LOCUS       NM_001401861            4981 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus forkhead box K2 (Foxk2), transcript variant 1,
            mRNA.
ACCESSION   NM_001401861 XM_006247890
VERSION     NM_001401861.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4981)
  AUTHORS   Sukonina,V., Ma,H., Zhang,W., Bartesaghi,S., Subhash,S.,
            Heglind,M., Foyn,H., Betz,M.J., Nilsson,D., Lidell,M.E.,
            Naumann,J., Haufs-Brusberg,S., Palmgren,H., Mondal,T., Beg,M.,
            Jedrychowski,M.P., Tasken,K., Pfeifer,A., Peng,X.R., Kanduri,C. and
            Enerback,S.
  TITLE     FOXK1 and FOXK2 regulate aerobic glycolysis
  JOURNAL   Nature 566 (7743), 279-283 (2019)
   PUBMED   30700909
REFERENCE   2  (bases 1 to 4981)
  AUTHORS   He,L., Gomes,A.P., Wang,X., Yoon,S.O., Lee,G., Nagiec,M.J., Cho,S.,
            Chavez,A., Islam,T., Yu,Y., Asara,J.M., Kim,B.Y. and Blenis,J.
  TITLE     mTORC1 Promotes Metabolic Reprogramming by the Suppression of
            GSK3-Dependent Foxk1 Phosphorylation
  JOURNAL   Mol Cell 70 (5), 949-960 (2018)
   PUBMED   29861159
REFERENCE   3  (bases 1 to 4981)
  AUTHORS   Okino,Y., Machida,Y., Frankland-Searby,S. and Machida,Y.J.
  TITLE     BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the
            ubiquitin-mediated activation of FoxK2 target genes
  JOURNAL   J Biol Chem 290 (3), 1580-1591 (2015)
   PUBMED   25451922
REFERENCE   4  (bases 1 to 4981)
  AUTHORS   Bowman,C.J., Ayer,D.E. and Dynlacht,B.D.
  TITLE     Foxk proteins repress the initiation of starvation-induced atrophy
            and autophagy programs
  JOURNAL   Nat Cell Biol 16 (12), 1202-1214 (2014)
   PUBMED   25402684
REFERENCE   5  (bases 1 to 4981)
  AUTHORS   Ji,Z., Donaldson,I.J., Liu,J., Hayes,A., Zeef,L.A. and
            Sharrocks,A.D.
  TITLE     The forkhead transcription factor FOXK2 promotes AP-1-mediated
            transcriptional regulation
  JOURNAL   Mol Cell Biol 32 (2), 385-398 (2012)
   PUBMED   22083952
  REMARK    Erratum:[Mol Cell Biol. 2014 May;34(10):1892]
REFERENCE   6  (bases 1 to 4981)
  AUTHORS   Wijchers,P.J., Hoekman,M.F., Burbach,J.P. and Smidt,M.P.
  TITLE     Identification of forkhead transcription factors in cortical and
            dopaminergic areas of the adult murine brain
  JOURNAL   Brain Res 1068 (1), 23-33 (2006)
   PUBMED   16376864
REFERENCE   7  (bases 1 to 4981)
  AUTHORS   Liu,P.P., Chen,Y.C., Li,C., Hsieh,Y.H., Chen,S.W., Chen,S.H.,
            Jeng,W.Y. and Chuang,W.J.
  TITLE     Solution structure of the DNA-binding domain of interleukin
            enhancer binding factor 1 (FOXK1a)
  JOURNAL   Proteins 49 (4), 543-553 (2002)
   PUBMED   12402362
REFERENCE   8  (bases 1 to 4981)
  AUTHORS   Nirula,A., Moore,D.J. and Gaynor,R.B.
  TITLE     Constitutive binding of the transcription factor interleukin-2
            (IL-2) enhancer binding factor to the IL-2 promoter
  JOURNAL   J Biol Chem 272 (12), 7736-7745 (1997)
   PUBMED   9065434
REFERENCE   9  (bases 1 to 4981)
  AUTHORS   Li,C., Lusis,A.J., Sparkes,R., Nirula,A. and Gaynor,R.
  TITLE     Characterization and chromosomal mapping of the gene encoding the
            cellular DNA binding protein ILF
  JOURNAL   Genomics 13 (3), 665-671 (1992)
   PUBMED   1339390
REFERENCE   10 (bases 1 to 4981)
  AUTHORS   Li,C., Lai,C.F., Sigman,D.S. and Gaynor,R.B.
  TITLE     Cloning of a cellular factor, interleukin binding factor, that
            binds to NFAT-like motifs in the human immunodeficiency virus long
            terminal repeat
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7739-7743 (1991)
   PUBMED   1909027
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 28, 2022 this sequence version replaced XM_006247890.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.68030.1,
                                           SRR26360181.1717298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               JAXUCZ010000010.1  107040933-107041457
            526-720             JAXUCZ010000010.1  107067081-107067275
            721-868             JAXUCZ010000010.1  107069327-107069474
            869-1015            JAXUCZ010000010.1  107071961-107072107
            1016-1209           JAXUCZ010000010.1  107077772-107077965
            1210-1385           JAXUCZ010000010.1  107078664-107078839
            1386-1679           JAXUCZ010000010.1  107080061-107080354
            1680-1889           JAXUCZ010000010.1  107081098-107081307
            1890-4981           JAXUCZ010000010.1  107087769-107090860
FEATURES             Location/Qualifiers
     source          1..4981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..4981
                     /gene="Foxk2"
                     /note="forkhead box K2"
                     /db_xref="GeneID:303753"
                     /db_xref="RGD:1305408"
     exon            1..525
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2086
                     /gene="Foxk2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     forkhead box protein K2"
                     /codon_start=1
                     /product="forkhead box protein K2 isoform 1"
                     /protein_id="NP_001388790.1"
                     /db_xref="GeneID:303753"
                     /db_xref="RGD:1305408"
                     /translation="MAAAAALSGAGAPPAGGGAGGGGSPPGGWAVARLEGREFEYLMK
                     KRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPPGGGHSAAAPEPAQPRPDAGGDF
                     YLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSSEKREKQEAPE
                     SPVKPVQPHISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKMGRV
                     IPSDLNLMADNSQPENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIY
                     THITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLV
                     EQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAP
                     LEPEPGASQPKLAVIQEARFAQSAPGSPLSSQPVLITVQRQLPPAIKPVTYTVATPVT
                     TPTSQPPVVQTVHVVHQIPAVAVTSVAGLAPANTYTVAGQAVVTQAAVLAPKTEPQEN
                     GDHREVRVKVEPVPAISPATLGAASRIIQTSQGTPVQTVTIVQQAPLGQHQLPIKTVT
                     QNGTHVVPMPTAVHSQVNNAVASPLHMLATHASASASLPTKRQNGDQAEQPELKRVKA
                     EDGESIVIALSVDAPPAAVREKAIQN"
     exon            526..720
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..868
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1015
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1209
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1385
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1679
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1889
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..4981
                     /gene="Foxk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagctcccg ccctcgcagc tctcctcgcc ggccggcggt ctccgcgacc gtgctccgct
       61 cgcgcggccc acgaccgcgc ccgggcctcg gcccgctagg gcgcccgcgc ggatcggcca
      121 ggcctcgcag gcgatggcgg ccgcggcggc gctctcgggc gcgggcgccc ctcccgcggg
      181 cggcggggcc gggggcggcg gatccccgcc gggcggctgg gccgtggcgc ggctcgaagg
      241 ccgcgagttc gagtacctca tgaagaagcg ttcggtgacc atcgggcgca actcgtcgca
      301 gggctcggta gatgtgagca tgggccactc gagcttcatc tcgcggcgcc acctggagat
      361 cttcacgccc ccgggcggcg gccatagcgc ggccgccccg gaacccgcgc agccccggcc
      421 ggacgcgggc ggcgacttct acctgcgctg tctcggcaag aacggcgtgt tcgtggacgg
      481 ggtgttccag cggcgggggg cgccgccgct gcagctgccg cgcgtgtgca ctttcaggtt
      541 tccgagcaca aatatcaaga taacattcac agccctatcc agcgagaaaa gagagaagca
      601 ggaagcacct gagtcgccag tgaagcctgt gcagccacac atctcacccc tgaccatcaa
      661 cattccagac acgatggccc acctcatcag cccccttccc tcccccacgg gaactatcag
      721 tgctgcaaac tcctgcccat ccagcccccg gggagcaggg tcttcagggt acaaaatggg
      781 ccgtgtgata ccatctgacc tcaatttaat ggctgacaat tcacagccag aaaatgaaaa
      841 ggaagcttca ggtggagata gcccaaagga tgactcaaaa ccaccttact cctatgcaca
      901 gttgatagta caagcaatta caatggctcc tgataaacaa cttaccctaa atgggatcta
      961 cacacacatc actaagaact atccatacta caggactgcg gacaagggct ggcagaattc
     1021 aatccgccac aatctctctc tgaaccgtta tttcatcaaa gtgccacgtt cccaggaaga
     1081 accaggcaaa ggctccttct ggaggataga tcctgcctcc gagagcaagc tggtagagca
     1141 ggcttttagg aaaagacggc ctaggggcgt gccttgcttt agaacccccc tgggaccact
     1201 ctcctctagg agtgccccag cttctcccaa ccatgctgga gtgctgtctg ctcactccag
     1261 tggcgcccag acccccgaga gcctgtcgag ggaaggctcc ccagccccct tggagcctga
     1321 gcccggtgcc tcacagccca aacttgctgt catccaggag gcgaggtttg cccagagtgc
     1381 accagggtca cctctctcta gtcagcccgt cttaattact gtccagcggc agctaccccc
     1441 ggccattaag cctgtcacct atactgttgc aaccccagtg accacaccca cctctcagcc
     1501 accggtcgtg cagacggtac atgttgtcca tcagatacca gcagtggcgg tcaccagcgt
     1561 ggctggactg gccccagcaa acacatacac agttgctgga caagctgtgg tcactcaggc
     1621 tgcggtgctg gctcctaaga ctgaaccaca agagaatggc gaccacagag aagtcagagt
     1681 gaaagtagaa cctgtccctg caattagccc agccacatta ggcgctgcta gccgaatcat
     1741 ccagacatca cagggcaccc ctgttcagac agtgaccata gtgcagcagg cgcctttagg
     1801 tcaacaccag cttccaataa aaactgtaac gcaaaacgga actcatgtgg taccaatgcc
     1861 tacagcagtg cacagccagg tgaacaatgc agtggcaagt cctctccata tgttggccac
     1921 ccatgcatca gcatcggcat ccctgcccac aaagcgccag aatggtgacc aggcagagca
     1981 gccagagctc aagagagtta aagcagaaga tggggagagc attgtcattg ccctgagtgt
     2041 ggatgcacca ccagcagctg tgagagaaaa ggcgatccag aactagtgtg ggaggccttt
     2101 tcttcagaca tcaactttgt ggtgccaaaa ggagatgctg cctctcactg aagcgggagc
     2161 acatcctcag tgggtaaaag ggccctgcgg ttggacttca cctctcagca ctgaaaacat
     2221 gaacccaggt ggccttaaaa ctccttaatt taaagacatc ttacacttga acagacccac
     2281 aacagcaacc ctggttccag aggtggtgtc tccgacagag cactcgctgg gctgtcgtct
     2341 gtgggctcag cttttactac aagcaagaac tccaggtccc aaaggactga gtctcctgtg
     2401 aggacgcagc acctgctaca agtggacctt gctggctttc ctttagggga cagagccaca
     2461 gccacctgct gcccttatag gatttgctgg ctgtggctga gagacaagac agtattttgt
     2521 tgtccacatg tggaattaga atacttgggg atgtcctttc tttactaaat aatggggtct
     2581 ttgacatttc atatcactcc atttctactc tggaaatttg agattcattt gggggaaagc
     2641 gcgtcattct gtttgtttct gtggtttgat tttagccgtg ggatggtttg ctctagtctg
     2701 tcctgcctgt gtttgggtgg ctctccctta ggacacctac ttgcccgttt cagtttagag
     2761 cagttacttg atgaatttga cctaccttgt gccattgtag agggtgggtg ggctaaggct
     2821 gcatggaccc ttgaggccag ggggcatcgg gataagaaac cctgggagcc ttctagcctt
     2881 caggctgcac gtacctgctc taacttgcgg gttttgttgt ctgttttttt tttatgtaga
     2941 ctttgtcctt ggcgtaattt tccactctag taaaacaagt ctcctacata ttgtgtatgc
     3001 ttaaagcaac agatcccttc ctctctcatg agaagcagat ccaggcctct gtcacacctt
     3061 ttcagaccac gggcataaat ctctctgaga acctggggaa tcttagggtc agctctgact
     3121 tcccactggt tatttgcatg gcacactcat gttggagaga tgttgctggt taacttgagg
     3181 gtcttgggaa tgaggcccca tggccaaata tcaagcgtcc aggccatttt ctgattttca
     3241 agagattttt ctgacttttc agaatgaaat cccacactaa tcctgactta tgtcatgtag
     3301 taagtaaaac tgagagggaa gggtgaggag aggtgggagg ccagcagccc agcccacact
     3361 caggatcacc actcaccttt ccagagcatt ctggacttag agctgagcaa caggcagagg
     3421 gcgttaatct aattgtttgt ttttttttct aatgtcatca tcataacgtt atttatttaa
     3481 atgtagttat tttggtattt aatttttttt aagagagggg gggaaaccct gtattttccg
     3541 ggtagaatga aatggctcag aatggtatat ttaggcaatt ttaaacatta tttacataaa
     3601 gaccaaatat gataagtctg ttctaagtat tgcttcaccc acagtatgga gctgtcacaa
     3661 tgttaatgca gatgatgcgt gttgacatgg agttactgca cacaagctgg atttatataa
     3721 ctcagccact taaacaataa aggtgagaca tcatgtgagt gagaactgtg tgccacagca
     3781 gtctgtctgc ctttggactc gagcccctca agcagcagtc tgcctcttcc atcgttttgc
     3841 aggtaacctc ggactgtctt atctcgtaaa ggtttgcagt ttgcaaagta ctttaaagta
     3901 gtttgggttg tattggcccg gcatgtgcat ccaggctatg gtcctcggtt aatgttgcac
     3961 tagcaagagg ccaccttagt caagggtggg ctcaggtacc accaactgga cacactgtgt
     4021 atctggagac gtgtgtgtag catgcttgac caggacttga ccctatgtga ggtctgcaga
     4081 ctcattacct ctgagcccca gacagacctt atggtctgca ggattttctt ttggggatca
     4141 tagaaaaaat ttaaagatgg aaggattttt ttctttaagg ccaccttctc agtctcaagt
     4201 gagtgaagtg tgctgctagg tgcactcatc ttttctcctt gctgctgtat cggcctcgat
     4261 gctgctttgg tgcataggaa tgtaaagctg ccaaggaggg cagaagctga accgcagact
     4321 cactgagtcc caaacccagg ttttcttccc ggtgtttaag gcactgcttt agttctatgt
     4381 tcatctgagt tcccagaagc ccagaagctg ggcttatctg ctttagcctc cctcaacagc
     4441 tatgatgtgg gacatacgat cctgacacaa gttgcttgca gcagttccca ggtccactgc
     4501 agcaccactg ctgaatgctt aaggagtctc tctttgacct ttaccaaact tctgagctcc
     4561 ctcagggact agataacctc agcagtgttg gcttgaacca cacagaacac aaagggaaac
     4621 tcacctgtgt cctgggtacg gtgcattcca gaatgtgtgt ggcataactt ggtatagcta
     4681 ttccccacac tgcagaatgt attcagacag cagctggtct ccataaacac cccaccccac
     4741 ttccctgtcc tctgctgagg ggctggtcag agtagctgta gtagttcaga aggggttggg
     4801 gagcatcagg acttgggttt tctatgctgt gtgatacaag gagagaagtg acaatcgtga
     4861 agtccaagca tctgcagttc cagagtaagc agagtgctga tctgtgtgca aagatttgga
     4921 atttttaaaa agtaccaagt tcctgaaatt caataaaata tttttattaa ttttaattga
     4981 a
//
