ctgctgggac
     2581 ctatgcaagc aataggatct cccagagtcc tccactccct gctggcaagt gaagtgggtg
     2641 tgacagagcc gtgaggacca ggaaatgccc acccattagt cacctgctgc tcctggcagg
     2701 ataacccttg taaatggtgt cagttcccca agttgtcctg taattataaa tgtagccata
     2761 ttcccttagc tctcattatc cagagactgc caggatgggt agggtgacaa ggggttgcat
     2821 tagcttctgc ttgtggcctt tgggggcagg acctgcagtt cagcctcttc acactgtggg
     2881 ttctgctgta ggcttctaga cacacaggtg tccttgccag gaccccactt actgcccttt
     2941 cctcacagct ccccctggtt ctaagccagt ggtactgcat gaagaaatcc tgcggcaaag
     3001 cctattggct ctgggtgtgt ggggacgggt gtgcctgaag caaaagcatg ggtactcacg
     3061 tgagtccttt aggtgtttct ctgatcgtgt tcccaatcat gccagggagt ctagcattga
     3121 gaactcaggc tgaggcctga ggaggaggag gaagtgacca ctgacttgcc tggcttcctt
     3181 agcttgcacc tgagttttgc aaaaagccac cctagacccc actctacaag ctagcacaag
     3241 aacactactg taactaccta ctgaataaag cccaggtggc ctgatctcgg aattgagtga
     3301 ggggtgatgg agcccggaga tgatgggcag gcctgcacct gctgcatggg ccttgcacag
     3361 gttgtctctc cacatccttc tttgactctg aaa
//
